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View article: Exogenous Nitric Oxide Promotes the Growth and Cadmium Accumulation of Alfalfa (Medicago sativa) Seedlings Under Cadmium Stress
Exogenous Nitric Oxide Promotes the Growth and Cadmium Accumulation of Alfalfa (Medicago sativa) Seedlings Under Cadmium Stress Open
As an important bioactive signaling molecule, nitric oxide (NO) participates in the responses of plants to various environmental stresses. The aim of this study was to investigate the influence of exogenous NO on the growth and cadmium (Cd…
View article: The Impact of Quarterback Performance Metrics on NFL Broadcast Viewership: A Decade-Long Correlation and Regression Analysis (20152024)
The Impact of Quarterback Performance Metrics on NFL Broadcast Viewership: A Decade-Long Correlation and Regression Analysis (20152024) Open
This study explores the relationship between National Football League (NFL) quarterbacks' performance metrics and television viewership trends from 2015 to 2024. Using data from Pro-Football-Reference for quarterback statistics and from St…
View article: CAR19 therapy drives expansion of clonal hematopoiesis and associated cytopenias
CAR19 therapy drives expansion of clonal hematopoiesis and associated cytopenias Open
CD19-directed chimeric antigen receptor T-cell therapy (CAR19) improves survival in patients with relapsed/refractory large B-cell lymphoma (rrLBCL) compared to immunochemotherapy with intent for autologous hematopoietic cell transplantati…
View article: Neonatal outcomes among pregnant women with COVID-19: a systematic scoping review and meta-analysis
Neonatal outcomes among pregnant women with COVID-19: a systematic scoping review and meta-analysis Open
View article: On the two-step hybrid design for augmenting randomized trials using real-world data
On the two-step hybrid design for augmenting randomized trials using real-world data Open
Hybrid clinical trials, which borrow real-world data (RWD) from patient registries, claims databases, or electronic health records (EHRs) to augment randomized clinical trials, are of increasing interest. Hybrid clinical trials are especia…
View article: Cytokine Regulation of Human Antibody Responses to Influenza Vaccines
Cytokine Regulation of Human Antibody Responses to Influenza Vaccines Open
Studies show that human vaccine responses widely vary. Here, we analyzed data measuring 66 cytokines from 4 different inactivated influenza vaccine (IIV) cohorts over 5 seasons (N=581) and identified a significant correlation between basel…
View article: Natural history study of recessive dystrophic epidermolysis bullosa wounds and patient reported outcomes using mobile application home photography
Natural history study of recessive dystrophic epidermolysis bullosa wounds and patient reported outcomes using mobile application home photography Open
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare, blistering genetic disease where wounding and wound pain are the most reported problems by patients. The natural history of RDEB wounds, specifically spontaneous wound closure be…
View article: A novel bispecific aptamer targeting LAG3 and HER2 enhances T cell-mediated immunotherapy against HER2-positive cancer cells
A novel bispecific aptamer targeting LAG3 and HER2 enhances T cell-mediated immunotherapy against HER2-positive cancer cells Open
Objective Malignant tumors are one of the leading causes of human death worldwide. In recent years, immunotherapy has become an emerging treatment method following surgery, radiotherapy, and chemotherapy. The study focused on two critical …
View article: GLP-1 RA Use and Survival Among Older Adults With Cancer and Type 2 Diabetes
GLP-1 RA Use and Survival Among Older Adults With Cancer and Type 2 Diabetes Open
This cohort study evaluates whether older adults with type 2 diabetes and cancer have improved survival when taking glucagon-like peptide-1 receptor agonists (GLP-1RAs) compared with sodium-glucose cotransporter-2 inhibitors and dipeptidyl…
View article: IDS-Net: A novel framework for few-shot photovoltaic power prediction with interpretable dynamic selection and feature information fusion
IDS-Net: A novel framework for few-shot photovoltaic power prediction with interpretable dynamic selection and feature information fusion Open
