Ying-Chih Lo
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View article: Allergy alerting and overrides for opioid analogues across two health systems
Allergy alerting and overrides for opioid analogues across two health systems Open
Objectives Despite opioids comprising a majority of drug allergy alert (DAA) overrides, few studies have designed recommendations for clinical decision support (CDS) systems. We determined the frequency of opioid analogue DAA overrides and…
View article: Building an allergy reconciliation module to eliminate allergy discrepancies in electronic health records
Building an allergy reconciliation module to eliminate allergy discrepancies in electronic health records Open
Objective Accurate, complete allergy histories are critical for decision-making and medication prescription. However, allergy information is often spread across the electronic health record (EHR); thus, allergy lists are often inaccurate o…
View article: Validating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism
Validating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism Open
View article: Clinical manifestations of drug reaction with eosinophilia and systemic symptoms in pediatric patients
Clinical manifestations of drug reaction with eosinophilia and systemic symptoms in pediatric patients Open
View article: Development of a Drug Allergy Alert Tiering Algorithm for Penicillins and Cephalosporins
Development of a Drug Allergy Alert Tiering Algorithm for Penicillins and Cephalosporins Open
View article: Streamlining Social Media Information Retrieval for COVID-19 Research with Deep Learning
Streamlining Social Media Information Retrieval for COVID-19 Research with Deep Learning Open
Objective: Social media-based public health research is crucial for epidemic surveillance, but most studies identify relevant corpora with keyword-matching. This study develops a system to streamline the process of curating colloquial medi…
View article: Drug reaction eosinophilia and systemic symptoms: Clinical phenotypic patterns according to causative drug
Drug reaction eosinophilia and systemic symptoms: Clinical phenotypic patterns according to causative drug Open
View article: Developing Validated Tools to Identify Pulmonary Embolism in Electronic Databases: Rationale and Design of the PE-EHR+ Study
Developing Validated Tools to Identify Pulmonary Embolism in Electronic Databases: Rationale and Design of the PE-EHR+ Study Open
Background Contemporary pulmonary embolism (PE) research, in many cases, relies on data from electronic health records (EHRs) and administrative databases that use International Classification of Diseases (ICD) codes. Natural language proc…
View article: Risk of Severe Alphaherpesvirus Infection after Solid Organ Transplantation: A Nationwide Population-Based Cohort Study
Risk of Severe Alphaherpesvirus Infection after Solid Organ Transplantation: A Nationwide Population-Based Cohort Study Open
Patients after solid organ transplantation (SOT) are more susceptible to various viral infections, including alphaherpesviruses. Therefore, the aim of our study was to investigate the risk of alphaherpesvirus infections, including herpes s…
View article: The Incidence and Disparities in Use of Stigmatizing Language in Clinical Notes for Patients With Substance Use Disorder
The Incidence and Disparities in Use of Stigmatizing Language in Clinical Notes for Patients With Substance Use Disorder Open
Objective The language used to describe people with substance use disorder impacts stigma and influences clinical decision making. This study evaluates the presence of stigmatizing language (SL) in clinical notes and detects patient- and p…
View article: Reconciling Allergy Information in the Electronic Health Record After a Drug Challenge Using Natural Language Processing
Reconciling Allergy Information in the Electronic Health Record After a Drug Challenge Using Natural Language Processing Open
Background Drug challenge tests serve to evaluate whether a patient is allergic to a medication. However, the allergy list in the electronic health record (EHR) is not consistently updated to reflect the results of the challenge, affecting…
View article: Development and Validation of a Deep Learning Model for Earlier Detection of Cognitive Decline From Clinical Notes in Electronic Health Records
Development and Validation of a Deep Learning Model for Earlier Detection of Cognitive Decline From Clinical Notes in Electronic Health Records Open
In this diagnostic study, a deep learning model accurately detected cognitive decline from clinical notes preceding MCI diagnosis and had better performance than keyword-based search and other machine learning models. These results suggest…
View article: PASCLex: A comprehensive post-acute sequelae of COVID-19 (PASC) symptom lexicon derived from electronic health record clinical notes
PASCLex: A comprehensive post-acute sequelae of COVID-19 (PASC) symptom lexicon derived from electronic health record clinical notes Open
View article: Development of a Post-Acute Sequelae of COVID-19 (PASC) Symptom Lexicon Using Electronic Health Record Clinical Notes
Development of a Post-Acute Sequelae of COVID-19 (PASC) Symptom Lexicon Using Electronic Health Record Clinical Notes Open
