Yiqiang Zhi
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View article: Lysosomal and mTORC1 signaling dysregulation underpin the pathology of spastic paraplegia type 80
Lysosomal and mTORC1 signaling dysregulation underpin the pathology of spastic paraplegia type 80 Open
Endosomal sorting complex required for transport (ESCRT) is the major membrane remodeling complex, closely associated with endolysosomal repair and hereditary spastic paraplegias (HSP) diseases. Loss of function mutations in the ESCRT-I co…
View article: WDR62 controls cortical radial migration and callosal projection of neurons in the developing cerebral cortex
WDR62 controls cortical radial migration and callosal projection of neurons in the developing cerebral cortex Open
WD repeat domain 62 (WDR62) was identified as the second most causative gene of autosomal recessive primary microcephaly (MCPH) frequently associated structural abnormalities such as lissencephaly, polymicrogyria as well as hypoplasia of t…
View article: JNK Acts as A Conserved Regulator Prevents Healthy Aging by Attenuating Proteostasis Stress During Aging
JNK Acts as A Conserved Regulator Prevents Healthy Aging by Attenuating Proteostasis Stress During Aging Open
Stress-activated C-JUN N-terminal kinases(JNKs), which belong to the mitogen-activated protein kinase (MAPK) family, are evolutionarily conserved signaling modules that orchestrate protective responses to adverse environmental conditions. …
View article: Neurodevelopmental Implications Underpinning Hereditary Spastic Paraplegia
Neurodevelopmental Implications Underpinning Hereditary Spastic Paraplegia Open
Background Hereditary spastic paraplegia (HSP) is a group of rare genetic neurodegenerative disorders characterized by corticospinal tract abnormalities. But frequently, abnormalities of proteins implicated in HSP have been identified in b…
View article: ESCRT-I protein UBAP1 controls ventricular expansion and cortical neurogenesis via modulating adherens junctions of radial glial cells
ESCRT-I protein UBAP1 controls ventricular expansion and cortical neurogenesis via modulating adherens junctions of radial glial cells Open
Intricate cerebral cortex formation is orchestrated by the precise behavior and division dynamics of radial glial cells (RGCs). Endocytosis functions in the recycling and remodeling of adherens junctions (AJs) in response to changes in RGC…
View article: Discovering additional genetic loci associated with six psychiatric disorders/traits<i>via</i>FDR regression model leveraging external genetic and biological data
Discovering additional genetic loci associated with six psychiatric disorders/traits<i>via</i>FDR regression model leveraging external genetic and biological data Open
Background Common psychiatric disorders have substantial heritability influenced by multiple genes. While a number of susceptibility variants have been identified, many associated variants remain undiscovered. This study aimed to identify …
View article: WDR62-deficiency Causes Autism-like Behaviors Independent of Microcephaly in Mice
WDR62-deficiency Causes Autism-like Behaviors Independent of Microcephaly in Mice Open
Brain size abnormality is correlated with an increased frequency of autism spectrum disorder (ASD) in offspring. Genetic analysis indicates that heterozygous mutations of the WD repeat domain 62 ( WDR62 ) are associated with ASD. However, …
View article: WDR62 deficiency results in synaptic dysfunction and ASD-like behaviors in mice, which can be ameliorated by RA repletion
WDR62 deficiency results in synaptic dysfunction and ASD-like behaviors in mice, which can be ameliorated by RA repletion Open
Background: Brain size abnormality is correlated with increased frequency of autism spectrum disorder (ASD) in offspring. Genetic analysis indicates that many heterozygous mutations of microcephaly-associated genes including WD repeat doma…
View article: Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases
Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases Open
The c-Jun N-terminal kinase (JNK) is highly evolutionarily conserved and plays important roles in a broad range of physiological and pathological processes. The WD40-repeat protein 62 (WDR62) is a scaffold protein that recruits different c…
View article: The Yin and Yang of Autosomal Recessive Primary Microcephaly Genes: Insights from Neurogenesis and Carcinogenesis
The Yin and Yang of Autosomal Recessive Primary Microcephaly Genes: Insights from Neurogenesis and Carcinogenesis Open
The stem cells of neurogenesis and carcinogenesis share many properties, including proliferative rate, an extensive replicative potential, the potential to generate different cell types of a given tissue, and an ability to independently mi…