Yiping He
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View article: Preparation and Properties of High Refractive Index and Temperature‐Resistant Polycarbonate Containing Fluorene
Preparation and Properties of High Refractive Index and Temperature‐Resistant Polycarbonate Containing Fluorene Open
To develop a polycarbonate with a high refractive index and good heat resistance, 9,9‐di[3‐phenyl‐4‐(2‐hydroxyethoxy)phenyl]fluorene (BPPEF) and diphenyl carbonate were used as monomers, and BPPEF‐based polycarbonate (BPPEF‐PC) was prepare…
View article: Supplementary Figure S6 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Supplementary Figure S6 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress Open
Inhibiting MTAP sensitizes tumor cells to DRP-104 treatments.
View article: Supplementary Figure S4 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Supplementary Figure S4 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress Open
Prostate cancer cells develop adaptation to purine shortage inducer, such as DRP-104, and employ microtubules to assemble purinosome to enhance purine biosynthesis efficiency.
View article: Supplementary Figure S3 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Supplementary Figure S3 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress Open
Gene expression and functional assays implicate purine biosynthesis as a driver of prostate cancer pathogenesis.
View article: Data from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Data from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress Open
Purpose:Purine metabolism is a promising therapeutic target in cancer; however, how cancer cells respond to purine shortage, particularly their adaptation and vulnerabilities, remains unclear.Experimental Design:Using the recently develope…
View article: Supplementary Figure S8 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Supplementary Figure S8 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress Open
DRP-104 simulates DNA damage and the cGAS-STING pathway.
View article: Supplementary Figure S2 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Supplementary Figure S2 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress Open
DRP-104 affects purine metabolism and purine supply.
View article: Supplementary Figure S1 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Supplementary Figure S1 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress Open
DON inhibits FGAMS, a de novo purine biosynthesis enzyme, with the lowest Ki.
View article: Supplementary Materials S1 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Supplementary Materials S1 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress Open
Supplementary Materials
View article: Supplementary Figure S5 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Supplementary Figure S5 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress Open
The MTAP-dependent purine salvage is a source of purine supply for cancer cells.
View article: Supplementary Table S1 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Supplementary Table S1 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress Open
Supplementary Table 1. Metabolite profiling of C4-2 and PC3 cells (LC-MS profiling results normalzied by cell confluency).
View article: Supplementary Figure S9 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Supplementary Figure S9 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress Open
A graphical abstract summarizing tumor cells’ strategies for adapting to and their vulnerabilities under purine shortage stress.
View article: Supplementary Figure S7 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Supplementary Figure S7 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress Open
Treating tumor-bearing mice with DRP-104 in combination with MTDIA does not affect animal’s body weight but alters the tumor’s immune microenvironment.
View article: Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress
Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress Open
Purpose: Purine metabolism is a promising therapeutic target in cancer; however, how cancer cells respond to purine shortage, particularly their adaptation and vulnerabilities, remains unclear. Experimental Design: Using the recently devel…
View article: Hyperspectral and Multispectral Remote Sensing Image Fusion Based on a Retractable Spatial–Spectral Transformer Network
Hyperspectral and Multispectral Remote Sensing Image Fusion Based on a Retractable Spatial–Spectral Transformer Network Open
Hyperspectral and multispectral remote sensing image fusion is an optimal approach for generating hyperspectral–spatial-resolution images, effectively overcoming the physical limitations of sensors. In transformer-based image fusion method…
View article: Assessing the relationships among the initial conditions, PSD and SWCC of compacted soil
Assessing the relationships among the initial conditions, PSD and SWCC of compacted soil Open
An understanding of the mechanical properties and macroscopic behavior of unsaturated soil can be improved through an in-depth microscopic insight of the variables controlling the soil-water characteristic curve (SWCC). In this study, the …
View article: Resilience and vulnerabilities of tumor cells under purine shortage stress
