Yujun Jiang
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View article: The impact of body mass index on the efficacy of CDK4/6 inhibitors in patients with metastatic breast cancer
The impact of body mass index on the efficacy of CDK4/6 inhibitors in patients with metastatic breast cancer Open
In HR positive advanced breast cancer patients treated with first-line CDK4/6 inhibitors, lower BMI is associated with poorer prognosis.
View article: Effect of heat-resistant protease of Pseudomonas fluorescens on the quality of liquid milk: A physicochemical and proteomic perspective
Effect of heat-resistant protease of Pseudomonas fluorescens on the quality of liquid milk: A physicochemical and proteomic perspective Open
Pseudomonas fluorescens is one of the common psychrophilic bacteria in liquid milk. The thermostable enzymes produced by P. fluorescens are an important cause of changes in quality and flavor of liquid milk during storage. In this study, 3…
View article: Lacticaseibacillus paracasei JY062 Postbiotic Alleviated 3% DSS-Induced Colitis in Mice via Integrated Antioxidant, Barrier Repair, Immunomodulatory and Microbiota Modulation
Lacticaseibacillus paracasei JY062 Postbiotic Alleviated 3% DSS-Induced Colitis in Mice via Integrated Antioxidant, Barrier Repair, Immunomodulatory and Microbiota Modulation Open
Ulcerative colitis (UC) with multifactorial etiology remains clinically challenging. While current pharmacotherapies alleviate symptoms, their long-term application is constrained by significant side effects. Lacticaseibacillus paracasei J…
View article: Application of modified laparoscopic stomach-partitioning gastrojejunostomy for stage IV gastric cancer with gastric outlet obstruction
Application of modified laparoscopic stomach-partitioning gastrojejunostomy for stage IV gastric cancer with gastric outlet obstruction Open
Gastric outlet obstruction (GOO) is a common complication in stage IV gastric cancer, often causing malnutrition and delaying conversion therapy. Compared with conventional gastrojejunostomy (CGJ), stomach-partitioning gastrojejunostomy (S…
View article: The flavor quality differences of infant formula: The synergistic effects of nutritional components and chemical reactions
The flavor quality differences of infant formula: The synergistic effects of nutritional components and chemical reactions Open
This study elucidates the interplay between nutritional composition and chemical reactions governing off-flavor formation in infant formula powder (IF). Sample Z, which is an IF of a raw bovine milk base with vegetable lipids (1,3-diolein-…
View article: The Nutritional Composition and Multi‐Omics Analysis of Raw Milk From Normande and Holstein Cows
The Nutritional Composition and Multi‐Omics Analysis of Raw Milk From Normande and Holstein Cows Open
Milk from Normande cows exhibits characteristically high protein and fat content, whereas Holstein milk is notable for its superior yield. However, compositional differences between these breeds remain inadequately explored. Thus, we emplo…
View article: Real-world efficacy and safety of inetetamab-based therapy in HER2-positive metastatic breast cancer patients with prior exposure to trastuzumab
Real-world efficacy and safety of inetetamab-based therapy in HER2-positive metastatic breast cancer patients with prior exposure to trastuzumab Open
Background Until now there has been no comprehensive data from extensive samples to evaluate the therapeutic potential of inetetamab in metastatic breast cancer (MBC) patients who had a history of trastuzumab treatment. Some previous studi…
View article: Dietary energy enhances conception in Holstein heifers via interactions with rumen microbiota
Dietary energy enhances conception in Holstein heifers via interactions with rumen microbiota Open
Objective: This study aimed to elucidate how dietary energy levels regulate the hypothalamic-pituitary-gonadal axis in Holstein heifers during initial breeding, with a focus on rumen microbiota-host interactions.Methods: Forty-four puberta…
View article: Emerging biosensors integrated with microfluidic devices: a promising analytical tool for on-site detection of mycotoxins
Emerging biosensors integrated with microfluidic devices: a promising analytical tool for on-site detection of mycotoxins Open
Rapid and sensitive detection of mycotoxins in foodstuffs is of great significance. As a powerful detection tool, biosensing technologies and microfluidic devices have shown a great potential in rapid and on-site detection of mycotoxins. T…
