Explanipedia

Dynamic clinical trial success rates for drugs in the 21st century Open

Ying Zhou, Yintao Zhang, Hangwei Xu, Zhen Chen, Shijie Huang , et al. · 2025

In clinical drug development, two fundamental questions must be addressed: what is the success rate of drugs in clinical trial; how does such rate change over time. Here, a dynamic strategy for calculating clinical trial success rate (Clin…

RadioPharm: the database of radiopharmaceuticals Open

Jie Liu, Xingang Liu, Y. F. Zhang, Xuedong Li, Yujie Sun , et al. · 2025

Radiopharmaceuticals (RPs) have emerged as a promising group of therapeutic/diagnostic agents with tremendous pharmaceutical advantages and profitable market value. With the rapid advances in this direction, there is an increasing demand f…

TPDdb: the comprehensive database of targeted protein degrader Open

Xinran Qin, Yin-Peng Zhang, Yajunzi Wang, Yintao Zhang, Jiang Jing , et al. · 2025

Targeted protein degraders (TPDs) have emerged in the past decade as a new drug modality of transformative paradigm, offering a powerful strategy to catalytically remove disease-relevant proteins, especially those long considered as “undru…

M6AREG 2.0: the landscape of m6A-centered crosstalk with diverse epigenetic regulation Open

Mengjie Yang, Ying Zhou, Liting Yang, Xinyuan Yu, Yichao Ge , et al. · 2025

m6A-centered crosstalk with epigenetic regulation (m6A-CT) is essential for understanding disease development and drug response. Based on different layers of epigenetic regulation, m6A-CT can be classified into four categories: m6A-centere…

Does transient serum phosphate or serum phosphate status cause chronic kidney disease-associated pruritus in peritoneal dialysis patients? A cross-sectional and group-based trajectory modeling study Open

Zijun Zhou, Hanqing Zhang, Yunze Xing, Tao Zhang, Yaxuan Fang , et al. · 2025

Our study confirmed the relationship between serum phosphate and CKD-aP within the past 3 months, to some extent explaining the controversy generated by previous studies. These results may help clinicians better understand the relationship…

Research On Challenges And Development Under The Construction Of Metaverse Ecology Of Vocational Educati Open

Haitao Chen, Yintao Zhang, Huanhuan Liang · 2025

The technical concept of the Metaverse has attracted much attention since its birth. In recent years, with the development of science and technology and social changes, the concept of the Metaverse has gradually entered real life. This art…

druglikeFilter 1.0: An AI powered filter for collectively measuring the drug-likeness of compounds Open

Minjie Mou, Yintao Zhang, Yuntao Qian, Zhimeng Zhou, Yang Liao , et al. · 2025

OncoSexome: the landscape of sex-based differences in oncologic diseases Open

Xinyi Shen, Yintao Zhang, Jiamin Li, Ying Zhou, Samuel D. Butensky , et al. · 2024

The NIH policy on sex as biological variable (SABV) emphasized the importance of sex-based differences in precision oncology. Over 50% of clinically actionable oncology genes are sex-biased, indicating differences in drug efficacy. Researc…

AI comes to the Nobel Prize and drug discovery Open

Ying Zhou, Yintao Zhang, Zhichao Zhang, Zhimeng Zhou, Feng Zhu · 2024

OrgXenomics: an integrated proteomic knowledge base for patient-derived organoid and xenograft Open

Yintao Zhang, Xichen Lian, Hangwei Xu, Sisi Zhu, Hao Zhang , et al. · 2024

Patient-derived models (PDMs, particularly organoids and xenografts) are irreplaceable tools for precision medicine, from target development to lead identification, then to preclinical evaluation, and finally to clinical decision-making. S…

SubCELL: the landscape of subcellular compartment-specific molecular interactions Open

Yintao Zhang, Wanghao Jiang, Li Teng, Hangwei Xu, Yimiao Zhu , et al. · 2024

The subcellular compartment-specific molecular interactions (SCSIs) are the building blocks for most molecular functions, biological processes and disease pathogeneses. Extensive experiments have therefore been conducted to accumulate the …

MolBiC: the cell-based landscape illustrating molecular bioactivities Open

Yichao Ge, Mengjie Yang, Xinyuan Yu, Ying Zhou, Yintao Zhang , et al. · 2024

The measurement of cell-based molecular bioactivity (CMB) is critical for almost every step of drug development. With the booming application of AI in biomedicine, it is essential to have the CMB data to promote the learning of cell-based …

PROSCA: an online platform for humanized scaffold mining facilitating rational protein engineering Open

Xiaona Wang, Yintao Zhang, Zengpeng Li, Zixin Duan, Menghan Guo , et al. · 2024

Protein scaffolds with small size, high stability and low immunogenicity show important applications in the field of protein engineering and design. However, no relevant computational platform has been reported yet to mining such scaffolds…

