Yining Hao
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View article: Comprehensive investigation identifies CPSF3 as a novel prognostic and oncogenic biomarker in bladder cancer
Comprehensive investigation identifies CPSF3 as a novel prognostic and oncogenic biomarker in bladder cancer Open
Background Bladder cancer (BC) remains a prevalent malignancy worldwide, with rising incidence rates each year. Despite progress in therapeutic strategies, many patients suffer recurrence or progression, emphasizing the urgent need for nov…
View article: Role of OCT3 and DRP1 in the Transport of Paraquat in Astrocytes: A Mouse Study
Role of OCT3 and DRP1 in the Transport of Paraquat in Astrocytes: A Mouse Study Open
The present study mainly focused on the transport mechanisms of PQ between the dopaminergic neurons and astrocytes. Lower OCT3 levels were found in the older or chronically PQ-treated mice. Astrocytes with DRP1 inhibition (by viral tools o…
View article: Accelerating the Optimization of Vertical Flow Assay Performance Guided by a Rational Systematic Model-Based Approach
Accelerating the Optimization of Vertical Flow Assay Performance Guided by a Rational Systematic Model-Based Approach Open
View article: Developing a SARS-CoV-2 Antigen Test Using Engineered Affinity Proteins
Developing a SARS-CoV-2 Antigen Test Using Engineered Affinity Proteins Open
The ongoing COVID-19 pandemic has clearly established how vital rapid, widely accessible diagnostic tests are in controlling infectious diseases and how difficult and slow it is to scale existing technologies. Here, we demonstrate the use …
View article: Microglial Exosomes in Neurodegenerative Disease
Microglial Exosomes in Neurodegenerative Disease Open
Microglia play an important role in neurodegenerative disease [i.e., Parkinson’s disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS)]. These diseases share some similar pathological changes and several microglia…
View article: Developing a SARS-CoV-2 Antigen Test Using Engineered Affinity Proteins
Developing a SARS-CoV-2 Antigen Test Using Engineered Affinity Proteins Open
The ongoing COVID-19 pandemic has clearly established how vital rapid, widely accessible diagnostic tests are in controlling infectious diseases and how difficult and slow it is to scale existing technologies. Here, we demonstrate the use …
View article: Developing a SARS-CoV-2 Antigen Test Using Engineered Affinity Proteins
Developing a SARS-CoV-2 Antigen Test Using Engineered Affinity Proteins Open
The ongoing COVID-19 pandemic has clearly established how vital rapid, widely accessible diagnostic tests are in controlling infectious diseases and how difficult and slow it is to scale existing technologies. Here, we demonstrate the use …
View article: Dl-3-n-Butylphthalide Alleviates Demyelination and Improves Cognitive Function by Promoting Mitochondrial Dynamics in White Matter Lesions
Dl-3-n-Butylphthalide Alleviates Demyelination and Improves Cognitive Function by Promoting Mitochondrial Dynamics in White Matter Lesions Open
White matter lesions (WMLs) are a type of cerebrovascular disorder accompanied by demyelination and cognitive decline. Dl-3-n-butylphthalide (D1-NBP) is a neuroprotective drug used for the treatment of ischemic cerebrovascular diseases, al…
View article: Screening for H <sub>2</sub>O <sub>2</sub>-Mediated Cancer Therapeutics Using a Genetically Encoded Probe
Screening for H <sub>2</sub>O <sub>2</sub>-Mediated Cancer Therapeutics Using a Genetically Encoded Probe Open
View article: STAT1 is a modulator of the expression of frequently rearranged in advanced T‑cell lymphomas�1 expression in U251 cells
STAT1 is a modulator of the expression of frequently rearranged in advanced T‑cell lymphomas�1 expression in U251 cells Open
Aberrant expression of frequently rearranged in advanced T-cell lymphomas 1 (FRAT1) contributes to poor prognosis in a number of carcinomas. However, its role in glioma remains controversial. In the present study, gene expression profiling…
View article: Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer’s Disease: From Physiological Performance to Pathological Impairment
Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer’s Disease: From Physiological Performance to Pathological Impairment Open
Lysophospholipids (LPLs) are bioactive signaling lipids that are generated from phospholipase-mediated hydrolyzation of membrane phospholipids (PLs) and sphingolipids (SLs). Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are…
View article: FRAT1 Enhances the Proliferation and Tumorigenesis of CD133<sup>+</sup>Nestin<sup>+</sup> Glioma Stem Cells In Vitro and In Vivo
FRAT1 Enhances the Proliferation and Tumorigenesis of CD133<sup>+</sup>Nestin<sup>+</sup> Glioma Stem Cells In Vitro and In Vivo Open
Glioma stem cells (GSCs) are considered the source for development, recurrence, and poor prognosis of glioma, so treatment targeted GSCs is of great interest. The frequently rearranged in advanced T cell lymphomas-1 (FRAT1) gene is an impo…