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View article: Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration
Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration Open
Inflammation is a hallmark of intervertebral disc degeneration (IVDD) characterized by immune cell infiltration and cytokine secretion. Stage‐specific transcriptomic analyses of IVDD via single‐cell RNA sequencing (scRNA‐seq) have primaril…
View article: Optogenetic activation of hypothalamic AgRP neurons in transgenic zebrafish larvae increased food intake
Optogenetic activation of hypothalamic AgRP neurons in transgenic zebrafish larvae increased food intake Open
Agouti Related Peptide (AgRP) neurons are located in the hypothalamus, and upon stimulation, these neurons regulate hunger and hunger-mediated behaviors, especially food-seeking and compulsive eating. AgRP neurons are naturally activated b…
View article: Calix[8]Arene‐Tethered Dendritic Octamer Acceptor with Ultrahigh Molecular Weight Enables 20.7% Efficiency Organic Solar Cells with Exceptional Stability
Calix[8]Arene‐Tethered Dendritic Octamer Acceptor with Ultrahigh Molecular Weight Enables 20.7% Efficiency Organic Solar Cells with Exceptional Stability Open
Increasing the molecular weight of the acceptor is an effective strategy to suppress excessive crystallization and molecular diffusion, thereby addressing morphological challenges in organic solar cells (OSCs). Therefore, designing high‐mo…
View article: Gliogenesis but not neurogenesis occurs during the acute phase of vestibular compensation after unilateral vestibular neurectomy
Gliogenesis but not neurogenesis occurs during the acute phase of vestibular compensation after unilateral vestibular neurectomy Open
Following unilateral loss of vestibular input, recovery of motor symptoms is achieved within 2 weeks in rodents. Given that neurogenesis was only reported at 1 month post-lesion, whether there is neurogenesis in this early phase of vestibu…
View article: Adverse cardiovascular outcomes due to potential drug-drug interactions in statin therapy: a population-based study
Adverse cardiovascular outcomes due to potential drug-drug interactions in statin therapy: a population-based study Open
Background Statins have been proven to reduce morbidity and mortality in patients with known atherosclerotic cardiovascular disease (ASCVD) and in primary prevention. Given their unique role in ASCVD, concomitant use of statins and other m…
View article: Intrinsic and extrinsic actions of human neural progenitors with SUFU inhibition promote tissue repair and functional recovery from severe spinal cord injury
Intrinsic and extrinsic actions of human neural progenitors with SUFU inhibition promote tissue repair and functional recovery from severe spinal cord injury Open
Neural progenitor cells (NPCs) derived from human pluripotent stem cells(hPSCs) provide major cell sources for repairing damaged neural circuitry and enabling axonal regeneration after spinal cord injury (SCI). However, the injury niche an…
View article: Pericyte derivation and transplantation for blood-CNS barrier reconstitution in CNS disorders
Pericyte derivation and transplantation for blood-CNS barrier reconstitution in CNS disorders Open
Disruption of the blood-central nervous system barrier (BCB) is increasingly recognized as a pathological factor in diseases and trauma of the central nervous system. Despite the neuropathological impact, current treatment modalities do no…
View article: Personalized cardiac resynchronization therapy guided by real-time electrocardiographic imaging for non-left bundle branch block patients
Personalized cardiac resynchronization therapy guided by real-time electrocardiographic imaging for non-left bundle branch block patients Open
Background Heart failure patients with non-left bundle branch block (non-LBBB) QRS pattern have limited response rate to biventricular pacing (BVP). Objective A personalized cardiac resynchronization therapy (CRT) implantation approach gui…
View article: Revealing the developmental origin and lineage predilection of neural progenitors within human bone marrow via single-cell analysis: implications for regenerative medicine
Revealing the developmental origin and lineage predilection of neural progenitors within human bone marrow via single-cell analysis: implications for regenerative medicine Open
Background Human bone marrow stromal cells (BMSCs) are an easily accessible and expandable progenitor population with the capacity to generate neural cell types in addition to mesoderm. Lineage tracing studies in transgenic animals have in…
View article: Virtual reality: a technology to promote active learning of physiology for students across multiple disciplines
Virtual reality: a technology to promote active learning of physiology for students across multiple disciplines Open
Virtual reality (VR) improves physiology education by promoting active learning in terms of interactive engagement, interest, problem-solving skills, and feedback. Positive responses toward multiple components of active learning were recei…
