Explanipedia

Multi-omics investigation of Bisphenol A in gastrointestinal carcinogenesis: a network toxicology and molecular docking approach Open

Jiayun Guan, Ke Yang, Tianyang Chen, Z Li, Ya Gao , et al. · 2025

Our study aims to systematically investigate the potential carcinogenic mechanisms of bisphenol A (BPA) in three gastrointestinal tumors: intrahepatic cholangiocarcinoma (ICC), colorectal cancer (CRC), and esophageal cancer. By systematica…

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β <sub>2</sub> Adrenergic Receptors and Impedes Wound Healing Open

Lu Huang, Xinran Ye, Chiakang Ho, Ya Gao, Dongsheng Wen , et al. · 2025

Despite advances in glucose‐lowering therapies, many diabetic patients still suffer inflammation‐related complications such as chronic non‐healing wounds. The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is identified as a c…

RALOX-HAIC (raltitrexed + oxaliplatin) combined with lenvatinib improves survival and safety in elderly patients with unresectable hepatocellular carcinoma Open

Haohao Lu, Ya Gao, Xiangwen Xia, Qing Fu, Dongqiao Xiang · 2025

PKM2-mediated collagen XVII expression is critical for wound repair Open

Yang Liu, Chiakang Ho, Dongsheng Wen, Jiaming Sun, Yuxin Liu , et al. · 2025

Chronic wounds have emerged as a tough clinical challenge. An improved understanding of wound-healing mechanisms is paramount. Collagen XVII (COL17), a pivotal constituent of hemidesmosomes, holds considerable promise for regulating epider…

Decoding Microglial Polarization and Metabolic Reprogramming in Neurodegenerative Diseases: Implications for Disease Progression and Therapy Open

Ran Gao, Ya Gao, Wenting Su, Renxi Wang · 2025

As the resident macrophages of the brain, microglia are crucial immune cells specific to the central nervous system (CNS). They constantly surveil their surroundings and trigger immunological reactions, playing a key role in various neurod…

Piezo1 and tissue fibrosis: insights into its role and potential for modulation Open

Yuxin Lin, Dongsheng Wen, Kai Chen, Zizhong Hu, Chiakang Ho , et al. · 2025

Fibrosis is a pathological process marked by excessive extracellular matrix deposition, ultimately resulting in irreversible tissue damage. This aberrant process manifests across multiple organs, including the skin, lung, cardiovascular sy…

Associations of saccharin intake with all-cause, cardiovascular and cancer mortality risk in USA adults Open

Ya Gao, Li Yin, Yuntao Zhang, Xianzhi Li, Lin Liu · 2024

Saccharin is a widely used sugar substitute, but little is known about the long-term health effects of saccharin intake. Our study aimed to examine the association between saccharin intake and mortality in diabetic and pre-diabetic populat…

Combination of problem-based and team-based learning in clinical teaching of plastic and reconstructive surgery Open

Ya Gao, Chiakang Ho, Dongsheng Wen, Yang Liu, Qingfeng Li , et al. · 2024

Establishment and application of a fibrosis/scar biospecimen repository and systematic research platform Open

Zhiyuan Zhou, Ya Gao, Chiakang Ho, Dongsheng Wen, Yang Liu , et al. · 2024

Fibrosis is a pathological outcome of a dysregulated repair response to injury, which can occur in any organ and have devastating effects on hundreds of millions of patients worldwide. However, challenges remain in delineating the complex …

Identifying genes for regulating osteogenic differentiation of human periodontal ligament stem cells in inflammatory environments by bioinformatics analysis Open

Qing Wang, Xiaojie Yang, Xuechun Wang, Xuan Wang, Jie Zhang , et al. · 2023

Background and Objectives Periodontitis is an immuno‐inflammatory disease caused by dental plaque biofilms and inflammations. The regeneration of bone tissue in inflammatory environment is of great significance for the treatment of periodo…