FERREG: ferroptosis-based regulation of disease occurrence, progression and therapeutic response Open

Yuan Zhou, Zhen Chen, Mengjie Yang, Fengyun Chen, Jiayi Yin , et al. · 2024

Ferroptosis is a non-apoptotic, iron-dependent regulatory form of cell death characterized by the accumulation of intracellular reactive oxygen species. In recent years, a large and growing body of literature has investigated ferroptosis. …

Dynamic Clinical Success Rates for Drugs in the 21st Century Open

Feng Zhu, Ying Zhou, Yintao Zhang, Zhen Chen, Shijie Huang , et al. · 2024

In clinical drug development, two fundamental questions remain unanswered: what is the success rate of drugs in clinical trial? how does such rate change over time? Herein, a systematic analysis on the dynamic change of drugs’ clinical suc…

Dynamic Clinical Success Rates for Drugs in the 21st Century Open

Ying Zhou, Yintao Zhang, Zhen Chen, Shijie Huang, Yinghong Li , et al. · 2024

In clinical drug development, two fundamental questions remain unanswered: what is the success rate of drugs in clinical trial? how does such rate change over time? Herein, a systematic analysis on the dynamic change of drugs’ clinical suc…

TheMarker: a comprehensive database of therapeutic biomarkers Open

Yintao Zhang, Ying Zhou, Yuan Zhou, Xinyuan Yu, Xinyi Shen , et al. · 2023

Distinct from the traditional diagnostic/prognostic biomarker (adopted as the indicator of disease state/process), the therapeutic biomarker (ThMAR) has emerged to be very crucial in the clinical development and clinical practice of all th…

SingPro: a knowledge base providing single-cell proteomic data Open

Xichen Lian, Yintao Zhang, Ying Zhou, Xiuna Sun, Shijie Huang , et al. · 2023

Single-cell proteomics (SCP) has emerged as a powerful tool for detecting cellular heterogeneity, offering unprecedented insights into biological mechanisms that are masked in bulk cell populations. With the rapid advancements in AI-based …

TTD: Therapeutic Target Database describing target druggability information Open

Ying Zhou, Yintao Zhang, Donghai Zhao, Xinyuan Yu, Xinyi Shen , et al. · 2023

Target discovery is one of the essential steps in modern drug development, and the identification of promising targets is fundamental for developing first-in-class drug. A variety of methods have emerged for target assessment based on drug…

RNAenrich: a web server for non-coding RNA enrichment Open

Song Zhang, Kuerbannisha Amahong, Yintao Zhang, Xiao Hu, Shijie Huang , et al. · 2023

Motivation With the rapid advances of RNA sequencing and microarray technologies in non-coding RNA (ncRNA) research, functional tools that perform enrichment analysis for ncRNAs are needed. On the one hand, because of the rapidly growing i…

DRESIS: the first comprehensive landscape of drug resistance information Open

Xiuna Sun, Yintao Zhang, Hanyang Li, Ying Zhou, Shuiyang Shi , et al. · 2022

Widespread drug resistance has become the key issue in global healthcare. Extensive efforts have been made to reveal not only diverse diseases experiencing drug resistance, but also the six distinct types of molecular mechanisms underlying…

M6AREG: m6A-centered regulation of disease development and drug response Open

Shuiping Liu, Lu Chen, Yintao Zhang, Ying Zhou, Ying He , et al. · 2022

As the most prevalent internal modification in eukaryotic RNAs, N6-methyladenosine (m6A) has been discovered to play an essential role in cellular proliferation, metabolic homeostasis, embryonic development, etc. With the rapid accumulatio…

Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents Open

Ying Zhou, Yintao Zhang, Xichen Lian, Fengcheng Li, Chaoxin Wang , et al. · 2021

Drug discovery relies on the knowledge of not only drugs and targets, but also the comparative agents and targets. These include poor binders and non-binders for developing discovery tools, prodrugs for improved therapeutics, co-targets of…

NPCDR: natural product-based drug combination and its disease-specific molecular regulation Open

Xueni Sun, Yintao Zhang, Ying Zhou, Xichen Lian, Lili Yan , et al. · 2021

Natural product (NP) has a long history in promoting modern drug discovery, which has derived or inspired a large number of currently prescribed drugs. Recently, the NPs have emerged as the ideal candidates to combine with other therapeuti…

Dengue Fever Outbreaks Caused by Varied Serotype Dengue Virus — Guangdong Province, China, 2019 Open

De Wu, Xin Zhang, Aiping Deng, Huan Zhang, Yintao Zhang , et al. · 2020

The introduction of DENV from DF endemic areas increased pressure on the prevention and control of DF in Guangdong. Early detection of suspected cases and typing and genotyping of circulating viruses should be prioritized and enhanced to p…

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