With the growing demand for renewable energy, countries are accelerating the construction of photovoltaic (PV) power stations. However, accurately forecasting power data for newly constructed PV stations is extremely challenging due to lim…
View article: Identification, Antioxidant and Immunomodulatory Activities of a Neutral Exopolysaccharide from Lactiplantibacillus plantarum DMDL 9010
Identification, Antioxidant and Immunomodulatory Activities of a Neutral Exopolysaccharide from Lactiplantibacillus plantarum DMDL 9010 Open
Objectives: This study investigated the properties of a neutral exopolysaccharide (EPS-LP1) with an average molecular weight of 55,637 Da, isolated from Lactiplantibacillus plantarum DMDL 9010 (LP9010). Results: The composition of EPS-LP1 …
View article: Home-based rehabilitation experience of children with congenital muscular torticollis: a qualitative study
Home-based rehabilitation experience of children with congenital muscular torticollis: a qualitative study Open
View article: Multi-Targeted Anti-Cancer Effects of Triptophenolide in Hormone-Responsive and Triple-Negative Breast Cancer Models
Multi-Targeted Anti-Cancer Effects of Triptophenolide in Hormone-Responsive and Triple-Negative Breast Cancer Models Open
Breast cancer (BC) remains a significant therapeutic challenge, necessitating novel agents with multi-target efficacy. Here, we demonstrate that triptophenolide (TRI), a bioactive compound from Tripterygium wilfordii, exerts potent anti-BC…
View article: Deep Learning-Assisted Diagnostic System: Implant Brand Detection Using Improved IB-YOLOv10 in Periapical Radiographs
Deep Learning-Assisted Diagnostic System: Implant Brand Detection Using Improved IB-YOLOv10 in Periapical Radiographs Open
Background and Objectives: Implant brand identification is critical in modern dental clinical diagnostics. With the increasing variety of implant brands and the difficulty of accurate identification in periapical radiographs, there is a gr…
View article: Correction: Clinical features of HAdV-55 in children with respiratory tract infections: a retrospective case series and literature review
Correction: Clinical features of HAdV-55 in children with respiratory tract infections: a retrospective case series and literature review Open
View article: Clinical features of HAdV-55 in children with respiratory tract infections: a retrospective case series and literature review
Clinical features of HAdV-55 in children with respiratory tract infections: a retrospective case series and literature review Open
Background Human adenovirus type 55 (HAdV-55) can lead to acute respiratory diseases, significant morbidity, and mortality in children. Methods Hospitalized children diagnosed with HAdV-55 between September 2016 and March 2024 at the Child…
View article: Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology
Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology Open
The intricate interaction between skeletal muscle biomechanics, the tumor microenvironment, and immunotherapy constitutes a pivotal research focus oncology. This work provides a comprehensive review of methodologies for evaluating skeletal…
View article: Age-dependent cytokine surge in blood precedes cancer diagnosis
Age-dependent cytokine surge in blood precedes cancer diagnosis Open
Aging is associated with increased variability and dysregulation of the immune system. We performed a system-level analysis of serum cytokines in a longitudinal cohort of 133 healthy individuals over 9 y. We found that cancer incidence is …
View article: Balancing the effective sample size in prior across different doses in the curve-free Bayesian decision-theoretic design for dose-finding trials
Balancing the effective sample size in prior across different doses in the curve-free Bayesian decision-theoretic design for dose-finding trials Open
The primary goal of dose allocation in phase I trials is to minimize patient exposure to subtherapeutic or excessively toxic doses, while accurately recommending a phase II dose that is as close as possible to the maximum tolerated dose (M…
View article: Smoking-related gut microbiota alteration is associated with obesity and obesity-related diseases: results from two cohorts with sibling comparison analyses
Smoking-related gut microbiota alteration is associated with obesity and obesity-related diseases: results from two cohorts with sibling comparison analyses Open
