Yingchao Wang
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View article: Hypoxia-induced exosomal LUCAT1 promotes osimertinib resistance in lung adenocarcinoma by stabilizing c-MET
Hypoxia-induced exosomal LUCAT1 promotes osimertinib resistance in lung adenocarcinoma by stabilizing c-MET Open
View article: Identification of intratumoral bacteria correlated with hepatitis B virus (HBV) levels: a prognostic indicator for patient outcomes in hepatocellular carcinoma patients
Identification of intratumoral bacteria correlated with hepatitis B virus (HBV) levels: a prognostic indicator for patient outcomes in hepatocellular carcinoma patients Open
Hepatocellular carcinoma (HCC) is a prevalent liver cancer associated with global health. The tumor microenvironment’s (TME) microbial composition significantly influences HCC’s development and prognosis. This study analyzed bacterial 16S …
View article: The acetyltransferase CysE modulates virulence and drug resistance of Mycobacterium tuberculosis by interfering with oxidative stress responses
The acetyltransferase CysE modulates virulence and drug resistance of Mycobacterium tuberculosis by interfering with oxidative stress responses Open
Acetyltransferases play a crucial role in biological processes by modifying a variety of substrates. However, their roles in the virulence of Mycobacterium tuberculosis (M. tb) are poorly understood. To systematically investigate the roles…
View article: An energy efficient hierarchical routing approach for UWSNs using biology inspired intelligent optimization
An energy efficient hierarchical routing approach for UWSNs using biology inspired intelligent optimization Open
View article: Correction: MiR-198 represses tumor growth and metastasis in colorectal cancer by targeting fucosyl transferase 8
Correction: MiR-198 represses tumor growth and metastasis in colorectal cancer by targeting fucosyl transferase 8 Open
View article: HIF-1α regulates the proliferation and differentiation of mouse cranial base sphenoid-occipital synchondrosis chondrocytes via PI3K/Akt signaling
HIF-1α regulates the proliferation and differentiation of mouse cranial base sphenoid-occipital synchondrosis chondrocytes via PI3K/Akt signaling Open
The cranial base synchondrosis (CBS) is a critical growth center in the craniofacial region, and its abnormal development can lead to various craniofacial deformities. In a hypoxic microenvironment, hypoxia-inducible factor-1α (HIF-1α) is …
View article: Fluid inclusion and H–O–S isotope constraints on the genesis of the Ashawayi gold deposit, Southern Tianshan, Xinjiang, NW China
Fluid inclusion and H–O–S isotope constraints on the genesis of the Ashawayi gold deposit, Southern Tianshan, Xinjiang, NW China Open
The Ashawayi gold deposit is situated in the eastern part of the Southern Tianshan Sb–Hg–Au metallogenic belt, a significant source of gold in China. This deposit exhibits typical disseminated mineralization controlled by faults or fractur…
View article: Identification of <i>Mycobacterium tuberculosis</i> intracellular survival-related virulence factors via CRISPR-based eukaryotic-like secretory protein mutant library screen
Identification of <i>Mycobacterium tuberculosis</i> intracellular survival-related virulence factors via CRISPR-based eukaryotic-like secretory protein mutant library screen Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis ( M.tb ), remains a serious infectious disease posing significant global health challenges. A critical evolutionary feature of M.tb is its genome encoding a set of eukaryotic-like sec…
View article: MRI monitoring of USPIO-labeled BMSCs combined with alginate scaffold for cartilage defect repair
MRI monitoring of USPIO-labeled BMSCs combined with alginate scaffold for cartilage defect repair Open
Objective This study aimed to evaluate the effectiveness of bone marrow mesenchymal stem cells (BMSCs) combined with sodium alginate scaffolds in repairing knee cartilage defects in New Zealand rabbits. Additionally, it assessed the potent…
View article: Comparison of the inverted internal limiting membrane flap technique without versus with an autologous blood clot for treating macular hole-associated retinal detachment
Comparison of the inverted internal limiting membrane flap technique without versus with an autologous blood clot for treating macular hole-associated retinal detachment Open
View article: Metabolomic Profiling in Pathologic Myopia Identifies Novel Pathways in Myopic Tractional Maculopathy
Metabolomic Profiling in Pathologic Myopia Identifies Novel Pathways in Myopic Tractional Maculopathy Open
View article: Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives
Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives Open
Osteoarthritis (OA) is one of the leading causes of disability worldwide, characterized by a complex pathological process involving cartilage degradation, synovial inflammation, and subchondral bone remodeling. In recent years, ferroptosis…
View article: Association of intratumoral microbiome diversity with hepatocellular carcinoma prognosis
Association of intratumoral microbiome diversity with hepatocellular carcinoma prognosis Open
The evidence that intratumoral microbiomes, as a rising hallmark of cancer, have a profound impact on cancer phenotypes is increasingly compelling. However, the impact of the composition and diversity of the intratumoral microbiome on the …
View article: Reduced glutathione enhances adipose tissue‐derived mesenchymal stem cell engraftment efficiency for liver fibrosis by targeting <scp>TGFβ1</scp>/<scp>SMAD3</scp>/<scp>NOX4</scp> pathway
Reduced glutathione enhances adipose tissue‐derived mesenchymal stem cell engraftment efficiency for liver fibrosis by targeting <span>TGFβ1</span>/<span>SMAD3</span>/<span>NOX4</span> pathway Open
Reduced glutathione (GSH) could reduce oxidative stress to improve adipose tissue‐derived mesenchymal stem cell (ADSC) engraftment efficiency in vivo. However, the underlying mechanisms remain unclear. Our goal is to investigate whether GS…
