Cynthia Y. He YOU? Author Swipe

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Rab2B promotes chaperonin-mediated actin folding and prevents developmental transcription reprogramming and quiescence in trypanosomes Open

Fengjun Li, Xiaoduo Dong, Yameng Huang, Donghui Hu, Eunyoung Chae , et al. · 2024

The Rab family of small GTPases are regulators of intracellular membrane trafficking. Rab2B, a Golgi-resident Rab GTPase, has been shown to function in ER-Golgi transport and autophagosome-lysosome fusion in mammalian cells and Drosophila …

Dynamic composition of stress granules in Trypanosoma brucei Open

Htay Mon Aye, Fengjun Li, Cynthia Y. He · 2024

Stress granules (SGs) are stress-induced RNA condensates consisting of stalled initiation complexes resulting from translational inhibition. The biochemical composition and function of SGs are highly diverse, and this diversity has been at…

ARL3 GTPases facilitate ODA16 unloading from IFT in motile cilia Open

Yameng Huang, Xiaoduo Dong, Stella Sun, Teck Kwang Lim, Qingsong Lin , et al. · 2024

Eukaryotic cilia and flagella are essential for cell motility and sensory functions. Their biogenesis and maintenance rely on the intraflagellar transport (IFT). Several cargo adapters have been identified to aid IFT cargo transport, but h…

Cytoplasmic preassembly of the flagellar outer dynein arm complex in Trypanosoma brucei Open

Karthika Balasubramaniam, Ting-ting He, Helen Chen, Zhewang Lin, Cynthia Y. He · 2024

The outer dynein arm (ODA) is a large, multimeric protein complex essential for ciliary motility. The composition and assembly of ODA are best characterized in the green algae Chlamydomonas reinhardtii, where individual ODA subunits are sy…

Arl3 regulates ODA16-mediated intraflagellar transport in motile cilia biogenesis Open

Yameng Huang, Xiaoduo Dong, Stella Sun, Teck-Kwang Lim, Qingsong Lin , et al. · 2023

Arl13b and Arl3 are ciliary GTPases implicated in human Joubert Syndrome, affecting ciliary membrane and axoneme organization. Although the mechanism of Arl13b as a guanine nucleotide exchange factor (GEF) of Arl3 and the function of Arl13…

Autophagy in protists and their hosts: When, how and why? Open

Patricia Silvia Romano, Takahiko Akematsu, Sébastien Besteiro, Annina Bindschedler, Vern B. Carruthers , et al. · 2023

Pathogenic protists are a group of organisms responsible for causing a variety of human diseases including malaria, sleeping sickness, Chagas disease, leishmaniasis, and toxoplasmosis, among others. These diseases, which affect more than o…

Towards Multi-Objective Statistically Fair Federated Learning Open

Ninareh Mehrabi, Cyprien de Lichy, John McKay, Cynthia Y. He, William W. Campbell · 2022

Federated Learning (FL) has emerged as a result of data ownership and privacy concerns to prevent data from being shared between multiple parties included in a training procedure. Although issues, such as privacy, have gained significant a…

Cell cycle and cleavage events during in vitro cultivation of bloodstream forms of Trypanosoma lewisi, a zoonotic pathogen Open

Xuan Zhang, Su-Jin Li, Ziyin Li, Cynthia Y. He, Geoff Hide , et al. · 2022

Trypanosoma (Herpetosoma) lewisi is a globally distributed rat trypanosome, currently considered as a zoonotic pathogen; however, a detailed understanding of the morphological events occurring during the cell cycle is …

Toxoplasma gondii SAG1 targeting host cell S100A6 for parasite invasion and host immunity Open

Lijuan Zhou, Jiao Peng, Min Chen, Lijie Yao, Wei-Hao Zou , et al. · 2021

Characterisation of novel functionality within the Blastocystis tryptophanase gene Open

Steven Santino Leonardi, Fengjun Li, Melissa Su Juan Chee, John Anthony Yason, Hui Yi Tay , et al. · 2021

