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View article: Personalized and Tumor Informed Circulating Tumor DNA Assay for Molecular Residual Disease Monitoring of Solid Malignancies
Personalized and Tumor Informed Circulating Tumor DNA Assay for Molecular Residual Disease Monitoring of Solid Malignancies Open
Emerging evidence suggests that minimal residual disease (MRD) monitoring in solid tumors has implications for prognosis, treatment response, and therapeutic intervention. However, detecting MRD requires highly sensitive and specific circu…
View article: Quorum-sensing regulator LsrR modulates avian pathogenic <i>Escherichia coli</i> pathogenicity through direct regulation of <i>cysN</i>
Quorum-sensing regulator LsrR modulates avian pathogenic <i>Escherichia coli</i> pathogenicity through direct regulation of <i>cysN</i> Open
Avian Pathogenic Escherichia coli (APEC) is a major cause of economic loss in poultry, exacerbated by the rising prevalence of antibiotic resistance. While sulfur metabolism is essential for bacterial growth, its specific role and regulati…
View article: Effects of Imposed Defocus on Inhibitor of DNA-Binding Gene Expression in Chick Posterior Ocular Tissues
Effects of Imposed Defocus on Inhibitor of DNA-Binding Gene Expression in Chick Posterior Ocular Tissues Open
Inhibitors of DNA-binding genes (Ids) are key downstream targets of bone morphogenetic proteins (BMPs), gene expression of which is differentially regulated in the chick retinal pigment epithelium (RPE) during altered eye growth. The curre…
View article: Customizing interfacial hydroxyl coverage on MnCoOxHy with electric field confinement for selective 5-hydroxymethylfurfural electrooxidation in dilute electrolyte
Customizing interfacial hydroxyl coverage on MnCoOxHy with electric field confinement for selective 5-hydroxymethylfurfural electrooxidation in dilute electrolyte Open
View article: Lower body mass index potentiates the association between late-night dinner and the prevalence of proteinuria
Lower body mass index potentiates the association between late-night dinner and the prevalence of proteinuria Open
Background The presence of proteinuria or microalbuminuria is significantly associated with an increased risk of cardiovascular disease and all-cause mortality. Several studies reported the association between unhealthy eating patterns and…
View article: Transcending Silos: An Interdisciplinary Project-Based Learning Approach to Science Education
Transcending Silos: An Interdisciplinary Project-Based Learning Approach to Science Education Open
In an era defined by complex, interconnected challenges like climate change, pandemics, and resource depletion, the traditional siloed approach to science education is proving increasingly insufficient. Interdisciplinary project-based lear…
View article: Cytoplasmic HMGB1 promotes and interacts with BECN1 through ZNF460 to induce autophagy and accelerate radioresistance in colorectal cancer cells
Cytoplasmic HMGB1 promotes and interacts with BECN1 through ZNF460 to induce autophagy and accelerate radioresistance in colorectal cancer cells Open
Radioresistance results in relapse and treatment failure in locally advanced colorectal cancer (CRC) patients. HMGB1 is reportedly associated with radioresistance in esophageal squamous cell carcinoma and breast cancer. However, its role i…
View article: Recent advances of DNA methylation in osteonecrosis of the femoral head
Recent advances of DNA methylation in osteonecrosis of the femoral head Open
DNA methylation, maintenance, and demethylation are essential for maintaining normal physiological functions. Recent studies have revealed that DNA methylation plays a crucial role in the progression of osteonecrosis of the femoral head. D…
View article: How Resilience Mitigates Depression After IVF-ET Failure: A Moderated Mediation Model of Hope, Social Relations, and Income in China
How Resilience Mitigates Depression After IVF-ET Failure: A Moderated Mediation Model of Hope, Social Relations, and Income in China Open
Resilience plays a critical role in mitigating depressive symptoms among women failed IVF-ET cycles in China, exerting both direct and indirect effects through the pathways of hope and social relations. Socioeconomic factors also serve as …
