Explanipedia

SUN-070 USP8 genotype is associated with recurrence risk in Cushing’s disease: an international, retrospective, multicenter cohort study Open

Qilin Zhang, Yixin Cai, Ana Paula Abreu, Michael Buchfelder, Boyuan Yao , et al. · 2025

Disclosure: Q. Zhang: None. Y. Cai: None. A. Abreu: None. M. Buchfelder: None. B. Yao: None. F. Hanzu: None. Y. Liu: None. J. Thorsteinsdottir: None. Z. Ma: None. J. Flitsch: None. S. Zhang: None. H. Ye: None. J. Honegger: None. R.S. Carro…

A frequency attention-embedded network for polyp segmentation Open

Rui Tang, Hejing Zhao, Yao Tong, Ruihui Mu, Yuqiang Wang , et al. · 2025

Gastrointestinal polyps are observed and treated under endoscopy, so there presents significant challenges to advance endoscopy imaging segmentation of polyps. Current methodologies often falter in distinguishing complex polyp structures w…

DIDS: Domain Impact-aware Data Sampling for Large Language Model Training Open

Weijie Shi, Jipeng Zhang, Yidong Wu, Jingzhi Fang, Shibo Zhang , et al. · 2025

Insights into anti-tuberculosis drug design on the scaffold of nitroimidazole derivatives using structure-based computer-aided approaches Open

Wei Yang, Hui Zhao, Zi‐Ai Zhao, Shaojun Pei, Zheng Zhu , et al. · 2025

Deazaflavin-dependent nitroreductase (Ddn) is a crucial enzyme involved in mycolic acid biosynthesis, a vital component of the cell wall in Mycobacterium tuberculosis (MTB)—the bacterial pathogen responsible for tuberculosis.

Development of Multi-Objective Spatial Position Testing Technology Open

Yao Zhao, Hejia Li · 2024

In recent years, single motion target detection, positioning, and tracking technology has been widely applied in fields such as national defense, military, traffic monitoring vehicle positioning, and drone target tracking. In response to t…

Proteogenomic characterization of skull-base chordoma Open

Qilin Zhang, Ziyan Xu, Rui Han, Yunzhi Wang, Zhen Ye , et al. · 2024

Skull-base chordoma is a rare, aggressive bone cancer with a high recurrence rate. Despite advances in genomic studies, its molecular characteristics and effective therapies remain unknown. Here, we conduct integrative genomics, transcript…

Mitigate Position Bias with Coupled Ranking Bias on CTR Prediction Open

Yao Zhao, Zhining Liu, Tianchi Cai, Haipeng Zhang, Chenyi Zhuang , et al. · 2024

Position bias, i.e., users' preference of an item is affected by its placing position, is well studied in the recommender system literature. However, most existing methods ignore the widely coupled ranking bias, which is also related to th…

DeepRisk network: an AI-based tool for digital pathology signature and treatment responsiveness of gastric cancer using whole-slide images Open

Meng‐Xin Tian, Yao Zhao, Yufu Zhou, Qiangjun Gan, Leihao Wang , et al. · 2024

Circulating Inflammatory Cytokines and Risk of Intracranial Aneurysm: A Mendelian-randomization Study Open

Quan Zhang, Tiantian Liu, Linlin Zhang, Rongcheng Yang, Yao Zhao , et al. · 2023

Background Multiple studies have established the significant influence of inflammatory factors on the initiation and advancement of intracranial aneurysm (IA). However, the causality between specific inflammatory cytokines and IA remains u…

Development and Validation of a Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery: A 6-Year, Multicenter, Retrospective and Prospective Diagnostic Cohort Study Open

Deshan Liu, Dixiang Song, Weihai Ning, Yuduo Guo, Ting Lei , et al. · 2023

Background: Based on the literature and data on its clinical trials, the incidence of venous thromboembolism (VTE) in patients undergoing neurosurgery has been 3.0%~26%. We used advanced machine learning techniques and statistical methods …

Early identification of postoperative remission for thyrotropin-secreting adenomas Open

Linling Fan, Zhihong Wang, Wanwan Sun, Qiaoli Cui, Wei Wu , et al. · 2023

Purpose Thyrotropin-secreting adenoma (TSHoma) is a rare type of pituitary adenoma, occurring in one per million people. Little is known about TSHoma. We summarized the demographic, clinical and hormonal characteristics of TSHoma based on …

Digital image analysis allows objective stratification of patients with silent <span>PIT1</span>‐lineage pituitary neuroendocrine tumors Open

Jiangyan Zhao, Chenxing Ji, Haixia Cheng, Zhen Ye, Boyuan Yao , et al. · 2023

Studies describing the clinical presentation and prognosis of patients with silent PIT1 (pituitary specific transcription factor)‐lineage pituitary neuroendocrine tumors (PitNETs) are rare. We identified patients with positive PIT1 tumor s…

Anti-reflux effects of a novel esophagogastric asymmetric anastomosis technique after laparoscopic proximal gastrectomy Open

Li-Qun Pang, Jie Zhang, Fang Shi, Cong Pang, Chengwan Zhang , et al. · 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current t…

Author Correction: Identification of recurrent USP48 and BRAF mutations in Cushing’s disease Open

Jianhua Chen, Xuemin Jian, Siyu Deng, Zengyi Ma, Xuefei Shou , et al. · 2023

Deep learning radiopathomics based on preoperative US images and biopsy whole slide images can distinguish between luminal and non-luminal tumors in early-stage breast cancers Open

Yini Huang, Yao Zhao, Lingling Li, Rushuang Mao, Weijun Huang , et al. · 2023

Natural Science Foundation of Guangdong Province (No. 2023A1515011564), and National Natural Science Foundation of China (No. 91959127; No. 81971631).

