Ying Chen
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View article: A study on strategies to optimize bladder volume consistency in radiotherapy patients
A study on strategies to optimize bladder volume consistency in radiotherapy patients Open
Multi-step workflow optimization reduced the standard deviation of differences between CBCT-derived and scanner-derived bladder volumes (VCBCT and VHD5), decreased the absolute volume discrepancy (|VCBCT-V<…
View article: Homology Modeling of Sesame Allergenic Protein and Prediction of B-Cell Linear Antigenic Epitopes Using Immunoinformatic Tools
Homology Modeling of Sesame Allergenic Protein and Prediction of B-Cell Linear Antigenic Epitopes Using Immunoinformatic Tools Open
Sesame (Sesamum indicum L.) has emerged as a significant food allergen and is now classified among the “Big Eight” allergens due to its increasing prevalence and potential to cause severe allergic reactions, including anaphylaxis. Seven se…
View article: Berberine Alleviates Intestinal Inflammation by Disrupting Pathological Macrophage–Epithelial Crosstalk in Macrophage–Organoid Co-Culture Model
Berberine Alleviates Intestinal Inflammation by Disrupting Pathological Macrophage–Epithelial Crosstalk in Macrophage–Organoid Co-Culture Model Open
Berberine (BBR), a benzylisoquinoline alkaloid isolated from Chinese herb Coptis chinensis, has been widely used clinically to treat intestinal infectious diseases. Recently, it has been found to have multiple pharmacological effects, incl…
View article: Exploring prognostic genes in the immune microenvironment of acute myeloid leukemia via weighted gene co-expression network analysis
Exploring prognostic genes in the immune microenvironment of acute myeloid leukemia via weighted gene co-expression network analysis Open
Background: Acute myeloid leukemia (AML) is a heterogeneous blood cancer that arises from transformed myeloid precursor cells in a compromised bone marrow microenvironment. This environment is essential for AML initiation, progression, and…
View article: Towards a global framework of entrustable professional activities for undergraduate clinical laboratory interns: a competency-based approach
Towards a global framework of entrustable professional activities for undergraduate clinical laboratory interns: a competency-based approach Open
Objectives The aim of this study is to develop a core competency-based EPAs framework for undergraduate interns in the clinical laboratory. Methods The EPAs framework was developed in three stages: formation of a research team, drafting of…
View article: Comparative analysis of biological activities and phytochemical constituents between <i>Pegaeophyton scapiflorum</i> and <i>Solms-laubachia eurycarpa</i> revealed by UPLC-Q-Orbitrap HRMS-based metabolomics
Comparative analysis of biological activities and phytochemical constituents between <i>Pegaeophyton scapiflorum</i> and <i>Solms-laubachia eurycarpa</i> revealed by UPLC-Q-Orbitrap HRMS-based metabolomics Open
Pegaeophyton scapiflorum (DHJ) and Solms-laubachia eurycarpa (KGCF) are perennial herbs from the cruciferous family. Historically, these two herbs have been documented to be effective in clearing lung heat and have been widely used clinica…
View article: Investigating the Mechanism of Yiqi Huoxue Jieyu Granules Against Ischemic Stroke Through Network Pharmacology, Molecular Docking and Experimental Verification
Investigating the Mechanism of Yiqi Huoxue Jieyu Granules Against Ischemic Stroke Through Network Pharmacology, Molecular Docking and Experimental Verification Open
Background: Ischemic stroke (IS) is a significant cause of global mortality and disability. Yiqi Huoxue Jieyu granules (YHJGs) show therapeutic potential for IS, but their mechanisms remain unclear. This study investigated YHJGs’ effects t…
View article: Comparing Two Varieties of Blood Orange: A Differential Methylation Region Within the Specific Encoding Sequence of a Retrotransposon Adjacent to the Ruby Locus
Comparing Two Varieties of Blood Orange: A Differential Methylation Region Within the Specific Encoding Sequence of a Retrotransposon Adjacent to the Ruby Locus Open
The blood orange arose from the insertion of a retrotransposon adjacent to the Ruby gene, an MYB-type transcriptional activator of anthocyanin production, as reported previously. However, the intricate process of anthocyanin regulation amo…
View article: Dihydroartemisinin enhances remyelination by switching microglia to the reparative phenotype
Dihydroartemisinin enhances remyelination by switching microglia to the reparative phenotype Open
By highlighting the importance of microglia in promoting myelin regeneration, our study proved DHA as a promising candidate for promoting remyelination.