In recent years, the human gut microbiome has been recognised to play a pivotal role in the health of the host. Intestinal homeostasis relies on this intricate and complex relationship between the gut microbiota and the human host. While m…

The challenge of ‘holding space’ while holding the pager Open

Cynthia Y. He · 2021

Structural studies of the shortest extended synaptotagmin with only two C2 domains from Trypanosoma brucei Open

Emma Stepinac, Nicolas Landrein, Daria Skwarzyńska, Patrycja Wójcik, Johannes Lesigang , et al. · 2021

Structural Studies of a Novel Extended Synaptotagmin with Only Two C2 Domains from Trypanosoma brucei Open

Emma Stepinac, Nicolas Landrein, Daria Skwarzyńska, Patrycja Wójcik, Johannes Lesigang , et al. · 2021

Toxoplasma gondii SAG1 Targeting Host Cell S100A6 for Parasite Invasion and Host Immunity Open

Lijuan Zhou, Jiao Peng, Min Chen, Lijie Yao, Wei Zou , et al. · 2021

Flagellar targeting of an arginine kinase requires a conserved lipidated protein intraflagellar transport (LIFT) pathway in Trypanosoma brucei Open

Maneesha Pandey, Yameng Huang, Teck Kwang Lim, Qingsong Lin, Cynthia Y. He · 2020

Basal Body Protein TbSAF1 Is Required for Microtubule Quartet Anchorage to the Basal Bodies in Trypanosoma brucei Open

Xiaoduo Dong, Teck Kwang Lim, Qingsong Lin, Cynthia Y. He · 2020

Trypanosoma brucei contains a large array of single-copied organelles and structures. Through extensive interorganelle connections, these structures replicate and divide following a strict temporal and spatial order. A microtubule quartet …

Flagellar targeting of an arginine kinase requires a conserved lipidated intraflagellar transport (LIFT) pathway inTrypanosoma brucei Open

Maneesha Pandey, Yameng Huang, Teck Kwang Lim, Qingsong Lin, Cynthia Y. He · 2020

Both intraflagellar transport (IFT) and lipidated intraflagellar transport (LIFT) pathways are essential for cilia/flagella biogenesis, motility and sensory functions. In the LIFT pathway, lipidated cargoes are transported into the cilia t…

Structural Studies of a Novel Extended Synaptotagmin with Only Two C2 Domains from Trypanosoma Brucei Open

Emma Stepinac, Nicolas Landrein, Daria Skwarzyńska, Patrycja Wójcik, Johannes Lesigang , et al. · 2020

Cell Cycle-Dependent Flagellar Disassembly in a Firebug Trypanosomatid Leptomonas pyrrhocoris Open

Cynthia Y. He, Adarsh Singh, Vyacheslav Yurchenko · 2019

Current understanding of flagellum biogenesis during the cell cycle in trypanosomatids is limited to a few pathogenic species, including Trypanosoma brucei , Trypanosoma cruzi , and Leishmania spp. The most notable characteristics of trypa…

Toxoplasma gondii ROP18 inhibits human glioblastoma cell apoptosis through a mitochondrial pathway by targeting host cell P2X1 Open

Lijuan Zhou, Min Chen, Santhosh Puthiyakunnon, Cheng He, Jing Xia , et al. · 2019

Toxoplasma gondii infection inhibits ATP-induced host cell apoptosis, regardless of strain virulence and host cell lines. TgROP18 targets the purinergic receptor P2X1 of the SF268 human neural cells and inhibits ATP-induced apoptosis throu…

Successful Genetic Transfection of the Colonic Protistan Parasite Blastocystis for Reliable Expression of Ectopic Genes Open

Fengjun Li, Anastasios D. Tsaousis, Tracy Purton, Vincent Chow, Cynthia Y. He , et al. · 2019

The microbial parasite Blastocystis colonizes the large intestines of numerous animal species and increasing evidence has linked Blastocystis infection to enteric diseases with signs and symptoms including abdominal pain, constipation, dia…

Cell cycle and cleavage events during in vitro cultivation of bloodstream forms of Trypanosoma lewisi, a zoonotic pathogen Open

