Yi‐Ming Shi
YOU?
Author Swipe
View article: Investigating the shared genetic architecture between post-traumatic stress disorder and neurodegenerative diseases: a large-scale genomewide cross-trait analysis
Investigating the shared genetic architecture between post-traumatic stress disorder and neurodegenerative diseases: a large-scale genomewide cross-trait analysis Open
Background: Post-traumatic stress disorder (PTSD), the most prevalent psychopathological consequence following traumatic events, profoundly impacts human life amidst global societal pressures. Emerging twin and family studies suggest that …
View article: Association between physical activity patterns and the risk of stroke phenotypes: an accelerometer-based prospective cohort study from the UK Biobank
Association between physical activity patterns and the risk of stroke phenotypes: an accelerometer-based prospective cohort study from the UK Biobank Open
View article: Genomic analysis for the identification of bioactive compounds in Xenorhabdus stockiae strain RT25.5
Genomic analysis for the identification of bioactive compounds in Xenorhabdus stockiae strain RT25.5 Open
View article: Quantitative Shape Irregularity and Density Heterogeneity of Preoperative Hematoma Can Predict Rebleeding following Minimally Invasive Catheter Evacuation for Intracerebral Hemorrhage
Quantitative Shape Irregularity and Density Heterogeneity of Preoperative Hematoma Can Predict Rebleeding following Minimally Invasive Catheter Evacuation for Intracerebral Hemorrhage Open
Hematoma shape irregularity and density heterogeneity are risk factors for rebleeding after MICE for ICH. SRI and DCV can be used to identify individuals at high risk of postoperative rebleeding.
View article: Polyketide synthase-derived sphingolipids mediate microbiota protection against a bacterial pathogen in C. elegans
Polyketide synthase-derived sphingolipids mediate microbiota protection against a bacterial pathogen in C. elegans Open
View article: First Report of Powdery Mildew of <i>Cocculus orbiculatus</i> var. <i>mollis</i> Caused by <i>Erysiphe pseudolonicerae</i> in China
First Report of Powdery Mildew of <i>Cocculus orbiculatus</i> var. <i>mollis</i> Caused by <i>Erysiphe pseudolonicerae</i> in China Open
The genus Cocculus comprises diverse medicinal plants in China, including two species C. laurifolius DC. and C. orbiculatus (L.) DC., and one variety C. orbiculatus (L.) DC. var. mollis (Kunming Institute…
View article: Effects of Dendrobium nobile on antioxidant capacity, hormone levels, testicular metabolism, and reproductive performance of aged roosters
Effects of Dendrobium nobile on antioxidant capacity, hormone levels, testicular metabolism, and reproductive performance of aged roosters Open
Oxidative stress is a major cause of semen quality decline in old roosters. Dendrobium nobile Lindl (DNL), a Chinese herbal medicine, exhibits excellent antioxidant activity. Therefore, the present study aimed to investigate the effects of…
View article: Effect of dietary Dendrobium nobile Lindl. On production performance, immune function and caecal microbiota of Chishui black-bone hens
Effect of dietary Dendrobium nobile Lindl. On production performance, immune function and caecal microbiota of Chishui black-bone hens Open
The objective of this study was to investigate the effects of dietary supplementation of Dendrobium nobile Lindl. (DNL) on production performance, immune function, and caecal microbiota of Chishui black-bone hens. A total of one hundred an…
View article: Hematoma surface irregularity predicts postoperative rebleeding and poor drainage in patients with spontaneous intracerebral hemorrhage following minimally invasive surgery: a retrospective cohort study at a high-volume stroke center
Hematoma surface irregularity predicts postoperative rebleeding and poor drainage in patients with spontaneous intracerebral hemorrhage following minimally invasive surgery: a retrospective cohort study at a high-volume stroke center Open
The hematoma SRI is an independent indicator of postoperative rebleeding and poor drainage in ICH patients following MIS.
View article: Pyrrolizwilline, a Unique Bacterial Alkaloid Assembled by a Nonribosomal Peptide Synthetase and non‐Enzymatic Dimerization
Pyrrolizwilline, a Unique Bacterial Alkaloid Assembled by a Nonribosomal Peptide Synthetase and non‐Enzymatic Dimerization Open
Pyrrolizidine alkaloids (PAs) are a structurally diverse group of heterocyclic specialized metabolites characterized by a core structure comprising a hexahydro‐1 H ‐pyrrolizine. PAs are synthesized through two main pathways. In plants, ass…
View article: Simplified methods for variance estimation in microbiome abundance count data analysis
Simplified methods for variance estimation in microbiome abundance count data analysis Open
The complex nature of microbiome data has made the differential abundance analysis challenging. Microbiome abundance counts are often skewed to the right and heteroscedastic (also known as overdispersion), potentially leading to incorrect …
View article: Whole chloroplast genome sequence and phylogenetic analysis of <i>Calanthe discolor</i> (Orchidaceae)
Whole chloroplast genome sequence and phylogenetic analysis of <i>Calanthe discolor</i> (Orchidaceae) Open
The orchid Calanthe discolor, which has high ornamental and medicinal value, is mainly distributed in Zhejiang, Jiangsu, and southeast Hubei Provinces of China, as well as in Japan and the southern Korean peninsula. In this study, t…
View article: Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in<i>C. elegans</i>
Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in<i>C. elegans</i> Open
Protection against pathogens is a major function of the gut microbiota. Although bacterial natural products have emerged as crucial components of host-microbiota interactions, their exact role in microbiota-mediated protection is largely u…
View article: Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans
Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans Open
Protection against pathogens is a major function of the gut microbiota. Although bacterial natural products have emerged as crucial components of host-microbiota interactions, their exact role in microbiota-mediated protection is largely u…
View article: Predicting Axillary Lymph Node Metastasis in Small Breast Cancers Using Convolutional Neural Networks for Multiparametric MRI
Predicting Axillary Lymph Node Metastasis in Small Breast Cancers Using Convolutional Neural Networks for Multiparametric MRI Open
View article: Genome mining reveals novel biosynthetic gene clusters in entomopathogenic bacteria
Genome mining reveals novel biosynthetic gene clusters in entomopathogenic bacteria Open
View article: A flexible quasi‐likelihood model for microbiome abundance count data
A flexible quasi‐likelihood model for microbiome abundance count data Open
In this article, we present a flexible model for microbiome count data. We consider a quasi‐likelihood framework, in which we do not make any assumptions on the distribution of the microbiome count except that its variance is an unknown bu…
View article: Comparison of Outcomes Between Early and Late Tracheostomy
Comparison of Outcomes Between Early and Late Tracheostomy Open
Early tracheostomy can reduce the occurrence of complications for ICU patients.