While smoking may reduce weight through various mechanisms, alterations in gut microbiota related to smoking are associated with weight gain. Further research is required to determine if changes in the smoking-related microbiome contribute…
View article: Patient-Selection of a Clinical Trial Primary Outcome: The ENHANCE-AF Outcomes Survey
Patient-Selection of a Clinical Trial Primary Outcome: The ENHANCE-AF Outcomes Survey Open
Introduction Before the initiation of the ENHANCE-AF clinical trial, which tested a novel digital shared decision-making tool to guide the use of anticoagulants in stroke prevention for patients with atrial fibrillation, this study aimed t…
View article: Effects of household concrete floors on maternal and child health: the CRADLE trial – a randomised controlled trial protocol
Effects of household concrete floors on maternal and child health: the CRADLE trial – a randomised controlled trial protocol Open
Introduction Early life soil-transmitted helminth (STH) infection and diarrhoea are associated with growth faltering, anaemia, impaired child development and mortality. Exposure to faecally contaminated soil inside the home may be a key co…
View article: Associations of Plasma Gut Microbiota-Derived TMAO and Precursors in Early Pregnancy with Gestational Diabetes Mellitus Risk: A Nested Case-Control Study
Associations of Plasma Gut Microbiota-Derived TMAO and Precursors in Early Pregnancy with Gestational Diabetes Mellitus Risk: A Nested Case-Control Study Open
Objectives: Gut microbiota-derived metabolites—trimethylamine N-oxide (TMAO) and its precursors choline, betaine, and carnitine—have been linked to various health outcomes. However, their role in gestational diabetes mellitus (GDM) remains…
View article: A nomogram for predicting T315I-free survival in chronic phase chronic myeloid leukemia patients: a multicenter retrospective study
A nomogram for predicting T315I-free survival in chronic phase chronic myeloid leukemia patients: a multicenter retrospective study Open
The T315I mutation poses a significant threat to patients with chronic phase chronic myeloid leukemia (CP-CML). This study aimed to establish a nomogram to predict the risk of T315I mutation in CP-CML patients. The training cohort included…
View article: An evaluation of a five-year program for newborn congenital heart disease screening in Jiangsu Province, 2019–2023
An evaluation of a five-year program for newborn congenital heart disease screening in Jiangsu Province, 2019–2023 Open
View article: Bidirectional Association of Gut Microbiota-Derived Trimethylamine N-Oxide and its Precursors with Estimated Glomerular Filtration Rate: A Cross-Lagged Cohort Study
Bidirectional Association of Gut Microbiota-Derived Trimethylamine N-Oxide and its Precursors with Estimated Glomerular Filtration Rate: A Cross-Lagged Cohort Study Open
Deceased eGFR is related to elevated serum carnitine concentrations and may be linked to choline. Conversely, elevated TMAO may be linked to reduced kidney function. This provides novel evidence that managing healthy kidney function helps …
View article: Decentralized Clinical Trials in the Era of Real‐World Evidence: A Statistical Perspective
Decentralized Clinical Trials in the Era of Real‐World Evidence: A Statistical Perspective Open
There has been a growing trend that activities relating to clinical trials take place at locations other than traditional trial sites (hence decentralized clinical trials or DCTs), some of which are at settings of real‐world clinical pract…
View article: On the two-step hybrid design for augmenting randomized trials using real-world data
On the two-step hybrid design for augmenting randomized trials using real-world data Open
Hybrid clinical trials, that borrow real-world data (RWD), are gaining interest, especially for rare diseases. They assume RWD and randomized control arm be exchangeable, but violations can bias results, inflate type I error, or reduce pow…
View article: Three-dimensional genome architecture in intrahepatic cholangiocarcinoma
Three-dimensional genome architecture in intrahepatic cholangiocarcinoma Open
View article: Donor regulatory T-cell therapy to prevent graft-versus-host disease
Donor regulatory T-cell therapy to prevent graft-versus-host disease Open
Allogeneic hematopoietic cell transplantation is a curative therapy limited by graft-versus-host disease (GVHD). In preclinical studies and early-phase clinical studies, enrichment of donor regulatory T cells (Tregs) appears to prevent GVH…