Yiling Ge
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View article: BMAL1 modulation alleviates inflammatory responses in monocytes by targeting the Fis1-mediated mitochondrial unfolded protein response in high-altitude hypoxia
BMAL1 modulation alleviates inflammatory responses in monocytes by targeting the Fis1-mediated mitochondrial unfolded protein response in high-altitude hypoxia Open
Our findings indicate that transcriptional activation of Bmal1 in monocytes can potentially serve as a novel biomarker of hypoxia-induced inflammation. Our findings also suggest a novel approach for modulating the intrinsic clock, which mi…
View article: Liver organoids uncover tire-derived 6-PPDQ-induced hepatotoxicity: A preliminary application of environmental toxicology and safety assessment
Liver organoids uncover tire-derived 6-PPDQ-induced hepatotoxicity: A preliminary application of environmental toxicology and safety assessment Open
The novel pollutant, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ) leaked out of the tire and has attracted extensive concerns due to its high lethal toxicity of salmon. However, the potential hepatotoxicity of 6-PPDQ…
View article: TNF-α and RPLP0 drive the apoptosis of endothelial cells and increase susceptibility to high-altitude pulmonary edema
TNF-α and RPLP0 drive the apoptosis of endothelial cells and increase susceptibility to high-altitude pulmonary edema Open
View article: TNF-α and RPLP0 driving apoptosis of endothelial cells as the shared molecular mechanism of high altitude pulmonary edema in sojourners and natives: bioinformatic analysis and experimental validation
TNF-α and RPLP0 driving apoptosis of endothelial cells as the shared molecular mechanism of high altitude pulmonary edema in sojourners and natives: bioinformatic analysis and experimental validation Open
High altitude pulmonary edema (HAPE) is a fatal threat for those sojourners who ascend rapidly without sufficient acclimatization. High altitude natives are insusceptible to HAPE resulting from evolved genetic specializations of adaption. …
View article: BMAL1/REV-ERBα loop as a novel inflammatory sensor to drive NF-κB-mediated inflammation in vascular smooth muscle cells by modulating oxidative stress
BMAL1/REV-ERBα loop as a novel inflammatory sensor to drive NF-κB-mediated inflammation in vascular smooth muscle cells by modulating oxidative stress Open
Objectives and design: As a pleiotropic inflammatory cytokine, TNF-α could act as a kind of zeitgeber mediator to integrate with circadian clock and modulate inflammatory signaling. We aimed to investigate how circadian gene Bmal1 regulati…
View article: Transcriptional activation of<i>Bmal1</i>drives the inflammatory activity of monocytes by modulating mitochondrial unfolded protein response during hypobaric hypoxic stress
Transcriptional activation of<i>Bmal1</i>drives the inflammatory activity of monocytes by modulating mitochondrial unfolded protein response during hypobaric hypoxic stress Open
Background Hypoxic stress-induced inflammation had been considered to play an important role in the onset and progression of altitude-related illnesses, but the origin of inflammatory cytokines, the specific responding cell types, and mole…
View article: Organoids and organoids-on-a-chip as the new testing strategies for environmental toxicology-applications & advantages
Organoids and organoids-on-a-chip as the new testing strategies for environmental toxicology-applications & advantages Open
An increasing number of harmful environmental factors are causing serious impacts on human health, and there is an urgent need to accurately identify the toxic effects and mechanisms of these harmful environmental factors. However, traditi…
View article: Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics
Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics Open
View article: Discovery of Salidroside as a Novel Non-Coding RNA Modulator to Delay Cellular Senescence and Promote BK-Dependent Apoptosis in Cerebrovascular Smooth Muscle Cells of Simulated Microgravity Rats
Discovery of Salidroside as a Novel Non-Coding RNA Modulator to Delay Cellular Senescence and Promote BK-Dependent Apoptosis in Cerebrovascular Smooth Muscle Cells of Simulated Microgravity Rats Open
Cardiovascular aging has been reported to accelerate in spaceflights, which is a great potential risk to astronauts’ health and performance. However, current exercise routines are not sufficient to reverse the adverse effects of microgravi…
View article: Polystyrene Nanoplastics Induce Lung Injury via Activating Oxidative Stress: Molecular Insights from Bioinformatics Analysis
Polystyrene Nanoplastics Induce Lung Injury via Activating Oxidative Stress: Molecular Insights from Bioinformatics Analysis Open
(1) Background: Increasing evidence reveals that airborne plastic particles will continue to degrade into nanoplastics which are then inhaled by humans, causing injury to the respiratory system with controversial molecular mechanisms. (2) …
View article: The influence of hypoglycemia on the specific quality of life in type 2 diabetes mellitus: a comparative cross-sectional study of diabetics with and without hypoglycemia in Xi’an, China
The influence of hypoglycemia on the specific quality of life in type 2 diabetes mellitus: a comparative cross-sectional study of diabetics with and without hypoglycemia in Xi’an, China Open
View article: The Influence of Hypoglycemia on the Specific Quality of Life in Type 2 Diabetes Mellitus: a Comparative Cross-sectional Study of Diabetics With and Without Hypoglycemia in Xi'an, China
The Influence of Hypoglycemia on the Specific Quality of Life in Type 2 Diabetes Mellitus: a Comparative Cross-sectional Study of Diabetics With and Without Hypoglycemia in Xi'an, China Open
Purpose This study aims to explore the incidence of hypoglycemia in patients with type 2 diabetes mellitus (T2DM) and the influence of hypoglycemia on the specific quality of life in T2DM patients.Methods It was a comparative cross-section…
View article: The combined effects of Lamaze breathing training and nursing intervention on the delivery in primipara
The combined effects of Lamaze breathing training and nursing intervention on the delivery in primipara Open
Background: Lamaze breathing has been widely used as a breathing training method. Nursing intervention including postural nursing, delivery ball, doula nursing, massage and psychological nursing is usually provided by nurses during labor. …
View article: A correlation study of emergency department nurses’ fatigue, perceived stress, social support and self-efficacy in grade III A hospitals of Xi’an
A correlation study of emergency department nurses’ fatigue, perceived stress, social support and self-efficacy in grade III A hospitals of Xi’an Open
Fatigue is a universal and challenging problem in a nurse's career, particularly for those working in the emergency department. Through analyzing the current status of emergency department nurses’ fatigue, the purpose of this study is to p…
View article: BMAL1 Disrupted Intrinsic Diurnal Oscillation in Rat Cerebrovascular Contractility of Simulated Microgravity Rats by Altering Circadian Regulation of miR-103/CaV1.2 Signal Pathway
BMAL1 Disrupted Intrinsic Diurnal Oscillation in Rat Cerebrovascular Contractility of Simulated Microgravity Rats by Altering Circadian Regulation of miR-103/CaV1.2 Signal Pathway Open
The functional and structural adaptations in cerebral arteries could be one of the fundamental causes in the occurrence of orthostatic intolerance after space flight. In addition, emerging studies have found that many cardiovascular functi…