Resilience and vulnerabilities of tumor cells under purine shortage stress Open
Purine metabolism is a promising therapeutic target in cancer; however how cancer cells respond to purine shortage,particularly their adaptation and vulnerabilities, remains unclear. Using the recently developed purine shortage-inducing pr…
View article: Analysis of the Influence of Process Parameters on Transverse Flux Induction Heating of Endless-Rolling Strip
Analysis of the Influence of Process Parameters on Transverse Flux Induction Heating of Endless-Rolling Strip Open
This study focuses on the effect of an induction heating device on the entry of a thin strip continuous casting and rolling line. A finite element model for the electromagnetic–thermal coupling of transverse magnetic flux induction heating…
View article: Construction and Analysis of the Ecological Security Pattern in Territorial Space in Shaanxi of the Yellow River Basin, China
Construction and Analysis of the Ecological Security Pattern in Territorial Space in Shaanxi of the Yellow River Basin, China Open
In the context of rapid urbanization and extreme climate change globally, balancing ecological resources and economic development for land spatial planning has become one of the pressing issues that need to be addressed. This study propose…
View article: Clemastine and hyperthermia enhance sensitization of osteosarcoma cells for apoptosis
Clemastine and hyperthermia enhance sensitization of osteosarcoma cells for apoptosis Open
Clemastine is an antagonist of histamine H1 receptor may provide benefits in the treatment of osteosarcoma (OS). In the current study, we used hyperthermia approach to sensitize OS cells to clemastine-mediated cell death. Osteosarcoma U-2 …
View article: Gene expression analysis suggests immunosuppressive roles of endolysosomes in glioblastoma
Gene expression analysis suggests immunosuppressive roles of endolysosomes in glioblastoma Open
Targeting endolysosomes is a strategy extensively pursued for treating cancers, including glioblastomas (GBMs), on the basis that the intact function of these subcellular organelles is key to tumor cell autophagy and survival. Through gene…
View article: Targeting glutamine dependence with DRP‐104 inhibits proliferation and tumor growth of castration‐resistant prostate cancer
Targeting glutamine dependence with DRP‐104 inhibits proliferation and tumor growth of castration‐resistant prostate cancer Open
Background Prostate cancer (PCa) continues to be one of the leading causes of cancer deaths in men. While androgen deprivation therapy is initially effective, castration‐resistant PCa (CRPC) often recurs and has limited treatment options. …
View article: IMMU-15. INTERPLAY BETWEEN <i>ATRX</i>AND <i>IDH1</i> MUTATIONS GOVERNS INNATE IMMUNE RESPONSES IN DIFFUSE GLIOMAS
IMMU-15. INTERPLAY BETWEEN <i>ATRX</i>AND <i>IDH1</i> MUTATIONS GOVERNS INNATE IMMUNE RESPONSES IN DIFFUSE GLIOMAS Open
Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations in alpha-thalassemia retardation X-linked (ATRX) are defining molecular alterations in IDH-mutant astrocyto…
View article: IMMU-11. <i>NLRP3+</i> TUMOR-ASSOCIATED MYELOID CELLS ARE ENRICHED IN ASTROCYTIC GLIOMAS AND REPRESENT A THERAPEUTIC VULNERABILITY
IMMU-11. <i>NLRP3+</i> TUMOR-ASSOCIATED MYELOID CELLS ARE ENRICHED IN ASTROCYTIC GLIOMAS AND REPRESENT A THERAPEUTIC VULNERABILITY Open
BACKGROUND Tumor-associated myeloid cells (TAMs) are known drivers of immunosuppression and glioma progression. Hence novel approaches for repolarizing TAMs from a protumorigenic to an antitumorigenic phenotype is an active area of investi…
View article: Repurposing Clemastine to Target Glioblastoma Cell Stemness
Repurposing Clemastine to Target Glioblastoma Cell Stemness Open
Brain tumor-initiating cells (BTICs) and tumor cell plasticity promote glioblastoma (GBM) progression. Here, we demonstrate that clemastine, an over-the-counter drug for treating hay fever and allergy symptoms, effectively attenuated the s…
View article: Gene expression analysis suggests immunosuppressive roles of endolysosomes in glioblastoma
Gene expression analysis suggests immunosuppressive roles of endolysosomes in glioblastoma Open
Targeting endolysosomes is a strategy extensively pursued for treating cancers, including glioblastomas (GBMs), mainly on the basis that the intact function of these subcellular organelles is key to tumor cell autophagy and survival. Here,…
View article: Data from Epigenetic Regulation of Fanconi Anemia Genes Implicates PRMT5 Blockage as a Strategy for Tumor Chemosensitization
Data from Epigenetic Regulation of Fanconi Anemia Genes Implicates PRMT5 Blockage as a Strategy for Tumor Chemosensitization Open
Strengthened DNA repair pathways in tumor cells contribute to the development of resistance to DNA-damaging agents. Consequently, targeting proteins in these pathways is a promising strategy for tumor chemosensitization. Here, we show that…
View article: Data from Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib
Data from Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib Open
Diffuse intrinsic pontine glioma (DIPG) is an invariably fatal brain tumor occurring predominantly in children. Up to 90% of pediatric DIPGs harbor a somatic heterozygous mutation resulting in the replacement of lysine 27 with methionine (…