Yingzheng Wang
YOU?
Author Swipe
View article: Notopterol Attenuates Synovitis via α7nAChR-Dependent Metabolic Reprogramming of Macrophage Polarisation
Notopterol Attenuates Synovitis via α7nAChR-Dependent Metabolic Reprogramming of Macrophage Polarisation Open
View article: Proteomic sensors for quantitative multiplexed and spatial monitoring of kinase signaling
Proteomic sensors for quantitative multiplexed and spatial monitoring of kinase signaling Open
View article: iRGD-modified co-loaded curcumin piperine liposomes inhibit angiogenesis in non-small cell lung cancer through the VEGFR2/P38/MK2 signaling axis
iRGD-modified co-loaded curcumin piperine liposomes inhibit angiogenesis in non-small cell lung cancer through the VEGFR2/P38/MK2 signaling axis Open
iRGD-LP-CUR-PIP reduces tumor angiogenesis and affects tumor growth by inhibiting the VEGFR2/P38/MK2 pathway. Among them, CUR affects VEGF and PIP may affect CTR1, which in turn affects CTR1-VEGFR2 co-internalization and downstream signali…
View article: Surging Processes and Mechanisms at Small Glaciers in the Qilian Mountains, Northwestern China, Revealed by Long‐Term, Temporally Dense Remote Sensing Observations
Surging Processes and Mechanisms at Small Glaciers in the Qilian Mountains, Northwestern China, Revealed by Long‐Term, Temporally Dense Remote Sensing Observations Open
A glacier surge, an exceptional phenomenon of mass redistribution, is one of the least understood dynamic processes in cryospheric science. Long‐term detailed changes in glacier elevation and flow velocity are crucial for assessing surge d…
View article: An ATM-PPM1D Circuit Controls the Processing and Restart of DNA Replication Forks
An ATM-PPM1D Circuit Controls the Processing and Restart of DNA Replication Forks Open
In response to DNA replication stress, DNA damage signaling kinases inhibit origin firing and promote the remodeling and stabilization of replication forks, leading to a systemic reduction in DNA synthesis that protects genomic integrity. …
View article: Prompt robust large language model for Chinese medical named entity recognition
Prompt robust large language model for Chinese medical named entity recognition Open
View article: Mapping taluses using deep learning and high-resolution satellite images
Mapping taluses using deep learning and high-resolution satellite images Open
Taluses are widely distributed in alpine regions such as the Tibetan Plateau. Despite their critical environmental and geohazard roles, taluses have only been mapped in limited regions. This study presents an effective approach to identify…
View article: Proteomic Sensors for Quantitative, Multiplexed and Spatial Monitoring of Kinase Signaling
Proteomic Sensors for Quantitative, Multiplexed and Spatial Monitoring of Kinase Signaling Open
View article: Patterns and change rates of glacial lake water levels across High Mountain Asia
Patterns and change rates of glacial lake water levels across High Mountain Asia Open
Using satellite altimetry data, this work quantifies the inter-annual trends and intra-annual fluctuations in water levels of glacial lakes in High Mountain Asia during 2019-2023.
