Yiteng Dang
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View article: Collective Gene Expression Fluctuations Encode the Regulatory State of Cells
Collective Gene Expression Fluctuations Encode the Regulatory State of Cells Open
Gene expression is inherently stochastic, but how fluctuations propagate at the macroscopic scale of gene networks and whether they play a functional role remains unclear. Here, we develop a theoretical and statistical learning framework t…
Self-propagating wave drives morphogenesis of skull bones in vivo Open
Cellular motion is a key feature of tissue morphogenesis and is often driven by migration. However, migration need not explain cell motion in contexts where there is little free space or no obvious substrate, such as those found during org…
View article: Transcriptional landscapes underlying Notch-induced lineage conversion and plasticity of mammary basal cells
Transcriptional landscapes underlying Notch-induced lineage conversion and plasticity of mammary basal cells Open
The mammary epithelium derives from multipotent mammary stem cells (MaSCs) that engage into differentiation during embryonic development. However, adult MaSCs maintain the ability to reactivate multipotency in non-physiological contexts. W…
View article: Transcriptional landscapes underlying Notch-induced lineage conversion and plasticity of mammary basal cells
Transcriptional landscapes underlying Notch-induced lineage conversion and plasticity of mammary basal cells Open
The mammary epithelium derives from multipotent mammary stem cells (MaSCs) that progressively restrict their potency and engage into lineage commitment during embryonic development. Although postnatal mammary progenitors are lineage-restri…
View article: Pre-cancerous Niche Remodelling Dictates Nascent Tumour Survival
Pre-cancerous Niche Remodelling Dictates Nascent Tumour Survival Open
Summary Interactions between mutant cells and their environment play a key role in determining cancer susceptibility. However, our understanding of how the pre-cancer microenvironment contributes to early tumorigenesis remains limited. Her…
Self-propagating wave drives noncanonical antidurotaxis of skull bones in vivo Open
Cell motility is a key feature of tissue morphogenesis, and it is thought to be driven primarily by the active migration of individual cells or collectives. However, this model is unlikely to apply to cells lacking overt cytoskeletal, stab…
Self-propagating wave drives noncanonical antidurotaxis of skull bones in vivo Open
Cell motility is a key feature of tissue morphogenesis, and it is thought to be driven primarily by the active migration of individual cells or collectives. However, this model is unlikely to apply to cells lacking overt cytoskeletal, stab…
Making sense of fragmentation and merging in lineage tracing experiments Open
Lineage tracing experiments give dynamic information on the functional behaviour of dividing cells. These experiments therefore have become an important tool for studying stem and progenitor cell fate behavior in vivo . When cell prolifera…
Collective dynamics and pattern formation in systems of communicating cells: Theory and Simulations Open
How a system of genetically identical biological cells organizes into spatially heterogeneous tissues is a central question in biology. Even when the molecular and genetic underpinnings of cell-cell interactions are known, how these lead t…
Cellular dialogues that enable self-organization of dynamic spatial patterns Open
Summary Cells form spatial patterns by coordinating their gene expressions. How a group of mesoscopic numbers (hundreds-to-thousands) of cells, without pre-defined morphogens and spatial organization, self-organizes spatial patterns remain…