Yang Yang
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View article: Analysis of Risk Factors for Severe Pneumonia Progression in Chlamydia psittaci Infections: A Retrospective Study
Analysis of Risk Factors for Severe Pneumonia Progression in Chlamydia psittaci Infections: A Retrospective Study Open
CVD history and progressive Hb decrease are independent risk factors for severe psittacosis pneumonia. Dynamic monitoring of LYM, Hb, LDH, and CVD history facilitates early risk stratification. The multivariate model demonstrates high pred…
View article: Profibrotic impact of PAD4-driven macrophage extracellular traps in ulcerative colitis
Profibrotic impact of PAD4-driven macrophage extracellular traps in ulcerative colitis Open
The inflammatory polarization of macrophages has been implicated in the pathogenesis of fibrosis in ulcerative colitis (UC). Our previous study found that macrophages in an inflammatory polarization state highly express peptidyl arginine d…
View article: Global, regional, and national burden of motor neuron disease in adults aged 65 years and older from 1990 to 2021 and forecast to 2040
Global, regional, and national burden of motor neuron disease in adults aged 65 years and older from 1990 to 2021 and forecast to 2040 Open
Aim Given the significant social burden of motor neuron disease (MND) among elderly patients (aged ≥ 65 years) and the lack of detailed research on its epidemiological characteristics, this study aims to elucidate the temporal trends and d…
View article: Omega-3 fatty acid normalizes postsynaptic density related miRNAs and proteins in hippocampus and prevents DEHP-induced impairment of learning and memory in mice
Omega-3 fatty acid normalizes postsynaptic density related miRNAs and proteins in hippocampus and prevents DEHP-induced impairment of learning and memory in mice Open
DEHP is the most widely used plasticizer in many products. However, growing evidence has indicated that DEHP may induce neurotoxicity. DEHP exposure affects mircoRNAs (miRNAs) expression in brain. A growing body of evidence suggests that n…
View article: Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors
Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors Open
High‐content screening (HCS) has become a powerful tool in drug discovery; however, its reliance on indirect readouts and surrogate markers limits HCS's ability to directly assess drug‐protein interactions at endogenous levels, particularl…
View article: Native Grasses Enhance Topsoil Organic Carbon and Nitrogen by Improving Soil Aggregates and Microbial Communities in Navel Orange Orchards in China
Native Grasses Enhance Topsoil Organic Carbon and Nitrogen by Improving Soil Aggregates and Microbial Communities in Navel Orange Orchards in China Open
In Gannan navel orange (Citrus sinensis) orchards—a typical sloped farmland ecosystem—selected native grasses outperform conventional green manure due to their stronger ecological adaptability and lower management requirements. However, fe…
View article: Clinical significance of caspase-1 in coronary artery lesions in Kawasaki disease and its mechanism of action on vascular smooth muscle cells
Clinical significance of caspase-1 in coronary artery lesions in Kawasaki disease and its mechanism of action on vascular smooth muscle cells Open
Caspase-1 is elevated in KD and shows an excellent diagnostic value for both KD and the occurrence of CAL in KD patients, possibly through promoting the abnormal proliferation of HCASMCs.
View article: Prevalence and associated risk factors of post COVID fatigue among Parkinson’s disease patients during one year follow up
Prevalence and associated risk factors of post COVID fatigue among Parkinson’s disease patients during one year follow up Open
One of the most common post-COVID-19 condition is persistent fatigue, while post-COVID fatigue among Parkinson's disease (PD) patients is less known. This study was aimed to investigate the prevalence and risk factors of post-COVID fatigue…
View article: Omega-3 fatty acid normalizes postsynaptic density proteins via miRNAs regulation in hippocampus and prevents DEHP-induced impairment of learning and memory in mice
Omega-3 fatty acid normalizes postsynaptic density proteins via miRNAs regulation in hippocampus and prevents DEHP-induced impairment of learning and memory in mice Open
s DEHP is the most widely used plasticizer in many products. However, growing evidence has indicated that DEHP may induce neurotoxicity. DEHP exposure affects mircoRNAs (miRNAs) expression in brain. A growing body of evidence suggests that…
View article: Arterial-Lymphatic-Like Endothelial Cells Appear in Hereditary Hemorrhagic Telangiectasia 2 and Contribute to Vascular Leakage and Arteriovenous Malformations
Arterial-Lymphatic-Like Endothelial Cells Appear in Hereditary Hemorrhagic Telangiectasia 2 and Contribute to Vascular Leakage and Arteriovenous Malformations Open
BACKGROUND: Arteriovenous malformations (AVMs) are characteristic of hereditary hemorrhagic telangiectasia. Loss-of-function mutations in the activin receptor‐like kinase 1 ( Alk1 ) are linked to hemorrhagic telangiectasia type 2. METHODS:…
View article: Study of Intergranular Corrosion Behaviors of Mn-Increased 5083 Al Alloy with Controlled Precipitation States of Al6Mn Formed during Homogenization Annealing
Study of Intergranular Corrosion Behaviors of Mn-Increased 5083 Al Alloy with Controlled Precipitation States of Al6Mn Formed during Homogenization Annealing Open
In this study, as a vital part of the production of Mn-increased 5083 Al alloy, i.e., homogenization annealing before hot rolling, the target states of key Al6Mn precipitation, including the dispersed, initial coarsening and intensive coar…
View article: Can Bisphosphonate Therapy Reduce Overall Mortality in Patients With Osteoporosis? A Meta-analysis of Randomized Controlled Trials
Can Bisphosphonate Therapy Reduce Overall Mortality in Patients With Osteoporosis? A Meta-analysis of Randomized Controlled Trials Open