Xuan Zhang, Su-Jin Li, Ziyin Li, Cynthia Y. He, Geoff Hide , et al. · 2019

Trypanosoma (Herpetosoma) lewisi is a globally distributed rat trypanosome, currently considered as a zoonotic pathogen; however, a detailed understanding of the morphological events occurring during the cell cycle is lacking. This study a…

Cell cycle and cleavage events during in vitro cultivation of bloodstream forms of Trypanosoma lewisi, a zoonotic pathogen Open

Xuan Zhang, Su-Jin Li, Ziyin Li, Cynthia Y. He, Geoff Hide , et al. · 2019

The unusual flagellar-targeting mechanism and functions of the trypanosome ortholog of the ciliary GTPase Arl13b Open

Yiliu Zhang, Yameng Huang, Amrita Srivathsan, Teck Kwang Lim, Qingsong Lin , et al. · 2018

The small GTPase Arl13b is one of the most conserved and ancient ciliary proteins. In human and animals, Arl13b is primarily associated with the ciliary membrane, where it acts as a guanine-nucleotide-exchange factor (GEF) for Arl3 and is …

Toxoplasma gondiiROP18 Inhibits Human Glioblastoma Cell Apoptosis through Mitochondrial Pathway by Targeting Host Cell P2X1 Open

Lijuan Zhou, Min Chen, Cheng He, Jing Xia, Cynthia Y. He , et al. · 2018

It is known that Toxoplasma gondii infection both initiates and inhibits host cell apoptosis through different proapoptotic signaling cascades, but the parasitic factors involved in these processes remain unclear. T. gondii virulence facto…

Flagellum couples cell shape to motility inTrypanosoma brucei Open

Stella Sun, Jason T. Kaelber, Muyuan Chen, Xiaoduo Dong, Yasaman Nematbakhsh , et al. · 2018

Significance Trypanosoma brucei is a highly invasive pathogen capable of penetrating deeply into host tissues. To understand how flagellar motility facilitates cell penetration, we used cryo-electron tomography (cryo-ET) to visualize two g…

Eleven quick tips for running an interdisciplinary short course for new graduate students Open

Timothy E. Saunders, Cynthia Y. He, Patrice Koehl, Lee‐Ling Sharon Ong, Peter T. C. So · 2018

Quantitative reasoning and techniques are increasingly ubiquitous across the life sciences. However, new graduate researchers with a biology background are often not equipped with the skills that are required to utilize such techniques cor…

Genome-Wide Bimolecular Fluorescence Complementation-Based Proteomic Analysis of Toxoplasma gondii ROP18’s Human Interactome Shows Its Key Role in Regulation of Cell Immunity and Apoptosis Open

Jing Xia, Ling Kong, Lijuan Zhou, Shuizhen Wu, Lijie Yao , et al. · 2018

Toxoplasma gondii rhoptry protein ROP18 (TgROP18) is a key virulence factor secreted into the host cell during invasion, where it modulates the host cell response by interacting with its host targets. However, only a few T…

View article: Kinetoplastid membrane protein‐11 adopts a four‐helix bundle fold in <scp>DPC</scp> micelle

Kinetoplastid membrane protein‐11 adopts a four‐helix bundle fold in DPC micelle Open

Liang Zhong Lim, Shermaine Ee, Jing Fu, Yanming Tan, Cynthia Y. He , et al. · 2017

Kinetoplastid membrane protein‐11 ( KMP 11) is a membrane‐associated surface protein of kinetoplastids, which has a strong antigenicity but no mammalian homolog, thus representing a promising vaccine candidate. Here, by CD and NMR , we rev…

View article: Autophagy in Protozoan Parasites: Trypanosoma Brucei as a Model

Autophagy in Protozoan Parasites: Trypanosoma Brucei as a Model Open

Fengjun Li, Cynthia Y. He · 2017

To gain further and more complete understanding of the mechanisms and functions of autophagy, both conserved and evolutionarily divergent, study of more divergent model systems