Ying‐Jin Lu
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View article: Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors
Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors Open
Pain and itch are distinct sensations arousing evasion and compulsive desire for scratching, respectively. It’s unclear whether they could invoke different neural networks in the brain. Here, we use the type 1 herpes simplex virus H129 str…
View article: <i>Zcchc12</i>-Containing Nociceptors Are Required for Noxious Heat Sensation
<i>Zcchc12</i>-Containing Nociceptors Are Required for Noxious Heat Sensation Open
DRG neurons are classified into distinct types to mediate the somatosensation with different modalities. Recently, transcriptional profilings of DRG neurons by single-cell RNA-sequencing have provided new insights into the neuron typing an…
View article: 5'-UTR SNP of FGF13 causes translational defect and intellectual disability
5'-UTR SNP of FGF13 causes translational defect and intellectual disability Open
The congenital intellectual disability (ID)-causing gene mutations remain largely unclear, although many genetic variations might relate to ID. We screened gene mutations in Chinese Han children suffering from severe ID and found a single-…
View article: FXYD6 promotes thermal nociception by regulating TRPV1
FXYD6 promotes thermal nociception by regulating TRPV1 Open
FXYD6, an unnecessary auxiliary subunit of Na + ,K + -ATPase, is expressed in the nervous system. However, its functions remain largely unclear. In the present study, we find that FXYD6 is involved in the thermal nociception. FXYD6 was mai…
View article: Nerve Injury-Induced Neuronal PAP-I Maintains Neuropathic Pain by Activating Spinal Microglia
Nerve Injury-Induced Neuronal PAP-I Maintains Neuropathic Pain by Activating Spinal Microglia Open
Pancreatitis-associated proteins (PAPs) display multiple functions in visceral diseases. Previous studies showed that the expression level of PAP-I was low in the DRG of naive rats but was de novo expressed after peripheral nerve injury. H…
View article: Clinical opioids differentially induce co-internalization of μ- and δ-opioid receptors
Clinical opioids differentially induce co-internalization of μ- and δ-opioid receptors Open
Opioid receptors play an important role in mediating the spinal analgesia. The μ-opioid receptor is the major target of opioid drugs widely used in clinics. However, the regulatory mechanisms of analgesic effect and tolerance for clinical …