Yingyuan Zhang
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View article: Efficacy and Safety of Rezafungin Versus Caspofungin for the Treatment of Candidemia and Invasive Candidiasis in a China Cohort of a Double‐Blind, Randomised, Phase 3 Trial ( <scp>ReSTORE</scp> China)
Efficacy and Safety of Rezafungin Versus Caspofungin for the Treatment of Candidemia and Invasive Candidiasis in a China Cohort of a Double‐Blind, Randomised, Phase 3 Trial ( <span>ReSTORE</span> China) Open
Background The global double‐blind, randomised, Phase 3 ReSTORE trial (NCT03667690) demonstrated noninferiority of rezafungin versus caspofungin for all‐cause mortality at Day 30 and global cure at Day 14 in patients with candidemia and/or…
View article: Effectiveness and safety of ceftazidime-avibactam in Chinese patients with hospital-acquired pneumonia, including ventilator-associated pneumonia: A Phase 4, multi-centre, open-label study
Effectiveness and safety of ceftazidime-avibactam in Chinese patients with hospital-acquired pneumonia, including ventilator-associated pneumonia: A Phase 4, multi-centre, open-label study Open
View article: Efficient “Core–Shell” Carbon‐Based Solar Evaporator with Honeycomb Structure for Large‐Scale Solar‐Driven Water Purification and Energy Harvesting
Efficient “Core–Shell” Carbon‐Based Solar Evaporator with Honeycomb Structure for Large‐Scale Solar‐Driven Water Purification and Energy Harvesting Open
Solar‐driven interfacial water evaporation holds a broad application prospect in the domain of seawater desalination. However, traditional interfacial desalination technology is facing the challenge of large‐scale preparation and desalting…
View article: Protective effect of ulinastatin against negative inflammatory response and organ dysfunction in acute aortic dissection surgery: The PANDA trial
Protective effect of ulinastatin against negative inflammatory response and organ dysfunction in acute aortic dissection surgery: The PANDA trial Open
Ulinastatin is a protease-inhibiting drug with anti-inflammatory and other pharmacological properties. Little is known regarding its role following acute type A aortic dissection (ATAAD) surgery. We perform a randomized controlled trial to…
View article: Burden and Temporal Trends of Valvular Heart Disease‐Related Heart Failure From 1990 to 2019 and Projection Up to 2030 in Group of 20 Countries: An Analysis for the Global Burden of Disease Study 2019
Burden and Temporal Trends of Valvular Heart Disease‐Related Heart Failure From 1990 to 2019 and Projection Up to 2030 in Group of 20 Countries: An Analysis for the Global Burden of Disease Study 2019 Open
Background The aim of this study was to characterize the burden of valvular heart disease (VHD)‐related heart failure (HF) in Group of 20 (G20) countries. Methods and Results Using data from the 2019 Global Burden of Disease Study, we esti…
View article: Association of marital status with cardiovascular death risk in patients with lung cancer: A population-based study
Association of marital status with cardiovascular death risk in patients with lung cancer: A population-based study Open
Unmarried status was associated with increased cardiovascular death risk in patients with lung cancer, which highlighted that more attention and humanistic/supportive care should be offered to unmarried lung cancer patients for improving t…
View article: A multicentre, randomised, double-blind, double-dummy, parallel-controlled, phase 3 clinical trial assessing the efficacy and safety of intravenous nemonoxacin malate vs. levofloxacin for community-acquired pneumonia in adult patients
A multicentre, randomised, double-blind, double-dummy, parallel-controlled, phase 3 clinical trial assessing the efficacy and safety of intravenous nemonoxacin malate vs. levofloxacin for community-acquired pneumonia in adult patients Open
Nemonoxacin 500 mg IV once daily for 7-14 days is effective and safe and non-inferior to levofloxacin for treating CAP in adult patients.
