Yingli Lu
YOU?
Author Swipe
View article: EAT-Lancet and plant-based diets, plasma metabolomic signatures, and biological aging
EAT-Lancet and plant-based diets, plasma metabolomic signatures, and biological aging Open
The EAT-Lancet diet has been recently recommended for its potential health and environmental benefits. Here, leveraging data from the UK Biobank, we performed a comparative analysis to examine the associations of adherence to the EAT-Lance…
View article: Chronic pain, inflammatory biomarkers, and risks of mortality and cardiovascular disease in individuals with type 2 diabetes: a prospective cohort study
Chronic pain, inflammatory biomarkers, and risks of mortality and cardiovascular disease in individuals with type 2 diabetes: a prospective cohort study Open
Background: Chronic pain is common in patients with type 2 diabetes mellitus (T2DM), but its relationship with cardiovascular disease (CVD) remains unclear. We aimed to examine the associations between the number of chronic pain sites and …
View article: LLTH induces white adipose tissue browning via NF κB inhibition in ATM
LLTH induces white adipose tissue browning via NF κB inhibition in ATM Open
This study aimed to explore the role of macrophage polarization and TLR4/NF-κB pathway in promoting browning of white adipose tissue through different hypoxic exercises. (1) Fifty obese female rats were selected after 16 weeks of high-fat …
View article: Construction and optimization of video-triggered cases in problem-based learning
Construction and optimization of video-triggered cases in problem-based learning Open
Objectives Problem-based learning (PBL) is widely used in medicine instruction worldwide. Little research has been done on video-triggered cases in medical education in China. The aim of this study is to determine whether video-triggered c…
View article: Non-invasive applications of Raman spectroscopy in assisted reproduction
Non-invasive applications of Raman spectroscopy in assisted reproduction Open
This review explores the non-invasive applications of Raman spectroscopy in assisted reproductive technology (ART). Raman spectroscopy, a powerful tool for analyzing biological samples, has shown great potential in enhancing ART outcomes t…
View article: The Identification of Biomarkers and Therapeutic Targets for Diabetic Kidney Disease by Integrating the Proteome with the Genome
The Identification of Biomarkers and Therapeutic Targets for Diabetic Kidney Disease by Integrating the Proteome with the Genome Open
Background: The blood proteome is a major source of biomarkers and therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) study to identify cardiometabolic protein markers for diabetic kidney disease (DKD). Methods:…
View article: Association of iodized salt intake with the risk of physical frailty in patients with type 2 diabetes
Association of iodized salt intake with the risk of physical frailty in patients with type 2 diabetes Open
Non-iodized salt consumed and low UIC were associated with an increased risk of frailty in diabetes, particularly in those with high TSH and low FT4. Maintaining adequate iodine intake is critically important for preventing frailty in diab…
View article: Association of polysocial risk score, cardiovascular health status, and the risk of premature mortality: Findings from the UK Biobank
Association of polysocial risk score, cardiovascular health status, and the risk of premature mortality: Findings from the UK Biobank Open
Polysocial risk score was associated with an increased risk of premature mortality, the association was exacerbated by poor CVH. Our findings indicate that limiting social inequities and encouraging people to achieve an ideal CVH are essen…
View article: Genetic and Plasma Proteomic Approaches to Identify Therapeutic Targets for Graves’ Disease and Graves’ Ophthalmopathy
Genetic and Plasma Proteomic Approaches to Identify Therapeutic Targets for Graves’ Disease and Graves’ Ophthalmopathy Open
By synthesizing proteomic and genetic data, we identified several protein biomarkers for GD, with one linked to both GD and GO and two other protein biomarkers specific to GO onset, which provides valuable insights into the etiology and po…
View article: Optimal calorie restriction threshold: effect of FATmax exercise combined with different proportions of calorie restriction on hypercholesterolemia
Optimal calorie restriction threshold: effect of FATmax exercise combined with different proportions of calorie restriction on hypercholesterolemia Open
Background/Objectives To evaluate the impact of maximal fat oxidation intensity exercise combined with calorie restriction intervention on lipid-related parameters in a hypercholesterolemic population, and to determine if an optimal range …
View article: Early-life famine exposure, genetic susceptibility and risk of MAFLD in adulthood
Early-life famine exposure, genetic susceptibility and risk of MAFLD in adulthood Open
The positive association between early-life famine exposure and MAFLD is intensified by high genetic susceptibility of MAFLD in women and in general population in China; while this association does not exist in men or in those with low gen…
View article: The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling
The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling Open
Our study demonstrated that B7-H4 plays an important role in regulating β-cell mass and insulin secretion, which may shed new light on the development of novel strategies for T2D treatment.
