Yubei Huang
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View article: Functional and clinical validation of tsRNA-defined molecular subtypes guides precision therapy in gastric cancer
Functional and clinical validation of tsRNA-defined molecular subtypes guides precision therapy in gastric cancer Open
Introduction Gastric cancer (GC) is a highly heterogeneous malignancy with poor prognosis, underscoring the urgent need for reliable biomarkers to guide precise stratification and therapy. Transfer RNA-derived small RNAs (tsRNAs) have emer…
View article: Pharmacovigilance-based 12-year post-marketing safety analysis of quadrivalent influenza vaccines in children: a VAERS surveillance study
Pharmacovigilance-based 12-year post-marketing safety analysis of quadrivalent influenza vaccines in children: a VAERS surveillance study Open
Background Quadrivalent influenza vaccines (QIVs) are extensively administered to children for seasonal influenza prevention. However, comprehensive long-term evaluations of post-marketing safety remain limited. Methods We conducted a comp…
View article: The epidemiological landscape of lung cancer: current status, temporal trend and future projections based on the latest estimates from GLOBOCAN 2022
The epidemiological landscape of lung cancer: current status, temporal trend and future projections based on the latest estimates from GLOBOCAN 2022 Open
Lung cancer maintained as the leading cancer burden worldwide. Unless timely preventive interventions in tobacco mitigation, early screening, and precise treatment, the global lung cancer burden is expected to increase in the future, espec…
View article: Global burden of female breast cancer: new estimates in 2022, temporal trend and future projections up to 2050 based on the latest release from GLOBOCAN
Global burden of female breast cancer: new estimates in 2022, temporal trend and future projections up to 2050 based on the latest release from GLOBOCAN Open
Breast cancer remains the leading cancer burden in women, particularly in transitioning countries. Addressing this growing burden requires urgent integration of primary prevention, early detection and high-quality treatment through multi-s…
View article: Global burden of cervical cancer: current estimates, temporal trend and future projections based on the GLOBOCAN 2022
Global burden of cervical cancer: current estimates, temporal trend and future projections based on the GLOBOCAN 2022 Open
View article: Decreased risk of cardiovascular disease mortality associated with occasional positive screens following cancer screenings
Decreased risk of cardiovascular disease mortality associated with occasional positive screens following cancer screenings Open
View article: Risk factors and prediction model of breast cancer-related lymphoedema in a Chinese cancer centre: a prospective cohort study protocol
Risk factors and prediction model of breast cancer-related lymphoedema in a Chinese cancer centre: a prospective cohort study protocol Open
Introduction Lymphoedema is a distressing and long-term complication for breast cancer survivors. However, the reported incidence of lymphoedema varies, and its risk factors remain underexplored. Currently, a well-established risk predicti…
View article: Risk-stratified screening and colorectal cancer incidence and mortality: A retrospective study from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Risk-stratified screening and colorectal cancer incidence and mortality: A retrospective study from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Open
FSG screening yielded more benefits for the high-risk group than for the low-risk and medium-risk groups, supporting the development of a risk-stratified CRC screening strategy.
View article: Preliminary effects of risk-adapted PSA screening for prostate cancer after integrating PRS-specific and age-specific variation
Preliminary effects of risk-adapted PSA screening for prostate cancer after integrating PRS-specific and age-specific variation Open
Background Although the risk of prostate cancer (PCa) varies across different ages and genetic risks, it’s unclear about the effects of genetic-specific and age-specific prostate-specific antigen (PSA) screening for PCa. Methods Weighed an…
View article: Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data
Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data Open
Objective: Few studies have evaluated the benefits of colorectal cancer (CRC) screening integrating both non-genetic and genetic risk factors. Here, we aimed to integrate an existing non-genetic risk model (QCancer-10) and a 139-variant po…
View article: Chemoradiotherapy versus surgery after neoadjuvant chemoimmunotherapy in patients with stage III NSCLC: a real-world multicenter retrospective study
Chemoradiotherapy versus surgery after neoadjuvant chemoimmunotherapy in patients with stage III NSCLC: a real-world multicenter retrospective study Open
Purpose The optimal treatment after neoadjuvant chemoimmunotherapy for patients with stage III non-small cell lung cancer (NSCLC) is unclear. This study aimed at comparing the efficacy and safety of chemoradiotherapy and surgery after neoa…
View article: Effects of joint screening for prostate, lung, colorectal, and ovarian cancer – results from a controlled trial
Effects of joint screening for prostate, lung, colorectal, and ovarian cancer – results from a controlled trial Open
Background Although screening is widely used to reduce cancer burden, untargeted cancers are frequently missed after single cancer screening. Joint cancer screening is presumed as a more effective strategy to reduce overall cancer burden. …
View article: Identification of Gastric Cancer-Specific Tsrna Subtypes and Prognostic Implications
Identification of Gastric Cancer-Specific Tsrna Subtypes and Prognostic Implications Open
View article: Pre-Diagnostic Systemic Inflammatory Markers and Triglyceride-Glucose Index with Risk of Colorectal Cancer, and Potential Modification of Healthy Lifestyle and Screening
Pre-Diagnostic Systemic Inflammatory Markers and Triglyceride-Glucose Index with Risk of Colorectal Cancer, and Potential Modification of Healthy Lifestyle and Screening Open
View article: Associations between BMI, polygenic risk score for BMI, lifestyle and the risk of upper gastrointestinal cancer
Associations between BMI, polygenic risk score for BMI, lifestyle and the risk of upper gastrointestinal cancer Open