View article: Chinese Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (5A) Registry protocol: rationale, design and methodology
Chinese Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (5A) Registry protocol: rationale, design and methodology Open
View article: Modeling Microbial Impact on Macrophyte Debris Decomposition in Macrophyte-Dominated Eutrophic Lakes
Modeling Microbial Impact on Macrophyte Debris Decomposition in Macrophyte-Dominated Eutrophic Lakes Open
View article: Modeling Microbial Impact on Macrophyte Debris Decomposition in Macrophyte-Dominated Eutrophic Lakes
Modeling Microbial Impact on Macrophyte Debris Decomposition in Macrophyte-Dominated Eutrophic Lakes Open
View article: Study on the Development of Distributed Energy in Northern China of Rural Energy Transformation
Study on the Development of Distributed Energy in Northern China of Rural Energy Transformation Open
Distributed energy is a crucial breakthrough and focus for the green and low-carbon transformation of rural energy in China. It has experienced rapid development in recent years. However, mismatches between rural energy production and cons…
View article: Phosphorus Accumulation During the Ice-On Season in the Macrophyte-Dominated Eutrophic Lakes and its Implications
Phosphorus Accumulation During the Ice-On Season in the Macrophyte-Dominated Eutrophic Lakes and its Implications Open
View article: Lateralization difference in functional activity during Stroop tasks: a functional near-infrared spectroscopy and EEG simultaneous study
Lateralization difference in functional activity during Stroop tasks: a functional near-infrared spectroscopy and EEG simultaneous study Open
Introduction Conflict monitoring and processing is an important part of the human cognitive system, it plays a key role in many studies of cognitive disorders. Methods Based on a Chinese word-color match Stroop task, which included incongr…
View article: Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection
Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection Open
The systemic benefits of anti-inflammatory pharmacotherapy vary across cardiovascular diseases in clinical practice. We aimed to evaluate the application of artificial intelligence to acute type A aortic dissection (ATAAD) patients to dete…
View article: Different heart failure phenotypes of valvular heart disease: the role of mitochondrial dysfunction
Different heart failure phenotypes of valvular heart disease: the role of mitochondrial dysfunction Open
Valvular heart disease (VHD)-related heart failure (HF) is a special subtype of HF with an increasingly concerned heterogeneity in pathophysiology, clinical phenotypes, and outcomes. The mechanism of VHD-related HF involves not only mechan…
View article: Integrative population pharmacokinetic/pharmacodynamic analysis of nemonoxacin capsule in Chinese patients with community-acquired pneumonia
Integrative population pharmacokinetic/pharmacodynamic analysis of nemonoxacin capsule in Chinese patients with community-acquired pneumonia Open
Introduction: Nemonoxacin is an innovative quinolone antibiotic for treatment of community-acquired pneumonia (CAP). As more data are available from clinical studies, it is necessary to perform an integrative pharmacokinetic/pharmacodynami…
View article: A multicenter investigation of 2,773 cases of bloodstream infections based on China antimicrobial surveillance network (CHINET)
A multicenter investigation of 2,773 cases of bloodstream infections based on China antimicrobial surveillance network (CHINET) Open
Background Bloodstream infections (BSIs), especially hospital-acquired BSIs, are a major cause of morbidity and mortality. However, the details about the pathogens and antimicrobial resistance profile of BSIs across China are still lacking…
View article: Circulating biomarker-based risk stratifications individualize arch repair strategy of acute Type A aortic dissection via the XGBoosting algorithm
Circulating biomarker-based risk stratifications individualize arch repair strategy of acute Type A aortic dissection via the XGBoosting algorithm Open
Aims The incremental usefulness of circulating biomarkers from different pathological pathways for predicting mortality has not been evaluated in acute Type A aortic dissection (ATAAD) patients. We aim to develop a risk prediction model an…
View article: A Novel Inflammation-Based Risk Score Predicts Mortality in Acute Type A Aortic Dissection Surgery: The Additive Anti-inflammatory Action for Aortopathy and Arteriopathy Score
A Novel Inflammation-Based Risk Score Predicts Mortality in Acute Type A Aortic Dissection Surgery: The Additive Anti-inflammatory Action for Aortopathy and Arteriopathy Score Open
clinicaltrials.gov Identifier: NCT04918108.
View article: Plain Language Summary: Use of Isavuconazole in Chinese Patients with an Invasive Fungal Disease
Plain Language Summary: Use of Isavuconazole in Chinese Patients with an Invasive Fungal Disease Open
These findings show that isavuconazole may be a suitable treatment for Chinese patients with IA using the same dose that is used in Western patients.
