Yingfei Li
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View article: Avian coronavirus IBV-induced activation of the NLRP3–Caspase-1–IL-1β axis in renal collecting ducts contributes to nephropathogenesis
Avian coronavirus IBV-induced activation of the NLRP3–Caspase-1–IL-1β axis in renal collecting ducts contributes to nephropathogenesis Open
Avian coronavirus infectious bronchitis virus (IBV) induces severe renal inflammation and urate deposition in chickens, but the underlying mechanisms remain incompletely understood. Here, we used both in vivo chicken infection models and i…
View article: Research on Intelligent Extraction Method of Influencing Factors of Loess Landslide Geological Disasters Based on Soft-Lexicon and GloVe
Research on Intelligent Extraction Method of Influencing Factors of Loess Landslide Geological Disasters Based on Soft-Lexicon and GloVe Open
Loess landslide disasters are influenced by a multitude of factors, including slope conditions, triggering mechanisms, and spatial attributes. Extracting these factors from unstructured geological texts is challenging due to nested entitie…
View article: Rapid reconstruction of infectious bronchitis virus expressing fluorescent protein from its nsp2 gene based on transformation-associated recombination platform
Rapid reconstruction of infectious bronchitis virus expressing fluorescent protein from its nsp2 gene based on transformation-associated recombination platform Open
Traditional reverse genetics strategies for large-genome RNA viruses are hindered by multiple technical bottlenecks, including dependence on specific restriction enzyme sites, cumbersome multi-step cloning, and genetic instability of overs…
View article: Meditation and Music Therapy in the Era of Digitalization: Challenges and Future Considerations
Meditation and Music Therapy in the Era of Digitalization: Challenges and Future Considerations Open
The integration of therapeutic meditation and music therapy has long been recognized for its profound impact on mental health, emotional well-being, and cognitive functioning. In the era of digitalization, these traditional practices are u…
View article: Physical regularized Hierarchical Generative Model for Metallic Glass Structural Generation and Energy Prediction
Physical regularized Hierarchical Generative Model for Metallic Glass Structural Generation and Energy Prediction Open
Disordered materials such as glasses, unlike crystals, lack long range atomic order and have no periodic unit cells, yielding a high dimensional configuration space with widely varying properties. The complexity not only increases computat…
View article: Colossal magnetoresistance from spin-polarized polarons in an Ising system
Colossal magnetoresistance from spin-polarized polarons in an Ising system Open
Recent experiments suggest a new paradigm toward novel colossal magnetoresistance (CMR) in a family of materials EuM X (M Cd, In, Zn; X P, As), distinct from the traditional avenues involving Kondo–Ruderman–Kittel–Kasuya–Yosida c…
View article: Colossal magnetoresistance from spin-polarized polarons in an Ising system
Colossal magnetoresistance from spin-polarized polarons in an Ising system Open
Recent experiments suggest a new paradigm towards novel colossal magnetoresistance (CMR) in a family of materials EuM$_2$X$_2$(M=Cd, In, Zn; X=P, As), distinct from the traditional avenues involving Kondo-RKKY crossovers, magnetic phase tr…
View article: Adaptive truncation of the S gene in IBV during chicken embryo passaging plays a crucial role in its attenuation
Adaptive truncation of the S gene in IBV during chicken embryo passaging plays a crucial role in its attenuation Open
Like all coronaviruses, infectious bronchitis virus, the causative agent of infectious bronchitis in chickens, exhibits a high mutation rate. Adaptive mutations that arise during the production of live attenuated vaccines against IBV often…
View article: Gasdermin E-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammation
Gasdermin E-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammation Open
Background Psoriasis is a common chronic inflammatory disease with an unclear aetiology. Keratinocytes in psoriasis are susceptible to exogenous triggers that induce inflammatory cell death. Objectives To investigate whether gasdermin E (G…
View article: Folium crataegi boosts skin regeneration for burn injury in rats through multiple ways
Folium crataegi boosts skin regeneration for burn injury in rats through multiple ways Open
Appropriate topical dressings for burn treatments are important to accelerate skin wound recovery and prevent external infections. This study aimed to evaluate the effect and investigate the mechanism of folium crataegi (Crataegus pinnatif…
View article: The status and risk factors for anxiety/depression in patients with atrophic chronic gastritis: a cross-sectional study
The status and risk factors for anxiety/depression in patients with atrophic chronic gastritis: a cross-sectional study Open
Potential anxiety and depression in ACG patients can be identified early by referring to risk factors and protective factors. The prediction model could be used to detect anxiety and depression in ACG patients at their earliest stage and p…
View article: Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing
Pharmacokinetics of baicalin and oroxyloside in plasma and different tissues of rats after transnasal aerosol inhalation and intravenous injection of Tanreqing Open