Virtual elastography ultrasound via generative adversarial network for breast cancer diagnosis Open

Yao Zhao, Ting Luo, Yijie Dong, Xiaohong Jia, Yinhui Deng , et al. · 2023

Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET Open

Qilin Zhang, Boyuan Yao, Xin Long, Zhengyuan Chen, Min He , et al. · 2023

Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors with variable recurrence rate. Currently, the recurrence prediction is unsatisfying and can be improved by understanding the cellular origins and differe…

Exploring the Antibacterial and Antiviral Mechanisms of Baiyaozi Via Network Pharmacology Open

Xu Jia, Danting Mao, Xiaoyang Zhao, Xingyue Fan, Yaqin Hou , et al. · 2023

This paper aims to analyze the antibacterial and antiviral active components of Baiyaozi and predict its molecular mechanisms via network pharmacology. The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (T…

Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors Open

Fan Zhang, Qilin Zhang, Jiajun Zhu, Boyuan Yao, Chi Ma , et al. · 2022

Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due to its extensive tumor heterogeneity and the lack of high-quality tissues for biomarker discovery, the causative molecular mechanisms are far from b…

Global changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma Open

Meng Wang, Chenxing Ji, Yichao Zhang, Zhiqiang Zhang, Yu Zhang , et al. · 2022

Deep Learning of Liver Contrast-Enhanced Ultrasound to Predict Microvascular Invasion and Prognosis in Hepatocellular Carcinoma Open

Yafang Zhang, Qingyue Wei, Yini Huang, Yao Zhao, Cuiju Yan , et al. · 2022

Background and Aims Microvascular invasion (MVI) is a well-known risk factor for poor prognosis in hepatocellular carcinoma (HCC). This study aimed to develop a deep convolutional neural network (DCNN) model based on contrast-enhanced ultr…

Recommendation to improve the WHO classification of posterior pituitary tumors as a unique entity: evidence from a large case series Open

Nidan Qiao, Haixia Cheng, Zhaoyun Zhang, Hongying Ye, Ming Shen , et al. · 2022

Introduction Most studies reporting posterior pituitary tumors (PPTs) are small case series or single cases. Methods Patients with a histological diagnosis of PPT from January 2010 to December 2021 in a tertiary center were identified. We …

The p300 Inhibitor A-485 Exerts Antitumor Activity in Growth Hormone Pituitary Adenoma Open

Chenxing Ji, Wen Xu, Hong Ding, Zhengyuan Chen, Chengzhang Shi , et al. · 2022

Context Growth hormone pituitary adenoma (GHPA), a major subtype of pituitary adenoma (PA), can lead to progressive somatic disfigurement, multiple complications, and even increased mortality. The efficacy of current treatments is limited;…

Machine Learning Prediction of Visual Outcome after Surgical Decompression of Sellar Region Tumors Open

Nidan Qiao, Yichen Ma, Xiaochen Chen, Ye Zhao, Hongying Ye , et al. · 2022

Introduction: This study aims to develop a machine learning-based model integrating clinical and ophthalmic features to predict visual outcomes after transsphenoidal resection of sellar region tumors. Methods: Adult patients with optic chi…

Germline-soma Supply Mitochondria for mtDNA Inheritance in Mouse Oogenesis Open

Hongying Sha, Zhao Ye, Zhen Ye, Sanbao Shi, Jianxin Pan , et al. · 2022

Maternal transmission paradigm of mtDNA remains controversial in mammalian oogenesis. Germline-soma-to-oocyte communication by numerous transzonal nanotubes (TZTs) reminds whether intercellular mitochondrial transfer is associated with mat…

Impact of Pituitary Stalk Preservation on Tumor Recurrence/Progression and Surgically Induced Endocrinopathy After Endoscopic Endonasal Resection of Suprasellar Craniopharyngiomas Open

Zhengyuan Chen, Zengyi Ma, Wenqiang He, Xuefei Shou, Zhao Ye , et al. · 2021

Objective: To investigate the factors associated with recurrence/progression after endoscopic endonasal resection of suprasellar craniopharyngiomas. Special attention was paid to assess the impact of pituitary stalk preservation on tumor r…

Clinical Outcomes of S2 Alar-Iliac (S2AI) Screw Technique in The Treatment of Severe Spinal Sagittal Imbalance: A Retrospective 2-Year Follow-Up Study Open

Yao Zhao, Beiyu Xu, Longtao Qi, Chunde Li, Zhengrong Yu , et al. · 2021

Background The treatment of adult spinal deformity (ASD) remains a significant challenge, especially in elderly patients. This study aimed to evaluate the outcomes of the S2AI screw technique in the treatment of severe spinal sagittal imba…

Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver Open

Yichao Zhang, Meng Wang, Chenxing Ji, Zhengyuan Chen, Hui Yang , et al. · 2021

Author Correction: Deep learning radiomics can predict axillary lymph node status in early-stage breast cancer Open

Xueyi Zheng, Yao Zhao, Yini Huang, Yanyan Yu, Yun Wang , et al. · 2021

Erectile Dysfunction Is Associated With Excessive Growth Hormone Levels in Male Patients With Acromegaly Open

Zhengyuan Chen, Xiaoqing Shao, Min He, Ming Shen, Wei Gong , et al. · 2021

Objective To determine the risk factors for erectile dysfunction (ED) in male patients with acromegaly and to prospectively investigate the short-term changes of erectile function after surgery or medical treatment. Methods Sixty-three mal…

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