Yingzhong Lin
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View article: Prevalence and prognostic impact of abnormal left ventricular ejection fraction in Hemodialysis patients with end-stage renal disease
Prevalence and prognostic impact of abnormal left ventricular ejection fraction in Hemodialysis patients with end-stage renal disease Open
View article: Integration of the hammerhead ribozyme into structured RNAs to measure ligand-binding events for riboswitch candidates and aptamers
Integration of the hammerhead ribozyme into structured RNAs to measure ligand-binding events for riboswitch candidates and aptamers Open
Some structured RNAs, such as riboswitches and aptamers, can bind to their cognate ligands and have been used in biosensors and gene expression control elements. However, current methods for detecting ligand binding to structured RNAs are …
View article: Integration of the hammerhead ribozyme into structured RNAs to measure ligand-binding events for riboswitch candidates and aptamers
Integration of the hammerhead ribozyme into structured RNAs to measure ligand-binding events for riboswitch candidates and aptamers Open
Some structured RNAs, such as riboswitches and aptamers, can bind their cognate ligands and have been used in biosensors and gene expression control elements. However, current methods for detecting ligand binding to structured RNAs are eit…
View article: Retraction notice to “Interleukin-22 deficiency alleviates doxorubicin-induced oxidative stress and cardiac injury via the p38 MAPK/macrophage/Fizz3 axis in mice” [Redox Biol. 36 (2020) 101636]
Retraction notice to “Interleukin-22 deficiency alleviates doxorubicin-induced oxidative stress and cardiac injury via the p38 MAPK/macrophage/Fizz3 axis in mice” [Redox Biol. 36 (2020) 101636] Open
View article: Identification of potential therapeutic targets for coronary artery disease based on protein array and Mendelian Randomization analysis
Identification of potential therapeutic targets for coronary artery disease based on protein array and Mendelian Randomization analysis Open
Background Currently, coronary artery disease (CAD) is a main cause of mortality worldwide. Exposing the unknown pathogenic mechanism and exploring potential therapeutic targets of CAD is a critical issue in current CAD research. We aimed …
View article: Left bundle branch pacing–optimized cardiac resynchronization therapy recovered heart failure in a patient with left ventricular noncompaction
Left bundle branch pacing–optimized cardiac resynchronization therapy recovered heart failure in a patient with left ventricular noncompaction Open
Left bundle branch pacing (LBBP) is a new method for treating patients with pacing indications. Studies have confirmed the feasibility and safety of LBBP, which can result in a narrow QRS duration and directly correct left bundle branch bl…
View article: Circulating IL‑37 levels are elevated in patients with hypertension
Circulating IL‑37 levels are elevated in patients with hypertension Open
Interleukin-37 (IL-37) has been reported to be closely linked to vascular diseases, including atherosclerosis and aortic calcification. The present study aimed to assess the expression levels of IL-37 in patients with hypertension. Blood s…
View article: Corrigendum to “Interleukin-22 deficiency alleviates doxorubicin-induced oxidative stress and cardiac injury via the p38 MAPK/macrophage/Fizz3 axis in mice” [Redox Biol. 2020 36 101636]
Corrigendum to “Interleukin-22 deficiency alleviates doxorubicin-induced oxidative stress and cardiac injury via the p38 MAPK/macrophage/Fizz3 axis in mice” [Redox Biol. 2020 36 101636] Open
View article: Effect of N-acetylcysteine on prevention of contrast-associated acute kidney injury in patients with STEMI undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis of randomised controlled trials
Effect of N-acetylcysteine on prevention of contrast-associated acute kidney injury in patients with STEMI undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis of randomised controlled trials Open
Objective Several studies evaluating the preventive effect of N-acetylcysteine (NAC) on contrast-associated acute kidney injury (CA-AKI) among patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous…
View article: ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis
ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis Open