View article: Pharmacokinetics and Pharmacodynamics of Colistin Methanesulfonate in Healthy Chinese Subjects after Multi-Dose Regimen
Pharmacokinetics and Pharmacodynamics of Colistin Methanesulfonate in Healthy Chinese Subjects after Multi-Dose Regimen Open
Colistin methanesulfonate (CMS) is an important treatment option for infections caused by carbapenem-resistant Gram-negative organisms (CROs). This study evaluated the pharmacokinetic/pharmacodynamic (PK/PD) profiles and safety of CMS in C…
View article: Combined PK/PD Index May Be a More Appropriate PK/PD Index for Cefoperazone/Sulbactam against Acinetobacter baumannii in Patients with Hospital-Acquired Pneumonia
Combined PK/PD Index May Be a More Appropriate PK/PD Index for Cefoperazone/Sulbactam against Acinetobacter baumannii in Patients with Hospital-Acquired Pneumonia Open
Cefoperazone/sulbactam (CPZ/SUL) is a β-lactam and β-lactamase inhibitor combination therapy for the treatment of respiratory tract infections. Using data from a prospective, multiple-center, open-label clinical trial in 54 patients with h…
View article: Clinical Pharmacology and Utility of Contezolid in Chinese Patients with Complicated Skin and Soft-Tissue Infections
Clinical Pharmacology and Utility of Contezolid in Chinese Patients with Complicated Skin and Soft-Tissue Infections Open
This study aimed to build a population pharmacokinetic (PopPK) model for contezolid tablet (MRX-I) in healthy subjects and adults with complicated skin and soft-tissue infections (cSSTIs) to further evaluate the efficacy and safety of cont…
View article: Construction of OH-functionalized MWCNT/solid waste composites with tubular/spherical heterostructures for enhanced electromagnetic wave absorption property
Construction of OH-functionalized MWCNT/solid waste composites with tubular/spherical heterostructures for enhanced electromagnetic wave absorption property Open
Novel MWCNT/FAC composites based on a tubular/spherical micro–nano structure system are designed and prepared through physical mixing for achieving enhanced EWA property.
View article: Nemonoxacin dosage adjustment in patients with severe renal impairment based on population pharmacokinetic and pharmacodynamic analysis
Nemonoxacin dosage adjustment in patients with severe renal impairment based on population pharmacokinetic and pharmacodynamic analysis Open
Aims To optimize the dosing regimen in patients with severe renal impairment based on population pharmacokinetic (PPK)/pharmacodynamic analysis. Methods The pharmacokinetics and safety of nemonoxacin was evaluated in a single‐dose, open‐la…
View article: A randomized, controlled, multicenter clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus moxifloxacin in adult patients with community-acquired pneumonia
A randomized, controlled, multicenter clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus moxifloxacin in adult patients with community-acquired pneumonia Open
To evaluate the efficacy and safety of oral sitafloxacin versus oral moxifloxacin in the treatment of Chinese adults with community-acquired pneumonia (CAP). This is a multicenter, randomized, open-label, positive-controlled clinical trial…
View article: Predictors of Prolonged Mechanical Ventilation in Paediatric Patients After Anatomical Correction of Simple Congenital Heart Disease
Predictors of Prolonged Mechanical Ventilation in Paediatric Patients After Anatomical Correction of Simple Congenital Heart Disease Open
Background: We aimed to use preoperative clinical data from paediatric patients with simple congenital heart disease to predict the risk of prolonged mechanical ventilation after surgery. Methods: The clinical data from paediatric patients…
View article: A randomized, controlled, multicenter clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus moxifloxacin in adult patients with community-acquired pneumonia
A randomized, controlled, multicenter clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus moxifloxacin in adult patients with community-acquired pneumonia Open
To evaluate the efficacy and safety of oral sitafloxacin versus oral moxifloxacin in the treatment of Chinese adults with community-acquired pneumonia (CAP). This is a multicenter, randomized, open-label, positive-controlled clinical trial…
View article: A randomized, controlled, multicenter clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus moxifloxacin in adult patients with community-acquired pneumonia
A randomized, controlled, multicenter clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus moxifloxacin in adult patients with community-acquired pneumonia Open
To evaluate the efficacy and safety of oral sitafloxacin versus oral moxifloxacin in the treatment of Chinese adults with community-acquired pneumonia (CAP). This is a multicenter, randomized, open-label, positive-controlled clinical trial…
View article: A randomized, active-controlled, multicentre clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated or complicated urinary tract infection
A randomized, active-controlled, multicentre clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated or complicated urinary tract infection Open
Oral sitafloxacin is as effective and safe as levofloxacin in treating acute uncomplicated and complicated UTI. KEY MESSAGE: Oral sitafloxacin showed similar clinical cure rate and bacterial eradication rate as levofloxacin for treatment o…