View article: The Effects of Ultrasonic Pretreatment and Enzymatic Modification on the Structure, Functional Properties, and In Vitro Digestion of Whey Protein Isolate
The Effects of Ultrasonic Pretreatment and Enzymatic Modification on the Structure, Functional Properties, and In Vitro Digestion of Whey Protein Isolate Open
In this study, the structure and functional and in vitro digestion properties of whey protein isolate (WPI) modified by ultrasonic pretreatment combined with a double oxidase system containing horseradish peroxidase (HRP), glucose oxidase …
View article: Pyrotinib and Nab‐Paclitaxel in <scp>HER2</scp>‐Positive Breast Cancer (<scp>PANHER</scp> Trial): A Prospective, Single‐Arm, Phase <scp>II</scp> Trial
Pyrotinib and Nab‐Paclitaxel in <span>HER2</span>‐Positive Breast Cancer (<span>PANHER</span> Trial): A Prospective, Single‐Arm, Phase <span>II</span> Trial Open
Trastuzumab and pertuzumab combined with chemotherapy represent the standard therapy for first‐line treatment of HER2‐positive metastatic breast cancer (BC). Due to challenges related to availability and cost in China, it is necessary to e…
View article: Significance of Whole-Genome Sequencing for the Traceability of Foodborne Pathogens: During the Processing of Meat and Dairy Products
Significance of Whole-Genome Sequencing for the Traceability of Foodborne Pathogens: During the Processing of Meat and Dairy Products Open
The complexity of tracing foodborne pathogens in the food chain has increased significantly due to the long and complicated chain, the involvement of numerous links, and the presence of various types of pathogens at different stages and en…
View article: Effects of Lactobacillus paracei JY062 Postbiotic on Intestinal Barrier, Immunity, and Gut Microbiota
Effects of Lactobacillus paracei JY062 Postbiotic on Intestinal Barrier, Immunity, and Gut Microbiota Open
Background/Objectives: Research on postbiotics derived from probiotic fermented milk bases require further expansion, and the mechanisms through which they exert their effects have yet to be fully elucidated. This study utilized in vitro c…
View article: Effects of selenylation on Chinese yam polysaccharides: Structure, antioxidant, and digestive properties
Effects of selenylation on Chinese yam polysaccharides: Structure, antioxidant, and digestive properties Open
Natural polysaccharides have unsatisfactory properties in production and processing due to structural limitations. Recent studies have shown that chemical modifications can improve the physicochemical and functional properties of plant pol…
View article: Structural characterization of the exopolysaccharide produced by Bacillus amyloliquefaciens JM033 and evaluation of its ability to regulate immunity and intestinal flora
Structural characterization of the exopolysaccharide produced by Bacillus amyloliquefaciens JM033 and evaluation of its ability to regulate immunity and intestinal flora Open
The probiotic strain Bacillus amyloliquefaciens JM033 (B. amyloliquefaciens JM033), isolated from the traditional Chinese fermented food Sufu (also known as Fu-ru or fermented bean curd), is distinguished by its high production of exopolys…
View article: Metabolic and Transcriptomic-Based Characterization of Streptococcus salivarius ssp. thermophilus Snew Fermentation in Milk
Metabolic and Transcriptomic-Based Characterization of Streptococcus salivarius ssp. thermophilus Snew Fermentation in Milk Open
Fermented milk has a long history. It is fermented by lactic acid bacteria and is rich in protein, minerals, vitamins, and other nutrients. As people’s pursuit of quality of life improves, consumers are paying increasing attention to ferme…
View article: Differences in storage stability of cow's milk-based and goat's milk-based infant formulas
Differences in storage stability of cow's milk-based and goat's milk-based infant formulas Open
Goat's milk-based infant formula (YIF) has the advantages of high nutritional value and hypoallergenicity, and fewer studies have been conducted on YIF. Therefore, this study examined the changes in physicochemical and functional propertie…
View article: Influence of Heat- and Cold-Stressed Raw Milk on the Stability of UHT Milk
Influence of Heat- and Cold-Stressed Raw Milk on the Stability of UHT Milk Open
This study investigated the variations and alterations in the concentrations of plasmin system components in raw and UHT (ultra-high-temperature) milk under cold stress (WCT ≤ −25 °C), heat stress (THI ≥ 80), and normal (THI < 70 and WCT ≥…