Yinan Kan
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View article: Genetic modifications designed for xenotransplantation attenuate sialoadhesin‐dependent binding of human erythrocytes to porcine macrophages
Genetic modifications designed for xenotransplantation attenuate sialoadhesin‐dependent binding of human erythrocytes to porcine macrophages Open
The phenomenon of diminishing hematocrit after in vivo liver and lung xenotransplantation and during ex vivo liver xenoperfusion has largely been attributed to action by resident liver porcine macrophages, which bind and destroy human eryt…
View article: Extensive Mammalian Germline Genome Engineering
Extensive Mammalian Germline Genome Engineering Open
Xenotransplantation, specifically the use of porcine organs for human transplantation, has long been sought after as an alternative for patients suffering from organ failure. However, clinical application of this approach has been impeded …
View article: DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase
DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase Open
Fusion of critically short or damaged telomeres is associated with the genomic rearrangements that support malignant transformation. We have demonstrated the fundamental contribution of DNA ligase 4-dependent classical non-homologous end-j…
View article: Correction: Corrigendum: Engineering and optimising deaminase fusions for genome editing
Correction: Corrigendum: Engineering and optimising deaminase fusions for genome editing Open
Nature Communications 7: Article number: 13330 (2016); Published 2 November 2016; Updated 9 October 2017. The original version of this Article contained an error in the email address of the corresponding author George Church. The correct e…
View article: FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response
FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response Open
Fanconi anemia (FA) is an inherited cancer predisposition syndrome characterized by cellular hypersensitivity to DNA interstrand crosslinks (ICLs). To repair these lesions, the FA proteins act in a linear hierarchy: following ICL detection…
View article: Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 Open
Taking the PERVs out of pigs With the severe shortage of organs needed for transplants, xenotransplantation (transplantation of nonhuman organs to humans) offers an alternative source. Some pig organs have similar size and function to thos…
View article: Mechanisms of precise genome editing using oligonucleotide donors
Mechanisms of precise genome editing using oligonucleotide donors Open
The use of programmable meganucleases is transforming genome editing and functional genomics. CRISPR/Cas9 was developed such that targeted genomic lesions could be introduced in vivo with unprecedented ease. In the presence of homology don…
View article: Mechanisms of precise genome editing using oligonucleotide donors
Mechanisms of precise genome editing using oligonucleotide donors Open
Sanger and NGS data for conversion tracts in HCT116, DLD-1 and RPE cells
View article: Engineering and optimising deaminase fusions for genome editing
Engineering and optimising deaminase fusions for genome editing Open
Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic lesions, homology donors and the endogenous DNA repair machinery. Here we engineer…
View article: Engineering and optimising deaminase fusions for genome editing
Engineering and optimising deaminase fusions for genome editing Open
Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic lesions, homology donors and the endogenous DNA repair machinery. Here we engineer…
View article: Genome Editing With Targeted Deaminases
Genome Editing With Targeted Deaminases Open
Precise genetic modifications are essential for biomedical research and gene therapy. Yet, traditional homology-directed genome editing is limited by the requirements for DNA cleavage, donor DNA template and the endogenous DNA break-repair…