Explanipedia

A bile acid-related prognostic signature in hepatocellular carcinoma Open

Wang Zhang, Yue Zhang, Yipeng Wan, Qi Liu, Xuan Zhu · 2022

Medicine Biology Computer science

Due to the high mortality of hepatocellular carcinoma (HCC), its prognostic models are urgently needed. Bile acid (BA) metabolic disturbance participates in hepatocarcinogenesis. We aim to develop a BA-related gene signature for HCC patien…

Ursolic acid alleviates Kupffer cells pyroptosis in liver fibrosis by the NOX2/NLRP3 inflammasome signaling pathway Open

Yipeng Wan, Wang Zhang, Chenkai Huang, Jie Jian, Yue Zhang , et al. · 2022

Chemistry Medicine Biology

Pyroptosis has an important role in liver inflammation and fibrosis. The role of KC pyroptosis in liver fibrosis was unclear. Ursolic acid (UA) has antifibrotic effects, but study on the effect and mechanism of UA on KC pyroptosis in liver…

CSTF2 Acts as a Prognostic Marker Correlated with Immune Infiltration in Hepatocellular Carcinoma Open

Wang Zhang, Yipeng Wan, Yue Zhang, Qi Liu, Xuan Zhu · 2022

Biology Medicine

High CSTF2 expression not only correlates with unfavorable outcomes but also affects immune cell infiltration and immune checkpoint expression in HCC. CSTF2 silencing can alleviate the malignant phenotypes of hepatic cancer cell by inactiv…

Ursolic acid reverses liver fibrosis by inhibiting NOX4/NLRP3 inflammasome pathways and bacterial dysbiosis Open

Qi Liu, Yuan Nie, Wang Zhang, Yipeng Wan, Chenkai Huang , et al. · 2021

Chemistry Biology Medicine

IntroductionActivation of the NOX4/NLRP3 inflammasome pathway has been associated with fibrosis in other organs. An imbalance in intestinal bacteria is an important driving factor of liver fibrosis through the liver-gut axis. This study ai…

Ursolic acid reverses liver fibrosis by inhibiting NOX4/NLRP3 inflammasome pathways and bacterial dysbiosis Open

Yuan Nie, Qi Liu, Wang Zhang, Yipeng Wan, Chenkai Huang , et al. · 2021

Biology Medicine

Activation of the NOX4/NLRP3 inflammasome pathway has been associated with fibrosis in other organs. An imbalance in intestinal bacteria is an important driving factor of liver fibrosis through the liver-gut axis. This study aimed to explo…

Clinical characteristics and efficacy of endoscopic treatment of gastrointestinal ectopic varices Open

Yipeng Wan, Anjiang Wang, Bimin Li, Huang Chenkai, Wan Size , et al. · 2020

Medicine

Background: Ectopic varices (EcVs) may cause massive bleeding, which can be difficult to control, with a high rate of mortality. The purpose of this study was to analyze the clinical characteristics of EcVs and the efficacy of endoscopic t…

Effectiveness and safety of endoscopic treatment for duodenal variceal bleeding: a systematic review Open

Yipeng Wan, Cong Liu, Sizhe Wan, Huang Chenkai, Anjiang Wang , et al. · 2020

Medicine Political science

Duodenal varix is a rare condition that involves massive bleeding, diagnostic difficulties, and a high rate of rebleeding and mortality. The purpose of this study was to systematically review endoscopic treatment for duodenal variceal blee…

Protective Effect of Ursolic Acid on the Intestinal Mucosal Barrier in a Rat Model of Liver Fibrosis Open

Wang Zhang, Dakai Gan, Jie Jian, Chenkai Huang, Fangyun Luo , et al. · 2019

Chemistry Medicine

Oxidative stress mediated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) plays an important role in intestinal mucosal barrier damage in various disease states. Recent evidence suggests that intestinal mucosal barrier…

Stock Net Entropy: Evidence from the Chinese Growth Enterprise Market Open

Qiuna Lv, Liyan Han, Yipeng Wan, Libo Yin · 2018

Economics Mathematics Physics

By introducing net entropy into a stock network, this paper focuses on investigating the impact of network entropy on market returns and trading in the Chinese Growth Enterprise Market (GEM). In this paper, indices of Wu structure entropy …

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