Yimin Chai
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View article: What is the postoperative prognosis of proximal humeral fractures in China? Protocol for a multicentre prospective cohort study (CAST)
What is the postoperative prognosis of proximal humeral fractures in China? Protocol for a multicentre prospective cohort study (CAST) Open
Introduction Proximal humeral fractures are increasingly common, particularly among older people, whereas the prognosis of surgical treatments for these fractures remains substantially uncertain. In China, where the ageing population is ra…
View article: Risk factors of osteonecrosis in patients with systemic lupus erythematosus: a meta-analysis
Risk factors of osteonecrosis in patients with systemic lupus erythematosus: a meta-analysis Open
Background This study aimed to explore risk factors for osteonecrosis in patients with systemic lupus erythematosus by meta-analysis. Methods PubMed, Embase, Web of Science, and Cochrane Library were searched for case–control/cohort studie…
View article: Association between air pollution and risk of non-alcoholic fatty liver disease: an updated meta-analysis
Association between air pollution and risk of non-alcoholic fatty liver disease: an updated meta-analysis Open
Objective: Air pollution is a major environmental risk to human health, with increasing evidence linking it to non-alcoholic fatty liver disease (NAFLD). However, findings remain inconsistent. This meta-analysis aimed to assess the relatio…
View article: Lipopolysaccharide (LPS)-Induced Tumor Necrosis Factor-Alpha (TNF-ɑ) Levels and Health Care Associated Infection (HAI) in Children with Multi-Organ Dysfunction Syndrome (MODS): Correspondence
Lipopolysaccharide (LPS)-Induced Tumor Necrosis Factor-Alpha (TNF-ɑ) Levels and Health Care Associated Infection (HAI) in Children with Multi-Organ Dysfunction Syndrome (MODS): Correspondence Open
View article: Reverse shoulder arthroplasty versus locking plate fixation for proximal humeral fracture dislocations in elderly patients: study protocol for a randomized controlled trial
Reverse shoulder arthroplasty versus locking plate fixation for proximal humeral fracture dislocations in elderly patients: study protocol for a randomized controlled trial Open
View article: Reverse shoulder arthroplasty versus locking plate fixation for proximal humeral fracture dislocations in elderly patients: study protocol for a randomized controlled trial
Reverse shoulder arthroplasty versus locking plate fixation for proximal humeral fracture dislocations in elderly patients: study protocol for a randomized controlled trial Open
Background: Proximal humeral fractures are common injuries in the elderly population, with their incidence expected to rise due to increased life expectancy. A small subset of these fractures may be associated with dislocating forces that …
View article: 3D-bioprinted functional scaffold based on synergistic induction of i-PRF and laponite exerts efficient and personalized bone regeneration via miRNA-mediated TGF-β/Smads signaling
3D-bioprinted functional scaffold based on synergistic induction of i-PRF and laponite exerts efficient and personalized bone regeneration via miRNA-mediated TGF-β/Smads signaling Open
Background: Limited stem cells, low vascularization efficiency, and weak osteoinductive activity plague the repair and reconstruction of bone defects with cell-free scaffolds. Methods: Herein, injectable platelet-rich fibrin (i-PRF) was lo…
View article: Recent advances of chitosan-based composite hydrogel materials in application of bone tissue engineering
Recent advances of chitosan-based composite hydrogel materials in application of bone tissue engineering Open
View article: Semaphorin3C identified as mediator of neuroinflammation and microglia polarization after spinal cord injury
Semaphorin3C identified as mediator of neuroinflammation and microglia polarization after spinal cord injury Open
Excessive neuroinflammation after spinal cord injury (SCI) is a major hurdle during nerve repair. Although proinflammatory macrophage/microglia-mediated neuroinflammation plays important roles, the underlying mechanism that triggers neuroi…
View article: Tensile Stress‐Activated and Exosome‐Transferred YAP/TAZ‐Notch Circuit Specifies Type H Endothelial Cell for Segmental Bone Regeneration