To avoid adverse drug reactions associated with injection, off-label nebulization of Tanreqing (TRQ) injection is often used in China to treat respiratory diseases. However, the aerodynamic properties and lung availability of TRQ aerosols …
View article: Instability Mechanism of Osimertinib in Plasma and a Solving Strategy in the Pharmacokinetics Study
Instability Mechanism of Osimertinib in Plasma and a Solving Strategy in the Pharmacokinetics Study Open
Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and a star medication used to treat non-small-cell lung carcinomas (NSCLCs). It has caused broad public concern that osimertinib has re…
View article: Antigenic Evolution Characteristics and Immunological Evaluation of H9N2 Avian Influenza Viruses from 1994–2019 in China
Antigenic Evolution Characteristics and Immunological Evaluation of H9N2 Avian Influenza Viruses from 1994–2019 in China Open
The H9N2 subtype avian influenza viruses (AIVs) have been circulating in China for more than 20 years, attracting more and more attention due to the potential threat of them. At present, vaccination is a common prevention and control strat…
View article: Pharmacokinetics, Tissue Distribution, and Excretion Characteristics of a Radix Polygoni Multiflori Extract in Rats
Pharmacokinetics, Tissue Distribution, and Excretion Characteristics of a Radix Polygoni Multiflori Extract in Rats Open
Although progress has been achieved in the pharmacological activity and toxicity of Radix Polygoni Multiflori (RPM), the chemical basis of its toxicity is still unclear. Here, we performed a multicompound pharmacokinetic analysis and inves…
View article: The Molecular Determinants of Antigenic Drift in a Novel Avian Influenza A (H9N2) Variant Virus
The Molecular Determinants of Antigenic Drift in a Novel Avian Influenza A (H9N2) Variant Virus Open
Background: In early 2020, a novel H9N2 AIV immune escape variant emerged in South China and rapidly spread throughout mainland China. The effectiveness of the current H9N2 vaccine is being challenged by emerging immune escape strains. Ass…
View article: Identification of candidate biomarkers correlated with the pathogenesis and prognosis of breast cancer via integrated bioinformatics analysis
Identification of candidate biomarkers correlated with the pathogenesis and prognosis of breast cancer via integrated bioinformatics analysis Open
Background: This study was carried out to identify potential key genes associated with the pathogenesis and prognosis of breast cancer (BC). Methods: Seven GEO datasets (GSE24124, GSE32641, GSE36295, GSE42568, GSE53752, GSE70947, GSE109169…
View article: Simultaneous Determination of 13 Constituents of Radix Polygoni Multiflori in Rat Plasma and Its Application in a Pharmacokinetic Study
Simultaneous Determination of 13 Constituents of Radix Polygoni Multiflori in Rat Plasma and Its Application in a Pharmacokinetic Study Open
Radix Polygoni Multiflori (RPM) has been widely used to treat various diseases in Asian countries for many centuries. Although, stilbenes and anthraquinones, two major components of RPM, show various bioactive effects, it has been speculat…
View article: Integrative Gene Expression Profiling Analysis to Investigate Potential Prognostic Biomarkers for Colorectal Cancer
Integrative Gene Expression Profiling Analysis to Investigate Potential Prognostic Biomarkers for Colorectal Cancer Open
Background: Despite noteworthy advancements in the multidisciplinary treatment of colorectal cancer (CRC) and deeper understanding in the molecular mechanisms of CRC, many of CRC patients with histologically identical tumors present differ…
View article: Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation
Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation Open
The effects of Reduning injection and nebulized inhalation for treating upper respiratory tract infections were compared, including anti-bacterial, anti-viral, anti-inflammatory, anti-pyretic, anti-tussive, and anti-phlegm. Using chlorogen…
View article: 3D Reconstruction and Calculation Methodology of Defect Using Ultrasonic Phased Arrays
3D Reconstruction and Calculation Methodology of Defect Using Ultrasonic Phased Arrays Open
In recent years, there has been a rapid development and application in the use of ultrasonic phased arrays for non-destructive examination, it’s a relatively mature technology to detect over the location and general size of defect. For a…
View article: Chemically specific termination control of oxide interfaces via layer-by-layer mean inner potential engineering
Chemically specific termination control of oxide interfaces via layer-by-layer mean inner potential engineering Open
Creating oxide interfaces with precise chemical specificity at the atomic layer level is desired for the engineering of quantum phases and electronic applications, but highly challenging, owing partially to the lack of in situ tools to mon…
View article: Exploring Chemical Basis of Toxicity Reduction for Processed Roots of<i> Stellera chamaejasme</i> L. Using Ultraperformance Liquid Chromatography–Triple Quadrupole Tandem Mass Spectrometry
Exploring Chemical Basis of Toxicity Reduction for Processed Roots of<i> Stellera chamaejasme</i> L. Using Ultraperformance Liquid Chromatography–Triple Quadrupole Tandem Mass Spectrometry Open
Some herbal medicines are treated with various processing methods to ensure their safe and effective use. However, chemical basis of toxicity reducing for most herbal medicines remains unclear. Stellera chamaejasme L., particularly the roo…