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View article: Elevated pre-pregnancy testosterone is associated with gestational diabetes mellitus: an observational cohort study
Elevated pre-pregnancy testosterone is associated with gestational diabetes mellitus: an observational cohort study Open
Context Pre-pregnancy testosterone increase may be closely related to the occurrence of gestational diabetes mellitus (GDM). Objective Our aim is to explain the relationship between pre-pregnancy testosterone levels and the risk of GDM and…
View article: Identifying key covariates of clinical outcomes for critically ill patients with Parkinson’s disease: analysis of the MIMIC-IV database
Identifying key covariates of clinical outcomes for critically ill patients with Parkinson’s disease: analysis of the MIMIC-IV database Open
Background Parkinson’s disease (PD) is a common chronic degenerative disease, and its exact pathological mechanism remains unclear. In this study, we identified covariates associated with the clinical outcomes of PD using patient data from…
View article: ELTD1 inhibits differentiation of hemogenic endothelium progenitors from human embryonic stem cells through the HPIP–Wnt pathway
ELTD1 inhibits differentiation of hemogenic endothelium progenitors from human embryonic stem cells through the HPIP–Wnt pathway Open
Human embryonic stem cells (hESCs) serve as an ideal cell source for generating hematopoietic stem cells (HSCs). In embryonic hematopoiesis, hemogenic endothelium has been identified as a source of HSCs, yet the regulatory mechanisms remai…
View article: Identification of Loci and Candidate Genes Associated with Arginine Content in Soybean
Identification of Loci and Candidate Genes Associated with Arginine Content in Soybean Open
Soybean (Glycine max) seeds are rich in amino acids, offering key nutritional and physiological benefits. In this study, 290 soybean accessions from the USDA Germplasm Collection based in Urbana, IL Information Network (GRIN) were analyzed…
View article: Network Pharmacology Combined with Proteomics Reveals That 3-Acetyl-11-keto-β-boswellic Acid Inhibits the Progression of Prostate Cancer by Regulating the IL-17 Signaling Pathway
Network Pharmacology Combined with Proteomics Reveals That 3-Acetyl-11-keto-β-boswellic Acid Inhibits the Progression of Prostate Cancer by Regulating the IL-17 Signaling Pathway Open
Through the methodologies of network pharmacology and transcriptomics, AKBA may exert its therapeutic effects on PCa by modulating the expression of the IL-17 signaling pathway.
View article: Identification of Loci and Candidate Genes Associated with Arginine Content in Soybean
Identification of Loci and Candidate Genes Associated with Arginine Content in Soybean Open
Soybean (Glycine max) seeds are rich in amino acids, offering key nutritional and physiological benefits. In this study, 290 soybean accessions from the USDA-ARS Germplasm Resources Information Network (GRIN) were analyzed. Four genome-wid…
View article: Landscape of rare‐allele variants in cultivated and wild soybean genomes
Landscape of rare‐allele variants in cultivated and wild soybean genomes Open
Rare‐allele variants are important for crop improvement because they can be linked to important traits. However, genome‐wide distribution and annotation of rare‐allele variants have not been reported. We analyzed sequencing data from 1556 …
View article: <scp>GPD1L</scp>‐Mediated Glycerophospholipid Metabolism Dysfunction in Women With Diminished Ovarian Reserve: Insights From Pseudotargeted Metabolomic Analysis of Follicular Fluid
<span>GPD1L</span>‐Mediated Glycerophospholipid Metabolism Dysfunction in Women With Diminished Ovarian Reserve: Insights From Pseudotargeted Metabolomic Analysis of Follicular Fluid Open
Diminished ovarian reserve (DOR) is a pathological condition characterised by reduced ovarian function, which refers to the decreased quality and quantity of oocytes, potentially causing female infertility and various health issues. Follic…
View article: Immunoregulatory Effects of Codonopsis pilosula Polysaccharide Modified Selenium Nanoparticles on H22 Tumor-Bearing Mice
Immunoregulatory Effects of Codonopsis pilosula Polysaccharide Modified Selenium Nanoparticles on H22 Tumor-Bearing Mice Open
Codonopsis pilosula polysaccharide (CPP) and rare element selenium (Se) have been proved to exert various biological activities, and our previous study demonstrated that selenium nanoparticles modified with CPP (CPP-SeNPs) possessed signif…
View article: Naturally occurring antibodies against ASC decrease during aging
Naturally occurring antibodies against ASC decrease during aging Open
Background: This study aims to investigate the variations of the naturally occurring antibodies against ASC (NAbs-ASC) among a healthy Chinese population and analyze their correlation with age. Methods: This cross-sectional study recruited…
View article: Stem cell transplantation extends the reproductive life span of naturally aging cynomolgus monkeys
Stem cell transplantation extends the reproductive life span of naturally aging cynomolgus monkeys Open
The ovary is crucial for female reproduction and health, as it generates oocytes and secretes sex hormones. Transplantation of mesenchymal stem cells (MSCs) has been shown to alleviate pathological ovarian aging. However, it is unclear whe…
View article: Long non-coding ribonucleic acid SNHG18 induced human granulosa cell apoptosis via disruption of glycolysis in ovarian aging
Long non-coding ribonucleic acid SNHG18 induced human granulosa cell apoptosis via disruption of glycolysis in ovarian aging Open
Altogether, our results revealed that folliculogenesis-related lncRNA SNHG18 participated in the pathogenesis of ovarian aging, which may provide novel biomarkers for ovarian function and new insights for the infertility treatment.