View article: Beyond the Trinket: Narrative and Authenticity in Contemporary Ceramic Cultural Product Design
Beyond the Trinket: Narrative and Authenticity in Contemporary Ceramic Cultural Product Design Open
Driven by both the upgrading of cultural consumption and the revival of traditional craftsmanship, contemporary ceramic products are undergoing a transformation from mere “trinkets” to cultural carriers, requiring designs that balance cult…
View article: Evaluating the diagnostic efficacy of metagenomic next-generation sequencing in bronchoalveolar lavage fluid for pulmonary cryptococcosis with different clinical and imaging characteristics
Evaluating the diagnostic efficacy of metagenomic next-generation sequencing in bronchoalveolar lavage fluid for pulmonary cryptococcosis with different clinical and imaging characteristics Open
View article: In Situ Construction of Cu <sup>+</sup> ‐O <sub>v</sub> ‐Ce <sup>3+</sup> Sites on CeO <sub>2</sub> for Efficient NH <sub>3</sub> Oxidation
In Situ Construction of Cu <sup>+</sup> ‐O <sub>v</sub> ‐Ce <sup>3+</sup> Sites on CeO <sub>2</sub> for Efficient NH <sub>3</sub> Oxidation Open
Ammonia (NH 3 ) emissions adversely affect both the environment and human health. The selective catalytic oxidation of NH 3 (NH 3 ‐SCO) holds great promise for NH 3 abatement; however, there remains a lack of cost‐effective NH 3 ‐SCO catal…
View article: Exploring Bidirectional Causal Relationships between Antibody Responses to Infectious Agents and Breast Cancer through Mendelian Randomization and Meta-Analyses
Exploring Bidirectional Causal Relationships between Antibody Responses to Infectious Agents and Breast Cancer through Mendelian Randomization and Meta-Analyses Open
View article: Unraveling the Redox Mechanisms Underlying FLASH Radiotherapy: Critical Dose Thresholds and NRF2-Driven Tissue Sparing
Unraveling the Redox Mechanisms Underlying FLASH Radiotherapy: Critical Dose Thresholds and NRF2-Driven Tissue Sparing Open
FLASH radiotherapy (FLASH-RT) achieves tumor control comparable to conventional dose-rate irradiation (CONV-RT) while significantly reducing radiation damage to normal tissues. However, the physical conditions triggering the FLASH sparing …
View article: Lactate modulates the function of myeloid-derived suppressor cells via Ten-Eleven-Translocation-2-mediated demethylation of glucocorticoid-inducible kinase 1 in lung cancer model
Lactate modulates the function of myeloid-derived suppressor cells via Ten-Eleven-Translocation-2-mediated demethylation of glucocorticoid-inducible kinase 1 in lung cancer model Open
Background Lactate has been shown to play an important immunosuppressive role in the tumor microenvironment (TME) and promote tumor progression through a variety of different mechanisms of action. Myeloid-derived suppressor cells (MDSCs) a…
View article: The Role of MHC-II Diversity over Enclosure Design in Gut Microbiota Structuring of Captive Bengal Slow Lorises
The Role of MHC-II Diversity over Enclosure Design in Gut Microbiota Structuring of Captive Bengal Slow Lorises Open
The endangered Bengal slow loris (Nycticebus bengalensis) relies heavily on captive/rescue populations for conservation. This study investigated the critical link between Major Histocompatibility Complex (MHC) class II DRB1 exon 2 (DRB1e2)…
View article: Successful Treatment of Diffuse Large B-Cell Lymphoma and Antisynthetase Syndrome with Bispecific Antibody Glofitamab
Successful Treatment of Diffuse Large B-Cell Lymphoma and Antisynthetase Syndrome with Bispecific Antibody Glofitamab Open
Glofitamab, a CD20×CD3 T-cell-engaging bispecific monoclonal antibody, has emerged as a promising therapeutic agent for relapsed/refractory B-cell non-Hodgkin lymphoma. The advent of chimeric antigen receptor T-cell therapy and T-cell-enga…
View article: A foundational triage system for improving accuracy in moderate acuity level emergency classifications
A foundational triage system for improving accuracy in moderate acuity level emergency classifications Open
KUTS provides a foundational framework and paradigm for the study of emergency triage, and facilitates the development of more efficient triage systems.
