Tien Yin Wong
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View article: Digital health technology use in clinical trials of rare diseases: a systematic review
Digital health technology use in clinical trials of rare diseases: a systematic review Open
Our findings reveal a growing trend toward digital integration in rare disease trials to support decentralized, scalable, and patient-centered research models. We propose a "4A" conceptual framework-Accessibility, Agility, Awareness, and A…
View article: Transforming Chinese cohort studies through artificial intelligence: a new era of population health research
Transforming Chinese cohort studies through artificial intelligence: a new era of population health research Open
Tien Yin Wong and colleagues explore how artificial intelligence can tackle persistent challenges in Chinese epidemiological studies and analyse the regulatory frameworks and barriers to implementation that must be overcome to ensure equit…
View article: Global innovative perspectives and trends on digital health and patient safety: highlights from the #DHPSP2024 networking event
Global innovative perspectives and trends on digital health and patient safety: highlights from the #DHPSP2024 networking event Open
Aim: This manuscript summarizes the key scientific and practical outcomes of the #DHPSP2024 digital networking event, focusing on emerging trends in digital health technologies, innovations in patient safety, and their implications for imp…
View article: Large language models and global health equity: a roadmap for equitable adoption in LMICs
Large language models and global health equity: a roadmap for equitable adoption in LMICs Open
View article: The experience of Déjà Vecu in a patient with behavioral variant frontotemporal dementia in the biomarker era
The experience of Déjà Vecu in a patient with behavioral variant frontotemporal dementia in the biomarker era Open
View article: How can artificial intelligence transform the training of medical students and physicians?
How can artificial intelligence transform the training of medical students and physicians? Open
Advances in artificial intelligence (AI), particularly generative AI, hold promise for transforming medical education and physician training in response to increasing health-care demands and shortages in the global health-care workforce. M…
View article: Urgent needs, opportunities and challenges of virtual reality in healthcare and medicine in the era of large language models
Urgent needs, opportunities and challenges of virtual reality in healthcare and medicine in the era of large language models Open
The convergence of large language models (LLMs) and virtual reality (VR) technologies has led to significant breakthroughs across multiple domains, particularly in healthcare and medicine. Owing to its immersive and interactive capabilitie…
View article: Corrigendum to “International consensuses and guidelines on etiology, diagnosis, treatment, and future developments of neovascular age-related macular degeneration (nAMD) by the Asia-Pacific Vitreo-retina Society (APVRS), the Asia-Pacific Ocular Imaging Society (APOIS) and the Academy of the Asia-Pacific Professors of Ophthalmology (AAPPO)” [Asia-Pac J Ophthalmol, Available online 29 August 2025, 100242 (2025) DOI:10.1016/j.apjo.2025.100242]
Corrigendum to “International consensuses and guidelines on etiology, diagnosis, treatment, and future developments of neovascular age-related macular degeneration (nAMD) by the Asia-Pacific Vitreo-retina Society (APVRS), the Asia-Pacific Ocular Imaging Society (APOIS) and the Academy of the Asia-Pacific Professors of Ophthalmology (AAPPO)” [Asia-Pac J Ophthalmol, Available online 29 August 2025, 100242 (2025) DOI:10.1016/j.apjo.2025.100242] Open
View article: EVLF-FM: Explainable Vision Language Foundation Model for Medicine
EVLF-FM: Explainable Vision Language Foundation Model for Medicine Open
Despite the promise of foundation models in medical AI, current systems remain limited - they are modality-specific and lack transparent reasoning processes, hindering clinical adoption. To address this gap, we present EVLF-FM, a multimoda…
View article: Ophthalmic drug discovery and development using artificial intelligence and digital health technologies
Ophthalmic drug discovery and development using artificial intelligence and digital health technologies Open
Globally, drug discovery and development programs are complex, multi-decade long and prohibitively expensive. Artificial intelligence (AI) and other digital health technologies have the potential to enhance and accelerate each stage of dru…
View article: Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis
Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis Open
View article: The prevalence of diabetic retinopathy in Indigenous and non-Indigenous populations in Canada: systematic review and meta-analysis
The prevalence of diabetic retinopathy in Indigenous and non-Indigenous populations in Canada: systematic review and meta-analysis Open
There may be no difference in the prevalence of DR between Indigenous and non-Indigenous Canadians; however, Indigenous Canadians likely have a higher prevalence of VTDR. The uniformly high prevalence across both populations underscores th…
View article: International consensuses and guidelines on etiology, diagnosis, treatment, and future developments of neovascular age-related macular degeneration (nAMD) by the Asia-Pacific Vitreo-retina Society (APVRS), the Asia-Pacific Ocular Imaging Society (APOIS) and the Academy of the Asia-Pacific Professors of Ophthalmology (AAPPO)
International consensuses and guidelines on etiology, diagnosis, treatment, and future developments of neovascular age-related macular degeneration (nAMD) by the Asia-Pacific Vitreo-retina Society (APVRS), the Asia-Pacific Ocular Imaging Society (APOIS) and the Academy of the Asia-Pacific Professors of Ophthalmology (AAPPO) Open
Neovascular age-related degeneration (nAMD) is one of the leading causes of visual impairment in older populations in the developed world. With the aging population, the incidence of nAMD is growing globally. Despite advancements in diagno…
View article: An artificial intelligence cloud platform for OCT-based retinal anomalies screening system in real clinical environments
An artificial intelligence cloud platform for OCT-based retinal anomalies screening system in real clinical environments Open
Millions of individuals worldwide suffer from retinal anomalies, which can lead to irreversible vision loss. However, the number of ophthalmologists is highly mismatched with the population base in China, especially in many rural and under…