View article: Saccharomyces boulardii (CNCM I-745) improves intestinal damage in sepsis by remodeling intestinal flora structure
Saccharomyces boulardii (CNCM I-745) improves intestinal damage in sepsis by remodeling intestinal flora structure Open
Background Sepsis is one of the leading causes of mortality among intensive care unit (ICU) patients. The intestinal tract is the primary organ affected by sepsis, resulting in dysbiosis of the gut microbiota and negatively impacting long-…
View article: Correlation analysis of satisfaction with subspecialty management model in operating rooms: a cross-sectional survey in China
Correlation analysis of satisfaction with subspecialty management model in operating rooms: a cross-sectional survey in China Open
The sub-specialty management model for operating rooms has markedly enhanced the professionalism and safety of surgical procedures, emerging as a pivotal trend in contemporary operating room management. The creation of a specialized manage…
View article: Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis
Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis Open
Background Acute liver injury (ALI) requires rapid hepatic regeneration to avert fatal liver failure. As key mechanisms, systemic metabolic remodeling and inter-organ crosstalk are critical for this regenerative process. Skeletal muscle, a…
View article: YTHDF1-mediated mitochondrial dysfunction and allergic airway inflammation by interaction with β-catenin/TCF4 signaling
YTHDF1-mediated mitochondrial dysfunction and allergic airway inflammation by interaction with β-catenin/TCF4 signaling Open
YTHDF1-mediated mitochondrial dysfunction and allergic airway inflammation by interaction with β-catenin/TCF4 signaling.
View article: Development and validation of a nomogram model for predicting postoperative delirium in elderly patients with oral cancer: a retrospective study
Development and validation of a nomogram model for predicting postoperative delirium in elderly patients with oral cancer: a retrospective study Open
We developed a new predictive model to predict risk factors for POD in elderly oral cancer patients. The nomogram can help physicians assess POD quickly and effectively.
View article: Preoperative CT-derived sarcopenia as a predictor of postoperative complications in patients undergoing laparoscopic radical resection for non-metastatic colorectal cancer: a retrospective study
Preoperative CT-derived sarcopenia as a predictor of postoperative complications in patients undergoing laparoscopic radical resection for non-metastatic colorectal cancer: a retrospective study Open
View article: αSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis
αSnap plays a pivotal role in the maintenance of Drosophila ISCs survival and tissue homeostasis Open
View article: Effects of Methyl Farnesoate on the Growth and Antioxidant Capacity of Neocaridina denticulata
Effects of Methyl Farnesoate on the Growth and Antioxidant Capacity of Neocaridina denticulata Open
Sesquiterpenoid hormones are widely present in arthropods and play crucial roles in growth, molting and reproduction. Methyl farnesoate (MF) functions similarly to juvenile hormone (JH) in crustaceans, playing a broad regulatory role in th…
View article: Increasing age in men is negatively associated with sperm quality and DNA integrity but not pregnancy outcomes in assisted reproductive technology
Increasing age in men is negatively associated with sperm quality and DNA integrity but not pregnancy outcomes in assisted reproductive technology Open
As the fertility risks for older males such as infertility and reduced success rates are on the rise, an increasing number of individuals are turning to Assisted Reproductive Technology (ART) to have offspring. However, the influence of pa…
View article: A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer
A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer Open
View article: A Cross-Tissue Transcriptome-Wide Association Study Reveals Novel Susceptibility Genes for Diabetic Kidney Disease in the FinnGen Cohort
A Cross-Tissue Transcriptome-Wide Association Study Reveals Novel Susceptibility Genes for Diabetic Kidney Disease in the FinnGen Cohort Open
Background/Objectives: Diabetic kidney disease (DKD) is a common diabetic complication, driven by a multifactorial pathogenesis that includes various genetic components. However, the precise causative genes and their underlying biological …
View article: Human umbilical cord mesenchymal stem cell therapy for atopic dermatitis through inhibition of neutrophil chemotaxis
Human umbilical cord mesenchymal stem cell therapy for atopic dermatitis through inhibition of neutrophil chemotaxis Open
