Yinyin Cao
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View article: Intrapulmonary penetration and pharmacokinetics of siderophore cephalosporin HRS-8427 injection in Chinese healthy subjects
Intrapulmonary penetration and pharmacokinetics of siderophore cephalosporin HRS-8427 injection in Chinese healthy subjects Open
HRS-8427, a novel siderophore cephalosporin antibiotic, is under development for treating Gram-negative infections. This study evaluated the intrapulmonary penetration and pharmacokinetic (PK) profile of HRS-8427 injection following single…
View article: Effects of blood flow restriction training on patients with chronic ankle instability: a systematic review and meta-analysis
Effects of blood flow restriction training on patients with chronic ankle instability: a systematic review and meta-analysis Open
View article: Haplotype-resolved genomes of Phlebopus portentosus reveal nuclear differentiation, TE-mediated variation, and saprotrophic potential
Haplotype-resolved genomes of Phlebopus portentosus reveal nuclear differentiation, TE-mediated variation, and saprotrophic potential Open
Phlebopus portentosus is a widely consumed edible mushroom and the only Boletales species currently cultivated on an industrial scale. Despite its economic importance, its trophic strategy and genomic adaptations remain elusive. Here, we p…
View article: Direct aesthetic restoration of black triangles in anterior teeth with a bio clear matrix: case series
Direct aesthetic restoration of black triangles in anterior teeth with a bio clear matrix: case series Open
The black triangle, a V-shaped gap between anterior teeth, affects both dental aesthetics and self-esteem. It can negatively impact dental aesthetics and patients' self-esteem. This study presents a series of cases in which a novel Bioclea…
View article: Transapical beating-heart septal myectomy for the treatment of hypertrophic obstructive cardiomyopathy
Transapical beating-heart septal myectomy for the treatment of hypertrophic obstructive cardiomyopathy Open
View article: Decoding maternal genetic background of Chinese Tujia people through extensive mitochondrial genome analyses
Decoding maternal genetic background of Chinese Tujia people through extensive mitochondrial genome analyses Open
Introduction The Tujia ethnic group, belonging to the Tibeto-Burman linguistic family, predominantly resides in the mountainous regions of central and southern China. Despite their substantial population size and rich historical background…
View article: [Retracted] Placenta‑derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance
[Retracted] Placenta‑derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance Open
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the flow cytometric plots shown in Fig. 4A and B, and Fig. 4D and E, respectively on p. 8142, these two pairs of plo…
View article: RNA-binding protein ZmFRKH1 promotes maize flowering by modulating the stability of multiple flowering regulator RNAs
RNA-binding protein ZmFRKH1 promotes maize flowering by modulating the stability of multiple flowering regulator RNAs Open
View article: Emerging Technologies and Clinical Practice: A Systematic Review of Jugular Venous Assessment Techniques
Emerging Technologies and Clinical Practice: A Systematic Review of Jugular Venous Assessment Techniques Open
Jugular venous (JV) assessment can be a fundamental component of cardiovascular examination, providing valuable insights into right-sided heart function and central venous pressure. Traditional methods are subjective and prone to inter-obs…
View article: Pulmonary sequestration in conjunction with thalassemia: A case report
Pulmonary sequestration in conjunction with thalassemia: A case report Open
View article: Corrigendum: Significance of detecting cardiac troponin I and creatine kinase MB in critically Ill children without primary cardiac illness
Corrigendum: Significance of detecting cardiac troponin I and creatine kinase MB in critically Ill children without primary cardiac illness Open
[This corrects the article DOI: 10.3389/fped.2024.1445651.].
View article: Significance of detecting cardiac troponin I and creatine kinase MB in critically Ill children without primary cardiac illness
Significance of detecting cardiac troponin I and creatine kinase MB in critically Ill children without primary cardiac illness Open
Objective To investigate the incidence of myocardial injury in children with critically ill children without primary cardiac disease and the association between elevated cardiac troponin I (cTnl) and creatine kinase MB (CK-MB) concentratio…
View article: Identification of key signaling pathways and hub genes related to immune infiltration in Kawasaki disease with resistance to intravenous immunoglobulin based on weighted gene co-expression network analysis
Identification of key signaling pathways and hub genes related to immune infiltration in Kawasaki disease with resistance to intravenous immunoglobulin based on weighted gene co-expression network analysis Open
Background: Kawasaki disease (KD) is an acute vasculitis, that is, the leading cause of acquired heart disease in children, with approximately 10%–20% of patients with KD suffering intravenous immunoglobulin (IVIG) resistance. Although the…
View article: Automated deep neural network-based identification, localization, and tracking of cardiac structures for ultrasound-guided interventional surgery
Automated deep neural network-based identification, localization, and tracking of cardiac structures for ultrasound-guided interventional surgery Open
The model outperformed most human experts and was comparable to the optimal performance of all human experts in cardiac structure identification and localization, and could be used in the external data sets.