Background: Acute aortic dissection (AAD) is associated with degeneration of the aortic media and accompanied by vascular extracellular matrix (ECM) remodeling. Recently, a disintegrin and metalloproteinase with thrombospondin type …
View article: IL-35 polymorphisms and cognitive decline did not show any association in patients with coronary heart disease over a 2-year period
IL-35 polymorphisms and cognitive decline did not show any association in patients with coronary heart disease over a 2-year period Open
Prior evidence suggested that inflammation and inflammatory cytokines polymorphisms might be essential in the development of coronary heart disease (CHD) and cognitive decline. The following study investigated the associations between inte…
View article: RETRACTED: Interleukin-22 deficiency alleviates doxorubicin-induced oxidative stress and cardiac injury via the p38 MAPK/macrophage/Fizz3 axis in mice
RETRACTED: Interleukin-22 deficiency alleviates doxorubicin-induced oxidative stress and cardiac injury via the p38 MAPK/macrophage/Fizz3 axis in mice Open
View article: Circulating Sestrin Levels Are Increased in Hypertension Patients
Circulating Sestrin Levels Are Increased in Hypertension Patients Open
Background . Sestrins (Sesns), a group of oxidative stress-related proteins, have been reported to be involved in various cardiovascular diseases, including aortic dissection and chronic heart failure. This study is aimed at investigating …
View article: Interleukin‑22 is elevated in the atrium and plasma of patients with atrial fibrillation and increases collagen synthesis in transforming growth factor‑β1‑treated cardiac fibroblasts via the JNK pathway
Interleukin‑22 is elevated in the atrium and plasma of patients with atrial fibrillation and increases collagen synthesis in transforming growth factor‑β1‑treated cardiac fibroblasts via the JNK pathway Open
Our previous studies demonstrated that interleukin (IL)-22 is involved in cardiovascular diseases such as hypertension, cardiac fibrosis and aortic dissection. The purpose of the present study was to detect IL-22 expression in patients wit…
View article: The Expression of IL-12 Family Members in Patients with Hypertension and Its Association with the Occurrence of Carotid Atherosclerosis
The Expression of IL-12 Family Members in Patients with Hypertension and Its Association with the Occurrence of Carotid Atherosclerosis Open
Background . The interleukin-12 (IL-12) family consists of four members, namely, IL-12, IL-23, IL-27, and IL-35. The aim of this study was to examine the expression of circulating IL-12, IL-23, IL-27, and IL-35 in hypertensive patients. Me…
View article: Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges
Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges Open
Cardiovascular diseases represent a complex group of clinical syndromes caused by a variety of interacting pathological factors. They include the most extensive disease population and rank first in all-cause mortality worldwide. Accumulati…
View article: Anti‐interleukin‐5‐neutralizing antibody attenuates caradiac injury and cadiac dysfunction by aggravating the inflammatory response in doxorubicin‐treated mice
Anti‐interleukin‐5‐neutralizing antibody attenuates caradiac injury and cadiac dysfunction by aggravating the inflammatory response in doxorubicin‐treated mice Open
Previous studies have demonstrated that interleukins (ILs) are closely associated with doxorubicin (DOX)‐induced cardiac injury. IL‐5 is an important member of the IL family, and this study was performed to investigate whether IL‐5 affects…
View article: IL‐22 produced by Th22 cells aggravates atherosclerosis development in ApoE<sup>−/−</sup> mice by enhancing DC‐induced Th17 cell proliferation
IL‐22 produced by Th22 cells aggravates atherosclerosis development in ApoE<sup>−/−</sup> mice by enhancing DC‐induced Th17 cell proliferation Open
Th22 cells are a novel subset of CD4 + T cells that primarily mediate biological effects through IL‐22, with both Th22 cells and IL‐22 being closely associated with multiple autoimmune and chronic inflammatory diseases. In this study, we i…
View article: Interleukin-12p35 deficiency enhances mitochondrial dysfunction and aggravates cardiac remodeling in aging mice
Interleukin-12p35 deficiency enhances mitochondrial dysfunction and aggravates cardiac remodeling in aging mice Open