View article: Mechanism of valproic acid-induced hepatic steatosis via enhancing NRF2-FATP2-mediated fatty acid uptake
Mechanism of valproic acid-induced hepatic steatosis via enhancing NRF2-FATP2-mediated fatty acid uptake Open
Rationale: Valproic acid (VPA), a first-line antiepileptic drug, can induce life-threatening hepatic steatosis with prolonged use; however, the underlying mechanisms remain inadequately elucidated. Nuclear factor E2-related factor 2…
View article: The crucial role of neutrophil extracellular traps and IL-17 signaling in indomethacin-induced gastric injury in mice
The crucial role of neutrophil extracellular traps and IL-17 signaling in indomethacin-induced gastric injury in mice Open
The homeostasis of gastric mucosa is extremely delicate. Neutrophils, the most abundant immune cells in human circulation, are regarded crutial in the regulation of gastric mucosal immune response. Non-steroidal anti-inflammatory drugs (NS…
View article: Effects of the subanesthetic dose of esketamine on postoperative sleep quality in patients undergoing modified radical mastectomy: a randomized, double-blind controlled trial
Effects of the subanesthetic dose of esketamine on postoperative sleep quality in patients undergoing modified radical mastectomy: a randomized, double-blind controlled trial Open
Background Breast cancer is the most common malignant tumor among women worldwide. Surgical intervention is a critical component of treatment, yet the associated stress and anxiety can significantly disrupt postoperative sleep quality. Eme…
View article: Global research frontiers and thematic trends in opioid-free anesthesia over the past 20 years: a bibliometric analysis
Global research frontiers and thematic trends in opioid-free anesthesia over the past 20 years: a bibliometric analysis Open
Objective Opioids have constituted an essential element of general anesthesia for a considerable length of time. However, with the increase in opioid misuse and associated postoperative adverse effects, studies related to opioid-free anest…
View article: Inhibition of Putative Ibrutinib Targets Promotes Atrial Fibrillation, Conduction Blocks, and Proarrhythmic Electrocardiogram Indices: A Mendelian Randomization Analysis
Inhibition of Putative Ibrutinib Targets Promotes Atrial Fibrillation, Conduction Blocks, and Proarrhythmic Electrocardiogram Indices: A Mendelian Randomization Analysis Open
Background The mechanism by which ibrutinib, a Bruton's tyrosine kinase inhibitor, can elevate the risk of arrhythmias is not fully elucidated. In this study, we explored how inhibition of off‐target kinases can contribute to this phenomen…
View article: Repeat-dose toxicity of human umbilical cord mesenchymal stem cells via subcutaneous injection in NOG mice
Repeat-dose toxicity of human umbilical cord mesenchymal stem cells via subcutaneous injection in NOG mice Open
Background Stem cell therapy shows promise for treating skin diseases and enhancing medical aesthetics. However, safety data for subcutaneous injection of stem cells remain limited. In this study, we evaluated the toxicity of human umbilic…
View article: The Opioid-Sparing Effects of Intraoperative Esketamine Combined with Dexmedetomidine During Laparoscopic Major Abdominal Surgery: A Randomized Controlled Double-Blind Trial
The Opioid-Sparing Effects of Intraoperative Esketamine Combined with Dexmedetomidine During Laparoscopic Major Abdominal Surgery: A Randomized Controlled Double-Blind Trial Open
ChiCTR2200060130.
View article: Exploration of Conditions for the Scaled Application of Laparoscopic Ovum Pick-Up in Sheep and Comparison of Follicular Development Differences Among Breeds
Exploration of Conditions for the Scaled Application of Laparoscopic Ovum Pick-Up in Sheep and Comparison of Follicular Development Differences Among Breeds Open
In small ruminants, laparotomy for ovarian exploration followed by oocyte collection has been progressively replaced by laparoscopic puncture of follicles, which has become an important method for obtaining oocytes in vivo. However, the su…
View article: Electroacupuncture alleviates functional constipation by upregulating host-derived miR-205-5p to modulate gut microbiota and tryptophan metabolism
Electroacupuncture alleviates functional constipation by upregulating host-derived miR-205-5p to modulate gut microbiota and tryptophan metabolism Open
Electroacupuncture (EA) has shown promise as a treatment for Functional constipation (FC), with growing evidence suggesting it may enhance gut motility. MicroRNAs (miRNAs) serve as key regulatory molecules mediating host-microbiota interac…