View article: Identification and Validation of Pyroptosis‐Associated Gene Signature in Primary Sjögren’s Syndrome
Identification and Validation of Pyroptosis‐Associated Gene Signature in Primary Sjögren’s Syndrome Open
Background Pyroptosis, a form of programmed cell death, has been implicated in autoimmune diseases (ADs) pathogenesis. However, its role in primary Sjögren’s syndrome (pSS) remains unclear. This study aims to identify pyroptosis‐related ge…
View article: Proteomic Sensors for Quantitative, Multiplexed and Spatial Monitoring of Kinase Signaling
Proteomic Sensors for Quantitative, Multiplexed and Spatial Monitoring of Kinase Signaling Open
Understanding kinase action requires precise quantitative measurements of their activity in vivo . In addition, the ability to capture spatial information of kinase activity is crucial to deconvolute complex signaling networks, interrogate…
View article: Atp6v0d2 deficiency partially restores defects in Mcoln1-deficient mouse corpus luteum
Atp6v0d2 deficiency partially restores defects in Mcoln1-deficient mouse corpus luteum Open
Objective: ATP6V0d2 is a subunit of the vacuolar-type H + -ATPase (V-ATPase) that pumps H + ions into lysosomes. TRPML1 ( MCOLN1 / Mcoln1 ) transports cations out of lysosomes. Mcoln1 −/− mice recapitulate the lysosomal storage disorder mu…
View article: Predicting Gross Primary Productivity under Future Climate Change for the Tibetan Plateau Based on Convolutional Neural Networks
Predicting Gross Primary Productivity under Future Climate Change for the Tibetan Plateau Based on Convolutional Neural Networks Open
Gross primary productivity (GPP) is vital for ecosystems and the global carbon cycle, serving as a sensitive indicator of ecosystems’ responses to climate change. However, the impact of future climate changes on GPP in the Tibetan Plateau,…
View article: The multifaceted mechanisms of Dihydrotanshinone I in the treatment of tumors
The multifaceted mechanisms of Dihydrotanshinone I in the treatment of tumors Open
The morbidity and mortality of malignant tumors are progressively rising on an annual basis. Traditional Chinese Medicine (TCM) holds promise as a possible therapeutic agent for the avoidance or therapy of malignant tumors. Salvia miltiorr…
View article: Cortex Lycii attenuates night sweat in Yin-deficient rat by downregulating β 2 AR/cAMP signaling: A proteomic approach
Cortex Lycii attenuates night sweat in Yin-deficient rat by downregulating β 2 AR/cAMP signaling: A proteomic approach Open
Purpose: To investigate the therapeutic effect of Cortex Lycii on the sweat secretion of YDH rats and its underlying mechanism. Methods : Male SD rats (N=36) were randomly assigned into Control, YDH, and DI groups (N=12 each group). YDH mo…
View article: Comparison of Machine Learning Models in Simulating Glacier Mass Balance: Insights from Maritime and Continental Glaciers in High Mountain Asia
Comparison of Machine Learning Models in Simulating Glacier Mass Balance: Insights from Maritime and Continental Glaciers in High Mountain Asia Open
Accurately simulating glacier mass balance (GMB) data is crucial for assessing the impacts of climate change on glacier dynamics. Since physical models often face challenges in comprehensively accounting for factors influencing glacial mel…
View article: Cortex Lycii Attenuates Sweat Secretion in Yin-Deficient Rat by Downregulating Β2ar/Camp Signaling: A Proteomic Approach
Cortex Lycii Attenuates Sweat Secretion in Yin-Deficient Rat by Downregulating Β2ar/Camp Signaling: A Proteomic Approach Open
View article: Mitochondrion-NLRP3 inflammasome activation in macrophages: A novel mechanism of the anti-inflammatory effect of Notopterygium in rheumatoid arthritis treatment
Mitochondrion-NLRP3 inflammasome activation in macrophages: A novel mechanism of the anti-inflammatory effect of Notopterygium in rheumatoid arthritis treatment Open
The anti-inflammatory and antirheumatic effect of NE may involve regulating NLRP3 inflammasome activation through mitochondria. NLRP3 is probably the key target molecule of NE in the treatment of RA.
