Yimin Zhao
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View article: Butyric Acid Suppresses Adipogenesis Triggered by Intermittent Hypoxia and Hypercapnia via sAC/cAMP/PKA Pathway Modulation
Butyric Acid Suppresses Adipogenesis Triggered by Intermittent Hypoxia and Hypercapnia via sAC/cAMP/PKA Pathway Modulation Open
Purpose: To explore whether intermittent hypoxia and hypercapnia i.e, intermittent hypoxic-hypercapnia (IHH), the main characteristics of obstructive sleep apnea (OSA), induce adipogenesis, and assess the inhibitory effect of butyric acid,…
View article: Fetal/Maternal-Determined Birth Weight and Adulthood Type 2 Diabetes and Its Subtypes: A Mendelian Randomization Study
Fetal/Maternal-Determined Birth Weight and Adulthood Type 2 Diabetes and Its Subtypes: A Mendelian Randomization Study Open
Background Lower birth weight (BW) might increase the risk of adulthood type 2 diabetes, but its associations with the highly heterogeneous type 2 diabetes subtypes remain to be studied. In addition, whether the associations between lower …
View article: Genetically determined blood pressure, antihypertensive drug classes, and frailty: A Mendelian randomization study
Genetically determined blood pressure, antihypertensive drug classes, and frailty: A Mendelian randomization study Open
Observational studies have suggested that the use of antihypertensive drugs was associated with the risk of frailty; however, these findings may be biased by confounding and reverse causality. This study aimed to explore the effect of gene…
View article: Associations of birth weight, plasma metabolome in adulthood and risk of type 2 diabetes
Associations of birth weight, plasma metabolome in adulthood and risk of type 2 diabetes Open
Aims We aimed to examine the longitudinal associations of birth weight with plasma metabolites in adulthood, and further quantify the proportions of the links between birth weight and incident adult type 2 diabetes (T2D) that were mediated…
View article: Elevated blood remnant cholesterol and triglycerides are causally related to the risks of cardiometabolic multimorbidity
Elevated blood remnant cholesterol and triglycerides are causally related to the risks of cardiometabolic multimorbidity Open
The connection between triglyceride-rich lipoproteins and cardiometabolic multimorbidity, characterized by the concurrence of at least two of type 2 diabetes, ischemic heart disease, and stroke, has not been definitively established. We ai…
View article: Associations of Cardiometabolic Multimorbidity with Risks of Cognitive Decline and Dementia and Modifying Effects of Genetic Susceptibility and Lifestyle Factors: A Prospective Cohort Study
Associations of Cardiometabolic Multimorbidity with Risks of Cognitive Decline and Dementia and Modifying Effects of Genetic Susceptibility and Lifestyle Factors: A Prospective Cohort Study Open
View article: Daily stair climbing, disease susceptibility, and risk of atherosclerotic cardiovascular disease: A prospective cohort study
Daily stair climbing, disease susceptibility, and risk of atherosclerotic cardiovascular disease: A prospective cohort study Open
View article: Association of TyG index with hypertension in Chinese adults: the China Health Examination Collaborative Study (CHEC Study).
Association of TyG index with hypertension in Chinese adults: the China Health Examination Collaborative Study (CHEC Study). Open
TyG index is associated with hypertension and shows the superior discriminative ability for hypertension compared with lipid and glycemic parameters.
