Ying Kong
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View article: O-GlcNAcylation-regulated classical programmed cell death in diseases: molecular crosstalk and therapeutic opportunities
O-GlcNAcylation-regulated classical programmed cell death in diseases: molecular crosstalk and therapeutic opportunities Open
O- linked β-N-acetylglucosamine ( O- GlcNAc) is a reversible post translational modification (PTM) involving the attachment of β-N-acetylglucosamine to serine or threonine residues of target proteins. This modification regulates a wide ran…
View article: Multi-omics analysis reveals that BUB1B is a cell cycle related gene promotes the bladder cancer development
Multi-omics analysis reveals that BUB1B is a cell cycle related gene promotes the bladder cancer development Open
Bladder cancer (BC) is characterized by a high incidence and frequent recurrence. Despite efforts to improve survival and reduce mortality among BC patients, significant progress remains elusive. The role of the cell cycle in BC has been i…
View article: Hyaluronic acid methacrylate microneedles loaded with astaxanthin alleviate rheumatoid arthritis by downregulating the PI3K-AKT pathway
Hyaluronic acid methacrylate microneedles loaded with astaxanthin alleviate rheumatoid arthritis by downregulating the PI3K-AKT pathway Open
View article: Identification of PLAC1 as a prognostic biomarker and molecular target in clear cell renal cell carcinoma
Identification of PLAC1 as a prognostic biomarker and molecular target in clear cell renal cell carcinoma Open
Clear cell renal cell carcinoma (ccRCC) is a common clinical tumor of the urinary system. The lack of effective diagnostic and treatment options poses a serious challenge to clinical treatment. Therefore, identifying effective molecular ta…
View article: Punicalin Ameliorates Vascular Endothelial Cell Pyroptosis and Dysfunction Induced by Hyperlipidemia and Hyperglycemia Through Activation of PPARγ
Punicalin Ameliorates Vascular Endothelial Cell Pyroptosis and Dysfunction Induced by Hyperlipidemia and Hyperglycemia Through Activation of PPARγ Open
View article: The comprehensive relationship between combined anti-inflammatory and healthy diets and all-cause mortality in rheumatoid arthritis: results from NHANES 2003–2018
The comprehensive relationship between combined anti-inflammatory and healthy diets and all-cause mortality in rheumatoid arthritis: results from NHANES 2003–2018 Open
These findings suggest that combining a higher HEI-2015 with a lower DII score correlates with reduced all-cause mortality risk among patients with RA, supporting dietary modification as a potential strategy to prevent premature death in t…
View article: Adjustment of the main biosynthesis modules to enhance the production of <scp>l</scp>‐homoserine in <i>Escherichia coli</i> W3110
Adjustment of the main biosynthesis modules to enhance the production of <span>l</span>‐homoserine in <i>Escherichia coli</i> W3110 Open
l ‐homoserine is an important platform compound of many valuable products. Construction of microbial cell factory for l ‐homoserine production from glucose has attracted a great deal of attention. In this study, l ‐homoserine biosynthesis …
View article: Dysregulated GLUT1 results in the pathogenesis of preeclampsia by impairing the function of trophoblast cells
Dysregulated GLUT1 results in the pathogenesis of preeclampsia by impairing the function of trophoblast cells Open
View article: Corrigendum: Nonmuscle myosin heavy chain IIA-mediated exosome release via regulation of the rho-associated kinase 1/myosin light chains/actin pathway
Corrigendum: Nonmuscle myosin heavy chain IIA-mediated exosome release via regulation of the rho-associated kinase 1/myosin light chains/actin pathway Open
[This corrects the article DOI: 10.3389/fphar.2020.598592.].
View article: Acetylation of TIR domains in the TLR4-Mal-MyD88 complex regulates immune responses in sepsis
Acetylation of TIR domains in the TLR4-Mal-MyD88 complex regulates immune responses in sepsis Open
View article: RETRACTED: The authors have requested that this preprint be removed from Research Square.
