Yingwei Mao
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View article: Research on Automatic Classification and Prognosis Prediction of Intracerebral Hemorrhage Based on Deep Learning Models
Research on Automatic Classification and Prognosis Prediction of Intracerebral Hemorrhage Based on Deep Learning Models Open
Intracerebral hemorrhage (ICH) poses significant challenges in clinical management due to its high morbidity and mortalityrates. Traditional prognostic models often rely on manual assessment and conventional statistical methods, which mayl…
View article: A spatially-resolved human brain proteome atlas for understanding function and disease
A spatially-resolved human brain proteome atlas for understanding function and disease Open
While the brain performs specialized functions across distinct regions, the spatial organization of the human brain proteome remains largely uncharted. Here we present a comprehensive spatially-resolved proteome atlas of the human brain, a…
View article: Integrated profiling of iPSC-derived motor neurons carrying C9orf72, FUS, TARDBP, or SOD1 mutations
Integrated profiling of iPSC-derived motor neurons carrying C9orf72, FUS, TARDBP, or SOD1 mutations Open
Here, we conducted temporal RNA sequencing (RNA-seq) profiling of human induced pluripotent stem cells (hiPSCs) and induced pluripotent stem cell (iPSC)-derived motor neurons (iMNs) carrying C9orf72, FUS, TARDBP, or SOD1 mutations in both …
View article: Integrated bioinformatic analysis reveals the underlying mitochondria-associated endoplasmic reticulum membranes-related biomarkers for atrial fibrillation
Integrated bioinformatic analysis reveals the underlying mitochondria-associated endoplasmic reticulum membranes-related biomarkers for atrial fibrillation Open
Purpose To provide novel insights into the diagnosis of atrial fibrillation (AF), we aimed to identify mitochondria-associated endoplasmic reticulum membranes (MAMs)-related biomarkers for AF. Methods The training and validation datasets o…
View article: <scp>SYHA1813</scp> , A <scp>VEGFR</scp> and <scp>CSF1R</scp> Inhibitor, in Patients With Recurrent High‐Grade Gliomas: A Multicenter, Open‐Label Phase I Study
<span>SYHA1813</span> , A <span>VEGFR</span> and <span>CSF1R</span> Inhibitor, in Patients With Recurrent High‐Grade Gliomas: A Multicenter, Open‐Label Phase I Study Open
Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813 , a dual inhibitor of VEGFR and CSF1R , in patients with recurrent high‐grade gl…
View article: The distribution characteristics of PD-1 pathway-related immune cells in esophageal cancer tissue and their prognostic significance
The distribution characteristics of PD-1 pathway-related immune cells in esophageal cancer tissue and their prognostic significance Open
Objective This study aims to elucidate the distribution patterns of immune cells associated with the programmed cell death protein 1 (PD-1) pathway within esophageal cancer (EC) tissues and to determine their correlation with patient progn…
View article: Eulerian method for flow and heat transfer characteristics in an internally circulating fluidized bed reactor driven by solar energy with initial situation
Eulerian method for flow and heat transfer characteristics in an internally circulating fluidized bed reactor driven by solar energy with initial situation Open
View article: Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development
Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development Open
View article: Artificial Intelligent‐Enhanced Metabolite Profiling for Intraoperative IDH1 Genotyping in Glioma Using an Orthogonally Responsive SERS Probe
Artificial Intelligent‐Enhanced Metabolite Profiling for Intraoperative IDH1 Genotyping in Glioma Using an Orthogonally Responsive SERS Probe Open
Intraoperative identification of the isocitrate dehydrogenase type 1 (IDH1) genotype, a key molecular marker in glioma, is essential for optimizing surgical strategies and tailoring post‐surgical treatments. However, current clinical pract…
View article: Spatially resolved transcriptomics reveals gene expression characteristics in uveal melanoma
Spatially resolved transcriptomics reveals gene expression characteristics in uveal melanoma Open
Purpose Uveal melanoma (UM) is the most common intraocular malignancy in adults. Previous studies have examined the intra-tumoral heterogeneity. However, the spatial distribution of tumor cells within the tumor microenvironment and its rel…