View article: Associations of healthy aging index and all-cause and cause-specific mortality: a prospective cohort study of UK Biobank participants
Associations of healthy aging index and all-cause and cause-specific mortality: a prospective cohort study of UK Biobank participants Open
View article: Efficacy of multilevel exercise programmes with different intensities on development and metabolic homeostasis in overweight and obese children: study protocol for a randomized controlled trial
Efficacy of multilevel exercise programmes with different intensities on development and metabolic homeostasis in overweight and obese children: study protocol for a randomized controlled trial Open
Background The prevalence of childhood obesity is rapidly increasing worldwide. Exercise has been suggested as the primary approach to manage body weight, but an effective exercise program tailored for school-age children is still lacking.…
View article: Unprocessed Red Meat and Processed Meat Consumption, Plasma Metabolome, and Risk of Ischemic Heart Disease: A Prospective Cohort Study of UK Biobank
Unprocessed Red Meat and Processed Meat Consumption, Plasma Metabolome, and Risk of Ischemic Heart Disease: A Prospective Cohort Study of UK Biobank Open
Background The evidence is equivocal on the association between meat consumption and ischemic heart disease (IHD) risk. To what extent the variation of individuals' metabolic responses to the same diet may account for this association is n…
View article: Associations of Modified Healthy Aging Index With Major Adverse Cardiac Events, Major Coronary Events, and Ischemic Heart Disease
Associations of Modified Healthy Aging Index With Major Adverse Cardiac Events, Major Coronary Events, and Ischemic Heart Disease Open
Background The Healthy Aging Index (HAI) has been regarded as useful in capturing the health status of multiple organ systems. However, to what extent the HAI is associated with major cardiovascular events remains largely unknown. The auth…
View article: Associations of Reproductive Risk Score and Joint Exposure to Ambient Air Pollutants with Chronic Obstructive Pulmonary Disease: A cohort study in UK Biobank
Associations of Reproductive Risk Score and Joint Exposure to Ambient Air Pollutants with Chronic Obstructive Pulmonary Disease: A cohort study in UK Biobank Open
Objective: To construct a reproductive risk score (RRS) and an air pollution score (APS) and assess independent and joint associations between the two with incident COPD risk. Design: Population-based prospective cohort study. Setting: UK …
View article: Associations of reproductive risk score and joint exposure to ambient air pollutants with chronic obstructive pulmonary disease: a cohort study in UK Biobank
Associations of reproductive risk score and joint exposure to ambient air pollutants with chronic obstructive pulmonary disease: a cohort study in UK Biobank Open
High RRS and high APS were jointly associated with increased COPD risks in a dose-response pattern. Using comprehensive indicators to identify women's reproductive risk factors, together with the control of air pollution, is effective for …
View article: Leisure-Time Television Viewing and Computer Use, Family History, and Incidence of Dementia
Leisure-Time Television Viewing and Computer Use, Family History, and Incidence of Dementia Open
Introduction: Time spent on screen-based sedentary activities is significantly associated with dementia risk, however, whether the associations vary by family history (FHx) of dementia is currently unknown. We aimed to examin…
View article: Associations of dietary flavonoids and subclasses with total and cardiovascular mortality among 369,827 older people: The NIH-AARP Diet and Health Study
Associations of dietary flavonoids and subclasses with total and cardiovascular mortality among 369,827 older people: The NIH-AARP Diet and Health Study Open
View article: Water-Soluble Tomato Concentrate, a Potential Antioxidant Supplement, Can Attenuate Platelet Apoptosis and Oxidative Stress in Healthy Middle-Aged and Elderly Adults: A Randomized, Double-Blinded, Crossover Clinical Trial
Water-Soluble Tomato Concentrate, a Potential Antioxidant Supplement, Can Attenuate Platelet Apoptosis and Oxidative Stress in Healthy Middle-Aged and Elderly Adults: A Randomized, Double-Blinded, Crossover Clinical Trial Open
Increased oxidative stress and platelet apoptotic in middle-aged and elderly adults are important risk factors for atherosclerotic cardiovascular disease (ASCVD). Therefore, it is of great significance to control the oxidative stress and p…
View article: Associations of polysocial risk score, lifestyle and genetic factors with incident type 2 diabetes: a prospective cohort study
Associations of polysocial risk score, lifestyle and genetic factors with incident type 2 diabetes: a prospective cohort study Open
