Yue Qiu
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View article: The current state of defensive medicine and its association with empathy: a cross-sectional study among graduate students in Guangxi, China
The current state of defensive medicine and its association with empathy: a cross-sectional study among graduate students in Guangxi, China Open
View article: Diversity and functional analysis of epiphytic and endophytic bacteria in three different parts of Brasenia schreberi
Diversity and functional analysis of epiphytic and endophytic bacteria in three different parts of Brasenia schreberi Open
Brasenia schreberi J.F. Gmel ( B. schreberi )is a traditional medicinal and edible plant in China, with its mucilage exhibiting antibacterial, anti-inflammatory, and antioxidant properties. This study aimed to investigate the community str…
View article: Advances in the Use of Immune Checkpoint Inhibitors for Colorectal Cancer Treatment
Advances in the Use of Immune Checkpoint Inhibitors for Colorectal Cancer Treatment Open
ICIs have driven the development of precision immunotherapy for CRC, and multi-target combination therapies hold promise for improving outcomes. However, clinical translation and efficacy improvements remain challenging. Future studies sho…
View article: Mitochondrial Oxidative Stress and Vascular Remodeling in Uric Acid Nephropathy: Mechanistic Insights and Therapeutic Implications
Mitochondrial Oxidative Stress and Vascular Remodeling in Uric Acid Nephropathy: Mechanistic Insights and Therapeutic Implications Open
Uric acid nephropathy (UAN), driven by sustained hyperuricemia, is an underrecognized but increasingly prevalent contributor to chronic kidney disease (CKD) progression. Mitochondrial oxidative stress and vascular remodeling are central to…
View article: Analysis of metabolite characteristics and signaling pathways in head and neck cancer based on metabolomics
Analysis of metabolite characteristics and signaling pathways in head and neck cancer based on metabolomics Open
Introduction: Head and neck cancer (HNC) represents a highly heterogeneous group of malignancies, including oral, pharyngeal, and laryngeal cancers. Despite advancements in diagnosis and treatment, early detection and personalized therapeu…
View article: Identifying Potential Vulnerability to Long COVID Through Global‐to‐Local Inequalities in Years Lived With Disability Attributed to COVID‐19, 2020–2021, Across 920 Locations
Identifying Potential Vulnerability to Long COVID Through Global‐to‐Local Inequalities in Years Lived With Disability Attributed to COVID‐19, 2020–2021, Across 920 Locations Open
The COVID‐19 pandemic has reshaped global health; however, the long‐term burden of long COVID remains poorly understood, especially in low‐ and middle‐income countries (LMICs), where limited surveillance and data gaps may obscure a substan…
View article: Targeting CSPG4 enhances the anti-tumor activity of CAR-NK cells for glioblastoma
Targeting CSPG4 enhances the anti-tumor activity of CAR-NK cells for glioblastoma Open
CSPG4-targeted CAR-NK cells exhibit potent anti-GBM activity, highlighting their potential as a novel immunotherapy. These findings provide a robust preclinical foundation for advancing CSPG4-directed CAR-NK cell therapy into clinical tria…
View article: Prolonged versus short-term infusion of meropenem for the treatment of sepsis: a systematic review and meta-analysis
Prolonged versus short-term infusion of meropenem for the treatment of sepsis: a systematic review and meta-analysis Open
Objectives: The effectiveness of prolonged infusion of meropenem in treating sepsis remains debated. This meta-analysis aims to compare the clinical effectiveness and safety of prolonged infusion versus short-term infusion of meropenem in …
View article: Global, Regional, National, and Local Burden of COVID‐19 With Inequality Analysis Across 920 Locations, 2020–2021
Global, Regional, National, and Local Burden of COVID‐19 With Inequality Analysis Across 920 Locations, 2020–2021 Open
Although the COVID‐19 pandemic has profoundly reshaped global health systems, a comprehensive and standardized quantification of its direct health burden across multiple spatial scales, particularly during its initial and most severe phase…
View article: Association between the Body Roundness Index and osteoarthritis: A population-based study
