Yirou Zhang
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View article: Somatostatin Ameliorates Corneal Nerve Abnormalities and Inflammation Through Regulation of Macrophage Activities in Dry Eye Disease
Somatostatin Ameliorates Corneal Nerve Abnormalities and Inflammation Through Regulation of Macrophage Activities in Dry Eye Disease Open
SOM230 alleviates nerve abnormalities in DED by suppressing inflammatory pathways (TNF-α, NF-κB) and promoting a shift in macrophage polarization from the pro-inflammatory M1 phenotype to the reparative M2 phenotype. These findings suggest…
View article: Engineered Un1Cas12f1 with boosted gene-editing activity and expanded genomic coverage
Engineered Un1Cas12f1 with boosted gene-editing activity and expanded genomic coverage Open
Compact programmable nucleases provide versatile genome editing tools with therapeutic potential, particularly when delivered via adeno-associated virus (AAV) vectors. However, their limited editing efficacy and stringent protospaceradjace…
View article: A Serum Resistant Polymer with Exceptional Endosomal Escape and mRNA Delivery Efficacy for CRISPR Gene Therapy
A Serum Resistant Polymer with Exceptional Endosomal Escape and mRNA Delivery Efficacy for CRISPR Gene Therapy Open
Nanoparticle‐based mRNA delivery offers a versatile platform for innovative therapies. However, most of the current delivery systems are limited by poor serum tolerance, suboptimal endosomal escape and mRNA delivery efficacy. Herein, a hig…
View article: Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients
Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients Open
Levels of tear CGRP and SP decreased in DED patients and showed meaningful correlations with clinical symptoms and signs, implying a potential relationship between tear neuropeptides and ocular neurosensory function.
View article: A Nucleic Acid‐Based LYTAC Plus Platform to Simultaneously Mediate Disease‐Driven Protein Downregulation
A Nucleic Acid‐Based LYTAC Plus Platform to Simultaneously Mediate Disease‐Driven Protein Downregulation Open
Protein degradation techniques, such as proteolysis‐targeting chimeras (PROTACs) and lysosome‐targeting chimeras (LYTACs), have emerged as promising therapeutic strategies for the treatment of diseases. However, the efficacy of current pro…
View article: Supplementary Material for: Different clinical features of pediatric generalized pustular psoriasis in patients with or without IL36RN variants
Supplementary Material for: Different clinical features of pediatric generalized pustular psoriasis in patients with or without IL36RN variants Open
Background: Generalized pustular psoriasis (GPP) is a rare and life-threatening autoinflammatory dermatological disease. IL36RN was reported to be the main pathogenetic basis for GPP. Only a few studies have reported on the correlation ana…