View article: Enhancing Flood Simulation in Data-Limited Glacial River Basins through Hybrid Modeling and Multi-Source Remote Sensing Data
Enhancing Flood Simulation in Data-Limited Glacial River Basins through Hybrid Modeling and Multi-Source Remote Sensing Data Open
Due to the scarcity of observational data and the intricate precipitation–runoff relationship, individually applying physically based hydrological models and machine learning (ML) techniques presents challenges in accurately predicting flo…
View article: The Antitumour Activity of a Curcumin and Piperine Loaded iRGD-Modified Liposome: In Vitro and In Vivo Evaluation
The Antitumour Activity of a Curcumin and Piperine Loaded iRGD-Modified Liposome: In Vitro and In Vivo Evaluation Open
Lung cancer is one of the most common cancers around the world, with a high mortality rate. Despite substantial advancements in diagnoses and therapies, the outlook and survival of patients with lung cancer remains dismal due to drug toler…
View article: Vitrification preserves follicular transcriptomic dynamics during ex vivo ovulation
Vitrification preserves follicular transcriptomic dynamics during ex vivo ovulation Open
Journal Article Corrected proof Vitrification preserves follicular transcriptomic dynamics during ex vivo ovulation Get access Jiyang Zhang, Jiyang Zhang Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Environme…
View article: Effects of Cyanobacterial Harmful Algal Bloom Toxin Microcystin-LR on Gonadotropin-Dependent Ovarian Follicle Maturation and Ovulation in Mice
Effects of Cyanobacterial Harmful Algal Bloom Toxin Microcystin-LR on Gonadotropin-Dependent Ovarian Follicle Maturation and Ovulation in Mice Open
Using both in vivo and in vitro murine and human model systems, we provide data suggesting that environmentally relevant exposure to the CyanoHAB toxin MC-LR interfered with gonadotropin-dependent follicle maturation and ovul…
View article: An<i>ex vivo</i>ovulation system enables the discovery of novel ovulatory pathways and nonhormonal contraceptive candidates
An<i>ex vivo</i>ovulation system enables the discovery of novel ovulatory pathways and nonhormonal contraceptive candidates Open
Ovulation is an integral part of women’s menstrual cycle and fertility. Understanding the mechanisms of ovulation has broad implications for the treatment of anovulatory diseases and the development of novel contraceptives. Now, few studie…
View article: Multitemporal Glacier Mass Balance and Area Changes in the Puruogangri Ice Field during 1975–2021 Based on Multisource Satellite Observations
Multitemporal Glacier Mass Balance and Area Changes in the Puruogangri Ice Field during 1975–2021 Based on Multisource Satellite Observations Open
Due to climate warming, the glaciers of the Tibetan Plateau have experienced rapid mass loss and the patterns of glacier changes have exhibited high spatiotemporal heterogeneity, especially in interior areas. As the largest ice field withi…
View article: Decadal Changes in Glacier Area, Surface Elevation and Mass Balance for 2000–2020 in the Eastern Tanggula Mountains Using Optical Images and TanDEM-X Radar Data
Decadal Changes in Glacier Area, Surface Elevation and Mass Balance for 2000–2020 in the Eastern Tanggula Mountains Using Optical Images and TanDEM-X Radar Data Open
The response of lake-terminating glaciers to climate change is complex, and their rapid changes are often closely linked to glacial-lake outburst floods. However, the eastern Tanggula Mountains, which are the only area where lake-terminati…
View article: Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated in vitro follicle growth system
Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated in vitro follicle growth system Open
This is the accepted manuscript version of the work published in its final form as Wang, Y., Drake, R. S., Russo, D. D., Pattarawat, P., Zhang, Q., Zelinski, M. B., Shalek, A. K., Brittany A Goods., & Xiao, S. (2021). Vitrification preserv…
View article: Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated<i>in vitro</i>follicle growth system
Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated<i>in vitro</i>follicle growth system Open
Dear editor, Vitrification is a method for long-term biological sample cryopreservation that transforms cells into a glass-like state by cooling without causing intra- and extra-cellular ice formation, which is a major driver of cell cryoi…
View article: Estimating the Changes in Glaciers and Glacial Lakes in the Xixabangma Massif, Central Himalayas, between 1974 and 2018 from Multisource Remote Sensing Data
Estimating the Changes in Glaciers and Glacial Lakes in the Xixabangma Massif, Central Himalayas, between 1974 and 2018 from Multisource Remote Sensing Data Open
The continuous melting of valley glaciers can impact the water levels of glacial lakes and create glacial lake outburst floods (GLOFs). The Xixabangma massif is one of the most populated areas in the Himalayas and has suffered from multipl…
View article: Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties
Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties Open
View article: A Tiered Female Ovarian Toxicity Screening Identifies Toxic Effects of Checkpoint Kinase 1 Inhibitors on Murine Growing Follicles
A Tiered Female Ovarian Toxicity Screening Identifies Toxic Effects of Checkpoint Kinase 1 Inhibitors on Murine Growing Follicles Open
Ovarian toxicity (ovotoxicity) is one of the major side effects of pharmaceutical compounds for women at or before reproductive age. The current gold standard for screening of compounds’ ovotoxicity largely relies on preclinical investigat…