Juying Qian
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View article: PIEZO1 gain-of-function mutation drives cardiomyopathy by disrupting myocardial lipid homeostasis besides iron overload
PIEZO1 gain-of-function mutation drives cardiomyopathy by disrupting myocardial lipid homeostasis besides iron overload Open
As a mechanosensitive channel, PIEZO1 translates mechanical stretching of cardiomyocytes into Ca 2+ signaling, underpinning the Frank-Starling law. This mechanism contributes to compensatory responses in heart failure. However, the relatio…
View article: Gut microbiota in combination with blood metabolites and inflammatory cytokines reveals characteristics of hypertrophic cardiomyopathy: a Mendelian randomization study
Gut microbiota in combination with blood metabolites and inflammatory cytokines reveals characteristics of hypertrophic cardiomyopathy: a Mendelian randomization study Open
Background and purpose: Hypertrophic cardiomyopathy (HCM) is the most prevalent form of cardiomyopathy and the leading cause of sudden cardiac death in young individuals. However, research on the precise intervention targets for this condi…
View article: Periprocedural Assessment of Coronary Microcirculatory Function to Predict Clinical Outcomes After Elective Percutaneous Coronary Intervention
Periprocedural Assessment of Coronary Microcirculatory Function to Predict Clinical Outcomes After Elective Percutaneous Coronary Intervention Open
Background Percutaneous coronary intervention (PCI) could restore epicardial blood flow through the stent‐based angioplasty. However, coronary microcirculatory function also affects clinical outcomes and can be quantified by the angiograph…
View article: Coronary plaque regression in an old female patient with moderate-intensity statin therapy
Coronary plaque regression in an old female patient with moderate-intensity statin therapy Open
Coronary plaque regression is the target of treatment for coronary heart disease. Many medications have been used to prevent plaque progression. Statins are the most important drugs for lipid management, but they do not work well for many …
View article: Position Statement on Antiplatelet Therapy for East Asians With Coronary Artery Disease
Position Statement on Antiplatelet Therapy for East Asians With Coronary Artery Disease Open
View article: Direct3D-S2: Gigascale 3D Generation Made Easy with Spatial Sparse Attention
Direct3D-S2: Gigascale 3D Generation Made Easy with Spatial Sparse Attention Open
Generating high-resolution 3D shapes using volumetric representations such as Signed Distance Functions (SDFs) presents substantial computational and memory challenges. We introduce Direct3D-S2, a scalable 3D generation framework based on …
View article: Angiography-derived index of microcirculatory resistance predicts long-term outcomes in late-presenting patients with ST-segment elevation myocardial infarction
Angiography-derived index of microcirculatory resistance predicts long-term outcomes in late-presenting patients with ST-segment elevation myocardial infarction Open
Our study indicated that caIMR was an important prognostic predictor in late-presenting STEMI patients who underwent delayed PCI. Preservation of coronary microcirculatory function during PCI could provide long-term prognostic benefits.
View article: Model-free Online Learning for the Kalman Filter: Forgetting Factor and Logarithmic Regret
Model-free Online Learning for the Kalman Filter: Forgetting Factor and Logarithmic Regret Open
We consider the problem of online prediction for an unknown, non-explosive linear stochastic system. With a known system model, the optimal predictor is the celebrated Kalman filter. In the case of unknown systems, existing approaches base…
View article: Short-term changes in myocardial perfusion of the predominant donor vessel after percutaneous coronary intervention for chronic total occlusion
Short-term changes in myocardial perfusion of the predominant donor vessel after percutaneous coronary intervention for chronic total occlusion Open
The myocardial perfusion in the predominant donor territory was positively associated with that in the CTO territory. The myocardial perfusion in the predominant donor territory increased within a short-term period after CTO PCI, specifica…
View article: Successful Management of a Fractured Microcatheter During Retrograde CTO Intervention
Successful Management of a Fractured Microcatheter During Retrograde CTO Intervention Open
We describe the successful management of a 60-year-old male patient with chronic chest pain, a history of hypertension, and previous percutaneous coronary intervention in the right coronary artery. After initial failure with an antegrade a…
View article: Sirolimus-Eluting Iron Bioresorbable Scaffolds Versus Everolimus-Eluting Stents in Patients with Coronary Artery Disease: A Single-Blind, Randomised Trial (IRONMAN II)