View article: Contents
Contents Open
View article: Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate‐Containing Natural Products in Diverse Bacteria
Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate‐Containing Natural Products in Diverse Bacteria Open
Benzoxazolinate is a rare bis‐heterocyclic moiety that interacts with proteins and DNA and confers extraordinary bioactivities on natural products, such as C‐1027. However, the biosynthetic gene responsible for the key cyclization step of …
View article: Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate‐Containing Natural Products in Diverse Bacteria
Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate‐Containing Natural Products in Diverse Bacteria Open
Benzoxazolinate is a rare bis‐heterocyclic moiety that interacts with proteins and DNA and confers extraordinary bioactivities on natural products, such as C‐1027. However, the biosynthetic gene responsible for the key cyclization step of …
View article: Cleavage Off-Loading and Post-assembly-Line Conversions Yield Products with Unusual Termini during Biosynthesis
Cleavage Off-Loading and Post-assembly-Line Conversions Yield Products with Unusual Termini during Biosynthesis Open
Piscibactins and photoxenobactins are metallophores and virulence factors, whose biosynthetic gene cluster, termed pxb, is the most prevalent polyketide synthase/non-ribosomal peptide synthetase hybrid cluster across entomopathogeni…
View article: Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria Open
Microorganisms contribute to the biology and physiology of eukaryotic hosts and affect other organisms through natural products. Xenorhabdus and Photorhabdus ( XP ) living in mutualistic symbiosis with entomopathogenic nematodes generate n…
View article: Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria Open
Microorganisms contribute to the biology and physiology of eukaryotic hosts and affect other organisms through natural products. Xenorhabdus and Photorhabdus ( XP ) living in mutualistic symbiosis with entomopathogenic nematodes produce a …
View article: The Chemical Structure of Widespread Microbial Aryl Polyene Lipids
The Chemical Structure of Widespread Microbial Aryl Polyene Lipids Open
Biosynthetic gene clusters (BGC) involved in aryl polyene (APE) biosynthesis are supposed to represent the most widespread BGC in the bacterial world. [1–3] Still, only hydrolysis products [4–8] and not the full-length product(s) have been…
View article: An Unconventional Melanin Biosynthesis Pathway in Ustilago maydis
An Unconventional Melanin Biosynthesis Pathway in Ustilago maydis Open
The fungus Ustilago maydis represents one of the major threats to maize plants since it is responsible for corn smut disease, which generates considerable economical losses around the world. Therefore, contributing to a better understandin…
View article: Identification of Feldin, an Antifungal Polyyne from the Beefsteak Fungus Fistulina hepatica
Identification of Feldin, an Antifungal Polyyne from the Beefsteak Fungus Fistulina hepatica Open
Fruiting body-forming members of the Basidiomycota maintain their ecological fitness against various antagonists like ascomycetous mycoparasites. To achieve that, they produce myriads of bioactive compounds, some of which are now being use…
View article: Publisher Correction: Engineering bacterial symbionts of nematodes improves their biocontrol potential to counter the western corn rootworm
Publisher Correction: Engineering bacterial symbionts of nematodes improves their biocontrol potential to counter the western corn rootworm Open
View article: An Unconventional Melanin Biosynthetic Pathway in<i>Ustilago maydis</i>
An Unconventional Melanin Biosynthetic Pathway in<i>Ustilago maydis</i> Open
Ustilago maydis is a phytopathogenic fungus responsible for corn smut disease. Although it is a very well established model organism for the study of plant-microbe interactions, its biosynthetic potential has not been totally explored. By …
View article: Rücktitelbild: Promoter Activation in Δ<i>hfq</i> Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (Angew. Chem. 52/2019)
Rücktitelbild: Promoter Activation in Δ<i>hfq</i> Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (Angew. Chem. 52/2019) Open
Die gezielte Aktivierung von Biosynthesegenclustern in Δhfq-Mutanten verschiedener Proteobakterien vereinfacht die Isolierung und biologische Testung der dadurch exklusiv produzierten Naturstoffe, wie E. Bode et al. in ihrem Forschungsarti…