Yikun Sun
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View article: Therapeutic effects of glial cell-derived extracellular vesicles on ischemic stroke in rodent models: A systematic review and meta-analysis
Therapeutic effects of glial cell-derived extracellular vesicles on ischemic stroke in rodent models: A systematic review and meta-analysis Open
View article: Pathological mechanisms and future therapeutic directions of thrombin in intracerebral hemorrhage: a systematic review
Pathological mechanisms and future therapeutic directions of thrombin in intracerebral hemorrhage: a systematic review Open
Intracerebral hemorrhage (ICH), a common subtype of hemorrhagic stroke, often causes severe disability or death. ICH induces adverse events that might lead to secondary brain injury (SBI), and there is currently a lack of specific effectiv…
View article: Elucidating the Mechanism of Shuangxia Decoction and its Core Compound Rosmarinic Acid Counteract Sleep Deprivation Using Progressive Metabolomics Approaches and Gut Microbiota Analysis
Elucidating the Mechanism of Shuangxia Decoction and its Core Compound Rosmarinic Acid Counteract Sleep Deprivation Using Progressive Metabolomics Approaches and Gut Microbiota Analysis Open
View article: Characterization of the Active Ingredient and Prediction of the Potential Mechanism of Dahuoluo Pill via Mass Spectrometry with the Network Pharmacology Method
Characterization of the Active Ingredient and Prediction of the Potential Mechanism of Dahuoluo Pill via Mass Spectrometry with the Network Pharmacology Method Open
The Dahuoluo pill (DHLP) is a classic Chinese patent medicine used to treat rheumatoid arthritis and other conditions. However, there has been no research on the chemical components of DHLP and the mechanisms by which it ameliorates rheuma…
View article: Effects of Xinglou Chengqi decoction on central and peripheral immune inflammation in mice with AIS are correlated with intestinal flora
Effects of Xinglou Chengqi decoction on central and peripheral immune inflammation in mice with AIS are correlated with intestinal flora Open
Objective: To explore the effect of Xinglou Chengqi decoction (XCD) on the brain-gut axis in mice with acute ischemic stroke. Methods: A cerebral ischemia-reperfusion model identified as phlegm-heat and fu-organ excess pattern was establis…
View article: Promoted Skin Wound Healing by Tail-Amputated<i>Eisenia foetida</i>Proteins via the Ras/Raf/MEK/ERK Signaling Pathway
Promoted Skin Wound Healing by Tail-Amputated<i>Eisenia foetida</i>Proteins via the Ras/Raf/MEK/ERK Signaling Pathway Open
Skin wound healing is an important fundamental problem in biological and medical fields. This study aimed to investigate wound healing promotion of protein extract from tail-amputated Eisenia foetida (E. foetida) and reveal t…
View article: Investigating the Active Substance and Mechanism of San-Jiu-Wei-Tai Granules via UPLC-QE-Orbitrap-MS and Network Pharmacology
Investigating the Active Substance and Mechanism of San-Jiu-Wei-Tai Granules via UPLC-QE-Orbitrap-MS and Network Pharmacology Open
San-Jiu-Wei-Tai granules (SJWTG) are a significant Chinese patent medicine for the treatment of chronic gastritis (CG), having outstanding advantages in long-term treatment; however, the chemical composition and potential mechanism have no…
View article: Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Berberine in the Treatment of Ischaemic Stroke
Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Berberine in the Treatment of Ischaemic Stroke Open
Aim. To elucidate the mechanism of action of berberine on ischaemic stroke based on network pharmacology, bioinformatics, and experimental verification. Methods. Berberine-related long noncoding RNAs (lncRNAs) were screened from public dat…
View article: Targeting the multifaceted roles of mitochondria in intracerebral hemorrhage and therapeutic prospects
Targeting the multifaceted roles of mitochondria in intracerebral hemorrhage and therapeutic prospects Open
View article: Discovery of the Potential Novel Pharmacodynamic Substances From Zhi-Zi-Hou-Po Decoction Based on the Concept of Co-Decoction Reaction and Analysis Strategy
Discovery of the Potential Novel Pharmacodynamic Substances From Zhi-Zi-Hou-Po Decoction Based on the Concept of Co-Decoction Reaction and Analysis Strategy Open