View article: Bayesian Inference and Dynamic Neural Feedback Promote the Clinical Application of Intelligent Congenital Heart Disease Diagnosis
Bayesian Inference and Dynamic Neural Feedback Promote the Clinical Application of Intelligent Congenital Heart Disease Diagnosis Open
Congenital heart disease (CHD) is the leading cause of infant death. An artificial intelligence (AI)-based CHD diagnosis network (CHDNet) is an echocardiogram video-based binary classification model that judges whether echocardiogram video…
View article: The RNF213 rs112735431 polymorphism might influence predisposition to moyamoya disease and exhibit different clinical features in Asian population
The RNF213 rs112735431 polymorphism might influence predisposition to moyamoya disease and exhibit different clinical features in Asian population Open
Many studies suggested that the RNF213 rs112735431 polymorphism plays an important role in the pathogenesis of moyamoya disease. We performed a statistical meta-analysis based on the collected information of 18 studies comprising of 3044 c…
View article: Effects of immunoglobulin plus prednisolone in reducing coronary artery lesions in patients with Kawasaki disease: study protocol for a phase III multicenter, open-label, blinded-endpoints randomized controlled trial
Effects of immunoglobulin plus prednisolone in reducing coronary artery lesions in patients with Kawasaki disease: study protocol for a phase III multicenter, open-label, blinded-endpoints randomized controlled trial Open
View article: Metabolomics analysis of the serum from children with urolithiasis using UPLC‐MS
Metabolomics analysis of the serum from children with urolithiasis using UPLC‐MS Open
Pediatric urolithiasis is a common urologic disease with high morbidity and recurrence rates. Recent studies have shown that metabolic dysfunction plays a vital role in the pathogenesis of urolithiasis, especially in children, but the spec…
View article: Uric acid and sphingomyelin enhance autophagy in iPS cell-originated cardiomyocytes through lncRNA MEG3/miR-7-5p/EGFR axis
Uric acid and sphingomyelin enhance autophagy in iPS cell-originated cardiomyocytes through lncRNA MEG3/miR-7-5p/EGFR axis Open
This study aimed to determine the metabolites associated with ventricular septal defect (VSD) and the underlying mechanisms. Blood samples and thymus tissues were collected from VSD patients to perform LC-MS-based metabolomics assay and ge…
View article: A novel ZIC3 gene mutation identified in patients with heterotaxy and congenital heart disease
A novel ZIC3 gene mutation identified in patients with heterotaxy and congenital heart disease Open
View article: The Efficacy and Safety of Mainstream Medications for Patients With cDMARD-Naïve Rheumatoid Arthritis: A Network Meta-Analysis
The Efficacy and Safety of Mainstream Medications for Patients With cDMARD-Naïve Rheumatoid Arthritis: A Network Meta-Analysis Open
Background: The mainstream medications for rheumatoid arthritis (RA) include conventional disease-modifying antirheumatic drugs (cDMARDs), which mostly are methotrexate (MTX), and biologic agents such as adalimumab (ADA), certolizum…
View article: Generation of a Urine-Derived Ips Cell Line from a Patient with a Ventricular Septal Defect and Heart Failure and the Robust Differentiation of These Cells to Cardiomyocytes via Small Molecules
Generation of a Urine-Derived Ips Cell Line from a Patient with a Ventricular Septal Defect and Heart Failure and the Robust Differentiation of These Cells to Cardiomyocytes via Small Molecules Open
Background/Aims: Ventricular septal defects (VSDs) are one of the most common types of congenital heart malformations. Volume overload resulting from large VSDs can lead to heart failure (HF) and constitutes a major cause of pediatric HF w…
View article: Placenta-derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance
Placenta-derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance Open
Mesenchymal stem cells (MSCs) possess reparative and immunoregulatory properties, representing a hope for stem cell‑based treatments. However, the mechanisms by which transplanted MSCs affect T helper (Th)17/regulatory T cell (Treg) balanc…
View article: Complete Genome Sequence of a Porcine Endogenous Retrovirus Isolated from a Bama Minipig in Guangxi, Southern China
Complete Genome Sequence of a Porcine Endogenous Retrovirus Isolated from a Bama Minipig in Guangxi, Southern China Open
A porcine endogenous retrovirus (PERV) strain, PERV-A-BM, was isolated from a Bama minipig in Guangxi, China. This is the first entire genome sequence of PERV isolated from Guangxi Bama minipigs. The isolate is closely related to isolates …