Yingdong Zhang
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View article: TREML2 Modulates Microglial Phagocytosis of Myelin Debris via TLR9 in Chronic Cerebral Ischemia
TREML2 Modulates Microglial Phagocytosis of Myelin Debris via TLR9 in Chronic Cerebral Ischemia Open
Demyelination is a significant pathological feature of chronic cerebral ischemia. Recent evidence suggested that microglia played a protective role in mitigating brain ischemic injury via phagocytosis of myelin debris resulting from demyel…
View article: The systemic inflammation markers as potential predictors of disease progression and survival time in amyotrophic lateral sclerosis
The systemic inflammation markers as potential predictors of disease progression and survival time in amyotrophic lateral sclerosis Open
Introduction Amyotrophic lateral sclerosis (ALS) is a fatal and untreatable neurodegenerative disease with only 3–5 years' survival time after diagnosis. Inflammation has been proven to play important roles in ALS progression. However, the…
View article: IL-34/TREM2 modulates microglia-mediated inflammation and provides neuroprotection in a mouse model of sporadic Alzheimer's disease
IL-34/TREM2 modulates microglia-mediated inflammation and provides neuroprotection in a mouse model of sporadic Alzheimer's disease Open
Background As a recently identified cytokine, interleukin-34 (IL-34) is predominantly produced by neurons and functions as a modulator for glial functions. Emerging evidence indicates that IL-34 exerted neuroprotective effects in Alzheimer…
View article: Association of pan-immune inflammation value with mortality in patients with pulmonary embolism: a cohort study
Association of pan-immune inflammation value with mortality in patients with pulmonary embolism: a cohort study Open
Pan-immune inflammation value (PIV) is associated with prognosis in immune and inflammatory diseases, and inflammation is a hallmark of pulmonary embolism (PE). Nonetheless, the link between PIV and prognosis in PE remains unclear. However…
View article: Microstructural alterations in gray matter after acute stress
Microstructural alterations in gray matter after acute stress Open
Structural and functional changes in stress-related gray matter (GM) regions have been found in trauma-exposed individuals. However, the nature of underlying microstructural abnormalities in traumatized individuals is unclear. In this stud…
View article: Knockdown of TREML2 Alleviates Neuropathological Hallmarks and Cognitive Deficiency in a Model of Sporadic Alzheimer’s Disease
Knockdown of TREML2 Alleviates Neuropathological Hallmarks and Cognitive Deficiency in a Model of Sporadic Alzheimer’s Disease Open
This study offers the first in vivo evidence that TREML2 contributes to the pathogenesis of AD. Furthermore, this study also proves that inhibition of TREML2 signaling may represent a potential treatment strategy for this disease.
View article: M1 Microglia-Derived Exosomes Promote A1 Astrocyte Activation and Aggravate Ischemic Injury via circSTRN3/miR-331-5p/MAVS/NF-κB Pathway
M1 Microglia-Derived Exosomes Promote A1 Astrocyte Activation and Aggravate Ischemic Injury via circSTRN3/miR-331-5p/MAVS/NF-κB Pathway Open
Taken together, our research indicated that circSTRN3 from M1-exos could promote A1 astrocyte activation and exacerbate ischemic brain injury via miR331-5p/MAVS/NF-κB axis.