Background: Zhi-Zi-Hou-Po Decoction (ZZHPD), a classic traditional Chinese medicine (TCM) formula, is clinically used to treat insomnia and depression. The analysis strategy based on the concept of co-decoction of TCM is helpful to analyse…
View article: Preliminary Study on Potential Compounds and Mechanism of Chuanxiong Chatiao Granules in Treating Migraine
Preliminary Study on Potential Compounds and Mechanism of Chuanxiong Chatiao Granules in Treating Migraine Open
View article: Effect of Xingnaojing injection on penumbra transformation in rats with acute cerebral ischemia
Effect of Xingnaojing injection on penumbra transformation in rats with acute cerebral ischemia Open
Objective: To observe the effect of Xingnaojing injection on penumbra transformation
\nin rats with acute cerebral ischemia. Methods: The rat model of middle cerebral artery
\nocclusion(Middle cerebral artery occlusion, MCAO) was establish…
View article: Investigating the active substance and mechanism of Jing-Fu-Kang granules via mass spectrometry technology and network pharmacology method
Investigating the active substance and mechanism of Jing-Fu-Kang granules via mass spectrometry technology and network pharmacology method Open
Jing-Fu-Kang granules (JFKG) is a famous Chinese patent medicine for the treatment of cervical spondylosis around the China, whereas the active substance and mechanism are not completely investigated clearly. In the current study, a rapid …
View article: Global Analysis the Potential Medicinal Substances of Shuangxia Decoction and the Process In Vivo via Mass Spectrometry Technology
Global Analysis the Potential Medicinal Substances of Shuangxia Decoction and the Process In Vivo via Mass Spectrometry Technology Open
Shuangxia decoction is an effective traditional Chinese medicine formula for treating insomnia. Up to now, there has not been any report about the effective substances. An omics data processing method based on mass spectrometry technology …
View article: Integrated Screening of Effective Anti-Insomnia Fractions of Zhi-Zi-Hou-Po Decoction via <i>Drosophila melanogaster</i> and Network Pharmacology Analysis of the Underlying Pharmacodynamic Material and Mechanism
Integrated Screening of Effective Anti-Insomnia Fractions of Zhi-Zi-Hou-Po Decoction via <i>Drosophila melanogaster</i> and Network Pharmacology Analysis of the Underlying Pharmacodynamic Material and Mechanism Open
[Image: see text] Insomnia is an anabatic epidemiology, while the mechanism is extremely complicated; it remains one of the major scientific challenges in life sciences. Because of the advantage of having a similar genetic background and c…
View article: Integrating UPLC-QE-Orbitrap-MS technology and network pharmacological method to reveal the mechanism of Bailemian capsule to relieve insomnia
Integrating UPLC-QE-Orbitrap-MS technology and network pharmacological method to reveal the mechanism of Bailemian capsule to relieve insomnia Open
Bailemian capsule (BLMC) is a Chinese patent drug for treating insomnia with excellent curative effects. But there are few researches on it. In this research, a rapid separation and identification method using UPLC-QE-Orbitrap-MS was estab…
View article: LC–MS-Based Qualitative Analysis and Pharmacokinetic Integration Network Pharmacology Strategy Reveals the Mechanism of <i>Phlomis brevidentata</i> H.W.Li Treatment of Pneumonia
LC–MS-Based Qualitative Analysis and Pharmacokinetic Integration Network Pharmacology Strategy Reveals the Mechanism of <i>Phlomis brevidentata</i> H.W.Li Treatment of Pneumonia Open
Phlomis brevidentata H.W.Li Radix (PbR) is a rare traditional Tibetan medicine, and it is widely used in the Chinese Tibetan region for the treatment of pharyngitis, pneumonia, and so forth. Nevertheless, there is very little…
View article: Bidirectional regulation of i-type lysozyme on cutaneous wound healing
Bidirectional regulation of i-type lysozyme on cutaneous wound healing Open
View article: Correction to: Shuangxia decoction alleviates p-chlorophenylalanine induced insomnia through the modification of serotonergic and immune system
Correction to: Shuangxia decoction alleviates p-chlorophenylalanine induced insomnia through the modification of serotonergic and immune system Open
View article: Oxidative Stress-Mediated Blood-Brain Barrier (BBB) Disruption in Neurological Diseases