RETRACTED: The authors have requested that this preprint be removed from Research Square. Open
The authors have requested that this preprint be removed from Research Square.
View article: O-GlcNAc Modification Is a Promising Therapeutic Target for Diabetic Retinopathy
O-GlcNAc Modification Is a Promising Therapeutic Target for Diabetic Retinopathy Open
Diabetic retinopathy (DR) is a very serious diabetes complication. Changes in the O-linked N-acetylglucosamine (O-GlcNAc) modification are associated with many diseases. However, its role in DR is not fully understood. In this research, we…
View article: IFI16 promotes the progression of clear cell renal cell carcinoma through the IL6/PI3K/AKT axis
IFI16 promotes the progression of clear cell renal cell carcinoma through the IL6/PI3K/AKT axis Open
Background Clear cell renal cell carcinoma (ccRCC) is a common disease in the urinary system, with a high incidence and poor prognosis in advanced stages. Although γ-interferon-inducible protein 16 (IFI16) has been reported to play a role …
View article: Long-chain acyl-CoA synthetase-4 regulates endometrial decidualization through a fatty acid β-oxidation pathway rather than lipid droplet accumulation
Long-chain acyl-CoA synthetase-4 regulates endometrial decidualization through a fatty acid β-oxidation pathway rather than lipid droplet accumulation Open
Our findings suggest that ACSL4 promotes endometrial decidualization by activating the β-oxidation pathway. This study provides interesting insights into our understanding of the mechanisms regulating lipid metabolism during decidualizatio…
View article: Corrigendum to “miR-196b inhibits cell migration and invasion through targeting MAP3K1 in hydatidiform mole” [Biomed. Pharmacother. 113 (2019) 108760]
Corrigendum to “miR-196b inhibits cell migration and invasion through targeting MAP3K1 in hydatidiform mole” [Biomed. Pharmacother. 113 (2019) 108760] Open
View article: Explore the value of carotid ultrasound radiomics nomogram in predicting ischemic stroke risk in patients with type 2 diabetes mellitus
Explore the value of carotid ultrasound radiomics nomogram in predicting ischemic stroke risk in patients with type 2 diabetes mellitus Open
Background and objective Type 2 Diabetes Mellitus (T2DM) with insulin resistance (IR) is prone to damage the vascular endothelial, leading to the formation of vulnerable carotid plaques and increasing ischemic stroke (IS) risk. The purpose…
View article: LncRNA NDUFA6-DT: A Comprehensive Analysis of a Potential LncRNA Biomarker and Its Regulatory Mechanisms in Gliomas
LncRNA NDUFA6-DT: A Comprehensive Analysis of a Potential LncRNA Biomarker and Its Regulatory Mechanisms in Gliomas Open
Gliomas are the most prevalent primary malignant tumors affecting the brain, with high recurrence and mortality rates. Accurate diagnoses and effective treatment challenges persist, emphasizing the need for identifying new biomarkers to gu…
View article: Correction to: Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion
Correction to: Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion Open
View article: Unlocking hidden potential: The Prognostic Value and Immunoinfiltration of CACUL1 in Malignant Tumours
Unlocking hidden potential: The Prognostic Value and Immunoinfiltration of CACUL1 in Malignant Tumours Open
Background: CDK2 associated cullin domain 1 (CACUL1), also named C10ORF46, is a poorly understood gene. Growing evidence illustrates that CACUL1 plays a potential role in malignant tumors. However, the prognostic value of CACUL1 in maligna…
View article: Progesterone inhibits endometrial cancer growth by inhibiting glutamine metabolism through ASCT2
Progesterone inhibits endometrial cancer growth by inhibiting glutamine metabolism through ASCT2 Open
Endometrial carcinoma (EC) is a common malignancy that originates from the endometrium and grows in the female reproductive system. Surgeries, as current treatments for cancer, however, cannot meet the fertility needs of young women patien…
View article: Identification and validation of Golgi apparatus-related signature for predicting prognosis and immunotherapy response in breast cancer