Association between the Body Roundness Index and osteoarthritis: A population-based study Open
Background Obesity is recognized as an independent risk factor for the development of osteoarthritis (OA). The Body Roundness Index (BRI) represents a novel metric for assessing obesity, yet its connection to OA remains unclear. This resea…
View article: Economic burden attributable to high BMI-caused cancers: a global level analysis between 2002 and 2021
Economic burden attributable to high BMI-caused cancers: a global level analysis between 2002 and 2021 Open
View article: Combined analysis of metabolomic, transcriptomic and proteomics to reveal the underlying mechanism of mucilage disappearance in Brasenia schreberi
Combined analysis of metabolomic, transcriptomic and proteomics to reveal the underlying mechanism of mucilage disappearance in Brasenia schreberi Open
View article: Research on the Measurement of Particulate Matter Concentration in Diesel Vehicle Exhaust Using the Light Scattering Method
Research on the Measurement of Particulate Matter Concentration in Diesel Vehicle Exhaust Using the Light Scattering Method Open
To address the current issues with diesel vehicle exhaust after-treatment system particulate sensors—such as low accuracy and inability to perform continuous measurements of particulate mass concentration—a new sensor based on the light sc…
View article: Identification of pyroptosis-related diagnostic model relate to immune infiltration in osteoarthritis
Identification of pyroptosis-related diagnostic model relate to immune infiltration in osteoarthritis Open
Background Osteoarthritis (OA) is a common chronic diseases which were associated with aging and progressive joint dysfunction. Pyroptosis, a novel mode of cell death. The effect of pyroptosis on osteoarthritis (OA) progression is still in…
View article: Correlation of the weight-adjusted waist circumference index with Klotho in the United States: differences by sex
Correlation of the weight-adjusted waist circumference index with Klotho in the United States: differences by sex Open
View article: [Differential expression profile of miRNAs in maternal amniotic fluid exosomes in fetuses with isolated ventriculomegaly].
[Differential expression profile of miRNAs in maternal amniotic fluid exosomes in fetuses with isolated ventriculomegaly]. Open
The highly abundant differentially expressed miRNAs in maternal amniotic fluid exosomes play important roles in the occurrence of fetal VM possibly by regulating the MAPK, PI3K-Akt, Wnt and cGMP-PKG signaling pathways.
View article: Association between serum Klotho and the prevalence of osteoarthritis: A cross-sectional study from NHANES 2007–2016
Association between serum Klotho and the prevalence of osteoarthritis: A cross-sectional study from NHANES 2007–2016 Open
Background Osteoarthritis (OA) is a degenerative joint disease prevalent in the elderly. Currently, the relationship between the senescence inhibitor Klotho and OA remains unclear. This study investigated the relationship between serum sol…
View article: pH-Responsive Deacetylated Sphingan WL Gum-Based Microgels for the Oral Delivery of Ciprofloxacin Hydrochloride
pH-Responsive Deacetylated Sphingan WL Gum-Based Microgels for the Oral Delivery of Ciprofloxacin Hydrochloride Open
Sphingan WL gum (WL) is an extracellular polysaccharide with a carboxyl group produced by Sphingomonas sp. WG. Recently, we have successfully obtained deacetylated WL (DWL) with good water solubility by alkaline treatment. In this s…
View article: R-loops’ m6A modification and its roles in cancers
R-loops’ m6A modification and its roles in cancers Open
R-loops are three-stranded nucleic acid structures composed of an RNA-DNA hybrid and a displaced DNA strand. They are widespread and play crucial roles in regulating gene expression, DNA replication, and DNA and histone modifications. Howe…
View article: UBR1 is a prognostic biomarker and therapeutic target associated with immune cell infiltration in gastric cancer
UBR1 is a prognostic biomarker and therapeutic target associated with immune cell infiltration in gastric cancer Open
UBR1 is overexpressed in STAD, promoting its progression and positively correlating with immune cell infiltration and immunotherapeutic responses. Therefore, UBR1 could be a promising biomarker for the prognosis and immunotherapy of STAD.
