Yi‐Ting Tsai
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View article: Lepidium meyenii Walpers Promotes the Regeneration of Salivary Gland and Prevents Xerostomia After Irradiation Injury
Lepidium meyenii Walpers Promotes the Regeneration of Salivary Gland and Prevents Xerostomia After Irradiation Injury Open
Objectives: Lepidium meyenii Walpers (LMW), a high-altitude plant, is known to stimulate hormone release, counteract neurodegeneration, and protect against oxidative stress. Saliva is vital for oral health, and reduced production leads to …
View article: Porphyromonas gingivalis GroEL Accelerates Abdominal Aortic Aneurysm Formation by Induction of M1 Polarization in Macrophages
Porphyromonas gingivalis GroEL Accelerates Abdominal Aortic Aneurysm Formation by Induction of M1 Polarization in Macrophages Open
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease characterized by chronic inflammation, extracellular matrix degradation, and smooth muscle cell apoptosis. Porphyromonas gingivalis (P. gingivalis), a key periodontal p…
View article: 1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway
1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway Open
1-Deoxysphingolipids are non-canonical sphingolipids linked to several diseases, but their cellular effects are poorly understood. Here, we utilize lipid chemical biology approaches to investigate the role of 1-deoxysphingolipid metabolism…
View article: <i>Porphyromonas gingivalis</i> GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2
<i>Porphyromonas gingivalis</i> GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2 Open
Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during A…
View article: A Leadless Pacemaker Implantation via the Right Internal Jugular Vein in a Fragile Taiwanese.
A Leadless Pacemaker Implantation via the Right Internal Jugular Vein in a Fragile Taiwanese. Open
View article: Risk Factors of Mortality and Long-Term Survival in Burn Patients With/Without Extracorporeal Membrane Oxygenation: A 16 Year Real-World Study
Risk Factors of Mortality and Long-Term Survival in Burn Patients With/Without Extracorporeal Membrane Oxygenation: A 16 Year Real-World Study Open
Burn patients face cardiopulmonary failure risks, with recent observational studies suggesting promising outcomes for extracorporeal membrane oxygenation (ECMO). However, the effectiveness and long-term survival remain unclear. Our study a…
View article: Targeting miR-181a/b in retinitis pigmentosa: implications for disease progression and therapy
Targeting miR-181a/b in retinitis pigmentosa: implications for disease progression and therapy Open
View article: <i>Porphyromonas gingivalis</i> GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function
<i>Porphyromonas gingivalis</i> GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function Open
Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porp…
View article: Drug Concentrations in the Air and their Influencing Factors in a Pediatric Intensive Care Unit
Drug Concentrations in the Air and their Influencing Factors in a Pediatric Intensive Care Unit Open
Aerosolized drug therapy is a common approach in treating respiratory diseases in clinical practice. This study aimed to assess air quality in the pediatric intensive care unit (PICU) of the medical center and investigate variations in dru…
View article: Reconstruction of the Left Anterior Descending Coronary Artery in a Patient with Diffusely Diseased Left Anterior Descending Coronary Artery.
Reconstruction of the Left Anterior Descending Coronary Artery in a Patient with Diffusely Diseased Left Anterior Descending Coronary Artery. Open
View article: Inflammatory Biomarkers and Blood Physical Property Transformations Following On-Pump Coronary Artery Bypass Graft Surgery
Inflammatory Biomarkers and Blood Physical Property Transformations Following On-Pump Coronary Artery Bypass Graft Surgery Open
Objective: This study aimed to compare the hemorheological and inflammatory changes before and after coronary artery bypass graft (CABG) surgery, as factors such as hypothermia, hemodilution, transfusion, and other variables affect blood v…
View article: A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators
A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators Open
Obesity and type 2 diabetes have reached pandemic proportion. ALDH2 (acetaldehyde dehydrogenase 2, mitochondrial) is the key metabolizing enzyme of acetaldehyde and other toxic aldehydes, such as 4-hydroxynonenal. A missense Glu504Lys muta…
View article: Rege-1 promotes C. elegans survival by modulating IIS and TOR pathways
Rege-1 promotes C. elegans survival by modulating IIS and TOR pathways Open
Metabolic pathways are known to sense the environmental stimuli and result in physiological adjustments. The responding processes need to be tightly controlled. Here, we show that upon encountering P . aeruginosa , C . elegans upregulate t…
View article: Risks after Gestational Diabetes Mellitus in Taiwanese Women: A Nationwide Retrospective Cohort Study
Risks after Gestational Diabetes Mellitus in Taiwanese Women: A Nationwide Retrospective Cohort Study Open
Objective: An increasing trend in the prevalence of gestational diabetes mellitus (GDM) has been reported in Taiwan. GDM has been linked to various adverse maternal outcomes over a long period, including cardiovascular disease (CVD) and ch…
View article: Targeted therapy in glomerular diseases
Targeted therapy in glomerular diseases Open
Targeted therapy has emerged as a more precise approach to treat glomerular diseases, focusing on specific molecular or cellular processes that contribute to disease development or progression. This approach complements or replaces traditi…
View article: GroEL of <i>Porphyromonas gingivalis</i>‐induced microRNAs accelerate tumor neovascularization by downregulating thrombomodulin expression in endothelial progenitor cells
