Explanipedia

Molecular characterization of the sea lamprey retina illuminates the evolutionary origin of retinal cell types Open

Junqiang Wang, Lin Zhang, Martina Cavallini, Ali Pahlevan, Junwei Sun , et al. · 2024

The lamprey, a primitive jawless vertebrate whose ancestors diverged from all other vertebrates over 500 million years ago, offers a unique window into the ancient formation of the retina. Using single-cell RNA-sequencing, we characterize …

Evolutionary and developmental specialization of foveal cell types in the marmoset Open

Lin Zhang, Martina Cavallini, Junqiang Wang, Ruiqi Xin, Qiangge Zhang , et al. · 2024

In primates, high-acuity vision is mediated by the fovea, a small specialized central region of the retina. The fovea, unique to the anthropoid lineage among mammals, undergoes notable neuronal morphological changes during postnatal matura…

Evolution of neuronal cell classes and types in the vertebrate retina Open

Joshua Hahn, Aboozar Monavarfeshani, Mu Qiao, Allison Kao, Yvonne Kölsch , et al. · 2023

Molecular Characterization of the Sea Lamprey Retina Illuminates the Evolutionary Origin of Retinal Cell Types Open

Junqiang Wang, Lin Zhang, Martina Cavallini, Ali Pahlevan, Junwei Sun , et al. · 2023

The lamprey, a primitive jawless vertebrate whose ancestors diverged from all other vertebrates over 500 million years ago, offers a unique window into the primordial formation of the retina. Using single-cell RNA-sequencing, we characteri…

Evolutionary and Developmental Specialization of Foveal Cell Types in the Marmoset Open

Lin Zhang, Martina Cavallini, Junqiang Wang, Ruiqi Xin, Qiangge Zhang , et al. · 2023

In primates, high-acuity vision is mediated by the fovea, a small specialized central region of the retina. The fovea, unique to the anthropoid lineage among mammals, undergoes notable neuronal morphological changes during postnatal matura…

Cell-type specification in the retina: Recent discoveries from transcriptomic approaches Open

Yi‐Rong Peng · 2023

Understanding the formation of the complex nervous system hinges on decoding the mechanism that specifies a vast array of neuronal types, each endowed with a unique morphology, physiology, and connectivity. As a pivotal step towards addres…

Evolution of neuronal cell classes and types in the vertebrate retina Open

Joshua Hahn, Aboozar Monavarfeshani, Mu Qiao, Allison Kao, Yvonne Kölsch , et al. · 2023

The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in their visual needs (Baden et al., 2020). One might expect that retinal cell types evolved to accommodate these varied needs, but this has not be…

Encoding of environmental illumination by primate melanopsin neurons Open

Andreas Liu, Elliott S. Milner, Yi‐Rong Peng, Hannah A. Blume, M. C. Brown , et al. · 2023

Light regulates physiology, mood, and behavior through signals sent to the brain by intrinsically photosensitive retinal ganglion cells (ipRGCs). How primate ipRGCs sense light is unclear, as they are rare and challenging to target for ele…

Author response: Diversification of multipotential postmitotic mouse retinal ganglion cell precursors into discrete types Open

Karthik Shekhar, Irene E. Whitney, Salwan Butrus, Yi‐Rong Peng, Joshua R. Sanes · 2022

Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The genesis of broad n…

Gender Differences Influence Gender Equality Awareness, Self-Esteem, and Subjective Well-Being Among School-Age Children in China Open

Yifei Li, Man Zuo, Yi‐Rong Peng, Jie Zhang, Yiping Chen , et al. · 2022

The objective of this study was to investigate and analyze the status and influential factors of gender equality awareness, self-esteem, and subjective well-being in school-age boys and girls. The results can help schools and teachers prov…

Exploring the Effect of Negotiation on UNCLOS Open

Yifan Cai, Yi‐Rong Peng, Ziyuan Xu, Mingze Yuan · 2022

This article provides an in-depth discussion of the circumstances surrounding the establishment of the United Nations Convention on the Law of the Sea and looks at the role that negotiation skills played in its creation.This law was create…

Diversification of multipotential postmitotic mouse retinal ganglion cell precursors into discrete types Open

Karthik Shekhar, Irene E. Whitney, Salwan Butrus, Yi‐Rong Peng, Joshua R. Sanes · 2021

The genesis of broad neuronal classes from multipotential neural progenitor cells has been extensively studied, but less is known about the diversification of a single neuronal class into multiple types. We used single-cell RNA-seq to stud…

Transcriptomic and genomic mapping of embryonic development of the human fovea Open

Lin Zhang, Ruchen Cai, Yi‐Rong Peng · 2021

Cell Atlas of The Human Fovea and Peripheral Retina Open

Wenjun Yan, Yi‐Rong Peng, Tavé van Zyl, Aviv Regev, Karthik Shekhar , et al. · 2020

Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis Open

Tavé van Zyl, Wenjun Yan, Alexi McAdams, Yi‐Rong Peng, Karthik Shekhar , et al. · 2020

Increased intraocular pressure (IOP) represents a major risk factor for glaucoma, a prevalent eye disease characterized by death of retinal ganglion cells; lowering IOP is the only proven treatment strategy to delay disease progression. Th…

LRR-ning the Rules: Synapse Organization in the Primary Rod Pathway Open

Yi‐Rong Peng, Alapakkam P. Sampath · 2020

Cell Atlas of the Human Fovea and Peripheral Retina Open

Wenjun Yan, Yi‐Rong Peng, Tavé van Zyl, Aviv Regev, Karthik Shekhar , et al. · 2020

Most irreversible blindness results from retinal disease. To advance our understanding of the etiology of blinding diseases, we used single-cell RNA-sequencing (scRNA-seq) to analyze the transcriptomes of ∼85,000 cells from the fovea and p…

Cell Atlas of Aqueous Humor Outflow Pathways in Eyes of Humans and Four Model Species Provides Insights into Glaucoma Pathogenesis Open

Tavé van Zyl, Wenjun Yan, Alexi McAdams, Yi‐Rong Peng, Karthik Shekhar , et al. · 2020

Increased intraocular pressure (IOP) represents a major risk factor for glaucoma, a prevalent eye disease characterized by death of retinal ganglion cells that carry information from the eye to the brain; lowering IOP is the only proven tr…

Molecular Classification of Cell Types in the Human Trabecular Meshwork and Surrounding Structures using Single-Cell RNAseq Open

Tavé van Zyl, Alexi McAdams, Wenjun Yan, Karthik Shekhar, Yi‐Rong Peng , et al. · 2019

Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina Open

Yi‐Rong Peng, Karthik Shekhar, Wenjun Yan, Dustin Herrmann, Anna Sappington , et al. · 2019

Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina Open

Yi‐Rong Peng, Karthik Shekhar, Wenjun Yan, Dustin Herrmann, Anna Sappington , et al. · 2018

High acuity vision in primates, including humans, is mediated by a small central retinal region called the fovea. As more accessible model organisms lack a fovea, its specialized function and dysfunction in ocular diseases remain poorly un…

Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold Open

Xin Duan, Arjun Krishnaswamy, Mallory A. Laboulaye, Jinyue Liu, Yi‐Rong Peng , et al. · 2018

Satb1 Regulates Contactin 5 to Pattern Dendrites of a Mammalian Retinal Ganglion Cell Open

Yi‐Rong Peng, Nicholas M. Tran, Arjun Krishnaswamy, Dimitar Kostadinov, Emily M. Martersteck , et al. · 2017

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