Objective To develop a comprehensive post-acute sequelae of COVID-19 (PASC) symptom lexicon from clinical notes to support PASC symptom identification and research. Methods We identified 26,117 COVID-19 positive patients from the Mass Gene…
View article: Implementation of an Electronic National Early Warning System to Decrease Clinical Deterioration in Hospitalized Patients at a Tertiary Medical Center
Implementation of an Electronic National Early Warning System to Decrease Clinical Deterioration in Hospitalized Patients at a Tertiary Medical Center Open
The National Early Warning Score (NEWS) is an early warning system that predicts clinical deterioration. The impact of the NEWS on the outcome of healthcare remains controversial. This study was conducted to evaluate the effectiveness of i…
View article: Methods for Identifying and Reconciling Allergy Information in the Electronic Health Record
Methods for Identifying and Reconciling Allergy Information in the Electronic Health Record Open
View article: AEP-DLA: Adverse Event Prediction in Hospitalized Adult Patients Using Deep Learning Algorithms
AEP-DLA: Adverse Event Prediction in Hospitalized Adult Patients Using Deep Learning Algorithms Open
Early prediction of clinical deterioration such as adverse events (AEs), improves patient safety. National Early Warning Score (NEWS) is widely used to predict AEs based on the aggregation of 6 physiological parameters. We took the same pa…
View article: A dynamic reaction picklist for improving allergy reaction documentation in the electronic health record
A dynamic reaction picklist for improving allergy reaction documentation in the electronic health record Open
Objective Incomplete and static reaction picklists in the allergy module led to free-text and missing entries that inhibit the clinical decision support intended to prevent adverse drug reactions. We developed a novel, data-driven, “dynami…
View article: Treatment of chronic active antibody-mediated rejection in renal transplant recipients – a single center retrospective study
Treatment of chronic active antibody-mediated rejection in renal transplant recipients – a single center retrospective study Open
View article: Treatment of Chronic Active Antibody-mediated Rejection in Renal Transplant Recipients – A single center retrospective study
Treatment of Chronic Active Antibody-mediated Rejection in Renal Transplant Recipients – A single center retrospective study Open
Background: Chronic active antibody-mediated rejection is a major etiology of graft loss in renal transplant recipients. However, there are no approved treatments. Methods: Computerized records from Taichung Veterans General Hospital were …
View article: Treatment of Chronic Active Antibody-mediated Rejection in Renal Transplant Recipients – A single center retrospective study
Treatment of Chronic Active Antibody-mediated Rejection in Renal Transplant Recipients – A single center retrospective study Open
Background: A plethora of evidences suggest that the most important cause of late graft loss in renal transplant recipients is chronic active antibody-mediated rejection. However, there are no consensus on treatment strategies. Methods: We…
View article: Treatment of Chronic Active Antibody-mediated Rejection in Renal Transplant Recipients – A single center retrospective study
Treatment of Chronic Active Antibody-mediated Rejection in Renal Transplant Recipients – A single center retrospective study Open
Background: A plethora of evidences suggest that the most important cause of late graft loss in renal transplant recipients is chronic active antibody-mediated rejection. However, there are no consensus on treatment strategies. Methods: We…
View article: Protocol for data analysis (Early warning score) v1
Protocol for data analysis (Early warning score) v1 Open
The protocol for data retrieval, data cleaning, and data analysis for the paper: Investigating the accuracy of National Early Warning Score for predicting clinical deterioration in different disease categories and time frames
View article: Duloxetine-Induced Hyponatremia in an Elderly Male Patient with Treatment-Refractory Major Depressive Disorder
Duloxetine-Induced Hyponatremia in an Elderly Male Patient with Treatment-Refractory Major Depressive Disorder Open
Several classes of antidepressants can induce syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH), thereby causing hyponatremia. Initial symptoms of hyponatremia include neuropsychiatric and gastrointestinal manifestation…
View article: SAT0005 Interleukin-33 ameliorates murine lupus via induction of regulatory t cells and m2 macrophage polarisation
SAT0005 Interleukin-33 ameliorates murine lupus via induction of regulatory t cells and m2 macrophage polarisation Open
View article: 348 Dectin-1 on monocytic cells mediates aberrant innate and adaptive immune responses in patients with systemic lupus erythematosus
348 Dectin-1 on monocytic cells mediates aberrant innate and adaptive immune responses in patients with systemic lupus erythematosus Open
Background and aims Dectin-1 is a c-type lectin like receptor that signals via syk and is involved in anti-fungal immunity. Dectin-1 was found to trigger experimental inflammatory arthritis, and likely play a role in the pathogenesis of so…