Explanipedia

[Sjögren disease complicated by primary breast lymphoma: A case report]. Open

Yudie Ning, X Zhang, Xiting Li, Yingni Li, Jing He , et al. · 2025

This case report describes the diagnostic and therapeutic management of a 67-year-old female with a 40-year history of Sjögren disease (SjD) who was hospitalized for evaluation of recurrent fever lasting over one month. The patient' s init…

A Comprehensive Dataset on Microbiome Dynamics in Rheumatoid Arthritis from a Large-Scale Cohort Study Open

Jing Li, Jun Xu, Jiayang Jin, Congmin Xu, Yuzhou Gan , et al. · 2025

Alterations in intestinal microbiota have been identified as a key risk factor in rheumatoid arthritis (RA). This study presents a multidimensional gut microbiota profile from a large cohort of RA patients, stratified by disease stage and …

Large-scale multicenter study reveals anticitrullinated SR-A peptide antibody as a biomarker and exacerbator for rheumatoid arthritis Open

Yang Xie, Chaonan Wei, Dongdong Fu, Wei Zhang, Yan Du , et al. · 2025

Current diagnosis and treatment of rheumatoid arthritis (RA) is still challenging. More than one-third of patients with RA could not be accurately diagnosed because of lacking biomarkers. Our recent study reported that scavenger receptor-A…

[Ovarian function in patients of childbearing age with systemic lupus erythematosus]. Open

Dandan Chen, Yun Li, Qing‐Yi Lu, Xiaohong Xiang, Feng Sun , et al. · 2024

Ovarian function is decreased in SLE patients of childbearing age, and age and disease duration are the risk factors. The utilization of biological agents demonstrates favorable safety profiles regarding ovarian function in childbearing-ag…

Profile of immunological biomarkers in Behcet’s syndrome: a large-scale single-center real-world study Open

Jiachen Li, Feng Sun, Yingni Li, Jing Zhao, Rulin Jia , et al. · 2024

An autoantibody profile identified by human genome‐wide protein arrays in rheumatoid arthritis Open

Xu Liu, Xiaoying Zhang, Yu‐Jian Kang, Fei Huang, Shuang Liu , et al. · 2024

Precise diagnostic biomarkers of anticitrullination protein antibody (ACPA)‐negative and early‐stage RA are still to be improved. We aimed to screen autoantibodies in ACPA‐negative patients and evaluated their diagnostic performance. The h…

Multidimensional profile of gut microbiota in a large cohort of stratified rheumatoid arthritis Open

Jing He, Jing Li, Congmin Xu, Jun Xu, Yue Fang , et al. · 2024

It is unknown if dysbiosis of microbiota plays a role in the initiation and severity of rheumatoid arthritis (RA). In a comprehensive study of 2297 individuals, including 1,064 RA patients and 1,233 healthy controls, we uncovered an age-re…

LSO-098 Decreased natural killer T-like cells correlated to disease activity in systemic lupus erythematosus Open

Sumei Tang, Yushu Wang, Xiangbo Ma, Xiaohong Xiang, Xinhua Zhou , et al. · 2023

Background The NKT-like cells were known to play a role of the suppression in many chronic inflammatory diseases. This study was designed to investigate both of the expression and the possible role of NKT-like cells in SLE patients. Method…

Serum sCD25 is an indicator for rheumatoid arthritis-associated interstitial lung disease Open

Shixiong Cao, Xu Liu, Yingni Li, Yue Yang, Xuanlin Cai , et al. · 2023

sCD25 was significantly elevated in RA-ILD (including UIP, NSIP and RA-ILA) compared to RA-no-ILD and HCs, which supports their value as a potential biomarker in RA-ILD screening and assessment.

Increased human neutrophil lipocalin and its clinical relevance in adult-onset Still's disease Open

Ji Li, Yingni Li, Ru Li, Xiangbo Ma, Lianjie Shi , et al. · 2023

Background: Human neutrophil lipocalin (HNL) has been used extensively to differentiate acute bacterial infection from febrile diseases as a biomarker to reflect the activation of the neutrophil. The serum HNL levels in the adult-onset Sti…

Antibody to peptidoglycan recognition protein (PGLYRP)-2 as a novel biomarker in rheumatoid arthritis Open

Fei Huang, Xu Liu, Yongjing Cheng, Xiaolin Sun, Yingni Li , et al. · 2021

Autoantibody against PGLYRP-2 was identified as a promising biomarker in RA, especially in early and seronegative patients.

Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study Open

Fanlei Hu, Xiang Jiang, Chunqing Guo, Yingni Li, Shixian Chen , et al. · 2020

Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 particip…

Activity of fibroblast-like synoviocytes in rheumatoid arthritis was impaired by dickkopf-1 targeting siRNA Open

Yanying Liu, Shiyao Wang, Yingni Li, Wenjie Bian, Linqi Zhang , et al. · 2020

Background Fibroblast-like synoviocytes (FLSs), resident mesenchymal cells of synovial joints, play an important role in the pathogenesis of rheumatoid arthritis (RA). Dickkopf-1 (DKK-1) has been proposed to be a master regulator of bone r…

[Significance of anti-carbamylated fibrinogen antibodies in systemic lupus erythematosus]. Open

Y N Li, Xianhong Xiang, Jin Zhao, Yingni Li, Feng Sun , et al. · 2019

The level of anti-CarP antibody was increased in the serum of patients with SLE. There were correlations between anti-CarP antibodies and clinical and laboratory indicators of SLE patients.

[Clinical analysis of myeloid neoplasms with t (3;21) (q26;q22)]. Open

Yingni Li, Q Liu, Z Wang, Y Z Qin, Harry Dang , et al. · 2019

Objective: To analyze the characteristics of myeloid neoplasms with t (3;21) (q26;q22) . Methods: Clinical data of patients with t (3; 21) (q26; q22) , diagnosed as hematologic malignancies in Peking University people's hospi…

Impaired CD27+IgD+ B Cells With Altered Gene Signature in Rheumatoid Arthritis Open

Fanlei Hu, Wei Zhang, Lianjie Shi, Xu Liu, Jia Yuan , et al. · 2018

Natural antibodies, particularly natural IgM, are proved to play indispensable roles in the immune defenses against common infections. More recently, the protective roles of these natural IgM were also recognized in autoimmune diseases. Th…

Elevated Levels of Soluble ST2 were Associated with Rheumatoid Arthritis Disease Activity and Ameliorated Inflammation in Synovial Fibroblasts Open

Lianjie Shi, Chen Liu, Jianhong Li, Xiaoyun Zhu, Yingni Li , et al. · 2018

Elevated levels of ST2 in the serum and synovial fluid were associated with disease activity and ameliorated IL-33 expression and IL-33-induced inflammation in RASFs, suggesting that soluble ST2 might be a potential therapeutic candidate f…

Soluble TAM receptor tyrosine kinases in rheumatoid arthritis: correlation with disease activity and bone destruction Open

Liling Xu, Fanlei Hu, Huaqun Zhu, X Liu, Lianjie Shi , et al. · 2017

Summary The TAM receptor tyrosine kinases (TAM RTK) are a subfamily of receptor tyrosine kinases, the role of which in autoimmune diseases such as systemic lupus erythematosus has been well explored, while their functions in rheumatoid art…

Identifying barriers to the care of the rheumatoid hand in China: comparing attitudes of rheumatologists and hand surgeons Open

Lauren E. Franzblau, Keming Wang, Xuebing Liang, Yang Guo, Yingni Li , et al. · 2016

Aim In China, hand surgeons treat fewer rheumatoid arthritis ( RA ) patients compared to other countries. We investigated whether physician and surgeon knowledge, attitudes and practices regarding RA hand deformities reflect current eviden…

Barriers to Reconstructive Hand Surgery for Rheumatoid Arthritis in China: A Multicenter Survey of Patients and Physicians Open

Lauren E. Franzblau, Xuebing Liang, Keming Wang, Zhanguo Li, Yingni Li , et al. · 2016

Background: China has a similar rheumatoid arthritis (RA) disease burden compared with other countries, yet RA patients rarely receive surgical treatment for hand deformities that limit function and impact appearance. We investigated poten…

Hypoxia‐inducible factor‐1α perpetuates synovial fibroblast interactions with T cells and B cells in rheumatoid arthritis Open

Fanlei Hu, Hongjiang Liu, Liling Xu, Yingni Li, Xu Liu , et al. · 2015

Synovial fibroblast hyperplasia, T‐cell hyperactivity, B‐cell overactivation, and the self‐perpetuating interactions among these cell types are major characteristics of rheumatoid arthritis (RA). The inflamed joints of RA patients are hypo…

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