GroEL of <i>Porphyromonas gingivalis</i>‐induced microRNAs accelerate tumor neovascularization by downregulating thrombomodulin expression in endothelial progenitor cells Open
We found that GroEL in Porphyromonas gingivalis accelerated tumor growth and increased mortality in tumor‐bearing mice; GroEL promoted proangiogenic function, which may be the reason for promoting tumor growth. To understand the regulatory…
View article: Animal Models for Heart Transplantation Focusing on the Pathological Conditions
Animal Models for Heart Transplantation Focusing on the Pathological Conditions Open
Cardiac transplant recipients face many complications due to transplant rejection. Scientists must conduct animal experiments to study disease onset mechanisms and develop countermeasures. Therefore, many animal models have been developed …
View article: Sediment pollutant exposures caused hepatotoxicity and disturbed glycogenesis
Sediment pollutant exposures caused hepatotoxicity and disturbed glycogenesis Open
Liver metabolic syndrome, which involves impaired hepatic glycogen synthesis, is persistently increased by exposure to environmental pollutants. Most studies have investigated the pathogenesis of liver damage caused by single metal species…
View article: Supercritical carbon dioxide-decellularized arteries exhibit physiologic-like vessel regeneration following xenotransplantation in rats
Supercritical carbon dioxide-decellularized arteries exhibit physiologic-like vessel regeneration following xenotransplantation in rats Open
ScCO 2 -decellularized artery graft having tremendous application in vascular regenerative medicine.It with physiological-like responses, including high potential of biocompatibility and long-term patency, lower risk of aneurysm after xeno…
View article: Antimicrobial Activity of P-113 against Bacterial Flora of the Human Oral Cavity
Antimicrobial Activity of P-113 against Bacterial Flora of the Human Oral Cavity Open
Periodontitis is a chronic disease associated with dental biofilm formation by bacteria. The primary clinical signs include plaque formation, gingivitis, gingival bleeding, and attachment loss. P-113, a 12-amino acid antimicrobial peptide,…
View article: Hypothyroidism Is Correlated with Ventilator Complications and Longer Hospital Days after Coronary Artery Bypass Grafting Surgery in a Relatively Young Population: A Nationwide, Population-Based Study
Hypothyroidism Is Correlated with Ventilator Complications and Longer Hospital Days after Coronary Artery Bypass Grafting Surgery in a Relatively Young Population: A Nationwide, Population-Based Study Open
Background: Some research indicated that hypothyroidism has huge adverse effects for the metabolic, cardiovascular, respiratory, and immune systems. However, there is no confirmed conclusion for the effect of cardiovascular surgery. This c…
View article: Extracorporeal Life Support and Temporary CentriMag Ventricular Assist Device to Salvage Cardiogenic-Shock Patients Suffering from Prolonged Cardiopulmonary Resuscitation
Extracorporeal Life Support and Temporary CentriMag Ventricular Assist Device to Salvage Cardiogenic-Shock Patients Suffering from Prolonged Cardiopulmonary Resuscitation Open
Background: The extracorporeal life support (ECLS) and temporary bilateral ventricular assist device (t-BiVAD) are commonly applied in patients with cardiogenic shock. Prolonged cardiopulmonary resuscitation (CPR) has poor prognosis. Herei…
View article: Far-Infrared Therapy Decreases Orthotopic Allograft Transplantation Vasculopathy
Far-Infrared Therapy Decreases Orthotopic Allograft Transplantation Vasculopathy Open
Orthotopic allograft transplantation (OAT) is a major strategy for solid heart and kidney failure. However, the recipient’s immunity-induced chronic rejection induces OAT vasculopathy that results in donor organ failure. With the exception…
View article: Restrictive cardiomyopathy caused by diffuse calcification of the left ventricle after 20 years of haemodialysis
Restrictive cardiomyopathy caused by diffuse calcification of the left ventricle after 20 years of haemodialysis Open
Valvular and vascular calcifications are common among patients with end-stage renal disease, but diffuse calcification of the left ventricle is rarely reported. We report on a rare case of restrictive cardiomyopathy resulting from severe m…
View article: Biodegradation of PBSA Films by Elite Aspergillus Isolates and Farmland Soil
Biodegradation of PBSA Films by Elite Aspergillus Isolates and Farmland Soil Open
Plastic films are widely used in current agricultural practices; however, most mulch films used are discarded and buried in the land after harvest, having adverse environmental impacts. To solve this environmental problem, the demand for b…
View article: Association between long-term usage of acetylcholinesterase inhibitors and lung cancer in the elderly: a nationwide cohort study
Association between long-term usage of acetylcholinesterase inhibitors and lung cancer in the elderly: a nationwide cohort study Open
View article: Efficacy of a temporary CentriMag ventricular assist device in acute fulminant myocarditis patients revived with extracorporeal cardiopulmonary resuscitation
Efficacy of a temporary CentriMag ventricular assist device in acute fulminant myocarditis patients revived with extracorporeal cardiopulmonary resuscitation Open
View article: CRISPR genome surgery in a novel humanized model for autosomal dominant retinitis pigmentosa
CRISPR genome surgery in a novel humanized model for autosomal dominant retinitis pigmentosa Open
View article: Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice
Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice Open
View article: Rhodium-Catalyzed Aerobic Conversion of 2-Diazo-1,3-Dicarbonyls to Vicinal Tricarbonyl Compounds and Their In-Situ Stability Toward Oxidative Degradation
Rhodium-Catalyzed Aerobic Conversion of 2-Diazo-1,3-Dicarbonyls to Vicinal Tricarbonyl Compounds and Their In-Situ Stability Toward Oxidative Degradation Open