Human Amniotic Membrane-Derived Mesenchymal Stem Cells Prevent Acute Graft-Versus-Host Disease in an Intestinal Microbiome-Dependent Manner Open

Xiaoyin Bu, Ya Gao, Weifeng Pan, Li‐Ping Liu, J Wang , et al. · 2023

Acute graft-versus-host disease (aGVHD) represents a fatal severe complication after allogeneic hematopoietic stem cell transplantation. As a promising cell therapeutic strategy of aGVHD, the mechanism of mesenchymal stem cells (MSC) to am…

Anti-PD-1 Therapy Reverses TIGIT + CD226 + NK Depletion in Immunotherapy Resistance of Hepatocellular Carcinoma through PVR/TIGIT Pathway Open

Jing Wang, Lin Yang, Yang Zhao, Songping Cui, Ya Gao , et al. · 2023

Background: Immunotherapy combined with targeted therapy significantly improved the prognosis of patients with hepatocellular carcinoma (HCC). Immunotherapy resistance conducts the main reason for the failure of PD-1-based immune checkpoin…

A gene feature based on histone modifications can predict the prognosis of prostate cancer Open

Xuee Zhou, Xiaolin Li, Jiahong Hong, Fuli Xie, Kuncai Liu , et al. · 2023

Background: Prostate cancer (PCa) is one of the most common malignant tumors in males, with a high recurrence rate and poor prognosis. Therefore, accurately predicting the prognosis of PCa patients and intervening as early as possible is o…

An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming Open

Mingxi Weng, Haoqing Hu, Matthew S. Graus, Daisylyn Senna Tan, Ya Gao , et al. · 2023

Advanced strategies to interconvert cell types provide promising avenues to model cellular pathologies and to develop therapies for neurological disorders. Yet, methods to directly transdifferentiate somatic cells into multipotent induced …

Identification of ferroptosis-related molecular subtypes and a methylation-related ferroptosis gene prognostic signature in cervical squamous cell carcinoma Open

Lijun Yu, Zhenwei Gao, Zeyu Li, Ping Liu, Ya Gao , et al. · 2023

Therapeutic Effects of HLA-G5 Overexpressing hAMSCs on aGVHD After Allo-HSCT: Involving in the Gut Microbiota at the Intestinal Barrier Open

Xiaoyin Bu, Weifeng Pan, J Wang, Liping Liu, Zhao Yin , et al. · 2023

We demonstrated that HLA-G might work with Tregs to create a regulatory network together to reduce the occurrence of aGVHD. HLA-G5 mediated hAMSCs to exert higher immunosuppressive properties in vivo and reverse the immune imbalance caused…

Matrix stiffness‐induced α‐tubulin acetylation is required for skin fibrosis formation through activation of Yes‐associated protein Open

Dongsheng Wen, Ya Gao, Yang Liu, Chiakang Ho, Jiaming Sun , et al. · 2023

Skin fibrosis, a pathological process featured by fibroblast activation and extracellular matrix (ECM) deposition, makes a significant contribution to morbidity. Studies have identified biomechanics as the central element in the complex ne…

Advancements in adipose-derived stem cell therapy for skin fibrosis Open

Yu-Xin Liu, Jiaming Sun, Chiakang Ho, Ya Gao, Dongsheng Wen , et al. · 2023

Pathological scarring and scleroderma, which are the most common conditions of skin fibrosis, pathologically manifest as fibroblast proliferation and extracellular matrix (ECM) hyperplasia. Fibroblast proliferation and ECM hyperplasia lead…

Extracellular matrix stiffness—The central cue for skin fibrosis Open

Kang Wang, Dongsheng Wen, Xuewen Xu, Rui Zhao, Feipeng Jiang , et al. · 2023

Skin fibrosis is a physiopathological process featuring the excessive deposition of extracellular matrix (ECM), which is the main architecture that provides structural support and constitutes the microenvironment for various cellular behav…

Human Amniotic Mesenchymal Stem Cells Alleviate aGVHD after allo-HSCT by Regulating Interactions between Gut Microbiota and Intestinal Immunity Open