View article: Numerical Simulation of Chemical Looping Combustion Applying Solar Energy to Dual Circulating Fluidized Bed Reactor
Numerical Simulation of Chemical Looping Combustion Applying Solar Energy to Dual Circulating Fluidized Bed Reactor Open
View article: Eulerian Method for Flow and Heat Transfer Characteristics in an Internally Circulating Fluidized Bed Reactor Driven by Solar Energy with Initial Situation
Eulerian Method for Flow and Heat Transfer Characteristics in an Internally Circulating Fluidized Bed Reactor Driven by Solar Energy with Initial Situation Open
View article: Comparison of the Performance of a Novel Acrylate Metal Complexes with Common Consolidants for Historical Red Sandstone of Xumishan Grottoes in China
Comparison of the Performance of a Novel Acrylate Metal Complexes with Common Consolidants for Historical Red Sandstone of Xumishan Grottoes in China Open
View article: Integrated temporal profiling of iPSCs-derived motor neurons from ALS patients carrying C9orf72, FUS, TARDBP, and SOD1 mutations
Integrated temporal profiling of iPSCs-derived motor neurons from ALS patients carrying C9orf72, FUS, TARDBP, and SOD1 mutations Open
Amyotrophic Lateral Sclerosis (ALS) is a lethal neurodegenerative disease that damages motor neurons in the central nervous system, causing progressive muscle weakness that ultimately leads to death. However, its underlying mechanisms stil…
View article: Histone demethylase enzymes KDM5A and KDM5B modulate immune response by suppressing transcription of endogenous retroviral elements
Histone demethylase enzymes KDM5A and KDM5B modulate immune response by suppressing transcription of endogenous retroviral elements Open
Epigenetic factors, including lysine-specific demethylases such as the KDM5 paralogs KDM5A and KDM5B have been implicated in cancer and the regulation of immune responses. Here, we performed a comprehensive multiomic study in cells lacking…
View article: The distribution characteristics of PD-1 pathway related immune cells in esophageal cancer tissue and their relationship with prognosis
The distribution characteristics of PD-1 pathway related immune cells in esophageal cancer tissue and their relationship with prognosis Open
Purpose Exploring the distribution characteristics of immune cells related to the programmed cell death receptor-1 (PD-1) pathway in esophageal cancer(EC) tissue and its relationship with prognosis. Methods Tissue samples of 236 patients w…
View article: The Exon Junction Complex Factor RBM8A in Glial Fibrillary Acid Protein-Expressing Astrocytes Modulates Locomotion Behaviors
The Exon Junction Complex Factor RBM8A in Glial Fibrillary Acid Protein-Expressing Astrocytes Modulates Locomotion Behaviors Open
The role of RNA Binding Motif Protein 8a (RBM8A), an exon junction complex (EJC) component, in neurodevelopmental disorders has been increasingly studied for its crucial role in regulating multiple levels of gene expression. It regulates m…
View article: Single-cell and spatial transcriptomics reveals that PTPRG activates the m6A methyltransferase VIRMA to block mitophagy-mediated neuronal death in Alzheimer’s disease
Single-cell and spatial transcriptomics reveals that PTPRG activates the m6A methyltransferase VIRMA to block mitophagy-mediated neuronal death in Alzheimer’s disease Open
Neuronal death is one of the key pathologies in Alzheimer's disease (AD). How neuronal death begins in AD is far from clear, so clarifying this process may help develop effective therapies. This study collected single-cell RNA sequencing d…
View article: LILRB3 suppresses immunity in glioma and is associated with poor prognosis
LILRB3 suppresses immunity in glioma and is associated with poor prognosis Open
Dear Editors, Gliomas are the most prevalent type of primary brain tumour. Within the glioma tumour microenvironments (TMEs), tumour-associated macrophages (TAMs) that hold high expression of co-inhibitory receptors constitute a significan…
View article: Transcriptomic Analyses of Brains of RBM8A Conditional Knockout Mice at Different Developmental Stages Reveal Conserved Signaling Pathways Contributing to Neurodevelopmental Diseases
Transcriptomic Analyses of Brains of RBM8A Conditional Knockout Mice at Different Developmental Stages Reveal Conserved Signaling Pathways Contributing to Neurodevelopmental Diseases Open