Tensile Stress‐Activated and Exosome‐Transferred YAP/TAZ‐Notch Circuit Specifies Type H Endothelial Cell for Segmental Bone Regeneration Open
The Ilizarov technique has been continuously innovated to utilize tensile stress (TS) for inducing a bone development‐like regenerative process, aiming to achieve skeletal elongation and reconstruction. However, it remains uncertain whethe…
View article: Ultrasmall MnO<sub><i>x</i></sub> Nanodots Catalyze Glucose for Reactive Oxygen Species‐Dependent Sequential Anti‐Infection and Regeneration Therapy
Ultrasmall MnO<sub><i>x</i></sub> Nanodots Catalyze Glucose for Reactive Oxygen Species‐Dependent Sequential Anti‐Infection and Regeneration Therapy Open
The management of diabetic wounds poses significant challenges due to persistent bacterial infections and chronic inflammation caused by hyperglycemia. Herein, a sequential two‐phase treatment strategy involving a reactive oxygen species (…
View article: Black Phosphorus/MnO<sub>2</sub> Nanocomposite Disrupting Bacterial Thermotolerance for Efficient Mild‐Temperature Photothermal Therapy
Black Phosphorus/MnO<sub>2</sub> Nanocomposite Disrupting Bacterial Thermotolerance for Efficient Mild‐Temperature Photothermal Therapy Open
The emergence of multi‐drug resistant (MDR) pathogens is a major public health concern, posing a substantial global economic burden. Photothermal therapy (PTT) at mild temperature presents a promising alternative to traditional antibiotics…
View article: Biomimetic hydrogel derived from decellularized dermal matrix facilitates skin wounds healing
Biomimetic hydrogel derived from decellularized dermal matrix facilitates skin wounds healing Open
Cutaneous wound healing affecting millions of people worldwide represents an unsolvable clinical issue that is frequently challenged by scar formation with dramatical pain, impaired mobility and disfigurement. Herein, we prepared a kind of…
View article: Epidemiological updates of post-traumatic related limb osteomyelitis in china: a 10 years multicentre cohort study
Epidemiological updates of post-traumatic related limb osteomyelitis in china: a 10 years multicentre cohort study Open
Background: Post-traumatic related limb osteomyelitis (PTRLO) is a complex bone infection. Currently, there are no available microbial data on a national scale that can guide appropriate antibiotic selection, and explore the dynamic change…
View article: Cobalt-Doped Mesoporous Silica Coated Magnetic Nanoparticles Promoting Accelerated Bone Healing in Distraction Osteogenesis
Cobalt-Doped Mesoporous Silica Coated Magnetic Nanoparticles Promoting Accelerated Bone Healing in Distraction Osteogenesis Open
This study demonstrated the significant potential of Co-MMSNs to shorten the DO treatment duration and effectively reduce the incidence of complications.
View article: Bacterial Contamination of Open Fractures: Pathogens and Antibiotic Resistance Patterns in East China
Bacterial Contamination of Open Fractures: Pathogens and Antibiotic Resistance Patterns in East China Open
Bacterial contamination of soft tissue in open fractures leads to high infection rates. Pathogens and their resistance against therapeutic agents change with time and vary in different regions. The purpose of this study was to characterize…
View article: Identification and comprehensive analysis of circRNA–miRNA–mRNA regulatory networks in osteoarthritis
Identification and comprehensive analysis of circRNA–miRNA–mRNA regulatory networks in osteoarthritis Open
Osteoarthritis (OA) is a common orthopedic degenerative disease, leading to high disability in activities of daily living. There remains an urgent need to identify the underlying mechanisms and identify new therapeutic targets in OA diagno…
View article: In vivo prevascularization strategy enhances neovascularization of β-tricalcium phosphate scaffolds in bone regeneration
In vivo prevascularization strategy enhances neovascularization of β-tricalcium phosphate scaffolds in bone regeneration Open
This study indicates a novel in vivo prevascularization strategy for growing vasculature on β-TCP scaffolds to be used for repair of large segmental bone defects, might serve as a promising tissue-engineered bone grafts in the future.
