Explanipedia

Corticosterone reprograms splenic responses to avian pathogenic Escherichia coli infection in broiler chickens Open

Mengru Chen, Zhenying Wang, Yifei He, Yimin Jia, Lei Wu , et al. · 2025

The spleen is a critical secondary immune organ. Various stressors encountered during rearing can induce a stress state in poultry, leading to splenic atrophy. However, the underlying mechanisms remain poorly understood. Moreover, research…

Plant extracellular vesicles: A promising bionic medicine platform for disease treatment and drug delivery Open

Jichun Yang, Yuhan Wang, Yunqian Fu, Sitong Wang, Yao Luo , et al. · 2025

Plant extracellular vesicles (PEVs) are nanoscale vesicles secreted by plant cells with intact membrane architecture, which encapsulate a diverse array of biomolecules, including lipids, proteins and RNA. They are integral to both intra‐ce…

Effects of astaxanthin on growth performance, intestinal integrity, and microbiota in Salmonella Enteritidis-infected chickens Open

Yong Lin, Jiansen Gong, Colin Buttimer, Xiaoqing Pan, Yimin Jia , et al. · 2025

This study investigated the effects of astaxanthin (AST) supplementation in drinking water on the growth performance, intestinal barrier function, and cecal microbiota of broilers challenged with Salmonella Enteritidis. During the 20-day e…

Liver transcriptome response to avian pathogenic Escherichia coli infection in broilers with corticosterone treatment Open

Mengru Chen, Yifei He, Yimin Jia, Lei Wu, Ruqian Zhao · 2025

Avian pathogenic Escherichia coli (APEC) infection has high morbidity and mortality, and multiple stressors encountered during rearing place poultry in a state of stress. However, research on how poultry cope with APEC infection under stre…

Analysis of Water Source Conservation Driving Factors Based on Machine Learning Open

Yimin Jia, Zhe Zhang, Chun‐Hua Huang, Shuibo Xie · 2025

This study focuses on the spatiotemporal dynamic changes in water retention capacity and the nonlinear research of its influencing factors. By using the InVEST model, the changing trends of water retention capacity in different regions and…

Alisma Orientalis Extract Ameliorates Hepatic Iron Deregulation in MAFLD Mice via FXR-Mediated Gene Repression Open

Yanlin Li, Ke Zhang, Yue Feng, Lei Wu, Yimin Jia , et al. · 2024

Iron is a vital trace element for our bodies and its imbalance can lead to various diseases. The progression of metabolic-associated fatty liver disease (MAFLD) is often accompanied by disturbances in iron metabolism. Alisma orientale extr…

Recent advance in phytonanomedicine and mineral nanomedicine delivery system of the treatment for acute myeloid leukemia Open

Yimin Jia, Cun Sun, Ting Chen, Hui Zhu, Tian‐Rui Wang , et al. · 2023

Acute myeloid leukemia (AML) is an invasive hematopoietic malignancy caused by excessive proliferation of myeloblasts. Classical chemotherapies and cell transplantation therapies have remarkable efficacy in AML treatment; however, 30–40% o…

Chronic Heat Stress Affects Bile Acid Profile and Gut Microbiota in Broilers Open

Yuting Zhang, Huimin Chen, Wei Cong, Ke Zhang, Yimin Jia , et al. · 2023

Heat stress (HS) can inhibit the growth performance of broilers and cause substantial economic losses. Alterations in bile acid (BA) pools have been reported to be correlated with chronic HS, yet the specific mechanism and whether it is re…

Chronic corticosterone exposure disrupts hepatic and intestinal bile acid metabolism in chicken Open

Lei Wu, Xinyi Liu, Aijia Zhang, Huimin Chen, Ruqian Zhao , et al. · 2023

Objective Chronic stress leads to a high circulating level of glucocorticoids, which disrupts lipid metabolism and causes non-alcoholic fatty liver disease in mice and humans. Meanwhile, bile acid (BA), a class of metabolites initially syn…

Back Cover: Facing inevitable PARPis resistance: mechanisms and therapeutic strategies for breast cancer treatment (Interdisciplinary Medicine 2/2023) Open

Haixia Liu, Xiaohui Chen, Yimin Jia, Hengyi Chen, Xiaohui Wang , et al. · 2023

Combining PARPis with chemotherapy, radiotherapy, immunotherapy, etc. can make PARPi break through the interference of various drug resistance mechanisms and better identify the target of drug action, improving efficacy and achieving the g…

Facing inevitable PARPis resistance: Mechanisms and therapeutic strategies for breast cancer treatment Open

Haixia Liu, Xiaohui Chen, Yimin Jia, Hengyi Chen, Xiaohui Wang , et al. · 2023

BRCA1/2 gene mutations, which result in a dysfunction of homologous recombination repair, have been discovered in at least 5% of breast cancer (BC) patients with the increase in BC incidence in recent years. PARP inhibitors (PARPis), the f…

GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway Open

Guoqiang Fan, Yanfei Li, Yibo Zong, Xiaoyi Suo, Yimin Jia , et al. · 2023

In the process of inflammatory activation, macrophages exhibit lipid metabolism disorders and accumulate lipid droplets. Kupffer cells (KCs) are the resident hepatic macrophage with critical defense functions in the pathogenesis of several…

DNA 5mC and RNA m6A modification successively facilitates the initiation and perpetuation stages of HSC activation in liver fibrosis progression Open

Yue Feng, Shihui Guo, Yulan Zhao, Haibo Dong, Jiayu Qian , et al. · 2023

m6A-Mediated PPARA Translational Suppression Contributes to Corticosterone-Induced Visceral Fat Deposition in Chickens Open

