Yijuan Zhang
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View article: The Aging Microenvironment is a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer
The Aging Microenvironment is a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer Open
Aging is a critical yet understudied determinant in pancreatic ductal adenocarcinoma (PDAC) risk and outcomes. Despite a strong epidemiological association with age, conventional PDAC preclinical models fail to capture the histopathologica…
View article: 474 Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer
474 Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer Open
View article: ULK1/2 Inhibitors that Degrade ATG13 Effectively Target KRAS-Mutant Cancers
ULK1/2 Inhibitors that Degrade ATG13 Effectively Target KRAS-Mutant Cancers Open
KRAS mutations drive tumorigenesis in multiple cancer types, including lung and pancreatic cancer. Autophagy is a cell survival pathway that supports tumor growth under metabolic stress and has been proposed to be a potential therapeutic a…
View article: Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer
Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer Open
Summary Pancreatic ductal adenocarcinoma (PDAC) tumors are deficient in glutamine, an amino acid that tumor cells and CAFs use to sustain their fitness. In PDAC, both cell types stimulate macropinocytosis as an adaptive response to glutami…
View article: Improving Printing Resolution and Surface Finish by Thermodynamics Control and Process Optimization During High-Precision Micro Laser Powder Bed Fusion (Μ-Lpbf) of Al-Mg-Sc-Zr Alloy
Improving Printing Resolution and Surface Finish by Thermodynamics Control and Process Optimization During High-Precision Micro Laser Powder Bed Fusion (Μ-Lpbf) of Al-Mg-Sc-Zr Alloy Open
View article: Lightweight load-bearing heat dissipation multifunctional pomelo peel-inspired structures fabricated by laser powder bed fusion
Lightweight load-bearing heat dissipation multifunctional pomelo peel-inspired structures fabricated by laser powder bed fusion Open
The heat dissipation structure used in modern airborne radar chassis not only requires lightweight, but also pursues better mechanical properties and heat dissipation performance. In this study, a stochastically porous pomelo …
View article: PSGL-1 deficiency eradicates orthotopic pancreatic ductal adenocarcinoma tumors in combination with anti-PD-1 therapy and enhances T cell anti-tumor immunity
PSGL-1 deficiency eradicates orthotopic pancreatic ductal adenocarcinoma tumors in combination with anti-PD-1 therapy and enhances T cell anti-tumor immunity Open
Background Pancreatic ductal adenocarcinoma (PDAC) is highly refractory to all current immune checkpoint blockade (ICB) therapies and display limited CD8+ T cell infiltration. We previously showed that deficiency of P-selectin glycoprotein…
View article: Data from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells
Data from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells Open
abstractCancer cells reprogram their metabolism to meet elevated energy demands and favor glycolysis for energy production. This boost in glycolytic flux supports proliferation, but also generates acid in the form of hydrogen ions that mus…
View article: Supplementary Figures from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells
Supplementary Figures from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells Open
Supplementary Figures
View article: Supplementary Methods from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells
Supplementary Methods from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells Open
Supplementary Methods
View article: Data from Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness
Data from Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness Open
Although pancreatic ductal adenocarcinoma (PDAC) cells are exposed to a nutrient-depleted tumor microenvironment, they can acquire nutrients via macropinocytosis, an endocytic form of protein scavenging that functions to support cancer met…
View article: Data from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells
Data from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells Open
abstractCancer cells reprogram their metabolism to meet elevated energy demands and favor glycolysis for energy production. This boost in glycolytic flux supports proliferation, but also generates acid in the form of hydrogen ions that mus…
View article: Supplementary Figures from Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness
Supplementary Figures from Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness Open
Supplementary Figures
View article: Supplementary Figures from Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness
Supplementary Figures from Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness Open
Supplementary Figures
View article: Supplementary Methods from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells
Supplementary Methods from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells Open
Supplementary Methods
View article: Supplementary Figures from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells
Supplementary Figures from Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells Open
Supplementary Figures
View article: Data from Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness
Data from Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness Open
Although pancreatic ductal adenocarcinoma (PDAC) cells are exposed to a nutrient-depleted tumor microenvironment, they can acquire nutrients via macropinocytosis, an endocytic form of protein scavenging that functions to support cancer met…
View article: Supplementary Information Figure S1 to S5 from HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1