View article: Intravitreal Aflibercept 8 mg in Neovascular Age-Related Macular Degeneration
Intravitreal Aflibercept 8 mg in Neovascular Age-Related Macular Degeneration Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: 429. RALOXIFENE INDUCES SEX-SPECIFIC CHANGES IN ANXIETY- AND DOPAMINE-RELATED BEHAVIOURS IN ADOLESCENT OFFSPRING FOLLOWING PRENATAL IMMUNE ACTIVATION
429. RALOXIFENE INDUCES SEX-SPECIFIC CHANGES IN ANXIETY- AND DOPAMINE-RELATED BEHAVIOURS IN ADOLESCENT OFFSPRING FOLLOWING PRENATAL IMMUNE ACTIVATION Open
Background Adolescence is a critical period for behavioural changes in schizophrenia. Psychotic symptoms often present at late adolescence. Adolescent anxiety is a risk for later psychosis. Raloxifene, an estrogen receptor modulator, can i…
View article: Plain language summary of publication of the 48-week results from the PULSAR study investigating how well a new dose of aflibercept works and how safe it is for people with wet age-related macular degeneration
Plain language summary of publication of the 48-week results from the PULSAR study investigating how well a new dose of aflibercept works and how safe it is for people with wet age-related macular degeneration Open
What is this summary about? • This is a summary of a publication about the PULSAR study, which was published in The Lancet scientific journal. • Wet age-related macular degeneration (or AMD) is a long-term eye disease in which abnormal blo…
View article: A deep learning system for detecting systemic lupus erythematosus from retinal images
A deep learning system for detecting systemic lupus erythematosus from retinal images Open
View article: An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial
An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial Open
Adolescents with obesity face numerous health risks and encounter barriers that lead to physical inactivity. We developed a virtual reality sports system, named REVERIE (Real-World Exercise and VR-Based Exercise Research in Education), whi…
View article: Relationship of Choroidal Thickness With Age-Related Macular Degeneration in Asians: An Asian Eye Epidemiology Consortium Meta-Analysis
Relationship of Choroidal Thickness With Age-Related Macular Degeneration in Asians: An Asian Eye Epidemiology Consortium Meta-Analysis Open
In a large Asian cohort, AMD is associated with a thicker choroid in early AMD, iAMD, and nAMD, but not in GA. Studying the CT will help to better characterize Asian AMD phenotypes, which may show differences compared with AMD phenotypes i…
View article: A deep learning system for detecting silent brain infarction and predicting stroke risk
A deep learning system for detecting silent brain infarction and predicting stroke risk Open
Current brain imaging to detect silent brain infarctions (SBIs) is not feasible for the general population. Here, to overcome this challenge, we developed a retinal image-based deep learning system, DeepRETStroke, to detect SBI and refine …
View article: Multi-Comparison of Different Ocular Imaging Modality-based Deep Learning Models for Visually Significant Cataract Detection
Multi-Comparison of Different Ocular Imaging Modality-based Deep Learning Models for Visually Significant Cataract Detection Open
View article: Myopia and high myopia trends in Chinese children and adolescents over 25 years: a nationwide study with projections to 2050
Myopia and high myopia trends in Chinese children and adolescents over 25 years: a nationwide study with projections to 2050 Open
National Natural Science Foundation of China (#82271086; #82388101; #72495123).
View article: Rantau & Rindu: Insights into the Lived Experiences of Penang People
Rantau & Rindu: Insights into the Lived Experiences of Penang People Open
An important part of social reality is the collective experiences of individuals within a particular community. This research shines a light onto the social reality of the people of Penang, Malaysia through the lens of the lived experience…
View article: Effective refractive error coverage in adults: a systematic review and meta-analysis of updated estimates from population-based surveys in 76 countries modelling the path towards the 2030 global target
Effective refractive error coverage in adults: a systematic review and meta-analysis of updated estimates from population-based surveys in 76 countries modelling the path towards the 2030 global target Open
For the French, Chinese and Spanish translations of the abstract see Supplementary Materials section.
View article: Large language model comparisons between English and Chinese query performance for cardiovascular prevention
Large language model comparisons between English and Chinese query performance for cardiovascular prevention Open
View article: Non-invasive biopsy diagnosis of diabetic kidney disease via deep learning applied to retinal images: a population-based study
Non-invasive biopsy diagnosis of diabetic kidney disease via deep learning applied to retinal images: a population-based study Open
National Key R & D Program of China, National Natural Science Foundation of China, Beijing Natural Science Foundation, Shanghai Municipal Key Clinical Specialty, Shanghai Research Centre for Endocrine and Metabolic Diseases, Innovative res…
View article: The Use of Large Language Models and Their Association With Enhanced Impact in Biomedical Research and Beyond
The Use of Large Language Models and Their Association With Enhanced Impact in Biomedical Research and Beyond Open
The release of ChatGPT in 2022 has catalyzed the adoption of large language models (LLMs) across diverse writing domains, including academic writing. However, this technological shift has raised critical questions regarding the prevalence …
View article: The Effect of Profitability Towards Financial Distress
The Effect of Profitability Towards Financial Distress Open
This study investigates the effect of profitability on financial distress in manufacturing companies listed on the Indonesia Stock Exchange (IDX) from 2017 to 2023, using a unique dataset from that period. From a population of 226 companie…
View article: Study protocol: Apps and peer support for a healthy future and living well with diabetes (APHLID-M)
Study protocol: Apps and peer support for a healthy future and living well with diabetes (APHLID-M) Open
APHLID-M will offer valuable insights into effects of digital technology in enhancing MH (particularly distress) physical health and well-being in young people with diabetes.