Sirolimus-Eluting Iron Bioresorbable Scaffolds Versus Everolimus-Eluting Stents in Patients with Coronary Artery Disease: A Single-Blind, Randomised Trial (IRONMAN II) Open
View article: The safety and efficacy of the microaxial SynFlow 3.0 flow pump system for patients undergoing high-risk percutaneous coronary intervention
The safety and efficacy of the microaxial SynFlow 3.0 flow pump system for patients undergoing high-risk percutaneous coronary intervention Open
Background and purpose: Percutaneous coronary intervention (PCI) in complex high-risk and indicated patients (CHIP-PCI) remains a challenging procedure. The objective of this study was to evaluate the safety and efficacy of the novel micro…
View article: Awareness and Perceptions towards the Role of Systemic Inflammation and High-Sensitivity C-reactive Protein as a Biomarker in Atherosclerotic Cardiovascular Disease and Chronic Kidney Disease: The Multinational FLAME-ASCVD Survey amongst Cardiologists
Awareness and Perceptions towards the Role of Systemic Inflammation and High-Sensitivity C-reactive Protein as a Biomarker in Atherosclerotic Cardiovascular Disease and Chronic Kidney Disease: The Multinational FLAME-ASCVD Survey amongst Cardiologists Open
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View article: Indobufen-based dual antiplatelet therapy in patients with multivessel coronary disease undergoing drug-eluting stent implantation insight from the OPTION trial
Indobufen-based dual antiplatelet therapy in patients with multivessel coronary disease undergoing drug-eluting stent implantation insight from the OPTION trial Open
The trial was registered at www.chictr.org. A Randomized Controlled Trial of Indobufen vs Aspirin after Coronary Drug-eluting Stent Implantation: the OPTION Trial (ChiCTR-IIR-17013505).
View article: Metabonomic Biomarkers of Plaque Burden and Instability in Patients With Coronary Atherosclerotic Disease After Moderate Lipid‐Lowering Therapy
Metabonomic Biomarkers of Plaque Burden and Instability in Patients With Coronary Atherosclerotic Disease After Moderate Lipid‐Lowering Therapy Open
Background Contemporary risk assessment in patients with coronary atherosclerotic disease (CAD) often relies on invasive angiography. However, we aimed to explore the potential of metabolomic biomarkers in reflecting residual risk in patie…
View article: The evaluation of combined fractional flow reserve and dynamic SPECT in chronic total occlusion
The evaluation of combined fractional flow reserve and dynamic SPECT in chronic total occlusion Open
View article: A Systematic Literature Review and Network Meta-analysis of Azilsartan Medoxomil Compared to Other Anti-hypertensives Efficacy in Lowering Blood Pressure Amongst Mild to Moderate Hypertensive Patients
A Systematic Literature Review and Network Meta-analysis of Azilsartan Medoxomil Compared to Other Anti-hypertensives Efficacy in Lowering Blood Pressure Amongst Mild to Moderate Hypertensive Patients Open
View article: ECMO versus IABP for patients with STEMI complicated by cardiogenic shock undergoing primary PCI: a Chinese National Study and propensity-matched analysis
ECMO versus IABP for patients with STEMI complicated by cardiogenic shock undergoing primary PCI: a Chinese National Study and propensity-matched analysis Open
Among patients undergoing primary PCI for STEMI complicated by cardiogenic shock, ECMO was associated with better in-hospital survival than IABP.
View article: 230 Understanding UK cardiologists’ perception of systemic inflammation and hsCRP in atherosclerotic cardiovascular disease and chronic kidney disease: insights from UK respondents to the multinational flame-ASCVD survey
230 Understanding UK cardiologists’ perception of systemic inflammation and hsCRP in atherosclerotic cardiovascular disease and chronic kidney disease: insights from UK respondents to the multinational flame-ASCVD survey Open
Introduction Despite advancements in managing atherosclerotic cardiovascular disease (ASCVD), mortality and morbidity rates remain high. This is partially attributed to systemic inflammation (SI) which leads to increased cardiovascular ris…
View article: Clinical factors associated with positive coronary angiography in patients undergoing cardiac surgery
Clinical factors associated with positive coronary angiography in patients undergoing cardiac surgery Open
Background: Many cardiovascular disease patients undergoing valve repair/replacement or other surgeries in hospitals require coronary angiography (CAG) examination. Positive results may lead to simultaneous bypass grafting, while negative …
View article: Differences in Clinical Profiles and Outcomes Between Early-onset and Older Patients Hospitalized for Coronary Artery Disease: A Prospective Cohort Study.