View article: Circ_0008146 Exacerbates Ferroptosis via Regulating the miR-342-5p/ACSL4 Axis After Cerebral Ischemic/Reperfusion
Circ_0008146 Exacerbates Ferroptosis via Regulating the miR-342-5p/ACSL4 Axis After Cerebral Ischemic/Reperfusion Open
This study provides the first in vivo evidence to show that circ_0008146 exacerbates neuronal ferroptosis after AIS via the miR-342-5p/ACSL4 axis. Furthermore, miR-342-5p/ACSL4 axis holds promise as a viable therapeutic target and practica…
View article: Increasing Atomic Electron Cloud Density Leads to Formation of Body Centered Cubic (BCC) Gold
Increasing Atomic Electron Cloud Density Leads to Formation of Body Centered Cubic (BCC) Gold Open
Most metallic elements possess one relatively close packed structure of body-centered cubic (BCC), face-centered cubic (FCC) and hexagonal close packed (HCP) structures. Access to these structures as a function of temperature and pressure …
View article: Trimethylamine N-oxide Aggravates Neuro-inflammation via lncRNA Fendrr/miR-145-5p/PXN axis in Vascular Dementia Rats
Trimethylamine N-oxide Aggravates Neuro-inflammation via lncRNA Fendrr/miR-145-5p/PXN axis in Vascular Dementia Rats Open
Vascular dementia (VaD) is the second most common dementia in the world, and our previous investigation demonstrated that Trimethylamine-N-oxide (TMAO) exacerbates cognitive impairment and neuropathological alterations in VaD rats. Thus, t…
View article: The TREM2 H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine Release
The TREM2 H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine Release Open
Previously, we reported that H157Y, a rare coding variant on exon 3 of the triggering receptor expressed on myeloid cells 2 gene (TREM2), was associated with Alzheimer’s disease (AD) risk in a Han Chinese population. To date, how this vari…
View article: AVE 0991 Suppresses Astrocyte-Mediated Neuroinflammation of Alzheimer’s Disease by Enhancing Autophagy
AVE 0991 Suppresses Astrocyte-Mediated Neuroinflammation of Alzheimer’s Disease by Enhancing Autophagy Open
These findings suggest that regulation of autophagy is critical for inhibiting astrocyte neuroinflammatory responses and demonstrate a potential neuroprotective mechanism by which AVE 0991 could suppress neuroinflammatory responses by enha…
View article: Variants of Face-Centered Cubic Phase in Pure Hafnium During the Hcp→Fcc Phase Transformation
Variants of Face-Centered Cubic Phase in Pure Hafnium During the Hcp→Fcc Phase Transformation Open
View article: The Alzheimer’s disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation
The Alzheimer’s disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation Open
Triggering receptor expressed on myeloid cells-like 2 (TREML2) is a newly identified susceptibility gene for Alzheimer's disease (AD). It encodes a microglial inflammation-associated receptor. To date, the potential role of microglial TREM…
View article: Lamotrigine protects against cognitive deficits, synapse and nerve cell damage, and hallmark neuropathologies in a mouse model of Alzheimer’s disease
Lamotrigine protects against cognitive deficits, synapse and nerve cell damage, and hallmark neuropathologies in a mouse model of Alzheimer’s disease Open
Lamotrigine (LTG) is a widely used drug for the treatment of epilepsy. Emerging clinical evidence suggests that LTG may improve cognitive function in patients with Alzheimer's disease. However, the underlying molecular mechanisms remain un…
View article: Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson’s disease
Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson’s disease Open
Pathological process in Parkinson’s disease (PD) is accompanied with functional and metabolic alterations. The time-varying properties of functional coherence and their coupling to regional perfusion are still rarely elucidated. To investi…
View article: AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway
AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway Open
The renin-angiotensin system (RAS) is a paracrine RAS within the central nervous system (CNS) and is closely related to Alzheimer’s disease (AD). The endogenous hexapeptide angiotensin IV (Ang IV), an important component of the brain RAS, …
View article: Angiotensin-(1–7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson’s disease
Angiotensin-(1–7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson’s disease Open
Abnormal accumulation of α-synuclein contributes to the formation of Lewy bodies in the substantia nigra, which is considered the typical pathological hallmark of Parkinson's disease. Recent research indicates that angiotensin-(1-7) plays …
View article: Altered Resting-State Functional Connectivity in the Default Mode Network in Male Juvenile Violent Offenders
Altered Resting-State Functional Connectivity in the Default Mode Network in Male Juvenile Violent Offenders Open