Identification and validation of Golgi apparatus-related signature for predicting prognosis and immunotherapy response in breast cancer Open
Background The Golgi apparatus plays a pivotal role in various aspects of cancer. This study aims to investigate the predictive value of Golgi apparatus-related genes (GARGs) in breast cancer prognosis and immunotherapy response evaluation…
View article: CD34 in Preeclampsia: The Role of Endothelial Cell Pyroptosis and Regulation by Melatonin via&nbsp;MT1
CD34 in Preeclampsia: The Role of Endothelial Cell Pyroptosis and Regulation by Melatonin via MT1 Open
View article: Advancements and applications of single-cell multi-omics techniques in cancer research: Unveiling heterogeneity and paving the way for precision therapeutics
Advancements and applications of single-cell multi-omics techniques in cancer research: Unveiling heterogeneity and paving the way for precision therapeutics Open
View article: Melatonin suppresses tumor proliferation and metastasis by targeting GATA2 in endometrial cancer
Melatonin suppresses tumor proliferation and metastasis by targeting GATA2 in endometrial cancer Open
Endometrial cancer (EC) is a reproductive system disease that occurs in perimenopausal and postmenopausal women. However, its etiology is unclear. Melatonin (MT) has been identified as a therapeutic agent for EC; however, its exact mechani…
View article: Multimodal prehabilitation to improve the clinical outcomes of frail elderly patients with gastric cancer: a study protocol for a multicentre randomised controlled trial (GISSG<sup>+</sup>2201)
Multimodal prehabilitation to improve the clinical outcomes of frail elderly patients with gastric cancer: a study protocol for a multicentre randomised controlled trial (GISSG<sup>+</sup>2201) Open
Introduction Gastric cancer (GC) diagnosed in the elderly population has become a serious public health problem worldwide. Given the combined effects of frailty and the consequences of cancer treatment, older individuals with GC are more l…
View article: OCLN as a novel biomarker for prognosis and immune infiltrates in kidney renal clear cell carcinoma: an integrative computational and experimental characterization
OCLN as a novel biomarker for prognosis and immune infiltrates in kidney renal clear cell carcinoma: an integrative computational and experimental characterization Open
Background Occludin (OCLN) is an important tight junction protein and has been reported to be abnormally expressed in the development of malignant tumors. However, its biomarker and carcinogenic roles in kidney renal clear cell carcinoma (…
View article: Fatty acid metabolism-related genes as a novel module biomarker for kidney renal clear cell carcinoma: Bioinformatics modeling with experimental verification
Fatty acid metabolism-related genes as a novel module biomarker for kidney renal clear cell carcinoma: Bioinformatics modeling with experimental verification Open
View article: Real-World Biomarker Test Utilization and Subsequent Treatment in Patients with Early-Stage Non-small Cell Lung Cancer in the United States, 2011−2021
Real-World Biomarker Test Utilization and Subsequent Treatment in Patients with Early-Stage Non-small Cell Lung Cancer in the United States, 2011−2021 Open
This study suggests a high biomarker testing rate among patients with eNSCLC in the US, with testing rates for various biomarkers increasing over the past decade, indicating a continuous trend towards the personalization of treatment decis…
View article: Ultrashort wave alleviates oxygen<b>-</b>glucose deprivation/reoxygenation injury via up<b>-</b>regulation of SPCA1 expression in N2a cells.
Ultrashort wave alleviates oxygen<b>-</b>glucose deprivation/reoxygenation injury via up<b>-</b>regulation of SPCA1 expression in N2a cells. Open
USW alleviates the injury of cellular OGD/R, and its protective effect may be related to its up-regulation of SPCA1 expression.
View article: Emerging field: O-GlcNAcylation in ferroptosis
Emerging field: O-GlcNAcylation in ferroptosis Open
In 2012, researchers proposed a non-apoptotic, iron-dependent form of cell death caused by lipid peroxidation called ferroptosis. During the past decade, a comprehensive understanding of ferroptosis has emerged. Ferroptosis is closely asso…