View article: Masquelet technique with radical debridement and alternative fixation in treatment of infected bone nonunion
Masquelet technique with radical debridement and alternative fixation in treatment of infected bone nonunion Open
Background Infected bone nonunion is the toughest problem in fracture-related infection, leading to high disability and recurrence. The aim of this study was to evaluate the effectiveness of the Masquelet technique with radical debridement…
View article: miR‐199a‐5p Plays a Pivotal Role on Wound Healing via Suppressing <i>VEGFA</i> and <i>ROCK1</i> in Diabetic Ulcer Foot
miR‐199a‐5p Plays a Pivotal Role on Wound Healing via Suppressing <i>VEGFA</i> and <i>ROCK1</i> in Diabetic Ulcer Foot Open
Diabetes mellitus (DM) is a growing health problem. As a common complication of DM, diabetic foot ulcer (DFU) results in delayed wound healing and is a leading cause of nontraumatic amputation. miR‐199a‐5p, a short noncoding RNA, had abnor…
View article: EGFL6 regulates angiogenesis and osteogenesis in distraction osteogenesis via Wnt/β-catenin signaling
EGFL6 regulates angiogenesis and osteogenesis in distraction osteogenesis via Wnt/β-catenin signaling Open
Background Osteogenesis is tightly coupled with angiogenesis during bone repair and regeneration. However, the underlying mechanisms linking these processes remain largely undefined. The present study aimed to test the hypothesis that epid…
View article: Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis
Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis Open
View article: Accelerated Bone Regeneration by Adrenomedullin 2 Through Improving the Coupling of Osteogenesis and Angiogenesis via β-Catenin Signaling
Accelerated Bone Regeneration by Adrenomedullin 2 Through Improving the Coupling of Osteogenesis and Angiogenesis via β-Catenin Signaling Open
Both osteogenic differentiation and the pro-angiogenic potential of bone marrow mesenchymal stem cells (BMSCs) contribute to bone regeneration during distraction osteogenesis (DO). Adrenomedullin 2 (ADM2), an endogenous bioactive peptide b…
View article: EGFL6&nbsp;Regulates the Interaction Between Angiogenesis and Osteogenesis via Wnt/β-catenin Signaling in Distraction Osteogenesis
EGFL6 Regulates the Interaction Between Angiogenesis and Osteogenesis via Wnt/β-catenin Signaling in Distraction Osteogenesis Open
Background: Osteogenesis is tightly coupled with angiogenesis during bone repair and regeneration. However, the underlying mechanisms linking these processes remain largely undefined. The present study aimed to test the hypothesis that epi…
View article: Additional file 3 of Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis
Additional file 3 of Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis Open
Additional file 3.
View article: Accelerated Bone Regeneration by Astragaloside IV through Stimulating the Coupling of Osteogenesis and Angiogenesis
Accelerated Bone Regeneration by Astragaloside IV through Stimulating the Coupling of Osteogenesis and Angiogenesis Open
Both osteoblasts and preosteoclasts contribute to the coupling of osteogenesis and angiogenesis, regulating bone regeneration. Astragaloside IV (AS-IV), a glycoside of cycloartane-type triterpene derived from the Chinese herb Astragalus…
View article: IL‐1<i>β</i> Impaired Diabetic Wound Healing by Regulating MMP‐2 and MMP‐9 through the p38 Pathway
IL‐1<i>β</i> Impaired Diabetic Wound Healing by Regulating MMP‐2 and MMP‐9 through the p38 Pathway Open
Diabetes mellitus is one of the most prominent metabolic disorders in the world, and insulin resistance in diabetic patients leads to several complications including increased inflammation and delayed wound healing. Fibroblast migration an…
View article: Additional file 2 of Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis
Additional file 2 of Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis Open
Additional file 2.
View article: Jingshu Keli for treating cervical spondylotic radiculopathy: The first multicenter, randomized, controlled clinical trial
Jingshu Keli for treating cervical spondylotic radiculopathy: The first multicenter, randomized, controlled clinical trial Open
This is the first prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial that confirmed the clinical efficacy and safety of Jingshu Keli for treating cervical spondylotic radiculopathy, which can provide evid…
View article: Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis
Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis Open
Background Both advanced glycation end products (AGEs) and AGE-mediated M1 macrophage polarization contribute to bone marrow mesenchymal stem cell (BMSC) dysfunction, leading to impaired bone regeneration in type 1 diabetes mellitus (T1DM)…