RNA-binding motif 8A (RBM8A) is a core component of the exon junction complex (EJC) that binds pre-mRNAs and regulates their splicing, transport, translation, and nonsense-mediated decay (NMD). Dysfunction in the core proteins has been lin…
View article: Animal models of chemotherapy‐induced peripheral neuropathy for hematological malignancies: A review
Animal models of chemotherapy‐induced peripheral neuropathy for hematological malignancies: A review Open
Chemotherapy is one of the main treatments for hematologic malignancies. However, chemotherapy‐induced peripheral neuropathy (CIPN) is one of the most common long‐term toxic reactions in chemotherapy, and the occurrence of CIPN affects pat…
View article: Diverse Roles of the Exon Junction Complex Factors in the Cell Cycle, Cancer, and Neurodevelopmental Disorders-Potential for Therapeutic Targeting
Diverse Roles of the Exon Junction Complex Factors in the Cell Cycle, Cancer, and Neurodevelopmental Disorders-Potential for Therapeutic Targeting Open
The exon junction complex (EJC) plays a crucial role in regulating gene expression at the levels of alternative splicing, translation, mRNA localization, and nonsense-mediated decay (NMD). The EJC is comprised of three core proteins: RNA-b…
View article: Neural excitatory rebound induced by valproic acid may predict its inadequate control of seizures
Neural excitatory rebound induced by valproic acid may predict its inadequate control of seizures Open
View article: CSCO expert consensus on the diagnosis and treatment of breast cancer brain metastasis
CSCO expert consensus on the diagnosis and treatment of breast cancer brain metastasis Open
Breast cancer is one of the most common malignancies among women worldwide. According to the International Agency for Research on Cancer, breast cancer affected more Chinese women than any other cancer in 2020. The brain is an increasingly…
View article: Enzymological and structural characterization of <i>Arabidopsis thaliana</i> heme oxygenase‐1
Enzymological and structural characterization of <i>Arabidopsis thaliana</i> heme oxygenase‐1 Open
Arabidopsis thaliana heme oxygenase‐1 (AtHO‐1), a metabolic enzyme in the heme degradation pathway, serves as a prototype for study of the bilin‐related functions in plants. Past biological analyses revealed that AtHO‐1 requires ferredoxin…
View article: Molecular Insights and Prognosis Associated With RBM8A in Glioblastoma
Molecular Insights and Prognosis Associated With RBM8A in Glioblastoma Open
Background: Glioblastoma (GBM) is the most invasive brain tumors, and it is associated with high rates of recurrence and mortality. The purpose of this study was to investigate the expression of RBM8A in GBM and the potential influence of …
View article: The Physiological Roles of the Exon Junction Complex in Development and Diseases
The Physiological Roles of the Exon Junction Complex in Development and Diseases Open
The exon junction complex (EJC) becomes an increasingly important regulator of early gene expression in the central nervous system (CNS) and other tissues. The EJC is comprised of three core proteins: RNA-binding motif 8A (RBM8A), Mago hom…
View article: PTPRG activates m6A methyltransferase VIRMA to block mitochondrial autophagy mediated neuronal death in Alzheimer’s disease
PTPRG activates m6A methyltransferase VIRMA to block mitochondrial autophagy mediated neuronal death in Alzheimer’s disease Open
In Alzheimer’s disease (AD), neuronal death is one of the key pathology. However, the initiation of neuronal death in AD is far from clear, and new targets are urgently needed to develop effective therapeutic methods. This study analyzed s…
View article: O-GlcNAcylation in Ventral Tegmental Area Dopaminergic Neurons Regulates Motor Learning and the Response to Natural Reward
O-GlcNAcylation in Ventral Tegmental Area Dopaminergic Neurons Regulates Motor Learning and the Response to Natural Reward Open
View article: Dissecting Molecular Genetic Mechanisms of 1q21.1 CNV in Neuropsychiatric Disorders
Dissecting Molecular Genetic Mechanisms of 1q21.1 CNV in Neuropsychiatric Disorders Open
Pathogenic copy number variations (CNVs) contribute to the etiology of neurodevelopmental/neuropsychiatric disorders (NDs). Increased CNV burden has been found to be critically involved in NDs compared with controls in clinical studies. Th…