Zixuan Zhou, Aijia Zhang, Xinyi Liu, Yang Yang, Ruqian Zhao , et al. · 2022

Excess fat deposition in broilers leads to great economic losses and is harmful to consumers’ health. Chronic stress in the life cycle of chickens could be an important trigger. However, the underlying mechanisms are still unclear. In this…

Betaine Alleviates High-Fat Diet-Induced Disruptionof Hepatic Lipid and Iron Homeostasis in Mice Open

Yanlin Li, Wenduo Jiang, Yue Feng, Lei Wu, Yimin Jia , et al. · 2022

Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive fat deposition in the liver, which is often associated with disrupted iron homeostasis. Betaine has been reported to be hepatoprotective, yet whether and how betaine a…

Chronic corticosterone disrupts the circadian rhythm of CRH expression and m6A RNA methylation in the chicken hypothalamus Open

Yang Yang, Wanwan Han, Aijia Zhang, Mindie Zhao, Wei Cong , et al. · 2022

Background Corticotropin-releasing hormone (CRH), the major secretagogue of the hypothalamic-pituitary-adrenal (HPA) axis, is intricately intertwined with the clock genes to regulate the circadian rhythm of various body functions. N6-methy…

CCDC 2101452: Experimental Crystal Structure Determination Open

Yushan Xiao, Yimin Jia, Jinfeng Huang, Xiangyu Li, Zhiwen Zhou , et al. · 2022

A Novel Function of Mitochondrial Phosphoenolpyruvate Carboxykinase as a Regulator of Inflammatory Response in Kupffer Cells Open

Haibo Dong, Yue Feng, Yang Yang, Yun Hu, Yimin Jia , et al. · 2021

Background: There has been a recent appreciation that some metabolic enzymes can profoundly influence the nature of the immune response produced in macrophages. However, the role of mitochondrial phosphoenolpyruvate carboxykinase (PCK2) in…

GR-mediated transcriptional regulation of m6A metabolic genes contributes to diet-induced fatty liver in hens Open

Yue Feng, Yanlin Li, Wenduo Jiang, Yun Hu, Yimin Jia , et al. · 2021

Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs Open

Yanwen Zhang, Li Ren, Xiaoxiao Sun, Zhilong Zhang, Jie Liu , et al. · 2021

Paternal environmental inputs can influence various phenotypes in offspring, presenting tremendous implications for basic biology and public health and policy. However, which signals function as a nexus to transmit paternal environmental i…

Chronic Corticosterone Disrupts The Circadian Rhythm of CRH Expression and m6A RNA Methylation In The Chicken Hypothalamus Open

Yang Yang, Wanwan Han, Aijia Zhang, Mindie Zhao, Wei Cong , et al. · 2021

Background: Corticotropin-releasing hormone (CRH), the major secretagogue of the hypothalamic-pituitary-adrenal (HPA) axis, is intricately intertwined with the clock genes to regulate the circadian rhythm of various body functions. N6-meth…

Chronic Corticosterone Disrupts the Circadian Rhythm of CRH Expression and M6a RNA Methylation in the Chicken Hypothalamus Open

Yang Yang, Wanwan Han, Aijia Zhang, Mindie Zhao, Wei Cong , et al. · 2021

Corticotropin-releasing hormone (CRH), the major secretagogue of the hypothalamic-pituitary-adrenal (HPA) axis, is intricately intertwined with the clock genes to regulate the circadian rhythm of various body functions. N6-methyladenosine …

CCDC 2052766: Experimental Crystal Structure Determination Open

Yimin Jia, Yuan Yuan, Jinfeng Huang, Zhong‐Xing Jiang, Zhigang Yang · 2021

CCDC 2054601: Experimental Crystal Structure Determination Open

Yimin Jia, Yuan Yuan, Jinfeng Huang, Zhong‐Xing Jiang, Zhigang Yang · 2021

METTL3/METTL14 Transactivation and m6A-Dependent TGF-β1 Translation in Activated Kupffer Cells Open

Yue Feng, Haibo Dong, Bo Sun, Yun Hu, Yang Yang , et al. · 2021

CCDC 2021741: Experimental Crystal Structure Determination Open

Na Wang, Yimin Jia, Hongmei Qin, Zhong-xing Jiang, Zhigang Yang · 2020

Stress Response Simulated by Continuous Injection of ACTH Attenuates Lipopolysaccharide-Induced Inflammation in Porcine Adrenal Gland Open

Zhiyuan Sun, Demin Cai, Xiaojing Yang, Yueli Shang, Xian Li , et al. · 2020

On modern farms, animals are at high risk of bacterial invasion due to environmental stress factors. The adrenal gland is the terminal organ of the stress response. The crosstalk between adrenal endocrine stress and innate immune response …

GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m6A on lipogenic mRNAs Open

Yun Hu, Yue Feng, Luchu Zhang, Yimin Jia, Demin Cai , et al. · 2020

Chronic stress or excessive exposure to glucocorticoids (GC) contributes to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Glucocorticoid receptor (GR) mediates the action of GC, but its downstream signalling is not fully u…

Mettl3/Mettl14 Transactivation and M 6A-Dependent TGF-β1 Translation Aggravate Non-Alcoholic Steatohepatitis to Fibrosis Transition Open

Yue Feng, Haibo Dong, Bo Sun, Yun Hu, Yang Yang , et al. · 2020

GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m6A on lipogenic mRNAs Open

Yun Hu, Yue Feng, Luchu Zhang, Yimin Jia, Demin Cai , et al. · 2020

Chronic stress or excessive exposure to glucocorticoids (GC) contributes to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Glucocorticoid receptor (GR) mediates the action of GC, but its downstream signalling is not fully u…

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