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View article: Identification and verification of hub biomarkers and immune-related pathways participating in the trabecular meshwork after using corticosteroid
Identification and verification of hub biomarkers and immune-related pathways participating in the trabecular meshwork after using corticosteroid Open
Background Clinically, ocular application of corticosteroids is common.But it always result in higher Intraocular pressure (IOP).The potential molecular events are not clearly explained.It was reported that immune cells may cause higher IO…
View article: Diagnosis and treatment strategy of acupuncture-moxibustion for advanced-age infertility in vitro fertilization and embryo transfer based on the temporal rhythm theory of traditional Chinese medicine
Diagnosis and treatment strategy of acupuncture-moxibustion for advanced-age infertility in vitro fertilization and embryo transfer based on the temporal rhythm theory of traditional Chinese medicine Open
The ability of natural conception decreases with age, leading many advanced-age women with fertility desire begin to attempt in vitro fertilization and embryo transfer (IVF-ET) technique nowadays. Traditional Chinese medicine (TCM) believe…
View article: Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65
Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65 Open
Acute lung injury (ALI), which poses a significant public health threat, is commonly caused by sepsis. ALI is associated with permeability and glycolysis changes in pulmonary microvascular endothelial cells. Our study demonstrates that hep…
View article: CD8+ T cells are necessary for improved sepsis survival induced by CD28 agonism in immunologically experienced mice
CD8+ T cells are necessary for improved sepsis survival induced by CD28 agonism in immunologically experienced mice Open
Introduction A hallmark of T cell dysregulation during sepsis is the downregulation of costimulatory molecules. CD28 is one of T cell costimulatory molecules significantly altered on memory T cells during sepsis. We recently showed that tr…
View article: IMMUNOSUPPRESSION CORRELATES WITH THE DETERIORATION OF SEPSIS-INDUCED DISSEMINATED INTRAVASCULAR COAGULATION
IMMUNOSUPPRESSION CORRELATES WITH THE DETERIORATION OF SEPSIS-INDUCED DISSEMINATED INTRAVASCULAR COAGULATION Open
Background: The dysregulated host responses play a crucial role in the pathophysiology process of sepsis-induced disseminated intravascular coagulation (DIC). The study aimed to characterize the dynamic alternation of immune-related biomar…
View article: Transforming growth factor‐β receptor type 2 is required for heparin‐binding protein–induced acute lung injury and vascular leakage for transforming growth factor‐β/Smad/Rho signaling pathway activation
Transforming growth factor‐β receptor type 2 is required for heparin‐binding protein–induced acute lung injury and vascular leakage for transforming growth factor‐β/Smad/Rho signaling pathway activation Open
Heparin‐binding protein (HBP), as a granule protein secreted by polymorphonuclear neutrophils, participates in the pathophysiological process of sepsis. It has been reported that HBP is a biomarker of sepsis related to the severity of sept…
View article: TGF-β-R2 is required for HBP induced acute lung injury and vascular leakage for TGF-β/Smad/Rho signaling pathway activation
TGF-β-R2 is required for HBP induced acute lung injury and vascular leakage for TGF-β/Smad/Rho signaling pathway activation Open
Heparin-binding protein (HBP), as a granule protein secreted by polymorphonuclear neutrophils (PMNs) participates in the pathophysiological process of sepsis. It has been reported that HBP is a biomarker of sepsis, which is related to the …
View article: Elevated coinhibitory molecule TIGIT mediates T cell exhaustion in septic patients
Elevated coinhibitory molecule TIGIT mediates T cell exhaustion in septic patients Open
Background: Sepsis-induced T cell exhaustion that is characterized by upregulated coinhibitory molecules and decreased cytokines release plays a crucial role in the immunosuppression during sepsis. Although PD-1 has shown a promising targe…
View article: TIGIT regulates apoptosis of risky memory T cell subsets implicated in belatacept-resistant rejection
TIGIT regulates apoptosis of risky memory T cell subsets implicated in belatacept-resistant rejection Open
Belatacept confers increased patient and graft survival in renal transplant recipients relative to calcineurin inhibitors, but is associated with an increased rate of acute rejection. Recent immunophenotypic studies comparing pretransplant…
View article: Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts
Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts Open
Mounting evidence suggests that the balance of T cell costimulatory and coinhibitory signals contributes to mortality during sepsis. Here, we identified a critical role of the coinhibitory molecule T cell Ig and ITIM domain (TIGIT) in regu…
View article: Membrane Permeant Inhibitor of Myosin Light Chain Kinase Worsens Survival in Murine Polymicrobial Sepsis
Membrane Permeant Inhibitor of Myosin Light Chain Kinase Worsens Survival in Murine Polymicrobial Sepsis Open
Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the peri-junctional actin-myosin ring. Genetic deletion of myosin light chain kinase (MLCK) reverses i…
View article: Unfractionated Heparin Improves the Intestinal Microcirculation in a Canine Septic Shock Model
Unfractionated Heparin Improves the Intestinal Microcirculation in a Canine Septic Shock Model Open
Background . Alterations of microcirculation are associated with organ hypoperfusion and high mortality in septic shock. This study is aimed at investigating the effects of unfractionated heparin (UFH) on intestinal microcirculatory perfus…
View article: CD28 Agonism Improves Survival in Immunologically Experienced Septic Mice via IL-10 Released by Foxp3+ Regulatory T Cells
CD28 Agonism Improves Survival in Immunologically Experienced Septic Mice via IL-10 Released by Foxp3+ Regulatory T Cells Open
Immune dysregulation during sepsis is mediated by an imbalance of T cell costimulatory and coinhibitory signaling. CD28 is downregulated during sepsis and is significantly altered on memory versus naive T cells. Thus, to study the role of …
View article: Persistently higher serum sCD40L levels are associated with mortality in septic patients
Persistently higher serum sCD40L levels are associated with mortality in septic patients Open
Background Soluble CD40 ligand (sCD40L) exhibits proinflammatory and procoagulant effects. Recent data indicated that sCD40L plays a significant role in septic patients. The aim of the present study was to determine sCD40L changes in surgi…
View article: The gut microbiome alters immunophenotype and survival from sepsis
The gut microbiome alters immunophenotype and survival from sepsis Open
The microbiome is increasingly implicated in immune regulation and mortality from sepsis. Mice with identical genetic backgrounds but distinct microbiomes were obtained from different vendors and analyzed following cecal ligation and punct…
View article: Increased attrition of memory T cells during sepsis requires 2B4
Increased attrition of memory T cells during sepsis requires 2B4 Open
Recent seminal studies have revealed that laboratory mice differ from adult humans with regard to the frequency, number, and distribution of memory T cells. Because our data show that memory T cells are more susceptible to sepsis-induced d…