Ying Xia
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View article: Lipidomics-Based Identification of Plasma Lipid Biomarkers in Tuberculosis-Coronary Artery Disease Comorbidity
Lipidomics-Based Identification of Plasma Lipid Biomarkers in Tuberculosis-Coronary Artery Disease Comorbidity Open
View article: An interpretable geometric graph neural network for enhancing the generalizability of drug–target interaction prediction
An interpretable geometric graph neural network for enhancing the generalizability of drug–target interaction prediction Open
Comprehensive benchmarking across in-domain and cross-domain DTI prediction tasks demonstrates that GPS-DTI outperforms existing methods, underscoring its strong generalization capability. Notably, the model achieves state-of-the-art perfo…
View article: Adipose TGR5 Deletion Promotes Hepatic Steatosis Through Decreasing Adiponectin Secretion in Mice
Adipose TGR5 Deletion Promotes Hepatic Steatosis Through Decreasing Adiponectin Secretion in Mice Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) has emerged as a global epidemic, yet its underlying molecular mechanisms remain elusive, and therapeutic options are limited. The interorgan communication between liver and …
View article: Combination of FTO and BTK inhibitors synergistically suppresses the malignancy of breast cancer cells
Combination of FTO and BTK inhibitors synergistically suppresses the malignancy of breast cancer cells Open
Despite significant progress in breast cancer treatment, more effective methods for its clinical management are still needed. Our data identified that fat mass and obesity-associated protein (FTO), an N 6-methyladenosine …
View article: Delta-opioid receptor ameliorates microglia-induced synapse loss by regulating C1q in Alzheimer disease pathology
Delta-opioid receptor ameliorates microglia-induced synapse loss by regulating C1q in Alzheimer disease pathology Open
While previous studies have well established δ-opioid receptor (DOR)-mediated neuroprotection against Alzheimer's pathology, the underlying mechanisms remain poorly understood. Our present work reveals a strong negative correlation between…
View article: DSI-Bench: A Benchmark for Dynamic Spatial Intelligence
DSI-Bench: A Benchmark for Dynamic Spatial Intelligence Open
Reasoning about dynamic spatial relationships is essential, as both observers and objects often move simultaneously. Although vision-language models (VLMs) and visual expertise models excel in 2D tasks and static scenarios, their ability t…
View article: Correction: Experimental procedures, influencing parameters, and future prospects of geological sequestration of carbon dioxide
Correction: Experimental procedures, influencing parameters, and future prospects of geological sequestration of carbon dioxide Open
View article: Correction: Psychometric evaluation of the Chinese version of the Caregiver-Centered Communication Questionnaire (CCCQ) in caregivers of cancer patients
Correction: Psychometric evaluation of the Chinese version of the Caregiver-Centered Communication Questionnaire (CCCQ) in caregivers of cancer patients Open
View article: Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner
Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner Open
View article: Delta-opioid receptor–mediated neural protection and regeneration
Delta-opioid receptor–mediated neural protection and regeneration Open
The delta-opioid receptor was previously viewed as a mediator in pain regulation. Recent data shed light on its specific role in neural protection and regeneration. An up-regulation of deltaopioid receptor expression and/or activity protec…
View article: Profiling of immune cell subsets and functional characteristics of cervical cancer based on single cell RNA sequencing
Profiling of immune cell subsets and functional characteristics of cervical cancer based on single cell RNA sequencing Open
Introduction A comprehensive characterization of immune cells within the tumor microenvironment (TME) of cervical squamous cell carcinoma (CSCC) is essential to advance understanding of tumor biology and guide immunotherapy development. Me…
View article: Correction: Silencing PinX1 enhances radiosensitivity and antitumor-immunity of radiotherapy in non-small cell lung cancer
Correction: Silencing PinX1 enhances radiosensitivity and antitumor-immunity of radiotherapy in non-small cell lung cancer Open
View article: Inverse Association Between the Dawn Phenomenon and Thyroid Feedback Quantile-Based Index in Type 2 Diabetes Using Continuous Glucose Monitoring: A Cross-Sectional Study
Inverse Association Between the Dawn Phenomenon and Thyroid Feedback Quantile-Based Index in Type 2 Diabetes Using Continuous Glucose Monitoring: A Cross-Sectional Study Open
The dawn phenomenon significantly correlates with glycemic fluctuation severity and TFQI. These findings indicate the relationship between thyroid hormones and glucose regulation, providing new insights into the mechanism of the dawn pheno…
View article: Psychometric evaluation of the Chinese version of the Caregiver-Centered Communication Questionnaire (CCCQ) in caregivers of cancer patients
Psychometric evaluation of the Chinese version of the Caregiver-Centered Communication Questionnaire (CCCQ) in caregivers of cancer patients Open
View article: A Systematic Exploration of Designing Project-based Assignments for Junior High School Science: Principles, Strategies and Case Studies
A Systematic Exploration of Designing Project-based Assignments for Junior High School Science: Principles, Strategies and Case Studies Open
With the curriculum reform oriented toward core competencies, traditional junior high school science teaching models have gradually exposed deficiencies of emphasizing theory over practice and knowledge over abilities. This paper focuses o…
View article: Spontaneous emission in Casimir-Rabi oscillations through a weak optomechanical coupling