Young males are often associated with more violence, leading to some serious negative consequences. However, the physiology and the neuroimaging patterns underlying juvenile violence remain unclear. Of the limited knowledge on juvenile vio…
View article: A New Cytotoxic Evodiamine Derivative From <i>Tetradium ruticarpum</i> (A. Jussieu) T. G. Hartley
A New Cytotoxic Evodiamine Derivative From <i>Tetradium ruticarpum</i> (A. Jussieu) T. G. Hartley Open
1-Hydroxymethyl goshuyuamide II (1), a new derivative of evodiamine with a quinazolinocarboline skeleton, along with nine known evodiamine derivatives were isolated from the dried and nearly ripe fruits of Tetradium ruticarpum (A. Jussieu)…
View article: Endovascular treatment of acute ischemic stroke due to anterior circulation large vessel occlusion beyond 6 hours: a real-world study in China
Endovascular treatment of acute ischemic stroke due to anterior circulation large vessel occlusion beyond 6 hours: a real-world study in China Open
Background We aimed to assess the safety and efficacy of endovascular treatment (EVT) in patients with anterior circulation emergent large vessel occlusion (ELVO) beyond 6 h from symptom onset in a real-world cohort of patients in China. M…
View article: The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in patients with acute ischemic stroke
The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in patients with acute ischemic stroke Open
View article: Deformation Twinning in Octahedron-Based Face-Centered Cubic Metallic Structures: Localized Shear-Force Dipoles Drive Atomic Displacements
Deformation Twinning in Octahedron-Based Face-Centered Cubic Metallic Structures: Localized Shear-Force Dipoles Drive Atomic Displacements Open
View article: A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and α2-containning GABA<sub>A</sub>Rs
A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and α2-containning GABA<sub>A</sub>Rs Open
Overactivation of N-methyl-D-aspartate receptor (NMDAR) in the spinal cord dorsal horn (SDH) in the setting of injury represents a key mechanism of neuropathic pain. However, directly blocking NMDAR or its downstream signaling, interaction…
View article: Shielding effect of a lead apron on the peripheral radiation dose outside the applicator of electron beams from an Elekta linear accelerator
Shielding effect of a lead apron on the peripheral radiation dose outside the applicator of electron beams from an Elekta linear accelerator Open
Purpose To evaluate the shielding effect of lead aprons (LAs) on peripheral radiation doses outside the applicator of electron beams from a linear accelerator. Methods Out‐of‐field radiation doses of 4‐, 6‐, 8‐, 10‐, 12‐, and 15‐MeV electr…
View article: The Association of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Lymphocyte-Monocyte Ratio With Post-Thrombolysis Early Neurological Outcomes in Patients With Acute Ischemic Stroke
The Association of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Lymphocyte-Monocyte Ratio With Post-Thrombolysis Early Neurological Outcomes in Patients With Acute Ischemic Stroke Open
Background and Purpose: To investigate the association of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) with post-thrombolysis early neurological outcomes including early neurologica…
View article: A Han Chinese Family With Early-Onset Parkinson's Disease Carrying Novel Frameshift Mutation and Compound Heterozygous Mutation of PRKN Appearing Incompatible With MDS Clinical Diagnostic Criteria
A Han Chinese Family With Early-Onset Parkinson's Disease Carrying Novel Frameshift Mutation and Compound Heterozygous Mutation of PRKN Appearing Incompatible With MDS Clinical Diagnostic Criteria Open
Around 15% of patients with Parkinson's disease (PD) have a family history, and 5-10% have confirmed genetic causes. PRKN is the most common gene responsible for early-onset Parkinson's disease (EOPD), while rare variants of PLA2…
View article: ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice
ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice Open
Previously, we revealed that brain Ang-(1-7) deficiency was involved in the pathogenesis of sporadic Alzheimer's disease (AD). We speculated that restoration of brain Ang-(1-7) levels might have a therapeutic effect against AD. However, th…
View article: Prolonged Use of NMDAR Antagonist Develops Analgesic Tolerance in Neuropathic Pain via Nitric Oxide Reduction-Induced GABAergic Disinhibition
Prolonged Use of NMDAR Antagonist Develops Analgesic Tolerance in Neuropathic Pain via Nitric Oxide Reduction-Induced GABAergic Disinhibition Open
View article: A <i>TREML2</i> missense variant influences specific hippocampal subfield volumes in cognitively normal elderly subjects
A <i>TREML2</i> missense variant influences specific hippocampal subfield volumes in cognitively normal elderly subjects Open
Introduction Triggering receptor expressed on myeloid cells‐like transcript 2 gene ( TREML2 ) is a newly identified AD susceptibility gene. Its missense variant rs3747742‐C substantially decreases AD risk in both Caucasians and Han Chinese…