Supplementary Information Figure S1 to S5 from HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1 Open
Supplementary Information - This file contains Supplemental Procedures, Supplemental References, Supplemental Table1, Supplementary Figure Legends, and Supplementary Figures. Supplemental Procedure describes the methods and PCR primers use…
View article: Supplementary Information Figure S1 to S5 from HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1
Supplementary Information Figure S1 to S5 from HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1 Open
Supplementary Information - This file contains Supplemental Procedures, Supplemental References, Supplemental Table1, Supplementary Figure Legends, and Supplementary Figures. Supplemental Procedure describes the methods and PCR primers use…
View article: Data from HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1
Data from HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1 Open
Studies of the estrogen receptor (ER) coactivator protein Mediator subunit 1 (MED1) have revealed its specific roles in pubertal mammary gland development and potential contributions to breast tumorigenesis, based on coamplification of MED…
View article: Data from HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1
Data from HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1 Open
Studies of the estrogen receptor (ER) coactivator protein Mediator subunit 1 (MED1) have revealed its specific roles in pubertal mammary gland development and potential contributions to breast tumorigenesis, based on coamplification of MED…
View article: Total Protein Content, Amino Acid Composition and Eating-Quality Evaluation of Foxtail Millet (Setaria italica (L.) P. Beauv)
Total Protein Content, Amino Acid Composition and Eating-Quality Evaluation of Foxtail Millet (Setaria italica (L.) P. Beauv) Open
Foxtail millet has attracted substantial attention in recent years because of its excellent properties as a cereal crop with high nutritional value. Although the cultivation area of foxtail millet keeps growing, the fundamental research in…
View article: Role of miRNAs in regulation of SA-mediated upregulation of genes involved in folate and methionine metabolism in foxtail millet
Role of miRNAs in regulation of SA-mediated upregulation of genes involved in folate and methionine metabolism in foxtail millet Open
The effect of exogenous salicylic acid (SA) on folate metabolism and the related gene regulatory mechanisms is still unclear. In this study, the panicle of foxtail millet treated with different SA concentrations showed that 6 mM SA doubled…
View article: Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma
Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma Open
In pancreatic ductal adenocarcinoma (PDAC), glutamine is a critical nutrient that drives a wide array of metabolic and biosynthetic processes that support tumor growth. Despite this established dependency, the targeting of specific enzymes…
View article: 1030 PSGL-1-deficiency suppresses tumor growth of orthotopic pancreatic ductal adenocarcinoma tumors and enhances immune cell infiltration and CD8<sup>+</sup> T cell responses
1030 PSGL-1-deficiency suppresses tumor growth of orthotopic pancreatic ductal adenocarcinoma tumors and enhances immune cell infiltration and CD8<sup>+</sup> T cell responses Open
Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, poorly immunogenic cancer that is increasing in incidence. PDAC tumors are highly refractory to all currently available treatments including existing immune checkpoint bl…
View article: Functional characterisation of SiFPGS2 gene of foxtail millet in folates accumulation and root development
Functional characterisation of SiFPGS2 gene of foxtail millet in folates accumulation and root development Open
Folates content in foxtail millet (Setaria italica) are higher than that in major crops. Polyglutamylation of folates could enhance their compartmentalization, reducing their transport, increase their affinities with enzymes and increase t…
View article: Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes
Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes Open
Macropinocytosis is a non-specific fluid-phase uptake pathway that allows cells to internalize large extracellular cargo, such as proteins, pathogens, and cell debris, through bulk endocytosis. This pathway plays an essential role in a var…
View article: Clinical effect of TESSYS technique under spinal endoscopy combined with drug therapy in patients with lumbar disc herniation and its effect on quality of life and serum inflammatory factors: results of a randomized trial
Clinical effect of TESSYS technique under spinal endoscopy combined with drug therapy in patients with lumbar disc herniation and its effect on quality of life and serum inflammatory factors: results of a randomized trial Open
Chinese Clinical Trial Registry ChiCTR2100049153.
View article: [Diagnosis and treatment of the fourth branchial fissure: a clinical report of 1 case and literature review].
[Diagnosis and treatment of the fourth branchial fissure: a clinical report of 1 case and literature review]. Open
The patient repeatedly suffer from pain in the left side neck for 4 years and had 1-2 recurrence per year. We used neck ultrasound and neck CT examination to find an abnormal soft tissue lumps exist in the patient's left neck root …
View article: The response of surface ozone to current mitigation strategies for reducing air pollution in Chinese megacity clusters
The response of surface ozone to current mitigation strategies for reducing air pollution in Chinese megacity clusters Open
<p>China, with rapid urbanization and industrialization, has experienced severe air quality deterioration in recent decades. To release heavy air pollution in China, Chinese government implement the Clean Air Action Plan initiated in…