View article: Momordica charantia L.-derived exosome-like nanovesicles stabilize p62 expression to ameliorate doxorubicin cardiotoxicity
Momordica charantia L.-derived exosome-like nanovesicles stabilize p62 expression to ameliorate doxorubicin cardiotoxicity Open
Background Doxorubicin (DOX) is a first-line chemotherapeutic drug for various malignancies that causes cardiotoxicity. Plant-derived exosome-like nanovesicles (P-ELNs) are growing as novel therapeutic agents. Here, we investigated the pro…
View article: Circular RNA‐based neoantigen vaccine for hepatocellular carcinoma immunotherapy
Circular RNA‐based neoantigen vaccine for hepatocellular carcinoma immunotherapy Open
mRNA vaccines are regarded as a highly promising avenue for next‐generation cancer therapy. Nevertheless, the intricacy of production, inherent instability, and low expression persistence of linear mRNA significantly restrict their extensi…
View article: scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory network
scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory network Open
View article: TROVE2 regulated invasion and migration of hepatocellular carcinoma cells via heparanase
TROVE2 regulated invasion and migration of hepatocellular carcinoma cells via heparanase Open
Background The role of TROVE domain family member 2 (TROVE2) has been well-demonstrated in autoimmune diseases; however, its involvement in liver cancer remains unclear. Therefore, this study aimed to explore the biological function and cl…
View article: Identification of important modules and biomarkers in tuberculosis based on WGCNA
Identification of important modules and biomarkers in tuberculosis based on WGCNA Open
Background Tuberculosis (TB) is a significant public health concern, particularly in China. Long noncoding RNAs (lncRNAs) can provide abundant pathological information regarding etiology and could include candidate biomarkers for diagnosis…
View article: Supplementary Data from RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion
Supplementary Data from RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion Open
Fig. S1-S9 Table S1-S4
View article: Data from RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion
Data from RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion Open
Immunotherapies such as immune checkpoint blockade have achieved remarkable success in treating cancer. Unfortunately, response rates have been limited in multiple cancers including hepatocellular carcinoma (HCC). The critical function of …
View article: Supplementary Data from RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion
Supplementary Data from RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion Open
Fig. S1-S9 Table S1-S4
View article: Data from RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion
Data from RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion Open
Immunotherapies such as immune checkpoint blockade have achieved remarkable success in treating cancer. Unfortunately, response rates have been limited in multiple cancers including hepatocellular carcinoma (HCC). The critical function of …
View article: Lnc-CCNH-8 promotes immune escape by up-regulating PD-L1 in hepatocellular carcinoma
Lnc-CCNH-8 promotes immune escape by up-regulating PD-L1 in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis. In recent years, immune checkpoint inhibitors (ICIs) have enabled breakthroughs in the clinical treatment of patients with HCC, but the overall response rate to ICI…
View article: Cell-free DNA testing for early hepatocellular carcinoma surveillance
Cell-free DNA testing for early hepatocellular carcinoma surveillance Open
View article: Proteomics-driven noninvasive screening of circulating serum protein panels for the early diagnosis of hepatocellular carcinoma
Proteomics-driven noninvasive screening of circulating serum protein panels for the early diagnosis of hepatocellular carcinoma Open
Early diagnosis of hepatocellular carcinoma (HCC) lacks highly sensitive and specific protein biomarkers. Here, we describe a staged mass spectrometry (MS)-based discovery-verification-validation proteomics workflow to explore serum proteo…
View article: Tripterygium wilfordii Hook. F. and Its Extracts for Psoriasis: Efficacy and Mechanism
Tripterygium wilfordii Hook. F. and Its Extracts for Psoriasis: Efficacy and Mechanism Open
Psoriasis is an inflammatory autoimmune skin condition that is clinically marked by chronic erythema and scaling. The traditional Chinese herb Tripterygium wilfordii Hook. F. (TwHF) is commonly used in the treatment of immune-relate…
View article: Integrated omics landscape of hepatocellular carcinoma suggests proteomic subtypes for precision therapy
Integrated omics landscape of hepatocellular carcinoma suggests proteomic subtypes for precision therapy Open
Patients with hepatocellular carcinoma (HCC) at the same clinical stage can have extremely different prognoses, and molecular subtyping provides an opportunity for individualized precision treatment. In this study, genomic, transcriptomic,…
View article: Hypoxia induces hepatocellular carcinoma metastasis via the HIF-1α/METTL16/lnc-CSMD1-7/RBFOX2 axis
Hypoxia induces hepatocellular carcinoma metastasis via the HIF-1α/METTL16/lnc-CSMD1-7/RBFOX2 axis Open
Hypoxic microenvironment is clinically associated with metastasis and poor prognosis of numerous cancers. The mechanisms by which intratumoral hypoxia regulates metastasis are not fully understood. Our study identifies a downregulation of …
View article: RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion
RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion Open
Immunotherapies such as immune checkpoint blockade have achieved remarkable success in treating cancer. Unfortunately, response rates have been limited in multiple cancers including hepatocellular carcinoma (HCC). The critical function of …