Ying‐Zheng Zhao
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View article: Lipid-coated nanoparticles enhance the delivery of bacterial virulence factors as a potent toxoid vaccine platform against bacterial infections
Lipid-coated nanoparticles enhance the delivery of bacterial virulence factors as a potent toxoid vaccine platform against bacterial infections Open
Antivirulence vaccination represents a promising strategy for infection prevention, but achieving both safety and efficacy in toxoid vaccine preparation remains a challenge. Cell membrane-based nanotoxoids offer a safe delivery platform fo…
View article: Mediation factors of the association between coronary heart disease and physical activity among rural residents: a cross-sectional study
Mediation factors of the association between coronary heart disease and physical activity among rural residents: a cross-sectional study Open
View article: Optimizing in vitro maturation of oocytes with nitric oxide-loaded microbubbles
Optimizing in vitro maturation of oocytes with nitric oxide-loaded microbubbles Open
Introduction Nitric oxide (NO) plays a pivotal role in female reproductive processes, yet its clinical translation is limited by its short half-life and rapid systemic clearance. This study aimed to develop a stabilized NO delivery system …
View article: Highly effective treatment of bacterial infection-accompanied wounds by fat extract-embedded phototherapeutic hydrogel
Highly effective treatment of bacterial infection-accompanied wounds by fat extract-embedded phototherapeutic hydrogel Open
Phototherapy presents an effective approach for treating localized methicillin-resistant Staphylococcus aureus (MRSA) infections; however, the tradeoff between therapeutic efficacy and negative off-target effect persists. To address these …
View article: Curcumin-loaded bioadhesive silk fibroin microsphere improves islet transplantation by mitigating oxidative stress and inhibiting apoptosis
Curcumin-loaded bioadhesive silk fibroin microsphere improves islet transplantation by mitigating oxidative stress and inhibiting apoptosis Open
Islet transplantation, a form of cell therapy involving the injection of healthy islet cells into the recipient's body for curative treatment of T1DM, often fails due to oxidative stress and inflammatory damage experienced by the transplan…
View article: Two-in-one: multifunctional poloxamer hydrogel accelerates endometrial regeneration and fertility restoration through synergistic regulation of KGF-2 and NO
Two-in-one: multifunctional poloxamer hydrogel accelerates endometrial regeneration and fertility restoration through synergistic regulation of KGF-2 and NO Open
A healthy endometrium is crucial for embryo implantation and pregnancy maintenance. Thin endometrium, reduced glands and fibrosis resulting from infection or mechanical injury, are the primary causes of long-term infertility and poor pregn…
View article: Red Blood Cell Membrane‐Coated Nanoparticles Enable Incompatible Blood Transfusions (Adv. Sci. 29/2024)
Red Blood Cell Membrane‐Coated Nanoparticles Enable Incompatible Blood Transfusions (Adv. Sci. 29/2024) Open
Enable Incompatible Blood Transfusions Red blood cell membrane‐coated nanoparticles enable neutralizing the incompatible blood transfusion‐related IgM or IgG antibodies accordingly, which may be applied to resolve the incompatible blood tr…
View article: Red Blood Cell Membrane‐Coated Nanoparticles Enable Incompatible Blood Transfusions
Red Blood Cell Membrane‐Coated Nanoparticles Enable Incompatible Blood Transfusions Open
Blood transfusions save lives and improve health every day. Despite the matching of blood types being stricter than it ever has been, emergency transfusions among incompatible blood types are still inevitable in the clinic when there is a …
View article: Opsonization Inveigles Macrophages Engulfing Carrier‐Free Bilirubin/JPH203 Nanoparticles to Suppress Inflammation for Osteoarthritis Therapy
Opsonization Inveigles Macrophages Engulfing Carrier‐Free Bilirubin/JPH203 Nanoparticles to Suppress Inflammation for Osteoarthritis Therapy Open
Osteoarthritis (OA) is a chronic inflammatory disease characterized by cartilage destruction, synovitis, and osteophyte formation. Disease‐modifying treatments for OA are currently lacking. Because inflammation mediated by an imbalance of …
View article: Lipid Microbubbles Delivery Effectively Control Nitric Oxide Release and Promote Female Germ Cell Development
Lipid Microbubbles Delivery Effectively Control Nitric Oxide Release and Promote Female Germ Cell Development Open
View article: Polydopamine-cladded montmorillonite micro-sheets as therapeutic platform repair the gut mucosal barrier of murine colitis through inhibiting oxidative stress
Polydopamine-cladded montmorillonite micro-sheets as therapeutic platform repair the gut mucosal barrier of murine colitis through inhibiting oxidative stress Open
View article: Self-assembled FGF21 nanoparticles alleviate drug-induced acute liver injury
Self-assembled FGF21 nanoparticles alleviate drug-induced acute liver injury Open
Acetaminophen (N-acetyl-p-aminophenol, APAP) is a common antipyretic agent and analgesic. An overdose of APAP can result in acute liver injury (ALI). Oxidative stress and inflammation are central to liver injury. N-acetylcysteine (NAC), a …
View article: Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity
Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity Open
Acute liver injury is a common clinical disease, which easily leads to liver failure and endangers life, seriously threatening human health. Naringenin is a natural flavonoid that holds therapeutic potential against various liver injuries;…
View article: Ultrasound-induced destruction of heparin-loaded microbubbles attenuates L-arginine-induced acute pancreatitis
Ultrasound-induced destruction of heparin-loaded microbubbles attenuates L-arginine-induced acute pancreatitis Open
UHPMB exhibits a strong ability not only to selectively target pancreatic lesions and release heparin but also to provide efficient protection by inhibiting oxidative stress and inflammation.