Oxidative Stress-Mediated Blood-Brain Barrier (BBB) Disruption in Neurological Diseases Open
The blood-brain barrier (BBB), as a crucial gate of brain-blood molecular exchange, is involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused by an imbalance between the production of reactive oxygen spe…
View article: In Vitro Evaluation of the Neuroprotective Effect of <i>Panax notoginseng</i> Saponins by Activating the EGFR/PI3K/AKT Pathway
In Vitro Evaluation of the Neuroprotective Effect of <i>Panax notoginseng</i> Saponins by Activating the EGFR/PI3K/AKT Pathway Open
Context . About 15 million people worldwide suffer strokes each year and 5 million people are left with permanent disabilities which is due to the loss of local blood supply to the brain, resulting in a neurologic deficit. Panax notoginsen…
View article: The up-regulation of two identified wound healing specific proteins-HSP70 and lysozyme in regenerated Eisenia fetida through transcriptome analysis
The up-regulation of two identified wound healing specific proteins-HSP70 and lysozyme in regenerated Eisenia fetida through transcriptome analysis Open
View article: Panax notoginseng saponins promotes cerebral recovery from ischemic injury by downregulating LINGO-1 and activating the EGFR/PI3K/AKT signaling pathways in vivo
Panax notoginseng saponins promotes cerebral recovery from ischemic injury by downregulating LINGO-1 and activating the EGFR/PI3K/AKT signaling pathways in vivo Open
Objective: Panax notoginseng saponins (PNS), extracted from rhizome of the herb Radix et Rhizoma Notoginseng (Panax notoginseng (Burk.) F.H. Chen), was recently discovered to have beneficial effects against neurological damage. This study …
View article: The Effects of Tai Chi Training in Patients with Heart Failure: A Systematic Review and Meta-Analysis
The Effects of Tai Chi Training in Patients with Heart Failure: A Systematic Review and Meta-Analysis Open
Heart Failure (HF) is associated with significantly high morbidity and mortality. We performed a meta-analysis and updated new evidences from randomized controlled trials (RCTs) to determine the effects of Tai Chi (TC) in patients with HF.…
View article: Ultra high performance liquid chromatography with tandem mass spectrometry for rapid separation and identification of main constituents in Chinese herbal formula Xuan Hu Suo San
Ultra high performance liquid chromatography with tandem mass spectrometry for rapid separation and identification of main constituents in Chinese herbal formula Xuan Hu Suo San Open
Xuan Hu Suo San (XHSS) is a traditional Chinese medicine that has been extensively applied in the treatment of osteoarthritis for many years, however, its chemical composition has not yet been elucidated. Thus, a rapid, efficient, and prec…
View article: A Systematic Review and Meta-Analysis on the Treatment of Cerebral Hemorrhage with NaoXueShu Oral Liquid
A Systematic Review and Meta-Analysis on the Treatment of Cerebral Hemorrhage with NaoXueShu Oral Liquid Open
NaoXueShu oral liquid invigorates Qi and promotes blood circulation, which is mainly used for treating the acute stage of the meridian of hemorrhagic apoplexy and acute blood stasis syndrome during early convalescence. Its main clinical ma…
View article: A Network Pharmacology Approach to Uncover the Pharmacological Mechanism of XuanHuSuo Powder on Osteoarthritis
A Network Pharmacology Approach to Uncover the Pharmacological Mechanism of XuanHuSuo Powder on Osteoarthritis Open
As the most familiar type of arthritis and a chronic illness of the joints, Osteoarthritis (OA) affects a great number of people on the global scale. XuanHuSuo powder (XHSP), a conventional herbal formula from China, has been extensively a…
View article: The Clinical Relevance of Serum NDKA, NMDA, PARK7, and UFDP Levels with Phlegm-Heat Syndrome and Treatment Efficacy Evaluation of Traditional Chinese Medicine in Acute Ischemic Stroke
The Clinical Relevance of Serum NDKA, NMDA, PARK7, and UFDP Levels with Phlegm-Heat Syndrome and Treatment Efficacy Evaluation of Traditional Chinese Medicine in Acute Ischemic Stroke Open
According to the methods of Patient-Reported Outcome (PRO) based on the patient reports internationally and referring to U.S. Food and Drug Administration (FDA) guide, some scholars developed this PRO of stroke which is consistent with Chi…