A higher PsRS was related to increased risks of type 2 diabetes. Adherence to a healthy lifestyle may attenuate elevated diabetes risks due to social vulnerability. Genetic susceptibility and disadvantaged social status may act synergistic…
View article: Total and regional fat‐to‐muscle mass ratio and risks of incident all‐cause dementia, Alzheimer's disease, and vascular dementia
Total and regional fat‐to‐muscle mass ratio and risks of incident all‐cause dementia, Alzheimer's disease, and vascular dementia Open
Background The fat‐to‐muscle mass ratio (FMR), which integrates the antagonistic effects of fat and muscle mass, has been proposed as a useful indicator to assess disease risk independent of overall obesity. However, little is known about …
View article: Four-Week Supplementation of Water-Soluble Tomato Extract Attenuates Platelet Function in Chinese Healthy Middle-Aged and Older Individuals: A Randomized, Double-Blinded, and Crossover Clinical Trial
Four-Week Supplementation of Water-Soluble Tomato Extract Attenuates Platelet Function in Chinese Healthy Middle-Aged and Older Individuals: A Randomized, Double-Blinded, and Crossover Clinical Trial Open
Background and Aims Platelets are linked to atherosclerotic development and pathological thrombosis. Single dose of water-soluble tomato extract (WTE) which is a natural extraction can exert anti-platelet effects after 3 or 7 h in British …
View article: Associations of a Polysocial Risk Score With Total and Cause-Specific Mortality: A Prospective Cohort Study
Associations of a Polysocial Risk Score With Total and Cause-Specific Mortality: A Prospective Cohort Study Open
View article: Associations of Healthy Aging Index with Major Adverse Cardiac Events, Major Coronary Events, and Ischemic Heart Disease
Associations of Healthy Aging Index with Major Adverse Cardiac Events, Major Coronary Events, and Ischemic Heart Disease Open
View article: Anthocyanins, Anthocyanin-Rich Berries, and Cardiovascular Risks: Systematic Review and Meta-Analysis of 44 Randomized Controlled Trials and 15 Prospective Cohort Studies
Anthocyanins, Anthocyanin-Rich Berries, and Cardiovascular Risks: Systematic Review and Meta-Analysis of 44 Randomized Controlled Trials and 15 Prospective Cohort Studies Open
Objective: The associations between intake of anthocyanins and anthocyanin-rich berries and cardiovascular risks remained to be established. We aimed to quantitatively summarize the effects of purified anthocyanins and anthocyanin-rich ber…
View article: Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial
Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial Open
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View article: Associations between Adherence to Four A Priori Dietary Indexes and Cardiometabolic Risk Factors among Hyperlipidemic Patients
Associations between Adherence to Four A Priori Dietary Indexes and Cardiometabolic Risk Factors among Hyperlipidemic Patients Open
Little is known about which currently available a priori dietary indexes provide best guidance for reducing cardiometabolic risk factors (CMRF) among hyperlipidemic patients. This study was designed to compare the associations between four…
View article: Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration
Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration Open
Rutin (R) and quercetin (Q) are two widespread dietary flavonoids. Previous studies regarding the plasma cholesterol-lowering activity of R and Q generated inconsistent results. The present study was therefore carried out to investigate th…
View article: Corrigendum to “Ginger attenuates trimethylamine-N-oxide (TMAO)-exacerbated disturbance in cholesterol metabolism and vascular inflammation” [J. Funct. Foods 52 (2019) 25–33]
Corrigendum to “Ginger attenuates trimethylamine-N-oxide (TMAO)-exacerbated disturbance in cholesterol metabolism and vascular inflammation” [J. Funct. Foods 52 (2019) 25–33] Open
View article: Betanin-enriched red beet extract attenuated platelet activation and aggregation by suppressing Akt and P38 Mitogen-activated protein kinases phosphorylation
Betanin-enriched red beet extract attenuated platelet activation and aggregation by suppressing Akt and P38 Mitogen-activated protein kinases phosphorylation Open
View article: Ginger attenuates trimethylamine-N-oxide (TMAO)-exacerbated disturbance in cholesterol metabolism and vascular inflammation
Ginger attenuates trimethylamine-N-oxide (TMAO)-exacerbated disturbance in cholesterol metabolism and vascular inflammation Open
View article: Plasma cholesterol-lowering activity of piperine is mediated by inhibition on cholesterol absorption via down-regulation of intestinal ACAT2 and MTP
Plasma cholesterol-lowering activity of piperine is mediated by inhibition on cholesterol absorption via down-regulation of intestinal ACAT2 and MTP Open