View article: Bacterial Toxin‐Responsive Biomimetic Nanobubbles for Precision Photodynamic Therapy against Bacterial Infections (Adv. Healthcare Mater. 18/2022)
Bacterial Toxin‐Responsive Biomimetic Nanobubbles for Precision Photodynamic Therapy against Bacterial Infections (Adv. Healthcare Mater. 18/2022) Open
Bacterial Infections Secreted bacterial toxins such as pore-forming toxins (PFTs) are capable of governing the photodynamic therapy (PDT) effect of RBC(IR780)-PFC(O2) nanobubble for treatment of source bacterial infections. Leveraging this…
View article: Immune-Protective Formulations and Process Strategies for Improved Survival and Function of Transplanted Islets
Immune-Protective Formulations and Process Strategies for Improved Survival and Function of Transplanted Islets Open
Type 1 diabetes (T1D) is an autoimmune disease caused by the immune system attacking and destroying insulin-producing β cells in the pancreas. Islet transplantation is becoming one of the most promising therapies for T1D patients. However,…
View article: Noninvasive Chromosome Screening for Evaluating the Clinical Outcomes of Patients With Recurrent Pregnancy Loss or Repeated Implantation Failure
Noninvasive Chromosome Screening for Evaluating the Clinical Outcomes of Patients With Recurrent Pregnancy Loss or Repeated Implantation Failure Open
This retrospective cohort study explores whether noninvasive chromosome screening (NICS) for aneuploidy can improve the clinical outcomes of patients with recurrent pregnancy loss (RPL) or repeated implantation failure (RIF) in assisted re…
View article: Ultrasound-Induced Destruction of Nitric Oxide–Loaded Microbubbles in the Treatment of Thrombus and Ischemia–Reperfusion Injury
Ultrasound-Induced Destruction of Nitric Oxide–Loaded Microbubbles in the Treatment of Thrombus and Ischemia–Reperfusion Injury Open
Objectives: Early recanalization of large vessels in thromboembolism, such as myocardial infarction and ischemic stroke, is associated with improved clinical outcomes. Nitric oxide (NO), a biological gas signaling molecule, has been proven…
View article: Noninvasive Chromosome Screening for Evaluating the Clinical Outcomes of Patients With Recurrent Pregnancy Loss or Repeated Implantation Failure
Noninvasive Chromosome Screening for Evaluating the Clinical Outcomes of Patients With Recurrent Pregnancy Loss or Repeated Implantation Failure Open
Background: This retrospective cohort study determines whether noninvasive chromosome screening (NICS) for aneuploidy can improve the clinical outcomes of patients with recurrent pregnancy loss (RPL) or repeated implantation failure (RIF) …
View article: Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers
Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers Open
This study applied bilirubin to the treatment of GU and confirmed that CS-BR nanoparticles are effective at alleviating acute GU in an experimental model. The findings provide innovative ideas for prophylaxis against or treatment of GU.