Differences in Clinical Profiles and Outcomes Between Early-onset and Older Patients Hospitalized for Coronary Artery Disease: A Prospective Cohort Study. Open
Background Contemporary data on age-dependent differences in risk factors, hospital care and outcomes between early-onset and older patients with coronary artery disease (CAD) is limited in Han Chinese. Methods In this nation-wide, prospec…
View article: Nicorandil alleviates cardiac microvascular ferroptosis in diabetic cardiomyopathy: Role of the mitochondria-localized AMPK-Parkin-ACSL4 signaling pathway
Nicorandil alleviates cardiac microvascular ferroptosis in diabetic cardiomyopathy: Role of the mitochondria-localized AMPK-Parkin-ACSL4 signaling pathway Open
Mitochondria-associated ferroptosis exacerbates cardiac microvascular dysfunction in diabetic cardiomyopathy (DCM). Nicorandil, an ATP-sensitive K+ channel opener, protects against endothelial dysfunction, mitochondrial dysfunction, and DC…
View article: Double kissing inflation outside the stent versus jailed balloon technique for coronary bifurcation lesions
Double kissing inflation outside the stent versus jailed balloon technique for coronary bifurcation lesions Open
Background Side branch (SB) occlusion remains challenging in percutaneous coronary intervention (PCI) for bifurcation lesions even in the era of jailed balloon technique (JBT). Our previous single-arm study introduced a novel method to pro…
View article: Dapagliflozin decreases atherosclerotic plaque instability via regulating macrophage pyroptosis
Dapagliflozin decreases atherosclerotic plaque instability via regulating macrophage pyroptosis Open
Background Vulnerable plaques are characterized by infiltration of inflammatory cells, playing a key role in the progression of acute coronary events. It’s important to clarify the inflammatory mechanism of unstable plaque formation. Sever…
View article: Integrative Proteomic Analysis Reveals the Cytoskeleton Regulation and Mitophagy Difference Between Ischemic Cardiomyopathy and Dilated Cardiomyopathy
Integrative Proteomic Analysis Reveals the Cytoskeleton Regulation and Mitophagy Difference Between Ischemic Cardiomyopathy and Dilated Cardiomyopathy Open
View article: Chronologic evolution and prognostic implications of impaired coronary flow after chronic total occlusion angioplasty
Chronologic evolution and prognostic implications of impaired coronary flow after chronic total occlusion angioplasty Open
SF has a significant influence on the prognosis of patients undergoing CTO PCI. Achieving normal coronary flow is essential in CTO revascularization.
View article: Long-term clinical outcomes of drug-coated balloon for the management of chronic total occlusions
Long-term clinical outcomes of drug-coated balloon for the management of chronic total occlusions Open
Objectives This study aims to compare the clinical outcomes of patients with de novo chronic total occlusion (CTO) lesions treated by hybrid strategy and drug-coated balloons (DCB)-only strategy. Backgrounds DCBs have been used as an alter…
View article: Hippo pathway-manipulating neutrophil-mimic hybrid nanoparticles for cardiac ischemic injury via modulation of local immunity and cardiac regeneration
Hippo pathway-manipulating neutrophil-mimic hybrid nanoparticles for cardiac ischemic injury via modulation of local immunity and cardiac regeneration Open
View article: Association between NLRP3 inflammasome and periprocedural myocardial injury following elective PCI
Association between NLRP3 inflammasome and periprocedural myocardial injury following elective PCI Open
We discovered that NLRP3 inflammasome was involved in PMI, thus providing evidence supporting the therapeutic value of NLRP3 inflammasome-targeted strategies in PMI.
View article: Efficiency of the Guide Extension Catheter-Facilitated Tip-in Technique in the Recanalization of Coronary Chronic Total Occlusion
Efficiency of the Guide Extension Catheter-Facilitated Tip-in Technique in the Recanalization of Coronary Chronic Total Occlusion Open
Guide extension catheter-facilitated tip-in is an efficient method to achieve the recanalization of CTO in a retrograde way, which would be pivotal when the retrograde microcatheter could not be advanced into the antegrade guide catheter.