View article: Earliest Cambrian Carbonate Platform Evolution, Environmental Change, and Organic Matter Accumulation in the Northwestern Yangtze Block, South China
Earliest Cambrian Carbonate Platform Evolution, Environmental Change, and Organic Matter Accumulation in the Northwestern Yangtze Block, South China Open
The earliest Cambrian (ca., 538.8–524.8 Ma) was an important period in geological history witnessing significant environmental change, during which organic-rich facies were developed in the Yangtze Platform, South China. However, the conte…
View article: PD-L1 expression in microvascular endothelial cells predicts the efficacy and side effects of anlotinib
PD-L1 expression in microvascular endothelial cells predicts the efficacy and side effects of anlotinib Open
Background Immunotherapy plays a crucial role in the treatment of tumors. However, few studies have investigated the relationship between the expression of Programmed Cell Death Ligand 1 (PD-L1, CD274) in microvascular endothelial cells (M…
View article: Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy
Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy Open
Chemoresistance and metastasis are key obstacles to successful ovarian cancer (OC) treatment. Here, α‐Hederin, a pentacyclic triterpenoid saponin, is identified as a potent and selective dual inhibitor of JAK1/JAK2 with promising therapeut…
View article: The impact of local government debt governance on carbon emissions: evidence from Chinese cities
The impact of local government debt governance on carbon emissions: evidence from Chinese cities Open
Introduction Integrating debt risk mitigation and carbon reduction is essential for superior economic development. Methods The study has selected panel data from 274 Chinese cities from 2009 to 2020 as the research sample. The 2015 Local G…
View article: Identification and functional verification of active volatiles recognition by the olfactory co-receptor Orco in <i>Chrysopa pallens</i> (Rambur) (Neuroptera: Chrysopidae)
Identification and functional verification of active volatiles recognition by the olfactory co-receptor Orco in <i>Chrysopa pallens</i> (Rambur) (Neuroptera: Chrysopidae) Open
Insect olfactory receptor co-receptor (Orco) plays a key role in olfactory organ formation and odor recognition during insect growth and development. In predatory insects, the olfactory system is important for the orientation, identificati…
View article: Long-term survival in advanced pulmonary large-cell neuroendocrine carcinoma after multi-line immunochemotherapy and anti-angiogenic therapy: a case report
Long-term survival in advanced pulmonary large-cell neuroendocrine carcinoma after multi-line immunochemotherapy and anti-angiogenic therapy: a case report Open
Background Pulmonary large-cell neuroendocrine carcinoma (PLCNEC) is a rare and highly aggressive subtype of lung cancer with neuroendocrine features, typically diagnosed at an advanced stage. Its clinical presentation and treatment respon…
View article: Effect of exercise intervention on quality of life and exercise capacity in patients with atrial fibrillation: a systematic review and network meta-analysis
Effect of exercise intervention on quality of life and exercise capacity in patients with atrial fibrillation: a systematic review and network meta-analysis Open
Background Atrial fibrillation (AF), the most prevalent cardiac arrhythmia, can significantly increase stroke risk, heart failure, and reduce quality of life. Despite growing evidence on the benefits of exercise for AF patients, data heter…
View article: Osthole attenuates trastuzumab-induced cardiotoxicity in mice by enhancing autophagy via regulating the p38MAPK/mTOR signaling pathway
Osthole attenuates trastuzumab-induced cardiotoxicity in mice by enhancing autophagy via regulating the p38MAPK/mTOR signaling pathway Open
View article: Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers
Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers Open
Posterior segment eye diseases (PSEDs) remain a leading cause of irreversible blindness, with the eye's dynamic and static barriers posing challenges to effective drug delivery through different administration routes. Currently, treatment …
View article: Nutritional and inflammatory indicators differ among patients with colorectal cancer with distinct microsatellite stability statuses
Nutritional and inflammatory indicators differ among patients with colorectal cancer with distinct microsatellite stability statuses Open
BACKGROUND Nutritional and inflammatory indicators are crucial in assessing the nutritional health and immune function of patients with cancer, which are factors closely associated with the diagnosis and treatment of colorectal cancer (CRC…
View article: Development and application of a whole transcriptome sequencing assay for the detection of gene fusions in clinical cancer specimens
Development and application of a whole transcriptome sequencing assay for the detection of gene fusions in clinical cancer specimens Open
We have developed a novel WTS assay with high sensitivity, specificity, repeatability and reproducibility. This assay can identify potentially actionable gene fusions and provides valuable insights into the fusion landscape in various canc…
View article: Enzymatic lacto-N-biose elongation of human milk oligosaccharides with the GH136 lacto-N-biosidase LnbX engineered for improved transglycosylation
Enzymatic lacto-N-biose elongation of human milk oligosaccharides with the GH136 lacto-N-biosidase LnbX engineered for improved transglycosylation Open
The lacto-N-biosidase (EC 3.2.1.140) LnbX from Bifidobacterium longum subsp. longum JCM 1217, a member of the glycoside hydrolase family 136 (GH136), was used for single-step lacto-N-biose (LNB) elongation of human milk oligosaccharides (H…