Yitong Xu
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View article: A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY
A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY Open
Rationale: Atherosclerotic cardiovascular disease (ASCVD) represents the predominant cause of mortality and morbidity globally. Given the established role of hypercholesterolemia as a significant risk factor for ASCVD, the discovery…
View article: Tetraspanin 3 promotes NSCLC cell proliferation via regulation of β1 integrin intracellular recycling
Tetraspanin 3 promotes NSCLC cell proliferation via regulation of β1 integrin intracellular recycling Open
View article: BRCA1‐associated‐protein‐1 inactivated melanocytic tumours: characterisation of the clinicopathological spectrum and immunohistochemical expression pattern of preferentially expressed antigen in melanoma
BRCA1‐associated‐protein‐1 inactivated melanocytic tumours: characterisation of the clinicopathological spectrum and immunohistochemical expression pattern of preferentially expressed antigen in melanoma Open
Aims BRCA1‐associaed protein‐1 (BAP1) inactivated tumours (BIMT) are rare melanocytic tumours that may be mistaken for Spitz tumours or melanoma. They occur sporadically or in association with the BAP1 tumour predisposition syndrome (BAP1–…
View article: A novel mouse model of familial combined hyperlipidemia and atherosclerosis
A novel mouse model of familial combined hyperlipidemia and atherosclerosis Open
View article: SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury
SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury Open
Background Neuropathic pain (NP) is a kind of intractable pain. The pathogenesis of NP remains a complicated issue for pain management practitioners. SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2 (SPOCK2) are members of th…
View article: Fibroblast Upregulation of Vitamin D Receptor Represents a Self-Protective Response to Limit Fibroblast Proliferation and Activation during Pulmonary Fibrosis
Fibroblast Upregulation of Vitamin D Receptor Represents a Self-Protective Response to Limit Fibroblast Proliferation and Activation during Pulmonary Fibrosis Open
Dysregulation of vitamin D receptor (VDR) is implicated in chronic obstructive pulmonary disease. However, whether VDR dysregulation contributes to the development of pulmonary fibrosis remains largely unknown. Analysis of bulk and single-…
View article: P1595: ACTIVATION OF CHAPERONE-MEDIATED AUTOPHAGY REDUCES NLRP3 AND PLATELET CLEARANCE IN IMMUNE THROMBOCYTOPENIA
P1595: ACTIVATION OF CHAPERONE-MEDIATED AUTOPHAGY REDUCES NLRP3 AND PLATELET CLEARANCE IN IMMUNE THROMBOCYTOPENIA Open
Topic: 32. Platelet disorders Background: Chaperone-mediated autophagy (CMA) is an autophagy which selectively degrades chaperone labelled cargos in lysosomes to regulate critical functions of immune cells. The key protein of CMA is lysoso…
View article: S Table 3 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment
S Table 3 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment Open
Validation of gene array by qPCR of specific genes altered by PA and ER interventions
View article: S Table 2 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment
S Table 2 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment Open
Comparison of the number of splenocytes and splenic populations among the treatment groups at day 35 post-tumor implantation and when tumor were equal size
View article: S Table 2 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment
S Table 2 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment Open
Comparison of the number of splenocytes and splenic populations among the treatment groups at day 35 post-tumor implantation and when tumor were equal size
View article: S Table 3 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment
S Table 3 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment Open
Validation of gene array by qPCR of specific genes altered by PA and ER interventions
View article: Data from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment
Data from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment Open
Physical activity and the prevention of weight gain decrease breast cancer incidence and improve survival. Unraveling the biological mechanisms underlying these cancer prevention effects is difficult because activity and dietary restrictio…
View article: Data from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment
Data from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment Open
Physical activity and the prevention of weight gain decrease breast cancer incidence and improve survival. Unraveling the biological mechanisms underlying these cancer prevention effects is difficult because activity and dietary restrictio…
View article: S Table 1 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment
S Table 1 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment Open
comparison of age, body weight and tumor measurements among young and middle aged mice
View article: S Figure 1 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment
S Figure 1 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment Open
splenic B cells and F480 macrophages at days 7,14,21,28 and 35 post tumor implantation
View article: S Figure 2 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment
S Figure 2 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment Open
tumor immune infitrates
View article: S Figure 2 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment
S Figure 2 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment Open
tumor immune infitrates
View article: S Figure 1 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment
S Figure 1 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment Open
splenic B cells and F480 macrophages at days 7,14,21,28 and 35 post tumor implantation
View article: S Table 1 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment
S Table 1 from Physical Activity Plus Energy Restriction Prevents 4T1.2 Mammary Tumor Progression, MDSC Accumulation, and an Immunosuppressive Tumor Microenvironment Open
comparison of age, body weight and tumor measurements among young and middle aged mice
View article: Case report: Complete atrio-ventricular block successfully reversed in newly diagnosed primary cardiac B-cell lymphoma
Case report: Complete atrio-ventricular block successfully reversed in newly diagnosed primary cardiac B-cell lymphoma Open
Primary cardiac tumors are extremely uncommon and primary cardiac lymphoma (PCL) is an even rarer subset. A definite diagnosis can be delayed, which increases the likelihood of a poor prognosis. We report a case involving a 64-year-old mal…
View article: X-PuDu at SemEval-2022 Task 6: Multilingual Learning for English and Arabic Sarcasm Detection
X-PuDu at SemEval-2022 Task 6: Multilingual Learning for English and Arabic Sarcasm Detection Open
Detecting sarcasm and verbal irony from people's subjective statements is crucial to understanding their intended meanings and real sentiments and positions in social scenarios. This paper describes the X-PuDu system that participated in S…
View article: Upregulation of KLHL17 promotes the proliferation and migration of non-small cell lung cancer by activating the Ras/MAPK signaling pathway
Upregulation of KLHL17 promotes the proliferation and migration of non-small cell lung cancer by activating the Ras/MAPK signaling pathway Open
View article: Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms
Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms Open
Jinghui Wang,1 Yuhua Zhang,2 Meifeng Zhang,1 Si Sun,1 Yang Zhong,1 Lei Han,1 Yitong Xu,1 Dong Wan,3 Junhui Zhang,4 Huifeng Zhu1 1College of Pharmaceutical Sciences & College of Chinese Medicine, Southwest University, Chongqing, 400715, Peo…
View article: Autophagy In Human Lens Epithelial Cells: Comparative Age-Related Study Integrating Single-Cell Rna-Sequencing Data
Autophagy In Human Lens Epithelial Cells: Comparative Age-Related Study Integrating Single-Cell Rna-Sequencing Data Open
View article: X-PuDu at SemEval-2022 Task 6: Multilingual Learning for English and Arabic Sarcasm Detection
X-PuDu at SemEval-2022 Task 6: Multilingual Learning for English and Arabic Sarcasm Detection Open
Detecting sarcasm and verbal irony from people’s subjective statements is crucial to understanding their intended meanings and real sentiments and positions in social scenarios. This paper describes the X-PuDu system that participated in S…
View article: TBC1 domain family member 23 interacts with Ras‐related protein Rab‐11A to promote poor prognosis of non‐small‐cell lung cancer via β1‐integrin
TBC1 domain family member 23 interacts with Ras‐related protein Rab‐11A to promote poor prognosis of non‐small‐cell lung cancer via β1‐integrin Open
Non‐small‐cell lung cancer (NSCLC) accounts for approximately 80% of lung cancer cases. TBC1D23, a member of the TBC/RABGAP family, is widely expressed in human tissues; however, its role in NSCLC is currently unknown. Immunohistochemical …
View article: Tetraspanin 3, as a Novel Regulator of Intracellular β1 Integrin Recycling, Promotes Non-Small Cell Lung Cancer Cell Proliferation
Tetraspanin 3, as a Novel Regulator of Intracellular β1 Integrin Recycling, Promotes Non-Small Cell Lung Cancer Cell Proliferation Open
Background: The role of tetraspanins in cancer development has been widely reported. However, the expression and roles of tetraspanin 3 (TSPAN3) in solid tumors, including non-small cell lung cancer (NSCLC), have not yet been extensively i…
View article: KLHL38 involvement in non-small cell lung cancer progression via activation of the Akt signaling pathway
KLHL38 involvement in non-small cell lung cancer progression via activation of the Akt signaling pathway Open
View article: SPOCK2 Expression Correlates with Non-Small Cell Lung Cancer Proliferation, Invasion, and Tumorigenesis
SPOCK2 Expression Correlates with Non-Small Cell Lung Cancer Proliferation, Invasion, and Tumorigenesis Open
Purpose: Lung cancer is one of the leading causes of death worldwide. Sparc (osteonectin), cwcv, and Kazal-like domains proteoglycan 2 (SPOCK2) play important roles in the development and progression of various types of human cancers. Howe…
View article: Temporal Changes in Immune Responses within the Tumor Microenvironment in the 4T1.2-HER2 Mammary Tumor Model
Temporal Changes in Immune Responses within the Tumor Microenvironment in the 4T1.2-HER2 Mammary Tumor Model Open
Background: The murine 4T1.2 triple-negative breast cancer model is widely used, but is poorly immunogenic with no defined tumor-associated antigens. A modified 4T1.2 model has been developed that stably expresses a surrogate tumor antigen…