View article: Case report: Suspicious laryngeal mass: a case of laryngeal lymphoma misdiagnosed as chronic inflammation
Case report: Suspicious laryngeal mass: a case of laryngeal lymphoma misdiagnosed as chronic inflammation Open
This case report aims to highlight the importance of considering lymphoma as a potential differential diagnosis in patients presenting with laryngeal mass and associated cervical lymphadenopathy, particularly those with a history of chroni…
View article: Association between heme oxygenase-1 and hyperlipidemia in pre-diabetic patients: a cross-sectional study
Association between heme oxygenase-1 and hyperlipidemia in pre-diabetic patients: a cross-sectional study Open
Background Although the importance and benefit of heme oxygenase-1 (HO-1) in diabetes rodent models has been known, the contribution of HO-1 in the pre-diabetic patients with hyperlipidemia risk still remains unclear. This cross-sectional …
View article: Correlations between the modification patterns mediated by pyroptosis-related genes, tumor microenvironment, and immunotherapy in soft tissue sarcoma
Correlations between the modification patterns mediated by pyroptosis-related genes, tumor microenvironment, and immunotherapy in soft tissue sarcoma Open
Soft tissue sarcoma (STS) incidence, progression, and metastasis are tightly linked to the tumor microenvironment (TME). The modification patterns mediated by pyroptosis-related genes (PRGs) in STS are unknown regarding the immune cell inf…
View article: RBP7 functions as a tumor suppressor in HR + breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid
RBP7 functions as a tumor suppressor in HR + breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid Open
Background Increasing evidence proves that RBP7 plays a significant role in breast cancer (BC). The present study was aimed to investigate the mechanism of RBP7. Methods Western Blotting and qRT-PCR were performed for evaluating the expres…
View article: A new tensile creep model for predicting long-term creep strengths with short-term test data for creep resistant alloys
A new tensile creep model for predicting long-term creep strengths with short-term test data for creep resistant alloys Open
The difficulties in using the conventional Norton creep model to rationalise short-term creep data and to subsequently predict long-term creep rupture strengths for creep resistant alloys are presented and analysed. The results of this stu…
View article: Exosome-mediated miR-144-3p promotes ferroptosis to inhibit osteosarcoma proliferation, migration, and invasion through regulating ZEB1
Exosome-mediated miR-144-3p promotes ferroptosis to inhibit osteosarcoma proliferation, migration, and invasion through regulating ZEB1 Open
Background Osteosarcoma (OS) is the most prevalent orthopedic malignancy with a dismal prognosis. The high iron absorption rate in OS cells of patients suggests that ferroptosis may be related to the progression of OS, but its potential mo…
View article: Bibliometric and visual analysis in the field of traditional Chinese medicine in cancer from 2002 to 2022
Bibliometric and visual analysis in the field of traditional Chinese medicine in cancer from 2002 to 2022 Open
Objective: Traditional Chinese medicine (TCM) has been used as a complementary treatment for cancer patients, but there has been no quantitative comprehensive analysis of TCM’s efficacy. The purpose of this paper is to explore the current …
View article: Asiatic acid ameliorates rifampicin‐ and isoniazid‐induced liver injury in vivo by regulating sphingolipid metabolism and mitogen‐activated protein kinase signalling pathways
Asiatic acid ameliorates rifampicin‐ and isoniazid‐induced liver injury in vivo by regulating sphingolipid metabolism and mitogen‐activated protein kinase signalling pathways Open
In this study, we aimed to determine whether asiatic acid (AA) exerts any therapeutic effects on rifampicin (RFP)‐ and isoniazid (INH)‐induced liver injury and elucidate the underlying mechanisms. Briefly, liver injury in mice was induced …
View article: Elevation of preoperative serum hs-CRP is an independent risk factor for malnutrition in patients with gastric cancer
Elevation of preoperative serum hs-CRP is an independent risk factor for malnutrition in patients with gastric cancer Open
Background Recent studies have reported hypersensitive C-reactive protein (hs-CRP) linked to clinicopathological characteristics and nutritional status of the tumor, but its clinical significance in GC remains unclear. This study aimed to …
View article: AIFM1 variants associated with auditory neuropathy spectrum disorder cause apoptosis due to impaired apoptosis-inducing factor dimerization
AIFM1 variants associated with auditory neuropathy spectrum disorder cause apoptosis due to impaired apoptosis-inducing factor dimerization Open
Auditory neuropathy spectrum disorder (ANSD) represents a variety of sensorineural deafness conditions characterized by abnormal inner hair cells and/or auditory nerve function, but with the preservation of outer hair cell function. ANSD r…