Explanipedia

Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease Open

Jing Cai, Hao Wu, Chenxing Wang, Yujiao Chen, Dingli Zhang , et al. · 2023

Sec1 Regulates Intestinal Mucosal Immunity in A Mouse Model of Inflammatory Bowel Disease Open

Jing Cai, Hao Wu, Chenxing Wang, Yujiao Chen, Dingli Zhang , et al. · 2023

Inflammatory bowel disease (IBD) is a common immune-mediated condition with its molecular pathogenesis remaining to be fully elucidated. This study aimed to deepen our understanding of the role of fut2 in human IBD, by studying a new surro…

Sodium butyrate exerts antioxidant stress effects and attenuates Aβ25-35-induced cytotoxicity in PC12 cells Open

Boyu Yuan, Mingming Liu, Yuhong Gong, Zifan Wang, Xinxin Jin , et al. · 2022

Alzheimer's disease (AD), a common neurodegenerative disease, is characterised by the deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles. An increasing number of studies have demonstrated that Aβ causes neuronal damage and mi…

Galangin as a direct inhibitor of vWbp protects mice from <i>Staphylococcus aureus</i>‐induced pneumonia Open

Yingli Jin, Panpan Yang, Li Wang, Zeyuan Gao, Jia Lv , et al. · 2021

The surge in multidrug resistance in Staphylococcus aureus ( S . aureus ) and the lag in antibiotic discovery necessitate the development of new anti‐infective strategies to reduce S . aureus infections. In S . aureus , von Willebrand fact…

Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux Open

Shuang Guan, Siyu Tao, Yixuan Huang, Yingli Jin, YuTing Hu , et al. · 2020

Carbon black (CB) and heavy metals are the main components of Particulate Matter (PM). Although the individual toxicities of CB and heavy metals have been extensively studied, the combined toxicity is much less understood. In this study, w…

Quercetin protects rats from catheter‐related <i>Staphylococcus aureus</i> infections by inhibiting coagulase activity Open

Lin Wang, BangBang Li, Xiaosa Si, Xingyuan Liu, Xuming Deng , et al. · 2019

Coagulase (Coa) activity is essential for the virulence of Staphylococcus aureus ( S aureus ), one of the most important pathogenic bacteria leading to catheter‐related bloodstream infections (CRBSI). We have demonstrated that the mutation…

An Inhibitory Effect of Dryocrassin ABBA on Staphylococcus aureus vWbp That Protects Mice From Pneumonia Open

Bangbang Li, Yingli Jin, Hua Xiang, Dan Mu, Panpan Yang , et al. · 2019

Von Willebrand factor-binding protein (vWbp), secreted by Staphylococcus aureus (S. aureus), can activate host prothrombin, convert fibrinogen to fibrin clots, induce blood clotting, and contribute to pathophysiology of S. aureus-related d…

Urinary kidney injury molecule-1 as an early diagnostic biomarker of obstructive acute kidney injury and development of a rapid detection method Open

Yingli Jin, Xiaona Shao, Bo Sun, Chunsheng Miao, Zhengqiang Li , et al. · 2017

The aim of the present study was to investigate whether urinary kidney injury molecule‑1 (KIM‑1) presents a suitable early diagnostic biomarker of obstructive nephropathy‑induced acute kidney injury (AKI), and to develop a rapid detection …

Downregulation of microRNA-637 Increases Risk of Hypoxia-Induced Pulmonary Hypertension by Modulating Expression of Cyclin Dependent Kinase 6 (CDK6) in Pulmonary Smooth Muscle Cells Open

Haiyan Sang, Yingli Jin, Wenqi Zhang, Libo Chen · 2016

BACKGROUND The objective of this study was to investigate the molecular mechanism by which miR-637 interferes with the expression of CDK6, which contributes to the development of pulmonary hypertension (PH) with chronic obstructive pulmona…

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