View article: The correlation between the thyroid function and urinary iodine/creatinine ratio of pregnant women attending a tertiary hospital in Beijing, China, during different trimesters
The correlation between the thyroid function and urinary iodine/creatinine ratio of pregnant women attending a tertiary hospital in Beijing, China, during different trimesters Open
UI/Cr is positively correlated with FT4 levels in early pregnancy, especially in women with certain risk factors. Regular monitoring of iodine status and thyroid function is recommended for pregnant women to ensure optimal maternal and fet…
View article: Combined with bioinformatics and machine learning, the diagnostic model, Immunological features and subtypes of stage IV endometriosis with infertility were analyzed
Combined with bioinformatics and machine learning, the diagnostic model, Immunological features and subtypes of stage IV endometriosis with infertility were analyzed Open
Many studies have shown that endometriosis can lead to infertility in women of reproductive age, but the mechanism is unknown. Our study aims to explore the pathogenesis of stage IV endometriosis with infertility and the role of characteri…
View article: The evolution of ovarian somatic cells characterized by transcriptome and chromatin accessibility across rodents, monkeys, and humans
The evolution of ovarian somatic cells characterized by transcriptome and chromatin accessibility across rodents, monkeys, and humans Open
The ovary plays a crucial role in the reproductive system of female mammals by producing mature oocytes through folliculogenesis. Non-human model organisms are extensively utilized in research on human ovarian biology, thus necessitating t…
View article: Primary Robotic Versus Conventional Laparoscopic Roux-en-Y Gastric Bypass in Morbidly Obese Patients: A Systematic Review and Meta-Analysis
Primary Robotic Versus Conventional Laparoscopic Roux-en-Y Gastric Bypass in Morbidly Obese Patients: A Systematic Review and Meta-Analysis Open
Background: Robotic Roux-en-Y gastric bypass (RRYGB) and conventional laparoscopic Roux-en-Y gastric bypass (LRYGB) are commonly performed as primary bariatric procedures. The aim of this article was to assess the role of RRYGB in patients…
View article: Nanodelivery system of traditional Chinese medicine bioactive compounds: Application in the treatment of prostate cancer
Nanodelivery system of traditional Chinese medicine bioactive compounds: Application in the treatment of prostate cancer Open
Research on nano-delivery systems for TCM bioactive compounds holds promising prospects for anti-PCa therapy. However, extensive clinical trials are necessary to evaluate the effectiveness and safety of these nanodrugs.
View article: <scp>ISRIB</scp> facilitates the co‐culture of human trophoblast stem cells and embryonic stem cells
<span>ISRIB</span> facilitates the co‐culture of human trophoblast stem cells and embryonic stem cells Open
The embryo‐like structures (embryoids) constructed by aggregating embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) have provided revolutionary tools for studying the intricate interaction between embryonic and extra‐embryonic …
View article: Interaction between plant-based dietary pattern and frailty on cognitive decline: a longitudinal analysis of the Chinese Longitudinal Healthy Longevity Survey cohort
Interaction between plant-based dietary pattern and frailty on cognitive decline: a longitudinal analysis of the Chinese Longitudinal Healthy Longevity Survey cohort Open
Objectives Frailty is a risk factor for faster cognitive decline, while plant-based dietary patterns are associated with decreased risk of cognitive decline. We aimed to explore their interaction with cognitive function among older adults.…
View article: <i>Helicobacter pylori</i> and Gastrointestinal Cancers: Recent Advances and Controversies
<i>Helicobacter pylori</i> and Gastrointestinal Cancers: Recent Advances and Controversies Open
Helicobacter pylori ( H pylori), a gastric bacterium, has been extensively studied for its association with gastritis, peptic ulcers, and gastric cancer. However, recent evidence suggests its potential implications beyond the stomach, link…
View article: Natural allelic diversities of <i>GmPrx16</i> confer drought tolerance in soybean
Natural allelic diversities of <i>GmPrx16</i> confer drought tolerance in soybean Open
Drought has a serious impact on agricultural production, which can result in production losses ranging between 30% and 90%, depending on the crop species (Hussain et al., 2019; Lesk et al., 2016). Soybean [Glycine max (L.) Merr.] is an imp…
View article: Immunogenicity and safety of concomitant administration of the sabin-strain-based inactivated poliovirus vaccine, the diphtheria-tetanus-acellular pertussis vaccine, and measles-mumps-rubella vaccine to healthy infants aged 18 months in China
Immunogenicity and safety of concomitant administration of the sabin-strain-based inactivated poliovirus vaccine, the diphtheria-tetanus-acellular pertussis vaccine, and measles-mumps-rubella vaccine to healthy infants aged 18 months in China Open
Co-administration of the sIPV, DTaP, and MMR was safe and did not impact immunogenicity, which would help to mitigate administrative costs and enhance vaccine coverage rates.
View article: The longitudinal single-cell panorama of cynomolgus monkey ovary throughout lifespan revealed a conserved ovarian clock between primates
The longitudinal single-cell panorama of cynomolgus monkey ovary throughout lifespan revealed a conserved ovarian clock between primates Open
Ovarian function is critical for female fertility and impacts reproductive longevity. It is of great importance to accurately predict the aging process within the ovary for fertility assessment and disease diagnosis. However, cell metrics …