View article: Association of night shift work and biological ageing: the mediating role of body mass index
Association of night shift work and biological ageing: the mediating role of body mass index Open
Background We aimed to examine whether current and lifetime night shift work is associated with accelerated biological ageing and the potential role of body mass index (BMI) in mediating the association. Methods Data were sourced from the …
View article: Revisiting the obesity paradox: lean body mass, fat mass, and mortality in patients with atrial fibrillation
Revisiting the obesity paradox: lean body mass, fat mass, and mortality in patients with atrial fibrillation Open
Background Obesity has been associated with risk of atrial fibrillation (AF), but once AF is established, it seems to be favorable, which is termed the obesity paradox. However, body mass index (BMI), the commonly used anthropometric marke…
View article: Long-term changes in frailty and incident atrial fibrillation: multicenter prospective cohort study
Long-term changes in frailty and incident atrial fibrillation: multicenter prospective cohort study Open
Background Atrial fibrillation is the most common sustained cardiac arrhythmia and is prevalent among the elderly. Previous findings indicated a higher prevalence of AF in frail adults and frailty prevalent in AF patients. However, the ass…
View article: Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes
Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes Open
Background: Identification of individuals with prediabetes who are at high risk of developing diabetes allows for precise interventions. We aimed to determine the role of nuclear magnetic resonance (NMR)-based metabolomic signature in pred…
View article: Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes
Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes Open
Identification of individuals with prediabetes who are at high risk of developing diabetes allows for precise interventions. We aimed to determine the role of nuclear magnetic resonance (NMR)-based metabolomic signature in predicting the p…
View article: Joint effects of physical frailty and traditional cardiovascular risk factor control on cardiovascular disease in patients with diabetes
Joint effects of physical frailty and traditional cardiovascular risk factor control on cardiovascular disease in patients with diabetes Open
Both prefrailty and frailty were associated with a higher risk of CVD in participants with type 2 diabetes. Moreover, physical frailty could interact with the degree of risk factor control in an additive manner to increase the CVD risk.
View article: Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes
Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes Open
Identification of individuals with prediabetes who are at high risk of developing diabetes allows for precise interventions. We aimed to determine the role of nuclear magnetic resonance (NMR)-based metabolomic signature in predicting the p…
View article: Author response: Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes
Author response: Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes Open
Identification of individuals with prediabetes who are at high risk of developing diabetes allows for precise interventions. We aimed to determine the role of nuclear magnetic resonance (NMR)-based metabolomic signature in predicting the p…
View article: Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes
Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes Open
Background: Identification of individuals with prediabetes who are at high risk of developing diabetes allows for precise interventions. We aimed to determine the role of nuclear magnetic resonance (NMR)-based metabolomic signature in pred…
View article: The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules
The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules Open
Increasing global concerns about psychoactive substance addiction and psychotic disorders highlight the need for comprehensive research into the structure-function relationship governing ligand recognition between these substances and thei…
View article: Integrated Bioinformatics Analysis Revealed Immune Checkpoint Genes Relevant to Type 2 Diabetes
Integrated Bioinformatics Analysis Revealed Immune Checkpoint Genes Relevant to Type 2 Diabetes Open
In conclusion, the identified ICGs may play an important role in T2D. Identification of these differential genes may provide new clues for the diagnosis and treatment of T2D.
View article: Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes
Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes Open
Background Identification of individuals with prediabetes who are at high risk of developing diabetes allows for precise interventions. We aimed to determine the role of nuclear magnetic resonance (NMR)-based metabolomic signature in predi…