View article: Ganoderma Lucidum Polysaccharides Enhance the Abscopal Effect of Photothermal Therapy in Hepatoma-Bearing Mice Through Immunomodulatory, Anti-Proliferative, Pro-Apoptotic and Anti-Angiogenic
Ganoderma Lucidum Polysaccharides Enhance the Abscopal Effect of Photothermal Therapy in Hepatoma-Bearing Mice Through Immunomodulatory, Anti-Proliferative, Pro-Apoptotic and Anti-Angiogenic Open
Hepatocellular carcinoma is a malignant tumor with high morbidity and mortality, a highly effective treatment with low side effects and tolerance is needed. Photothermal immunotherapy is a promising treatment combining photothermal therapy…
View article: Progress in the Application of Nano- and Micro-based Drug Delivery Systems in Pulmonary Drug Delivery
Progress in the Application of Nano- and Micro-based Drug Delivery Systems in Pulmonary Drug Delivery Open
Nanotechnology is associated with the development of particles in the nano-size range that can be used in a wide range of applications in the medical field. It has gained more importance in the pharmaceutical research field particularly in…
View article: Using Recombinant Human Collagen With Basic Fibroblast Growth Factor to Provide a Simulated Extracellular Matrix Microenvironment for the Revascularization and Attachment of Islets to the Transplantation Region
Using Recombinant Human Collagen With Basic Fibroblast Growth Factor to Provide a Simulated Extracellular Matrix Microenvironment for the Revascularization and Attachment of Islets to the Transplantation Region Open
Islet transplantation is considered a potential therapeutic option to reverse diabetes. The pancreatic basement membrane contains a variety of extracellular matrix (ECM) proteins. The abundant ECM is essential for the survival of transplan…
View article: Assessment of the Preventive Effect Against Diabetic Cardiomyopathy of FGF1-Loaded Nanoliposomes Combined With Microbubble Cavitation by Ultrasound
Assessment of the Preventive Effect Against Diabetic Cardiomyopathy of FGF1-Loaded Nanoliposomes Combined With Microbubble Cavitation by Ultrasound Open
Acidic fibroblast growth factor (FGF1) has great potential in preventing diabetic cardiomyopathy. This study aimed to evaluate the preventive effect of FGF1-loaded nanoliposomes (FGF1-nlip) combined with ultrasound-targeted microbubble des…
View article: Polylysine-Bilirubin Conjugates Maintain Functional Islets and Promote M2 Macrophage Polarization
Polylysine-Bilirubin Conjugates Maintain Functional Islets and Promote M2 Macrophage Polarization Open
View article: Biomimetic and osteogenic 3D silk fibroin composite scaffolds with nano MgO and mineralized hydroxyapatite for bone regeneration
Biomimetic and osteogenic 3D silk fibroin composite scaffolds with nano MgO and mineralized hydroxyapatite for bone regeneration Open
Artificial bioactive materials have received increasing attention worldwide in clinical orthopedics to repair bone defects that are caused by trauma, infections or tumors, especially dedicated to the multifunctional composite effect of mat…
View article: Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing
Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing Open
Rationale: Photothermal therapy employs the photoabsorbers to generate heat under the near-infrared (NIR) irradiation for thermal tumor ablation. However, NIR irradiation might damage the adjacent tissue due to the leakage of the ph…
View article: 骨再生のためのナノMgOおよびミネラル化ヒドロキシアパタイトを有する生体模倣および骨形成3D絹フィブロイン複合材料足場【JST・京大機械翻訳】
骨再生のためのナノMgOおよびミネラル化ヒドロキシアパタイトを有する生体模倣および骨形成3D絹フィブロイン複合材料足場【JST・京大機械翻訳】 Open
View article: <i>In vitro</i> and <i>in vivo</i> evaluation of didymin cyclodextrin inclusion complexes: characterization and chemosensitization activity
<i>In vitro</i> and <i>in vivo</i> evaluation of didymin cyclodextrin inclusion complexes: characterization and chemosensitization activity Open
Didymin is a dietary flavonoid that first found in citrus fruits, and possesses antioxidant properties. Our preliminary experiments first discovered that didymin was able to sensitize the resistant cancer cells against chemotherapeutics an…
View article: Exploiting crosslinked decellularized matrix to achieve uterus regeneration and construction
Exploiting crosslinked decellularized matrix to achieve uterus regeneration and construction Open
Decellularized extracellular matrix (dECM) has been considered as a promising scaffold in xenotransplantation, yet natural tissue dECM is often mechanically weak and rapidly degraded, compromising the outcomes. How to restore the mechanica…