Our previous studies have demonstrated that interleukin-12p35 knockout (IL-12p35 KO) regulates the progression of various cardiovascular diseases, such as acute cardiac injury and hypertension. The aims of this study were to investigate wh…
View article: Effects of circulating levels of Th17 cells on the outcomes of acute Stanford B aortic dissection patients after thoracic endovascular aortic repair
Effects of circulating levels of Th17 cells on the outcomes of acute Stanford B aortic dissection patients after thoracic endovascular aortic repair Open
T helper 17 (Th17) cells are related to the progression of aortic dissection. This study aimed to determine whether circulating Th17 levels are associated with the prognosis of acute Stanford type B aortic dissection (STBAD) after thoracic…
View article: Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice
Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice Open
Interleukin- (IL-) 35, a novel functional cytokine of regulatory T cells (Treg) comprised of the IL-12p35 subunit and the other subunit Epstein-Barr virus-induced gene 3 (EBI3), regulates the activity of CD4+ T cells and macrophages, there…
View article: Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure
Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure Open
Background . Interleukin-11 (IL-11) is an important inflammatory cytokine and has been demonstrated to participate in cardiovascular diseases. However, there have been no studies about the role of IL-11 in heart failure (HF). The present s…
View article: IL-22 Produced by Th22 Cells Aggravates Atherosclerosis Development in ApoE-/- Mice by Enhancing DC-Induced Th17 Cell Proliferation
IL-22 Produced by Th22 Cells Aggravates Atherosclerosis Development in ApoE-/- Mice by Enhancing DC-Induced Th17 Cell Proliferation Open
View article: Table of Contents
Table of Contents Open
View article: Circulating Th1, Th2, Th9, Th17, Th22, and Treg Levels in Aortic Dissection Patients
Circulating Th1, Th2, Th9, Th17, Th22, and Treg Levels in Aortic Dissection Patients Open
Background . Previous studies demonstrated that the subsets of CD4+ T helper (Th) cells are closely related to vascular diseases, including atherosclerosis and hypertension. This study is aimed at investigating the circulating Th1, Th2, Th…
View article: Interleukin-12p35 Knock Out Aggravates Doxorubicin-Induced Cardiac Injury and Dysfunction by Aggravating the Inflammatory Response, Oxidative Stress, Apoptosis and Autophagy in Mice
Interleukin-12p35 Knock Out Aggravates Doxorubicin-Induced Cardiac Injury and Dysfunction by Aggravating the Inflammatory Response, Oxidative Stress, Apoptosis and Autophagy in Mice Open
IL-12p35 KO aggravated DOX-induced cardiac injury by amplifying the levels of inflammation, oxidative stress, apoptosis and autophagy. (234 words).
View article: The clinical potential of IL-12/IL-35 in treating chemotherapy drug-induced cardiac injury – Authors' reply
The clinical potential of IL-12/IL-35 in treating chemotherapy drug-induced cardiac injury – Authors' reply Open
Doxorubicin (DOX) is an important chemotherapy drug that can be used in a variety of chemotherapy regimens for cancer patients, but it can lead to serious clinical complications, especially heart damage. In our recent paper, we found that …
View article: Erratum to “Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice”
Erratum to “Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice” Open
In the article "Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice" [1], there was an error in Figure 1(a), where the IL-22, β-MHC, and GAPDH bands were triplicated, due to a production …
View article: Epidemiology and Serum Metabolic Characteristics of Acute Myocardial Infarction Patients in Chest Pain Centers.
Epidemiology and Serum Metabolic Characteristics of Acute Myocardial Infarction Patients in Chest Pain Centers. Open
The epidemiology and serum metabolic phenotypes observed here demonstrated that integration of metabolomics with other techniques could be useful for better understanding the biochemistry of AMI and for potential AMI molecular diagnosis. W…
View article: IL-37 Inhibits the Maturation of Dendritic Cells Through the IL1R8-TLR4-NF-κB Pathway
IL-37 Inhibits the Maturation of Dendritic Cells Through the IL1R8-TLR4-NF-κB Pathway Open