Background For patients with osteoporosis, bisphosphonate therapy can reduce the risk of fractures, but its effect on reducing mortality remains unclear. Previous studies on this topic have produced conflicting results and generally have b…
View article: Phoenixin‐14 maintains the contractile type of vascular smooth muscle cells in cerebral aneurysms rats
Phoenixin‐14 maintains the contractile type of vascular smooth muscle cells in cerebral aneurysms rats Open
The rupture of intracranial aneurysm (IA) is the primary reason contributing to the occurrence of life‐threatening subarachnoid hemorrhages. The oxidative stress‐induced phenotypic transformation from the contractile phenotype to the synth…
View article: Inhibition of endothelial histone deacetylase 2 shifts endothelial-mesenchymal transitions in cerebral arteriovenous malformation models
Inhibition of endothelial histone deacetylase 2 shifts endothelial-mesenchymal transitions in cerebral arteriovenous malformation models Open
Cerebral arteriovenous malformations (AVMs) are the most common vascular malformations worldwide and the leading cause of hemorrhagic strokes that may result in crippling neurological deficits. Here, using recently generated mouse models, …
View article: The role of coagulopathy and subdural hematoma thickness at admission in predicting the prognoses of patients with severe traumatic brain injury: a multicenter retrospective cohort study from China
The role of coagulopathy and subdural hematoma thickness at admission in predicting the prognoses of patients with severe traumatic brain injury: a multicenter retrospective cohort study from China Open
Background: Traumatic brain injury (TBI) is one of the diseases with high disability and mortality worldwide. Recent studies have shown that TBI-related factors may change the complex balance between bleeding and thrombosis, leading to coa…
View article: Comparing efficacy and safety of mirabegron, tamsulosin, and solifenacin in ureteral stent-related symptoms: outcomes from a network meta-analysis
Comparing efficacy and safety of mirabegron, tamsulosin, and solifenacin in ureteral stent-related symptoms: outcomes from a network meta-analysis Open
Compared with traditional drugs for relieving SRSs, mirabegron performs best in terms of alleviating body pain, sexual matters, and adverse events, with little difference in urinary symptoms and general health. Further high-quality prospec…
View article: Effects of Tirofiban on Neurological Deterioration in Patients With Acute Ischemic Stroke
Effects of Tirofiban on Neurological Deterioration in Patients With Acute Ischemic Stroke Open
Importance Evidence supports using antiplatelet therapy in patients with acute ischemic stroke. However, neurological deterioration remains common under the currently recommended antiplatelet regimen, leading to poor clinical outcomes. Obj…
View article: Liver transplantation for hepatocellular carcinoma: a proposal for including preoperative serological indicators improves the Milan criteria expanded
Liver transplantation for hepatocellular carcinoma: a proposal for including preoperative serological indicators improves the Milan criteria expanded Open
Objective: To evaluate the predictive effect of preoperative serological indicators on long-term overall survival (OS) and tumor recurrence-free survival (TFS) of patients with hepatocellular carcinoma (HCC) after liver transplantation (LT…
View article: CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification.
CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification. Open
Vascular calcification is a severe complication of cardiovascular diseases. Previous studies demonstrated that endothelial lineage cells transitioned into osteoblast-like cells and contributed to vascular calcification. Here, we found that…
View article: The efficacy and safety of third-generation antiseizure medications and non-invasive brain stimulation to treat refractory epilepsy: a systematic review and network meta-analysis study
The efficacy and safety of third-generation antiseizure medications and non-invasive brain stimulation to treat refractory epilepsy: a systematic review and network meta-analysis study Open
Background The new antiseizure medications (ASMs) and non-invasive brain stimulation (NIBS) are controversial in controlling seizures. So, this network meta-analysis aimed to evaluate the efficacy and safety of five third-generation ASMs a…
View article: <i>p</i>-Cymene and pachymic acid alleviate adalimumab-resistance cell line inflammatory response via inhibiting PI3K/AKT/mTOR signaling pathway
<i>p</i>-Cymene and pachymic acid alleviate adalimumab-resistance cell line inflammatory response via inhibiting PI3K/AKT/mTOR signaling pathway Open
Background: In the management of inflammatory bowel disease, the emergence of drug resistance to monoclonal antibodies has come out as a significant impediment to achieving desired therapeutic outcomes. However, extensive evidence has subs…
View article: [Application of peroral endoscopic-assisted laryngeal microsurgery in children with laryngeal neurofibromas].
[Application of peroral endoscopic-assisted laryngeal microsurgery in children with laryngeal neurofibromas]. Open
Objective:To investigate the clinical manifestations and the effect of peroral endoscopic-assisted laryngeal microsurgery for children with laryngeal neurofibroma, and to provide clinical reference for the diagnosis and treatment of this d…
View article: METTL14 promotes neuroblastoma by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism
METTL14 promotes neuroblastoma by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism Open
Neuroblastoma (NB) is a widely recognized childhood tumor with high global incidence. The regulatory role of RNA N6-methyladenosine (m6A) in gene expression has gained significant attention, and the impact of methyltransferase-like 14 (MET…