Spontaneous emission in Casimir-Rabi oscillations through a weak optomechanical coupling Open
When the mechanical oscillator is initially in an excited state, its free evolution, driven by the dynamical Casimir effect (DCE), leads to the generation of radiation in the vacuum, analogous to the spontaneous emission of an excited atom…
View article: $d+1$ Measurement Bases are Sufficient for Determining $d$-Dimensional Quantum States: Theory and Experiment
$d+1$ Measurement Bases are Sufficient for Determining $d$-Dimensional Quantum States: Theory and Experiment Open
A long-standing problem in quantum physics is to determine the minimal number of measurement bases required for the complete characterization of unknown quantum states, a question of particular relevance to high-dimensional quantum informa…
View article: A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signaling
A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signaling Open
Introduction Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by decreased memory and cognitive impairment. Abnormal tau hyperphosphorylation ultimately forms neurofibrillary tangles, which is one of the mo…
View article: Imaging CRISPR-Edited CAR-T Cell Therapies with Optical and Positron Emission Tomography Reporters
Imaging CRISPR-Edited CAR-T Cell Therapies with Optical and Positron Emission Tomography Reporters Open
Rationale Chimeric antigen receptor (CAR) T cell therapies have shown remarkable success in treating hematological cancers and are increasingly demonstrating potential for solid tumors. CRISPR-based genome editing offers a promising approa…
View article: The Effect of Potassium Deficiencyon the Growth and PhysiologicalCharacteristics of Walnut Seedlings
The Effect of Potassium Deficiencyon the Growth and PhysiologicalCharacteristics of Walnut Seedlings Open
View article: Efficient generation of arbitrary photon-number-squeezed light via shortcuts to adiabaticity
Efficient generation of arbitrary photon-number-squeezed light via shortcuts to adiabaticity Open
The implementation of shortcuts to adiabaticity (STA) enables a substantial reduction in the evolution time relative to traditional adiabatic methods, concurrently mitigating detrimental environmental interference. In this manuscript, we p…
View article: Utilizing the Pentadehydro-Diels–Alder Reaction for Polycyclic Aromatic Compound Synthesis: Diels–Alder-Based Linker Transformation
Utilizing the Pentadehydro-Diels–Alder Reaction for Polycyclic Aromatic Compound Synthesis: Diels–Alder-Based Linker Transformation Open
This study introduces a traceless linker strategy for pentadehydro-Diels–Alder (PDDA) cyclization, in which the sulfide/sulfone linker is strategically repurposed as a diene surrogate. As excellent electron-donating dienes, these linkers r…
View article: Optimal dose of bone marrow mesenchymal stem cell transplantation for experimental ulcerative colitis
Optimal dose of bone marrow mesenchymal stem cell transplantation for experimental ulcerative colitis Open
View article: Unraveling the role of lncRNAs and their associated nearby coding genes in the pathogenesis of systemic lupus erythematosus
Unraveling the role of lncRNAs and their associated nearby coding genes in the pathogenesis of systemic lupus erythematosus Open
The current study provides insights into the dysregulation of lncRNAs and nearby mRNAs in SLE, highlighting potential key players in the pathogenesis of the disease.
View article: Design of light- and chemically responsive protein assemblies through host-guest interactions
Design of light- and chemically responsive protein assemblies through host-guest interactions Open
View article: Achieving electrode smoothing by controlling the nucleation phase of metal deposition through polymer-substrate binding
Achieving electrode smoothing by controlling the nucleation phase of metal deposition through polymer-substrate binding Open
Polymer additives [like polyethylene oxide (PEO)] are widely used for smooth electrode deposition in aqueous zinc and a number of other battery systems currently investigated for energy storage applications. However, the precise mechanism …
View article: Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer’s disease by regulating microglia homeostasis and inhibiting HMGB1 pathway
Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer’s disease by regulating microglia homeostasis and inhibiting HMGB1 pathway Open
These novel findings uncover previously unappreciated roles of DOR in neuroprotection against AD injury via modulating microglia-related inflammatory responses.
View article: Experimental procedures, influencing parameters, and future prospects of geological sequestration of carbon dioxide
Experimental procedures, influencing parameters, and future prospects of geological sequestration of carbon dioxide Open
Carbon capture and storage (CCS) is receiving increasing attention as a technology to mitigate the increasingly serious impacts of climate change. This review explains the CCS process, providing details of important factors influencing its…
View article: Development of a risk prediction nomogram model of pyrotinib-induced severe diarrhea
Development of a risk prediction nomogram model of pyrotinib-induced severe diarrhea Open
The risk prediction nomogram model of pyrotinib-induced severe diarrhea constructed in this study may identify high risk populations earlier so that clinicians can make appropriate decisions in time.
View article: How does personal utility depend on clinical setting? Evidence from 3 cohorts
How does personal utility depend on clinical setting? Evidence from 3 cohorts Open
We identified shared and unique elements of personal utility across cohorts from 3 clinical settings, suggesting the need to tailor utility assessment to the clinical setting and patient population.