Xiaoyin Bu, Junhui Wang, Zhao Yin, Weifeng Pan, Li‐Ping Liu , et al. · 2023

Acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation poses one of the most vexing challenges. Gut microbiota dysbiosis can proceed aGVHD and mesenchymal stem cells (MSCs) have promising therapeut…

Epigenetics as a versatile regulator of fibrosis Open

Yang Liu, Dongsheng Wen, Chiakang Ho, Yu Li, Danning Zheng , et al. · 2023

The homeodomain of Oct4 is a dimeric binder of methylated CpG elements Open

Daisylyn Senna Tan, Shun Lai Cheung, Ya Gao, Maike Weinbuch, Haoqing Hu , et al. · 2023

Oct4 is essential to maintain pluripotency and has a pivotal role in establishing the germline. Its DNA-binding POU domain was recently found to bind motifs with methylated CpG elements normally associated with epigenetic silencing. Howeve…

LRG‐1 promotes fat graft survival through the RAB31‐mediated inhibition of hypoxia‐induced apoptosis Open

Chiakang Ho, Danning Zheng, Jiaming Sun, Dongsheng Wen, Shan Wu , et al. · 2022

Autologous adipose tissue is an ideal soft tissue filling material, and its biocompatibility is better than that of artificial tissue substitutes, foreign bodies and heterogeneous materials. Although autologous fat transplantation has many…

Focusing on Mechanoregulation Axis in Fibrosis: Sensing, Transduction and Effecting Open

Dongsheng Wen, Ya Gao, Chiakang Ho, Yu Li, Yuguang Zhang , et al. · 2022

Fibrosis, a pathologic process featured by the excessive deposition of connective tissue components, can affect virtually every organ and has no satisfactory therapy yet. Fibrotic diseases are often associated with organ dysfunction which …

Application effect of different catheterization methods in patients with neurogenic bladder：A network meta-analysis Open

Mingming Niu, Ya Gao, Meili Yan, Li Zhang, Yan Zhang , et al. · 2022

Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair Open

Yang Liu, Chiakang Ho, Dongsheng Wen, Jiaming Sun, Lu Huang , et al. · 2022

The skin epidermis and appendages undergo ongoing renewal throughout life. Stem cells residing in the epidermis and hair follicles are pivotal for sustaining skin homeostasis. The self-renewal ability of stem cells significantly decreases …

HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation Open

Ya Gao, Yang Liu, Danning Zheng, Chiakang Ho, Dongsheng Wen , et al. · 2022

Transforming growth factor-β (TGF-β) signaling plays a key role in excessive fibrosis. As a class IIa family histone deacetylase (HDAC), HDAC5 shows a close relationship with TGF-β signaling and fibrosis. However, the effect and regulatory…

Establishment of Prognosis Model in Acute Myeloid Leukemia Based on Hypoxia Microenvironment, and Exploration of Hypoxia-Related Mechanisms Open

Jinman Zhong, Hang Wu, Xiaoyin Bu, Weiru Li, Shengchun Cai , et al. · 2021

Acute myeloid leukemia (AML) is a highly heterogeneous hematologic neoplasm with poor survival outcomes. However, the routine clinical features are not sufficient to accurately predict the prognosis of AML. The expression of hypoxia-relate…

Salvianolic acid-B improves fat graft survival by promoting proliferation and adipogenesis Open

Jiaming Sun, Chiakang Ho, Ya Gao, Chio-Hou Chong, Danning Zheng , et al. · 2021

Human Amniotic Mesenchymal Stem Cells Inhibit aGVHD by Regulating Balance of Treg and T Effector Cells Open

Ya Gao, Weiru Li, Xiaoyin Bu, Ying Xu, Shengchun Cai , et al. · 2021

The NPG murine environment was capable of activating human T cells to produce aGVHD pathology to mimic aGVHD as in humans. The hAMSCs controlled aGVHD by decreasing inflammatory cytokine secretion within target organs by modulating the bal…

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