Yinli Zhang
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View article: Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation
Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation Open
Polycystic ovary syndrome (PCOS) patients with hyperandrogenemia exhibit an increased risk of early pregnancy loss; however, the underlying mechanisms remain poorly understood. Ferroptosis, an iron‐dependent form of cell death driven by ph…
View article: Polyethylene and Polyvinyl Chloride Nanoplastics in Human Follicular Fluid and Seminal Plasma: Impact on Fertilization and Sperm Quality
Polyethylene and Polyvinyl Chloride Nanoplastics in Human Follicular Fluid and Seminal Plasma: Impact on Fertilization and Sperm Quality Open
Plastic pollution is a growing global issue, with nanoplastics (NPs) posing a greater threat than microplastics. Micro/nanoplastics have been detected in various human tissues and bodily fluids, but their impacts on human fertility remain …
View article: The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription
The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription Open
Metabolic processes and epigenetic reprogramming are intricately interconnected; however, their mechanistic interplay remains unclear. This study elucidates the role of ATP‐citrate lyase (ACLY), an essential enzyme in acetyl‐CoA production…
View article: Single-oocyte proteome-transcriptome co-profiling reveals a role of dysregulated lactate metabolism in oocyte aging
Single-oocyte proteome-transcriptome co-profiling reveals a role of dysregulated lactate metabolism in oocyte aging Open
The declined oocyte quality with age is a major risk factor for female infertility. Although transcriptomic changes have been examined in aged oocytes, the proteomic landscape, which reflects the primary functional executors of genes, and …
View article: Obox1 deficiency impairs fertility in female mice
Obox1 deficiency impairs fertility in female mice Open
OBOX1 is a maternal factor involved in oogenesis and follicle development, yet its specific role remains unclear. Here, we demonstrated that Obox1 knockout female mice exhibit subfertility, characterized by reduced litter size and i…
View article: Extramural venous invasion in gastric cancer: 9.4T magnetic resonance imaging assessment and circular RNA functional analysis
Extramural venous invasion in gastric cancer: 9.4T magnetic resonance imaging assessment and circular RNA functional analysis Open
BACKGROUND Extramural venous invasion (EMVI) is a critical prognostic factor in gastric cancer (GC); however, its detection and underlying molecular mechanisms remain underexplored. AIM To investigate the relationship between EMVI and expr…
View article: <scp>CT</scp>‐Imaging Manifestations and Diagnostic Insights in Pulmonary Intravascular Large B‐Cell Lymphoma: A Case Series and Literature Review
<span>CT</span>‐Imaging Manifestations and Diagnostic Insights in Pulmonary Intravascular Large B‐Cell Lymphoma: A Case Series and Literature Review Open
Background Intravascular large B‐cell lymphoma (IVLBCL) is a rare and aggressive subtype of non‐Hodgkin lymphoma. Although autopsy findings have revealed that IVLBCL often involves the lungs, its clinical features and imaging manifestation…
View article: ZAR1/2‐Regulated Epigenetic Modifications are Essential for Age‐Associated Oocyte Quality Maintenance and Zygotic Activation
ZAR1/2‐Regulated Epigenetic Modifications are Essential for Age‐Associated Oocyte Quality Maintenance and Zygotic Activation Open
The developmental competence and epigenetic progression of oocytes gradually become dysregulated with increasing maternal age. However, the mechanisms underlying age‐related epigenetic regulation in oocytes remain poorly understood. Zygote…
View article: PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation
PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation Open
Background Oocyte maturation defect (OMD) and early embryonic arrest result in female infertility. Previous studies have linked biallelic mutations in the PATL2 gene to OMD, yet the underlying mechanism remains largely unknown. Results Thi…
View article: The embryological characteristics and clinical outcomes of oocytes with indented zona pellucida
The embryological characteristics and clinical outcomes of oocytes with indented zona pellucida Open
Our study aimed to investigate the embryological characteristics and clinical outcomes of oocytes with indented zona pellucida (iZP). Cases with all oocytes containing iZP were compared with subjects whose oocytes presented morphologically…
View article: Identification of cancer-associated fibrolast subtypes and distinctive role of MFAP5 in CT-detected extramural venous invasion in gastric cancer
Identification of cancer-associated fibrolast subtypes and distinctive role of MFAP5 in CT-detected extramural venous invasion in gastric cancer Open
View article: Multi-omics PGT: re-evaluation of euploid blastocysts for implantation potential based on RNA sequencing
Multi-omics PGT: re-evaluation of euploid blastocysts for implantation potential based on RNA sequencing Open
STUDY QUESTION In addition to chromosomal euploidy, can the transcriptome of blastocysts be used as a novel predictor of embryo implantation potential? SUMMARY ANSWER This retrospective analysis showed that based on differentially expresse…
View article: CRL4DCAF13 E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes
CRL4DCAF13 E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes Open
View article: MFAP5+ Cancer-associated fibroblasts promote EMT in gastric cancer via lactylation modification leading to CT-detected extramural venous invasion
MFAP5+ Cancer-associated fibroblasts promote EMT in gastric cancer via lactylation modification leading to CT-detected extramural venous invasion Open
Background Computed tomography (CT)-detecte d extramural venous invasion (EMVI) has been identified as independent risk factors for distant metastasis in patients with advanced gastric cancer (GC). Cancer-associated fibroblasts (CAFs) are …
View article: The EZH2-H3K27me3 axis modulates aberrant transcription and apoptosis in cyclophosphamide-induced ovarian granulosa cell injury
The EZH2-H3K27me3 axis modulates aberrant transcription and apoptosis in cyclophosphamide-induced ovarian granulosa cell injury Open