View article: Transplanting Human Neural Stem Cells with ≈50% Reduction of <i>SOX9</i> Gene Dosage Promotes Tissue Repair and Functional Recovery from Severe Spinal Cord Injury
Transplanting Human Neural Stem Cells with ≈50% Reduction of <i>SOX9</i> Gene Dosage Promotes Tissue Repair and Functional Recovery from Severe Spinal Cord Injury Open
Neural stem cells (NSCs) derived from human pluripotent stem cells (hPSCs) are considered a major cell source for reconstructing damaged neural circuitry and enabling axonal regeneration. However, the microenvironment at the site of spinal…
View article: IPSC-Derived Sensory Neurons Directing Fate Commitment of Human BMSC-Derived Schwann Cells: Applications in Traumatic Neural Injuries
IPSC-Derived Sensory Neurons Directing Fate Commitment of Human BMSC-Derived Schwann Cells: Applications in Traumatic Neural Injuries Open
The in vitro derivation of Schwann cells from human bone marrow stromal cells (hBMSCs) opens avenues for autologous transplantation to achieve remyelination therapy for post-traumatic neural regeneration. Towards this end, we exploited hum…
View article: Breast-Implant-Related Fibromatosis in a Patient with Free Silicone Injection: a Case Report
Breast-Implant-Related Fibromatosis in a Patient with Free Silicone Injection: a Case Report Open
A 36-year-old woman, gravida 4 and parity 1 with three previous miscarriages, with good past health and no family history of malignancy, was referred to our institution.She had been prescribed oral contraceptives for the last 13 years but …
View article: A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition
A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition Open
Cholecystokinin (CCK) enables excitatory circuit long-term potentiation (LTP). Here, we investigated its involvement in the enhancement of inhibitory synapses. Activation of GABA neurons suppressed neuronal responses in the neocortex to a …
View article: Prelimbic Cortical Stimulation with L-methionine Enhances Cognition through Hippocampal DNA Methylation and Neuroplasticity Mechanisms
Prelimbic Cortical Stimulation with L-methionine Enhances Cognition through Hippocampal DNA Methylation and Neuroplasticity Mechanisms Open
Declining global DNA methylation and cognitive impairment are reported to occur in the normal aging process. It is not known if DNA methylation plays a role in the efficacy of memory-enhancing therapies. In this study, aged animals were ad…
View article: SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms
SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms Open
The in vivo mechanisms underlying dominant syndromes caused by mutations in SRY-Box Transcription Factor 9 ( SOX9 ) and SOX10 ( SOXE ) transcription factors, when they either are expressed alone or are coexpressed, are ill-defined. We crea…
View article: Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models
Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models Open
Dementia is a major burden on global health for which there are no effective treatments. The use of noninvasive visual stimulation to ameliorate cognitive deficits is a novel concept that may be applicable for treating dementia. In this st…
View article: A New Vestibular Stimulation Mode for Motion Sickness With Emphatic Analysis of Pica
A New Vestibular Stimulation Mode for Motion Sickness With Emphatic Analysis of Pica Open
Motion sickness (MS) was frequently introduced for rodents in research work through passive motion that disturbed vestibular signals in the presence of visual and aleatory, proprioceptive inputs. Inducement of MS in this way causes conflic…
View article: Table of Contents
Table of Contents Open
On the Cover: Example of evoked potential and streamline analysis for a single stimulation volume.Two treatment-resistant depression patients underwent neurosurgical treatment involving DBS.We compare tractography from pre-surgical MRI to …
View article: Antidepressant-like effects of transcorneal electrical stimulation in rat models
Antidepressant-like effects of transcorneal electrical stimulation in rat models Open
The overall findings suggest a possible neuroplasticity mechanism of the antidepressant-like effects of TES.
View article: A near-infrared AIE fluorescent probe for myelin imaging: From sciatic nerve to the optically cleared brain tissue in 3D
A near-infrared AIE fluorescent probe for myelin imaging: From sciatic nerve to the optically cleared brain tissue in 3D Open
Significance The high spatial resolution of three-dimensional (3D) fluorescence imaging of myelinated fibers will greatly facilitate the understanding of 3D neural networks and the pathophysiology of demyelinating diseases. However, existi…
View article: Derivation of Oligodendrocyte Precursors from Adult Bone Marrow Stromal Cells for Remyelination Therapy
Derivation of Oligodendrocyte Precursors from Adult Bone Marrow Stromal Cells for Remyelination Therapy Open
Transplantation of oligodendrocyte precursors (OPs) is potentially therapeutic for myelin disorders but a safe and accessible cell source remains to be identified. Here we report a two-step protocol for derivation of highly enriched popula…