Objective To investigate the risk of upper gastrointestinal (UG) cancer associated with BMI across different polygenic risk score for BMI (PRSBMI), and to investigate whether healthy lifestyles could attenuate this risk. Methods…
View article: Biomarkers for predicting the severity of spinal cord injury by proteomic analysis
Biomarkers for predicting the severity of spinal cord injury by proteomic analysis Open
Purpose Currently, there is a shortage of the protein biomarkers for classifying spinal cord injury (SCI) severity. We attempted to explore the candidate biomarkers for predicting SCI severity. Methods SCI rat models with mild, moderate, a…
View article: Chinese herbal injections in combination with radiotherapy for advanced pancreatic cancer: A systematic review and network meta-analysis
Chinese herbal injections in combination with radiotherapy for advanced pancreatic cancer: A systematic review and network meta-analysis Open
View article: Cohort profile: design and methods of the Chinese colorectal, breast, lung, liver, and stomach cancer screening trial (C-BLAST)
Cohort profile: design and methods of the Chinese colorectal, breast, lung, liver, and stomach cancer screening trial (C-BLAST) Open
Given the rapid changes in social structure (urbanization), economic structure (industrialization), and demographic structure (population aging) in China, cancer has become a major public health problem[1][1]. Extensive evidence has indica…
View article: Associations of chest X-ray trajectories, smoking, and the risk of lung cancer in two population-based cohort studies
Associations of chest X-ray trajectories, smoking, and the risk of lung cancer in two population-based cohort studies Open
Objectives Despite the increasing use of computed tomography (CT), chest X-ray (CXR) remains the first-line investigation for suspected lung cancer (LC) in primary care. However, the associations of CXR trajectories, smoking and LC risk re…
View article: Comparisons of clinical characteristics, prognosis, epidemiological factors, and genetic susceptibility between <scp>HER2</scp>‐low and <scp>HER2</scp>‐zero breast cancer among Chinese females
Comparisons of clinical characteristics, prognosis, epidemiological factors, and genetic susceptibility between <span>HER2</span>‐low and <span>HER2</span>‐zero breast cancer among Chinese females Open
Background Traditional human epidermal growth factor receptor 2 (HER2)‐negative breast cancer (BC) is recommended to be divided into HER2‐low and HER2‐zero subtypes due to different prognosis. However, few studies investigated their differ…
View article: The changes of subtype markers between first and second primary breast cancers
The changes of subtype markers between first and second primary breast cancers Open
Background Previous studies investigated the changes of subtype markers [estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)] in several clinical settings, but not for second primary brea…
View article: Higher risk of cardiovascular mortality than cancer mortality among long-term cancer survivors
Higher risk of cardiovascular mortality than cancer mortality among long-term cancer survivors Open
Background Previous studies focused more on the short-term risk of cardiovascular (CV) death due to traumatic psychological stress after a cancer diagnosis and the acute cardiotoxicity of anticancer treatments than on the long-term risk of…
View article: Prospective Study on the Effectiveness of Risk-Stratified Screening for Colorectal Cancer
Prospective Study on the Effectiveness of Risk-Stratified Screening for Colorectal Cancer Open
View article: TRPV1 participates in neuropathic pain after spinal cord injury by mediating the proliferation and activation of CX3CL1-positive glial cells in the spinal dorsal horn
TRPV1 participates in neuropathic pain after spinal cord injury by mediating the proliferation and activation of CX3CL1-positive glial cells in the spinal dorsal horn Open
Background Patients with spinal cord injury (SCI) often present with different degrees of neuropathic pain (NP). Glia-mediated inflammatory response plays a key role. The transient receptor potential vanilloid subtype 1 (TRPV1), as an ion …
View article: Chinese herbal injections versus intrapleural cisplatin for lung cancer patients with malignant pleural effusion: A Bayesian network meta-analysis of randomized controlled trials
Chinese herbal injections versus intrapleural cisplatin for lung cancer patients with malignant pleural effusion: A Bayesian network meta-analysis of randomized controlled trials Open
Background Malignant pleural effusion (MPE) is a common complication in patients with advanced lung cancer that can severely compromise the quality of life and limit life expectancy. Randomized controlled trials (RCTs) have shown that Chin…
View article: Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population
Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case–control study in Chinese population Open
View article: Instability of molecular subtype markers between first and second primary breast cancers
Instability of molecular subtype markers between first and second primary breast cancers Open
Background: Previous studies investigated the instability of molecular subtype markers [estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)] in several clinical settings, but not for seco…
View article: Consumption of flavonoids and risk of hormone-related cancers: a systematic review and meta-analysis of observational studies
Consumption of flavonoids and risk of hormone-related cancers: a systematic review and meta-analysis of observational studies Open
View article: Screening performance in high-risk groups of breast cancer by integrating classical risk factors, mammographic density and polygenic risk
Screening performance in high-risk groups of breast cancer by integrating classical risk factors, mammographic density and polygenic risk Open
Background : Risk prediction models integrating classical risk factors (CRF), mammographic density (MD), and polygenic risk score (PRS) are increasingly developed to identify high-risk groups of breast cancer. Few studies investigate the s…
View article: Higher risk of cardiovascular death than cancer death among long-term cancer survivors
Higher risk of cardiovascular death than cancer death among long-term cancer survivors Open
Background Most previous studies have focused more on the short-term risk of cardiovascular death related to traumatic psychological stress after cancer diagnosis, but less on the long-term risk of cardiovascular death. Recent studies sugg…