Chemotherapy-induced ovarian damage and infertility are significant concerns for women of childbearing age with cancer; however, the underlying mechanisms are still not fully understood. Our study has revealed a close association between e…
View article: Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation
Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation Open
Background Epigenetic reprogramming is involved in luteinizing hormone (LH)-induced ovulation; however, the underlying mechanisms are largely unknown. Results We here observed a rapid histone deacetylation process between two waves of acti…
View article: Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients Open
Endometriosis is a common gynecological disorder that causes female infertility. Our recent research found that excessive oxidative stress in ovaries of endometriosis patients induced senescence of cumulus granulosa cells. Here, we analyze…
View article: HucMSC-EVs Facilitate In Vitro Development of Maternally Aged Preantral Follicles and Oocytes
HucMSC-EVs Facilitate In Vitro Development of Maternally Aged Preantral Follicles and Oocytes Open
View article: Genomic and Transcriptomic Characterization Revealed the High Sensitivity of Targeted Therapy and Immunotherapy in a Subset of Endometrial Stromal Sarcoma
Genomic and Transcriptomic Characterization Revealed the High Sensitivity of Targeted Therapy and Immunotherapy in a Subset of Endometrial Stromal Sarcoma Open
Purpose The unique chromosomal rearrangements of endometrial stromal sarcoma (ESS) make it possible to distinguish high-grade ESS (HGESS) and low-grade ESS (LGESS) from the molecular perspective. Analysis of ESS at the genomic and transcri…
View article: Computed tomography-detected extramural venous invasion-related gene signature: a potential negative biomarker of immune checkpoint inhibitor treatment in patients with gastric cancer
Computed tomography-detected extramural venous invasion-related gene signature: a potential negative biomarker of immune checkpoint inhibitor treatment in patients with gastric cancer Open
Background To investigate the association between computed tomography (CT)-detected extramural venous invasion (EMVI)-related genes and immunotherapy resistance and immune escape in patients with gastric cancer (GC). Methods Thirteen patie…
View article: Study on Construction and Performance of Immobilized Enzyme Reactors by Carboxyl-functionalized Fe<sub>3</sub>O<sub>4</sub>
Study on Construction and Performance of Immobilized Enzyme Reactors by Carboxyl-functionalized Fe<sub>3</sub>O<sub>4</sub> Open
The interface connection between carrier and enzyme can be improved by functionalizing the carrier of immobilized enzyme.This facilitates the formation of highly ordered two-dimensional arrangement of enzyme molecules on the surface of the…
View article: Decreased Expression of EZH2 in Granulosa Cells Contributes to Endometriosis-Associated Infertility by Targeting IL-1R2
Decreased Expression of EZH2 in Granulosa Cells Contributes to Endometriosis-Associated Infertility by Targeting IL-1R2 Open
The mechanism by which endometriosis, a common gynecological disease characterized by chronic pelvic pain and infertility, causes infertility remains elusive. Luteinized unruptured follicle syndrome, the most common type of ovulatory dysfu…
View article: Decreased histidine-rich glycoprotein and increased complement C4-B protein levels in follicular fluid predict the IVF outcomes of recurrent spontaneous abortion
Decreased histidine-rich glycoprotein and increased complement C4-B protein levels in follicular fluid predict the IVF outcomes of recurrent spontaneous abortion Open
View article: S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1
S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1 Open
Recurrent pregnancy loss (RPL) is a severe complication of pregnancy that is caused by genetic abnormalities, immune dysfunction, aberrant cell biology, and tissue structure destruction. Among which, placental dysfunction is crucial in the…
View article: Mutations in <i>OOEP</i> and <i>NLRP5</i> identified in infertile patients with early embryonic arrest
Mutations in <i>OOEP</i> and <i>NLRP5</i> identified in infertile patients with early embryonic arrest Open
The subcortical maternal complex (SCMC), composed of several maternal-effect genes, is vital for the development of oocytes and early embryos. Variants of SCMC-encoding genes (NLRP2, NLRP5, TLE6, PADI6, and KHDC3L, but not OOEP and ZBED3) …
View article: DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting <i>PERP</i> expression
DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting <i>PERP</i> expression Open
Evolutionarily conserved DDB1‐and CUL4‐associated factor 13 (DCAF13) is a recently discovered substrate receptor for the cullin RING‐finger ubiquitin ligase 4 (CRL4) E3 ubiquitin ligase that regulates cell cycle progression. DCAF13 is over…
View article: Biallelic mutations in <i>MOS</i> cause female infertility characterized by human early embryonic arrest and fragmentation
Biallelic mutations in <i>MOS</i> cause female infertility characterized by human early embryonic arrest and fragmentation Open
View article: Novel WEE2 compound heterozygous mutations identified in patients with fertilization failure or poor fertilization
Novel WEE2 compound heterozygous mutations identified in patients with fertilization failure or poor fertilization Open
View article: Unresponsive thin endometrium caused by Asherman syndrome treated with umbilical cord mesenchymal stem cells on collagen scaffolds: a pilot study
Unresponsive thin endometrium caused by Asherman syndrome treated with umbilical cord mesenchymal stem cells on collagen scaffolds: a pilot study Open
Background Unresponsive thin endometrium caused by Asherman syndrome (AS) is the major cause of uterine infertility. However, current therapies are ineffective. This study is to evaluate the effect of transplantation with collagen scaffold…
View article: Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transcription During Oocyte Growth
Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transcription During Oocyte Growth Open
Cyclophosphamide (CTX) is widely used in various cancer therapies and in immunosuppression, and patients can still have babies after CTX chemotherapy. CTX directly causes primordial follicle loss with overactivation and DNA damage-induced …